When is diphenoxylate hydrochloride and atropine sulfate indicated for the treatment of diarrhea?
Diphenoxylate-Atropine - Uses, Side Effects, and More Uses This medication is used to treat diarrhea. It helps to decrease the number and frequency of bowel movements. It …
How many mg of diphenoxylate and atropine are in a tablet?
diphenoxylate-atropine 2.5 mg-0.025 mg tablet. ... Diphenoxylate is similar to opioid pain relievers, but it acts mainly to slow the gut. Atropine belongs to a class of drugs known as anticholinergics, which help to dry up body fluids and also slow gut movement. ... In children, the dosage is also based on weight. If you need to continue ...
What is atropine used for?
Feb 08, 2021 · Diphenoxylate hydrochloride and atropine sulfate is classified as a Schedule V controlled substance by federal regulation. Diphenoxylate hydrochloride is chemically related to the narcotic analgesic meperidine. Drug abuse and dependence In doses used for the treatment of diarrhea, whether acute or chronic, diphenoxylate has not produced addiction.
What is Lomotil (diphenoxylate/atropine)?
Nov 17, 2021 · Diphenoxylate hydrochloride/atropine sulfate combination is available as the fixed-dose composition of 2.5 mg/0.025 mg. Diphenoxylate/atropine is available in both tablet and liquid preparation. Only the liquid preparation can …
What is the drug atropine used for?
Atropine is a prescription medicine used to treat the symptoms of low heart rate (bradycardia), reduce salivation and bronchial secretions before surgery or as an antidote for overdose of cholinergic drugs or mushroom poisoning. Atropine may be used alone or with other medications.
Does diphenoxylate atropine relieve pain?
Why is Lomotil (diphenoxylate / atropine) a controlled substance? Lomotil (diphenoxylate / atropine) is a controlled medication, because it contains diphenoxylate, which is an opioid medication. At smaller doses, it's used to treat diarrhea and does not cause pain-relieving effects like morphine at recommended doses.
What does atropine do to the heart?
Abstract. The use of atropine in cardiovascular disorders is mainly in the management of patients with bradycardia. Atropine increases the heart rate and improves the atrioventricular conduction by blocking the parasympathetic influences on the heart.
What is the use of diphenoxylate hydrochloride and atropine sulfate?
This medication is used to treat diarrhea. It helps to decrease the number and frequency of bowel movements. It works by slowing the movement of the intestines. Diphenoxylate is similar to opioid pain relievers, but it acts mainly to slow the gut.
How does diphenoxylate atropine make you feel?
Drowsiness, dizziness, headache, tiredness, blurred vision, dry mouth, and loss of appetite may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Does atropine make you sleepy?
This medicine may cause drowsiness, blurred vision, or make your eyes sensitive to light. Wear sunglasses while you are using this medicine. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Do not drive until your pupils are no longer dilated.Feb 1, 2022
Is atropine a blocker?
Atropine, which is on the WHO List of Essential Medicines, is a non-selective muscarinic receptor inhibitor used to treat acute sinus node dysfunction associated with bradycardia, complete atrioventricular block, and organophosphate and beta-blocker poisoning.Nov 9, 2017
What does atropine do to BP?
Atropine in clinical doses counteracts the peripheral dilatation and abrupt decrease in blood pressure produced by choline esters. However, when given by itself, atropine does not exert a striking or uniform effect on blood vessels or blood pressure.
Does atropine slow the heart?
Low-dose atropine slows heart rate but does not change overall levels of MSNA. High-dose atropine causes a decrease in MSNA and tachycardia.
Does atropine help with nausea?
Atropine to Prevent Nausea and Vomiting After Spinal Anesthesia for Caesarean Section.Jun 16, 2009
How long does it take for atropine to work?
Usually atropine drops take about 1 hour to work. The exact time varies for each child. Blue eyes are more sensitive to the medication and dilate faster than brown eyes.
Is Lomotil good for stomach pain?
Lomotil Tablet is a medication used to treat diarrhea. It manages symptoms of diarrhea such as stomach pain, cramping, and loose stools. Lomotil Tablet is taken with or without food at the dose and duration recommended by the doctor.
Why is Lomotil (diphenoxylate / atropine) a controlled substance?
Lomotil (diphenoxylate / atropine) is a controlled medication, because it contains diphenoxylate, which is an opioid medication. At smaller doses,...
Are loperamide (Imodium) and Lomotil (diphenoxylate / atropine) the same?
