Medication
Treatment - Stomach ulcer
- Antibiotics
- Proton pump inhibitors (PPIs)
- H2-receptor antagonists
- Antacids and alginates
Procedures
With treatment, most ulcers heal in a month or two. If your stomach ulcer is caused by a Helicobacter pylori (H. pylori) bacterial infection, a course of antibiotics and a medication called a proton pump inhibitor (PPI) is recommended.
Nutrition
Over-the-counter medications that treat ulcers are available at your local drug store. Antacids, digestive tract-fortifying medicines like Pepto-Bismol, and topical creams are available, along with other medications that may help relieve pain and hasten the healing process. However, although OTC drugs like antacids can reduce the pain caused by an ulcer, do not consider it a replacement for seeking medical attention if it is necessary.
What is best cure for peptic ulcer?
Over time, some types of antibiotics can no longer destroy certain types of H. pylori. Antibiotics can cure most peptic ulcers caused by H. pylori or H. pylori -induced peptic ulcers. However, getting rid of the bacteria can be difficult.
How long is the treatment of a peptic ulcer?
What over the counter medicine for ulcers?
Are antibiotics useful in the treatment of peptic ulcer?
Why is triple therapy used?
Uses for Triple Therapy This medicine is used to treat patients with H. pylori infection and duodenal ulcers caused by H. pylori bacteria.
What is triple therapy?
Triple therapy combines three types of medication to help improve lung function, manage symptoms, and prevent exacerbations. It delivers these medications through an inhaler, which provides relief from swelling in the lungs and opens the airways so that the person can breathe.
What are the 3 drug classes used to treat peptic ulcers?
Peptic Ulcer Disease Treatment: MedicationAntacids neutralize gastric acid. ... Histamine (H2) blockers reduce gastric acid by blocking the H2 receptors. ... Proton pump inhibitors (PPIs) are drugs that block the three major pathways for acid production. ... Medications to protect and strengthen the mucous lining of the stomach.More items...
What type of triple therapy is most commonly used to treat ulcers caused by Helicobacter pylori?
STANDARD TRIPLE THERAPY A seven- to 10-day triple drug regimen consisting of a PPI, amoxicillin 1 g, and clarithromycin 500 mg (Biaxin) twice daily has long been the first-line therapy to eradicate H. pylori.
What is triple therapy for gastritis?
Triple therapies (with indicated adult dosing) Lansoprazole 30 mg, omeprazole 20 mg, or ranitidine bismuth citrate 400 mg orally twice daily. Clarithromycin 500 mg orally twice daily. Amoxicillin 1000 mg or metronidazole 500 mg orally twice daily.
What is the best treatment of peptic ulcer?
Proton pump inhibitors (PPIs) PPIs work by reducing the amount of acid your stomach produces, preventing further damage to the ulcer as it heals naturally. They're usually prescribed for 4 to 8 weeks. Omeprazole, pantoprazole and lansoprazole are the PPIs most commonly used to treat stomach ulcers.
Which class of drug is used in peptic ulcer?
In general, the treatment of peptic ulcers mainly depends on whether the cause is H. pylori infection, NSAIDs or both. If it is caused by H. pylori infection, eradication therapy involves taking a combination of a course of antibiotics and an antisecretory drug such as proton pump inhibitor (PPI) will be used.
What is the first line treatment for peptic ulcer?
Vonoprazan (VPZ) with antibiotics is recommended as the first-line treatment for H. pylori eradication, and PPIs or VPZ with antibiotics is recommended as a second-line therapy. Patients who do not use NSAIDs and are H. pylori negative are considered to have idiopathic peptic ulcers.
Which combination of drugs is recommended for peptic ulcers?
Combination drug therapy regimens commonly used to treat an H. pylori infection include the following options: A proton pump inhibitor (PPI) plus clarithromycin plus amoxicillin or metronidazole. A proton pump inhibitor plus a bismuth compound plus metronidazole plus tetracycline.
What is the triple treatment for H. pylori?
Abstract. Background: Triple therapy (proton pump inhibitor, clarithromycin and amoxicillin or an imidazole) is the first-line treatment for Helicobacter pylori infection. However, the effectiveness of triple therapy is decreasing due to the increase in antibiotic resistance.
How effective is triple therapy for Helicobacter?
Proton pump inhibitor–based triple-therapy regimens were significantly more effective than all other treatment regimens combined (87% vs 70%; P=. 001) in eradicating H pylori.
Does triple therapy for H. pylori work?
The recommended standard triple therapy for Helicobacter pylori infection, consisting of a proton pump inhibitor, clarithromycin and amoxicillin or metronidazole, can reach eradication rates in over 90%.
What is the best treatment for peptic ulcers?
Protectants. Protectants coat ulcers and protect them against acid and enzymes so that healing can occur. Doctors only prescribe one protectant— sucralfate (Carafate) —for peptic ulcer disease. Tell your doctor if the medicines make you feel sick or dizzy or cause diarrhea or headaches.
