what is first line treatment

What is the definition of first line therapy?

first-line therapy (... THAYR-uh-pee) The first treatment given for a disease. It is often part of a standard set of treatments, such as surgery followed by chemotherapy and radiation. When …

What is first line of therapy?

first-line treatment The initial, preferred, or best treatment for a disease. It is often the therapy that combines the best efficacy with the best safety profile and/or the lowest cost. Synonym: first-line therapy Medical Dictionary, © 2009 Farlex and Partners Want to thank TFD for its existence?

What is the best first line of treatment for hypertension?

First line therapy is the treatment regimen or regimens that are generally accepted by the medical establishment for initial treatment of a given type and stage of cancer. It is also called primary treatment or therapy. The intent of first-line therapy is to cure the cancer if possible.

What is first-line chemotherapy?

First-line treatment of essential hypertension: A real-world analysis across four antihypertensive treatment classes Abstract The relative efficacy of antihypertensive treatment has been assessed primarily by randomized clinical trials (RCTs).

What is the difference between first-line and second line treatment?

Second-line treatment is treatment for a disease or condition after the initial treatment (first-line treatment) has failed, stopped working, or has side effects that aren't tolerated.Jun 9, 2020

What is 2nd line therapy?

Treatment that is given when initial treatment (first-line therapy) doesn't work, or stops working.

What does line of treatment mean?

“Lines of therapy” is the term used to describe the order in which different therapies are given to people as their disease progresses.May 5, 2021

What is first-line and second line drugs?

First-line antituberculosis drugs- Isoniazid (INH), rifampicin (RIF), ethambutol (EMB), pyrazinamide (PZA) and streptomycin (SM). Second-line antituberculosis drugs- Sub divided into two. Fluoroquinolones- Ofloxacin (OFX), levofloxacin (LEV), moxifloxacin (MOX) and ciprofloxacin (CIP).

What is first-line and second line chemotherapy?

How well your treatment works often varies. Your first-line treatment may not work, may start but then stop working, or may cause serious side effects. Your doctor may then suggest a second-line treatment, also called second-line therapy. It is a different treatment that is likely to be effective.

What is a first-line antibiotic?

Amoxicillin or amoxicillin/clavulanate is the recommended first-line therapy. Macrolides such as azithromycin are not recommended due to high levels of Streptococcus pneumoniae antibiotic resistance (~40%).

Is adjuvant therapy first-line?

Adjuvant therapy is any type of therapy that follows the primary treatment. So, adjuvant chemotherapy takes place after you've had first-line treatment, such as surgery to remove a cancerous tumor.Mar 10, 2021

How long does it take for a tumor to shrink after radiation?

For tumors that divide slowly, the mass may shrink over a long, extended period after radiation stops. The median time for a prostate cancer to shrink is about 18 months (some quicker, some slower).

Why is DTG used in HIV treatment?

NOTE OF CAUTION The organisation says it is updating its HIV therapy guidelines to strengthen its recommendation for dolutegravir (DTG) drug as the first-line treatment because of its efficacy, tolerability and a high genetic barrier to resistance. WHO recommends once feared drug to treat HIV.

Is Palbociclib a first line treatment?

Pfizer's NDA for palbociclib, in combination with letrozole, has been accepted for filing and granted Priority Review by the FDA as a first-line treatment for postmenopausal women with estrogen receptor positive (ER+), human epidermal growth factor receptor 2 negative (HER2-) advanced breast cancer who have not received previous treatment.

What is the first line of treatment?

First line therapy is the treatment regimen or regimens that are generally accepted by the medical establishment for initial treatment of a given type and stage of cancer. It is also called primary treatment or therapy. The intent of first-line therapy is to cure the cancer if possible. Also called induction therapy, this primary therapy is the first assault of chemotherapy drugs on the malignancy.

What happens if older drugs don't work?

The idea is that if the older drugs and regimens used don’t work, there is less to lose by using the new drug. After years of experience and many patients treated with the new drug, the manufacturer may ask the FDA to expand the labeling to include first-line treatment and/or treatment on other forms of cancer.