No, loperamide (Imodium) and Lomotil (diphenoxylate / atropine) are two different medications that can both be used for diarrhea. One of the bigges...
How many Lomotil (diphenoxylate / atropine) tablets can I take in a day?
The maximum dose for adults is 20 mg of diphenoxylate per day. Each tablet has 2.5 mg of diphenoxylate, so 20 mg is equivalent to 8 tablets a day.
What happens if I take too much Lomotil (diphenoxylate / atropine)?
It's possible to overdose on Lomotil (diphenoxylate / atropine) and the result can be life-threatening. Symptoms can include slow breathing, coma,...
Can I get addicted to Lomotil (diphenoxylate / atropine), since it's a controlled substance?
Lomotil (diphenoxylate / atropine) is used in smaller doses to treat diarrhea, so when used correctly, it doesn't cause morphine-like effects or ca...
What is the difference between lomotil and diphenoxylate?
This medication is used to treat diarrhea. It helps to decrease the number and frequency of bowel movements. It works by slowing the movement of the intestines. Diphenoxylate is similar to opioid pain relievers, but it acts mainly to slow the gut.
What to do if you have dehydration?
You may also need to change to a bland diet during this time to reduce irritation to your stomach/intestines. Consult your doctor or pharmacist for more information.
How often should I take a sulfate sulfate?
How to use. Take this medication by mouth, usually 4 times a day or as directed by your doctor. The dosage is based on your medical condition and response to treatment. In children, the dosage is also based on weight.
Can marijuana make you dizzy?
Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely.
What happens if you stop taking a med?
If you suddenly stop using this medication, you may have withdrawal symptoms (such as stomach cramps, nausea, vomiting). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used this medication for a long time or in high doses.
Can Down's syndrome cause fatalities?
Children, particularly those with Down's syndrome, may be more sensitive to the side effects of this drug. Very serious (possibly fatal) effects may occur if too much of this medication is taken by children. During pregnancy, this medication should be used only when clearly needed.
What are the symptoms of overdose in Canada?
Symptoms of overdose may include: severe drowsiness, muscle weakness, fast heartbeat, high fever, unusually fast/slow/irregular breathing, seizures, loss of consciousness. Do not share this medication with others. Sharing it is against the law.
What is diphenoxylate hydrochloride?
Diphenoxylate hydrochloride and atropine sulfate is recommended as adjunctive therapy for the management of diarrhea in patients 13 years of age and older. Consider the nutritional status and degree of dehydration in patients prior to initiating therapy with Diphenoxylate hydrochloride and atropine sulfate.
What is the best medicine for respiratory depression?
A pure narcotic antagonist (e.g., naloxone) should be used in the treatment of respiratory depression caused by Diphenoxylate hydrochloride and atropine sulfate. Refer to the prescribing information for naloxone.
What drugs cause CNS depression?
Other Drugs that Cause CNS Depression. The concurrent use of Diphenoxylate hydrochloride and atropine sulfate with other drugs that cause CNS depression (e.g., barbiturates, benzodiazepines, opioids, buspirone, antihistamines, muscle relaxants), may potentiate the effects of Diphenoxylate hydrochloride and atropine sulfate (see WARNINGS ).
Is atropine sulfate toxic?
Toxicities associated with the atropine and diphenoxylate components of Diphenoxylate hydrochloride and atropine sulfate have been reported. The initial presenting symptoms may be delayed by up to 30 hours due to prolonged gastric emptying time induced by diphenoxylate hydrochloride.
Is diphenoxylate hydrochloride safe for diarrhea?
Diphenoxylate Hydrochloride and Atropine Sulfate is contraindicated in patients with diarrhea associated with organisms that penetrate the GI mucosa (toxigenic E. coli, Salmonella, Shigella ), and pseudomembranous enterocolitis ( Clostridium difficile) associated with broad-spectrum antibiotics (see CONTRAINDICATIONS ).
Does diphenoxylate cause dizziness?
Diphenoxylate hydrochloride may potentiate the action of other drugs that cause dizziness or drowsiness, including barbiturates, benzodiazepines and other sedatives/hypnotics, anxiolytics, and tranquilizers, muscle relaxants, general anesthetics, antipsychotics, other opioids, and alcohol.
Does alcohol cause depression?
Alcohol. Alcohol may increase the CNS depressant effects of Diphenoxylate hydrochloride and atropine sulfate and may cause drowsiness (see WARNINGS ). Avoid concomitant use of Diphenoxylate hydrochloride and atropine sulfate with alcohol. Other Drugs that Cause CNS Depression.