How do doctors treat peptic ulcer disease?
There are several types of medicines used to treat a peptic ulcer. Your doctor will decide the best treatment based on the cause of your peptic ulcer.
How do doctors treat an H.pylori -induced peptic ulcer?
Doctors may prescribe triple therapy, quadruple therapy, or sequential therapy to treat an H. pylori -induced peptic ulcer.
How can I prevent a peptic ulcer?
To help prevent a peptic ulcer caused by NSAIDs, ask your doctor if you should
What to do if you have a peptic ulcer and you don't have an H. p?
If NSAIDs are causing your peptic ulcer and you don’t have an H. pylori infection, your doctor may tell you to. stop taking the NSAID. reduce how much of the NSAID you take. switch to another medicine that won’t cause a peptic ulcer.
What is the best treatment for H. pylori?
pylori infection, a doctor will treat your NSAID-induced peptic ulcer with PPIs or histamine receptor blockers and other medicines, such as antibiotics, bismuth subsalicylates, or antacids. PPIs reduce stomach acid and protect the lining of your stomach and duodenum.
How long does quadruple therapy last?
For quadruple therapy, your doctor will prescribe that you take the following for 14 days :
How to treat peptic ulcers?
Peptic Ulcer Disease Treatment: Medication. Several different medication therapies are available to help reduce gastric acid and coat the ulcers: Antacids neutralize gastric acid. The disadvantage is that you need to take a relatively large dose for them to be effective, and they can cause unwanted side effects like diarrhea.
What causes peptic ulcers?
Peptic ulcers are often caused by an overproduction of gastric acid. Many treatment options focus on reducing or suppressing gastric acid production. If your doctor determines that you have an H. pylori infection, you will need treatment for that as well.
Do PPIs suppress acid production?
PPIs suppress acid production much more effectively than H2 blockers. PPIs are the gold standard in medication therapy of peptic ulcer disease. Medications to protect and strengthen the mucous lining of the stomach. See animation: mechanism of normal acid production, H2 blockers and proton pump inhibiting drugs.
Examples
Combination drug therapy regimens commonly used to treat an H. pylori infection include the following options:
How It Works
The right antibiotics combinations usually kill Helicobacter pylori ( H. pylori) bacteria that are the cause of many peptic ulcers. At least two antibiotics are used, because combination treatment works better and is less likely to fail because of resistance to the antibiotics.
Why It Is Used
Combination drug therapy that includes at least two antibiotics, an acid reducer, and sometimes a bismuth compound is recommended for people who have peptic ulcer disease and are known to be infected with Helicobacter pylori ( H. pylori ).
How Well It Works
Helicobacter pylori ( H. pylori) infections are cured 70% to 85% of the time when the right combination drug treatment is used.
Side Effects
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
What To Think About
It is very important that you take all of the medicine prescribed. Do not stop taking your medicine even if you feel better. It may seem like a lot of pills to take, but it is also important to take a regimen that contains at least three medicines to cure Helicobacter pylori ( H. pylori ).
What is the treatment for peptic ulcer disease?
Given the current understanding of the pathogenesis of peptic ulcer disease, most patients with peptic ulcer disease are treated successfully with cure of H pylori infection and/or avoidance of nonsteroidal anti-inflammatory agents (NSAIDs), along with the appropriate use of antisecretory therapy.
What is the procedure for a peptic ulcer?
The appropriate surgical procedure depends on the location and nature of the ulcer. Many authorities recommend simple oversewing of the ulcer with treatment of the underlying H pylori infection or cessation of NSAIDs for bleeding peptic ulcer disease . Additional surgical options for refractory or complicated peptic ulcer disease include vagotomy and pyloroplasty, vagotomy and antrectomy with gastroduodenal reconstruction (Billroth I) or gastrojejunal reconstruction (Billroth II), or a highly selective vagotomy.
What is the treatment for H pylori?
Treatment options include empiric antisecretory therapy, empiric triple therapy for H pylori infection, endoscopy followed by appropriate therapy based on findings , and H pylori serology followed by triple therapy for patients who are infected. Breath testing for active H pylori infection may be used.
How long does it take for a gastric ulcer to heal?
Endoscopy is required to document healing of gastric ulcers and to rule out gastric cancer. This usually is performed 6-8 weeks after the initial diagnosis of peptic ulcer disease.
How to treat bleeding ulcers?
Hemoclips have been used successfully to treat an acutely bleeding ulcer by approximating two folds and clipping them together. Several clips may need to be deployed to approximate the gastric ulcer folds. In treating high-risk bleeding ulcers, combined therapy with epinephrine and hemoclips seems to be more efficacious than injection alone. However, it is not clear whether hemoclip use or thermal coagulation is more effective in treating an acutely bleeding ulcer; both modalities are used depending on physician experience and the equipment availability.