What is the intent of first line therapy?

The intent of first-line therapy is to cure the cancer if possible. Also called induction therapy, this primary therapy is the first assault of chemotherapy drugs on the malignancy.

What is second line therapy?

Second-line therapies are those tried when the first ones do not work adequately. The management of a cancer case requires regular evaluation of treatment and adjustment as needed. A break with the primary treatment and an adoption of a new regimen signals “second-line treatment.”.

Can oncologists use third line therapy?

Of course, oncologists still have the freedom to use these drugs for first-line treatment also; the drugs are just “labeled” for second-line treatment, and some insurance companies may not pay for them when used as first-line. The terms “third-line therapy” and even “fourth-line therapy” are occasionally used for subsequent treatment, ...

Is salvage therapy considered third line therapy?

The terms “third-line therapy ” and even “fourth-line therapy” are occasionally used for subsequent treatment, but salvage therapy is also used. Written guidelines rarely specify anything beyond second-line therapy. The same treatments can be used for subsequent treatment.

Can a first line therapy be approved for second line therapy?

Sometimes first-line therapies show progress for a period of time followed by a stalling or continued growth of the cancer. Often the FDA will specifically approve a new drug for second-line therapy. This labeling is common for new drugs that treat cancers which already have accepted treatments.

What are the best asthma medications?

These medicines are well accepted by the medical community. For asthma, they include systemic corticosteroids like Flovent, Asmanex, and Qvar. They include combination inhalers like Advair, Symbicort, Dulera, and Breo. These medicines are the first choices doctors will prescribe when trying to help you obtain better asthma control.

What makes a drug first line?

What makes a drug first-line? These are the medicines doctors first resort to for a given disease (the doctors first choice try). They are the most commonly prescribed medicines for a particular disease. These medicines are well accepted by the medical community. For asthma, they include systemic corticosteroids like Flovent, Asmanex, and Qvar.

Is albuterol safe for asthma?

They have both been well studied. They are proven safe and effective for asthma. Albuterol ends asthma attacks and Advair prevents them. Side effects are minimal. You can tolerate or easily treat side effects if they occur. Side effects to albuterol and Advair are considered negligible.

Can albuterol cause thrush?

Both medicines may cause tremors, but it’s often considered a good trade-off for being able to breathe. Advair may cause thrush. But, it’s both preventable by rinsing and treatable. It’s cost effective.

Is Atrovent a first line asthma medicine?

Atrovent was once-upon-a-time considered a first-line asthma medicine. It fit all the qualifications of one. But, subsequent studies did not show it benefited most asthmatics. Studies do show, however, that it does help most COPDers. So, it remains a first-line treatment for COPD.

Does Advair keep you awake?

It opened airways and kept them open. But, it also had some unwanted side effects, such as it kept you awake, like coffee does . The advent of combination inhalers like Advair made it so most asthmatics could be weaned off theophylline. This helped to relegate Advair to first-line status.

Do corticosteroids work for asthma?

There’s a greater risk for side effects. Systemic corticosteroids fit nicely into this category. They work great for ending asthma attacks and controlling asthma. But, the risk for side effects is too great. So, they sit as second-line treatments ready to be prescribed if and when needed. It’s not cost effective.

What antibiotics are used for UTI?

Other antibiotics used to treat UTI include: 1 Beta-lactams, including penicillins and cephalosporins ( amoxicillin, Augmentin, Keflex, Duricef, Ceftin, Lorabid, Rocephin, Cephalexin, Suprax and others). Many organisms have shown resistance to some of these drugs. 2 Trimethoprim-sulfamethoxazole combination antibiotic (Bactrim DS and Septra DS). Many organisms have shown resistance to some of these drugs. 3 Fluoroquinolones ( Cipro, Levaquin and Floxin). The risk of antibiotic resistance to this is developing. These should not be given to pregnant women or children. 4 Tetracyclines (Sumycin, Vibramycin or Minocin) are used for Mycoplasma or Chlamydia infections. These should not be given to pregnant women or children. 5 Aminoglycosides (gentamicin, amikacin and tobramycin) are usually used in combination with other antibiotics to treat severe UTIs. 6 Macrolides ( clarithromycin, azithromycin and erythromycin) are often used to treat urinary problems caused by sexually transmitted diseases. 7 Fosfomycin ( Monurol) is a synthetic phosphonic acid derivative and used for acute cystitis but not for more complicated UTIs.

