Precautions
It is used to lower the number of lung infections and help lung function in cystic fibrosis. What do I need to tell my doctor BEFORE I take Dornase Alfa? If you have an allergy to dornase alfa or any other part of dornase alfa.
What is Dornase alfa used to treat?
Possible side effects of dornase alpha. Most common. Change in voice. Runny nose. Sore throat. Eye irritation.
What are the side effects of Dornase Alpha?
Other inhaled medicines may be used in a clean nebulizer before or after your treatment with dornase alfa. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine.
Can I use other inhaled medicines with Dornase alfa?
Dornase alfa should be used with the eRapid™ nebulizer system or a jet nebulizer that is connected to an air compressor. An air compressor is used with a nebulizer to turn the medicine into a fine spray. You will breathe in the spray through your mouth. Use the mouthpiece of the nebulizer to breathe in Pulmozyme®.
How do you use Dornase alfa nebulizer?
What does dornase alfa do?
Dornase alfa inhalation solution is used together with other medicines (eg, antibiotics, bronchodilators, and steroids) to control symptoms of cystic fibrosis. Cystic fibrosis is a condition in which a thick mucus is formed in the lungs and breathing passages.
When should I take dornase alfa?
Directions for administration For dornase alfa Expert sources advise usually once daily at least 1 hour before physiotherapy.
What are the side effects of dornase alfa?
Common side effects of Pulmozyme include:sore/dry throat and hoarseness,eye redness and irritation,rash,laryngitis,eye inflammation, or.runny or stuffy nose.
What type of drug is Dornase?
EnzymeDornase alfa / ClassificationEnzymes are proteins that act as biological catalysts. Catalysts accelerate chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Wikipedia
Is Dornase Alfa an antibiotic?
Dornase alfa is used to reduce the number of lung infections and to improve lung function in patients with cystic fibrosis. It breaks down the thick secretions in the airways, allowing air to flow better and preventing bacteria from building up.
How is Dornase alfa administered?
Dornase alfa should be used with the eRapid™ nebulizer system or a jet nebulizer that is connected to an air compressor. An air compressor is used with a nebulizer to turn the medicine into a fine spray. You will breathe in the spray through your mouth.
How effective is Dornase Alfa?
Measurements and results: Dornase alfa improved the mean percent change in FEV1 from baseline by 9.4% compared with 2.1% for placebo (p < 0.001). The actively treated group showed a 12.4% improvement in FVC compared with 7.3% for placebo (p < 0.01).
What is another name for Dornase?
PULMOZYME® (dornase alfa) is indicated for daily administration in conjunction with standard therapies for the management of cystic fibrosis (CF) patients to improve pulmonary function.
What drug class is Dornase Alfa?
EnzymeDornase alfa / Classification
Is dornase alfa a mucolytic?
Dornase alfa (Pulmozyme®) is an inhaled medication that thins mucus. Sometimes referred to as a mucolytic or DNase, dornase alfa acts like scissors by cutting up the long DNA strands contained in white blood cells.
Who makes dornase alfa?
An aerosolised solution of dornase alfa has been developed by Genentech (Roche) for the treatment of patients with cystic fibrosis. It has been approved approximately in 70 countries, including the US and Europe.
What drugs should not be taken with theophylline?
Examples of drugs not found to have a significant effect on theophylline pharmacokinetics are ranitidine, josamycin, midecamycin, amoxycillin, tetracycline, cephalexin, cefaclor, orciprenaline, metoprolol, antacids, medroxyprogesterone acetete, metoclopramide, and metronidazole.
How to administer dornase alfa?
Dornase alfa is administered by inhalation using a recommended nebulizer. Your doctor or other healthcare provider will give you detailed instructions on the use and maintenance of the nebulizer. Do not dilute or mix the dornase alfa solution with any other drugs in the nebulizer.
What are the side effects of Dornase Alfa?
If you experience any of the following serious side effects while taking dornase alfa, seek emergency medical attention or contact your doctor immediately: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives ); increased difficulty breathing; chest pain; or.
What is the purpose of dronase alfa?
Dornase alfa is a synthetic protein that breaks down excess DNA in the pulmonary secretions of people with cystic fibrosis. Dornase alfa is used to improve lung function in people with cystic fibrosis by thinning pulmonary secretions and reducing the risk of respiratory tract infections. Dornase alfa may also be used for purposes other ...
Can you use Dornase Alfa on cloudy ampules?
Do not use any dornase alfa solution that is cloudy or discolored. Throw away any unused dornase alfa on the expiration date stamped on the ampule. Dornase alfa should be used on a regular basis to get the most benefit.
Can you mix dornase alfa with other drugs?
Mixing of dornase alfa with other drugs could lead to changes in the actions of the medications. If you are also taking other respiratory medications, use them in the order directed by your doctor (e.g., a bronchodilator, followed by chest physiotherapy, then dornase alfa, etc.)