What to do if you miss a dose of a sulfate sulfate?
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
What is the best medicine for diarrhea?
Diphenoxylate and atropine combination is used along with other measures (eg, fluid and electrolyte treatment) to treat severe diarrhea. Diphen oxylate helps stop diarrhea by slowing down the movements of the intestines.
Does alcohol affect the CNS?
The use of alcohol or other medicines that affect the CNS with diphenoxylate and atropine combination may worsen the side effects of this medicine , such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping.
How to store a med?
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use.
Can you take two different meds together?
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
How long does diarrhea last after taking a sulfate supplement?
Diarrhea usually stops 2 days after treatment with this medicine. If your symptoms do not improve or if they get worse within 10 days of treatment, check with your doctor. This medicine may cause serious stomach or bowel problems (eg, toxic megacolon). This is more likely if you also have ulcerative colitis.
Can you take a medicine with food?
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
What is the difference between Lomotil and Diphenoxylate?
It is used to treat acute diarrhea ( diarrhea of limited duration). Diphenoxylate is a man-made narcotic chemically related to meperidine ( Demerol ). Like other narcotics, diphenoxylate reduces diarrhea by interfering with the propulsion of intestinal contents through ...
What is the drug for diarrhea?
Diphenoxylate and atropine (Lomotil) is a drug prescribed for the treatment of acute diarrhea. Side effects, drug interactions, dosage, and pregnancy safety should be reviewed prior to taking this medication.
Where to report side effects of a drug?
Report Problems to the Food and Drug Administration. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088. See more info: diphenoxylate and atropine on RxList. References.
Can you take atropine with diphenoxylate?
In order to prevent abuse of diphenoxylate for its mood-elevating effects, atropine is combined with diphenoxylate in small quantities. As a result, if Lomotil is taken in greater than recommended doses unpleasant side effects from too much atropine will occur. Lomotil was approved by the FDA in 1960.
DESCRIPTION SECTION
Each diphenoxylate hydrochloride and atropine sulfate tablet contains:
CLINICAL PHARMACOLOGY SECTION
Diphenoxylate is rapidly and extensively metabolized in man by ester hydrolysis to diphenoxylic acid (difenoxine), which is biologically active and the major metabolite in the blood.
INDICATIONS & USAGE SECTION
Diphenoxylate hydrochloride is effective as adjunctive therapy in the management of diarrhea.
WARNINGS SECTION
DIPHENOXYLATE HYDROCHLORIDE IS NOT AN INNOCUOUS DRUG AND DOSAGE RECOMMENDATIONS SHOULD BE STRICTLY ADHERED TO, ESPECIALLY IN CHILDREN. DIPHENOXYLATE HYDROCHLORIDE IS NOT RECOMMENDED FOR CHILDREN UNDER 2 YEARS OF AGE.
PRECAUTIONS SECTION
Since a subtherapeutic dose of atropine has been added to the diphenoxylate hydrochloride, consideration should be given to the precautions relating to the use of atropine.
ADVERSE REACTIONS SECTION
At therapeutic doses, the following have been reported; they are listed in decreasing order of severity, but not of frequency:
DRUG ABUSE AND DEPENDENCE SECTION
Diphenoxylate hydrochloride is classified as a Schedule V controlled substance by federal regulation. Diphenoxylate hydrochloride is chemically related to the narcotic analgesic meperidine.
How long does it take for atropine to cause side effects?
Some side effects may occur up to 30 hours after you take this medicine.
What is diphenoxylate used for?
Diphenoxylate is an antidiarrheal medication. Atropine and diphenoxylate is a combination medicine used to treat diarrhea in adults and children who are at least 13 years old. Atropine and diphenoxylate may also be used for purposes not listed in this medication guide.
What are the side effects of dehydration?
Common side effects may include: drowsiness, dizziness, feeling restless; headache; numbness in your hands or feet; depression, not feeling well; confusion, feelings of extreme happiness;
Is atropine safe for children?
Atropine and diphenoxylate is not approved for use by anyone younger than 6 years old. This medicine has not been proven safe or effective in children younger than 13 years old. Tell your doctor if you have ever had: a blockage in your intestines; ulcerative colitis; asthma or other breathing problems; glaucoma; urination problems;
Can you take atropine with diphenoxylate?
You should not use atropine and diphenoxylate if you have a bile duct disorder causing jaundice (yellowing of your skin or eyes). Keep this medicine where a child cannot reach it. An overdose can be fatal to a child.