What are the symptoms of a UTI in a child?

Urinary Tract Infections in Children. Urinary tract infections (UTIs) are very common in children. Symptoms and signs include fever and abdominal pain. Associated symptoms and signs include flank pain, vomiting , and blood in the urine. Treatment for a UTI involves antibiotic therapy.

How much is Cefdinir?

Cefdinir (Omnicef) 300 mg twice daily for 10 days. $40 ($119) Cefpodoxime. 100 mg twice daily for 7 days. $71 (NA) Since there is a lower chance of antibiotic resistancewith nitrofurantoin and fosfomycin as compared to other classes of antibiotics, they are often used as first-line antibiotics for the treatment of UTI.

What is the UTI in the urinary tract?

Urinary Tract Infection (UTI) A urinary tract infection (UTI) is an infection of the bladder, kidneys, ureters, or urethra. E. coli, a type of bacteria that lives in the bowel and near the anus, causes most UTIs. UTI symptoms include pain, abdominal pain, mild fever, urinary urgency and frequency.

How many tubes are there in the urinary system?

Urinary Tract Infection or Urinary Infection. The urinary system of your body includes two kidneys, two tubes (ureters), a urine sac (bladder) and an opening to expel the urine from the body (urethra).

Can pregnant women take fluoroquinolone?

Fluoroquinolones (Cipro, Levaquinand Floxin). The risk of antibiotic resistance to this is developing. These should not be given to pregnantwomen or children. Tetracyclines (Sumycin, Vibramycinor Minocin) are used for Mycoplasma or Chlamydiainfections.

What is the first line of treatment for type 2 diabetes?

Keywords: first-line therapy, metformin, type 2 diabetes. Introduction. Metformin is a biguanide that is used as first-line treatment of type 2 diabetes mellitus and is effective as monotherapy and in combination with other glucose-lowering medications.

What is metformin used for?

Within a year, metformin was prescribed in Europe for the treatment of type 2 diabetes mellitus, and Sterne dubbed the drug “glucophage” for its perceived ability to devour blood glucose.3.

Is metformin a monotherapy?

Metformin is a biguanide that is used as first-line treatment of type 2 diabetes mellitus and is effective as monotherapy and in combination with other glucose-lowering medications. It is generally well-tolerated with minimal side effects and is affordable.

What is the first line of treatment for acne vulgaris?

First-line treatment for severe acne vulgaris includes an oral antibiotic, benzoyl peroxide, and a topical antibiotic (erythromycin or clarithromycin), topical retinoid, or both. Oral isotretinoin can also be considered as a first-line option. Alternative treatment options to consider include changing the oral antibiotic;

What is the best treatment for acne?

Azelaic acid (Finacea) can be used to manage dyspigmentation that occurs with inflammatory acne. For acne in children who have not reached adolescence, topical adapalene (Differin), tretinoin (Retin-A), and benzoyl peroxide are safe to use.

What antibiotics are used for acne?

Moderate to severe acne, as well as inflammatory acne in which topical medications have been ineffective, can be treated with systemic antibiotics. Data are limited regarding the use of antibiotics that are not tetracyclines or macrolides; therefore, their use should be avoided. Doxycycline and minocycline (Minocin) have been shown to be more effective than tetracycline. Oral erythromycin and azithromycin (Zithromax) should be used only in patients in whom tetracyclines are contraindicated (e.g., pregnant women, children younger than eight years), but erythromycin use should be limited given its associated drug resistance. Trimethoprim/sulfamethoxazole or trimethoprim should be used only in patients who cannot take tetracyclines or in whom tetracyclines have been ineffective.

Understanding First-Line Treatment

See more on verywellhealth.com

Questions to Ask

Alternative and Complementary Treatments