Is docetaxel a strong chemotherapy?
Because the active ingredient, docetaxel, is a strong chemotherapy drug, it also has a long list of side effects. Most of them are typical for drugs in this class, such as nausea, vomiting and temporary alopecia (hair loss).
What is the success rate of docetaxel?
Combination of docetaxel with one other antineoplastic resulted in objective response rates of 20 to 54% in chemotherapy-naive patients; triple chemotherapy combinations produced responses in 51 and 60% of patients.
How long can you live with docetaxel?
The median overall survival (OS) was 81 months with docetaxel plus standard of care (hormonal therapy with or without radiotherapy) versus 71 months with standard of care alone (0.78; 95% CI, 0.66-0ยท93;P= . 006).
What cancer is docetaxel used for?
Descriptions. Docetaxel injection is used to treat advanced or metastatic (cancer that has spread) breast cancer in patients who have previously received other cancer medicines that did not work well.
Do you always lose your hair with docetaxel?
Docetaxel causes hair loss. Most people will lose all their hair, including eyebrows, eyelashes and body hair. You may begin to lose your hair about two weeks after the first treatment, but it can happen earlier.
What is the most common side effect of docetaxel?
The most common adverse reactions across all TAXOTERE indications are infections, neutropenia, anemia, febrile neutropenia, hypersensitivity, thrombocytopenia, neuropathy, dysgeusia, dyspnea, constipation, anorexia, nail disorders, fluid retention, asthenia, pain, nausea, diarrhea, vomiting, mucositis, alopecia, skin ...
How good is docetaxel?
a 9% absolute improvement in overall survival with docetaxel compared with ADT alone (49% compared with 40%, p<0.0001, number needed to treat [NNT] 12) a 16% absolute improvement in time to disease progression with docetaxel compared with ADT alone (treatment failure 64% compared with 80%, p<0.0001, NNT 7).
How many cycles of docetaxel can you have?
In a clinical trial of docetaxel for CRPC, the frequencies of PN were 32% [1] (maximum 10 cycles) and 41% (maximum 12 cycles) [17]. Considering the results of the present study, the incidence of PN with docetaxel is higher in patients with CRPC than in those with other cancers.
What is after docetaxel?
In 2011, the hormonal agent abiraterone was also reported to improve survival in patients previously treated with docetaxel. Both cabazitaxel and abiraterone are now approved for use in Canada for the treatment of mCRPC that has progressed during or after docetaxel-based chemotherapy.
What If docetaxel does not work?
Types of Chemotherapy Drugs If docetaxel does not work or stops working, cabazitaxel (Jevtana) may be used.
How long does it take to administer docetaxel?
Each treatment takes about an hour and you have it once every 3 weeks.
How is docetaxel given?
Docetaxel is given through a vein (intravenously, IV) There is no pill form of docetaxel. Premedication with a corticosteroid pill starting a day prior to docetaxel infusion for 3 days is given to reduce the severity of fluid retention and allergic reactions. Your doctor will prescribe the exact regimen.