Is dornase alfa harmful to babies?
Dornase alfa is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether dornase alfa passes into breast milk.
Can you take Dornase Alfa with Chinese Hamster Ovary?
Before taking this medicine. Do not use dornase alfa if you have had an allergic reaction to it or to other Chinese Hamster Ovary cell products. Before using dornase alfa, tell your doctor if you have any other medical conditions or if you take other prescription or over-the-counter medicines.
What to tell your doctor before taking Dornase Alfa?
tell your doctor and pharmacist what prescription and nonprescription medications you are taking, including vitamins. tell your doctor if you are pregnant , plan to become pregnant , or are breast-feeding.
Can you stop using dornase alfa?
Continue to use dornase alfa even if you feel well. Do not stop using dornase alfa without talking to your doctor. Before you use dornase alfa the first time, read the written instructions that come with it. Ask your doctor, pharmacist, or respiratory therapist to demonstrate the proper technique.
Can you take dornase alfa with cystic fibrosis?
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use dornase alfa exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor. Dornase alfa is used to treat cystic fibrosis but does not cure it.
Can you dilute dornase alfa?
Your doctor may order certain lab tests to check your response to dornase alfa. Do not dilute or mix dornase alfa with other drugs in the nebulizer. Inhalation devices require regular cleaning. Follow the manufacturer's written instructions for the care of the nebulizer. Do not let anyone else use your medication.
What is Dornase Alfa used for?
Dornase alfa inhalation solution is used together with other medicines (eg, antibiotics, bronchodilators, and steroids) to control symptoms of cystic fibrosis. Cystic fibrosis is a condition in which a thick mucus is formed in the lungs and breathing passages.
Does Dornase Alfa help with cystic fibrosis?
Dornase alfa will not cure cystic fibrosis. However, when it is used every day, it helps make breathing easier and reduces the number of serious lung infections that require treatment with antibiotics. This medicine is available only with your doctor's prescription.
Can you use dornase alfa inhalation solution?
To do so may cause your lung condition to become worse. To use: Dornase alfa inhalation solution comes in small plastic containers called ampules. Each ampule contains one full dose of dornase alfa. Do not use an ampule that has already been opened.
Can you use Dornase Alfa with a nebulizer?
Dornase alfa should be used with the eRapid™ nebulizer system or a jet nebulizer that is connected to an air compressor. An air compressor is used with a nebulizer to turn the medicine into a fine spray. You will breathe in the spray through your mouth. Use the mouthpiece of the nebulizer to breathe in Pulmozyme®.
How to store Pulmozyme
Pulmozyme should be refrigerated (2°C to 8°C/36°F to 46°F) in the protective foil to protect from light
Establishing regular routines for CF treatments early can pay off later
Set small goals —like taking Pulmozyme daily—to help you stay on track
Special considerations for Parents & Caregivers
It’s important to help your child develop healthy ways of dealing with any problems they may have. As children with CF get older, they seek more independence. Establishing clear communication with consistent treatment routines can smooth the transition from childhood to adulthood. Here are some ways you can help.
What is dornase alpha?
Dornase alfa, also called Pulmozyme®, is a medicine for cystic fibrosis. It can lower the number of lung infections you have. It can also help your lungs work better. Your doctor might also give you dornase alfa for another condition. Your doctor can explain why you need this medicine.
How to take dornase alpha
Your nurse, doctor, or respiratory therapist will show you how to use dornase alfa in your nebulizer machine. You will also learn how to clean the machine before and after using it.
Special instructions for dornase alpha
Do not put any other medicine in the nebulizer with dornase alfa. Wash your hands with soap and water before you get the dose ready to use.
Medical uses
This medication is used to improve breathing and reduce the risk of lung infections in people with cystic fibrosis. It is used along with other treatments for this disease (e.g., chest physical therapy, medications, nutritional supplements).
May Treat: Respiratory cystic fibrosis
Brand Names: Pulmozyme
Drug Class: Mucolytics
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: Consult a doctor before using
- Know how to use before taking.
- Read directions carefully before start of therapy
- Use in nebulizer with adequate flow rate
- Know how to use before taking.
- Read directions carefully before start of therapy
- Use in nebulizer with adequate flow rate
- Use at the same time(s) daily as directed.
- Don't use if solution has particles or color change
- Do not take more than package label recommends
- Do not stop medicine without calling doctor
- Store in the refrigerator Do not freeze
Administration
Risks
Prevention
Diagnosis
- Dornase alfa is used to reduce the number of lung infections and to improve lung function in patients with cystic fibrosis. It breaks down the thick secretions in the airways, allowing air to flow better and preventing bacteria from building up.
Preparation
- Dornase alfa comes as a solution to inhale by mouth. It usually is taken one or two times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use dornase alfa exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.