Is peptic ulcer disease the same as gastritis?
Presentations of peptic ulcer disease and gastritis usually are indistinguishable in the emergency department (ED) and, thus, the management is generally the same. Treatment goals in the acute setting are the relief of discomfort and protection of the gastric mucosal barrier to promote healing. Administer supportive therapy as needed. Most patients with gastritis or peptic ulcer disease do not require acute interventions.
Can you have a peptic ulcer surgery after two failed attempts?
The indications for urgent surgery include failure to achieve hemostasis endoscopically, recurrent bleeding despite endoscopic attempts at achieving hemostasis (many advocate surgery after two failed endoscopic attempts), and perforation. Many authorities recommend simple oversewing of the ulcer with treatment of the underlying H pylori infection or cessation of NSAIDs for bleeding peptic ulcer disease. Additional surgical options for refractory or complicated peptic ulcer disease include vagotomy and pyloroplasty, vagotomy and antrectomy with gastroduodenal reconstruction (Billroth I) or gastrojejunal reconstruction (Billroth II), or a highly selective vagotomy.
What is the treatment for peptic ulcers?
Non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori (H. pylori)infection are the two major factors disrupting the mucosal resistance to injury. Conventional treatments of peptic ulcers, such as proton pump inhibitors (PPIs) and histamine-2 (H2) receptor antagonists, have demonstrated adverse effects, relapses, and various drug interactions. On the other hand, medicinal plants and their chemical compounds are useful in the prevention and treatment of numerous diseases. Hence, this review presents common medicinal plants that may be used for the treatment or prevention of peptic ulcers.
What is a peptic ulcer?
Peptic ulcer is an acid-induced lesion of the digestive tract that is usually located in the stomach or proximal duodenum, and is characterized by denuded mucosa with the defect extending into the submucosa or muscularis propria [1]. The estimated prevalence of peptic ulcer disease in the general population is 5–10% [2], but recent epidemiological studies have shown a decrease in the incidence, rates of hospital admissions, and mortality associated with peptic ulcer [3,4]. This is most likely secondary to the introduction of new therapies and improved hygiene, which resulted in a decline in Helicobacter pylori (H. pylori)infections.
What causes acid peptic ulcers?
Traditionally, mucosal disruption in patients with the acid peptic disease is considered to be a result of a hypersecretory acidic environment together with dietary factors or stress. Risk factors for developing peptic ulcer include H. pyloriinfection, alcohol and tobacco consumption, non-steroidal anti-inflammatory drugs (NSAIDs) use, and Zollinger–Ellison syndrome [5]. The main risk factors for both gastric and duodenal ulcers are H. pyloriinfection and NSAID use [6]. However, only a small proportion of people affected with H. pylorior using NSAIDs develop peptic ulcer disease, meaning that individual susceptibility is important in the beginning of mucosal damage. Functional polymorphisms in different cytokine genes are associated with peptic ulcers. For example, polymorphisms of interleukin 1 beta (IL1B)affect mucosal interleukin 1β production, causing H. pylori-associated gastroduodenal diseases [7].
What is the most common cause of peptic ulcer disease?
Almost half of the world’s population is colonized by H. pylori, which remains one of the most common causes of peptic ulcer disease [14]. The prevalence of H. pyloriis higher in developing countries, especially in Africa, Central America, Central Asia, and Eastern Europe [15]. The organism is usually acquired in childhood in an environment of unsanitary conditions and crowding, mostly in countries with lower socioeconomic status. H. pyloricauses epithelial cell degeneration and injury, which is usually more severe in the antrum, by the inflammatory response with neutrophils, lymphocytes, plasma cells, and macrophages.
How long does bismuth therapy last?
The recommended standard first-line therapy is either a bismuth-containing quadruple therapy for 14 days (PPI, a bismuth salt, tetracycline, and metronidazole) or a 14-day concomitant therapy for patients intolerant of bismuth (PPI, clarithromycin, amoxicillin, and metronidazole); both regimens yield eradication rates higher than 90% [38].
What antibiotics are in PPI?
PPI + two antibiotics (clarithromycin + metronidazile or amoxicilin)
Does aspirin cause peptic ulcers?
On the other hand, the risk of complications of peptic ulcer is increased four times in NSAID users, and two times in aspirin users [8]. The concomitant use of NSAIDs or aspirin with anticoagulants, corticosteroids, and selective serotonin reuptake inhibitors increase the risk of upper gastrointestinal bleeding [9]. Although many people who use NSAIDs or aspirin have concurrent H. pyloriinfection, their interaction in the pathogenesis of peptic ulcer disease remains controversial. A meta-analysis of observational studies resulted in a conclusion that NSAIDs, aspirin use, and H. pyloriinfection increase the risk of peptic ulcer disease independently [10].