Full Answer
What is the typical course of treatment for Pep?
All persons offered PEP should be prescribed a 28-day course of a 3-drug antiretroviral regimen. Since adherence is critical for PEP efficacy, it is preferable to select regimens that minimize side effects, number of doses per day and the number of pills per dose.
How does PEP therapy work?
PEP (positive expiratory pressure) therapy helps open and move mucus out of your lungs. You breathe into a small handheld device that has a valve. You breathe out against a set amount of pressure. The pressure helps hold your airways open. It also allows air to get behind and loosen mucus. The air moves mucus so you are able to cough it up and out.
What is the Pep HIV treatment?
PEP is the use of antiretroviral medication to prevent HIV infection in an HIV-negative person who has had a specific high-risk exposure to HIV. Such an exposure typically occurs through sex or sharing syringes (or other injection equipment) with someone who has or might have HIV.
What is PEP therapy for COPD?
PEP (positive expiratory pressure) therapy helps open and move mucus out of your lungs. You breathe into a small handheld device that has a valve. You breathe out against a set amount of pressure. The pressure helps hold your airways open. It also allows air to get behind and loosen mucus.
What does PEP treatment consist of?
PEP is a combination of three drugs. You take them once or twice a day for 28 days: For adults, the CDC recommends tenofovir, emtricitabine (these two drugs come in one pill), and a third drug, either raltegravir or dolutegravir.
What is PEP treatment used for?
PEP (post-exposure prophylaxis) means taking medicine to prevent HIV after a possible exposure. PEP should be used only in emergency situations and must be started within 72 hours after a recent possible exposure to HIV. This section answers some of the most common questions about PEP.
What are side effects of PEP?
The most common side-effects were fatigue (37% of PEP users), diarrhoea (25%), nausea (24%), flatulence (24%), abdominal cramps (21%), bloating (16%), headache (15%), vivid dreams (15%), depression (10%) and thirst (10%).
Who qualifies for PEP?
PEP is only indicated for potentially exposed people without HIV infection. PEP is unlikely to be effective in people who have been exposed more than 72 hours before seeking medical assistance. PEP should be provided only for infrequent exposures.
What is the success rate of PEP?
Among studies assessing two-drug regimens, PEP completion rates were significantly higher for TDF-based regimens (78.4%) compared to ZDV-based regimens (58.8%).
How long is PEP treatment?
How Long Do You Need to Take PEP? If you are prescribed PEP, you will need to take the HIV medicines every day for 28 days. You will also need to return to your health care provider at certain times while taking PEP and after you finish taking it for HIV testing and other tests.
Is PEP hard on the body?
PEP is safe but may cause side effects like nausea in some people. In almost all cases, these side effects can be treated and aren't life-threatening.
How much is a PEP?
The cost of PEP ranges from $600 to over $1000. Many health insurance plans, including Medicaid, cover PEP in full or in part. If you don't have insurance, talk to your medical provider about available drug assistance programs.
Does PEP hurt your liver?
The most common side effects seen in the studies of Truvada as PrEP include headache, nausea, vomiting, rash and loss of appetite. In some people, tenofovir can increase creatinine and transaminases. These are enzymes related to the kidneys and liver. High levels can indicate damage to these organs.
Can I get PEP at pharmacy?
You can buy the emergency contraceptive pill from chemists, and it is usually also available from GPs, sexual health clinics and A&E departments.
When is PEP not recommended?
Request for PEP later than 72 hours post exposure: Because evidence indicates that PEP is not effective when initiated more than 72 hours post exposure, clinicians should not initiate PEP after this time point [Beymer, et al. 2017; Otten, et al.
When is PEP recommended?
Key Points. Post-exposure prophylaxis (PEP) means taking HIV medicines within 72 hours (3 days) after a possible exposure to HIV to prevent HIV infection. PEP should be used only in emergency situations. It is not meant for regular use by people who may be exposed to HIV frequently.
Is PEP same as ARVs?
Post-exposure prophylaxis (PEP) is the short-term use of antiretrovirals (ARVs) to reduce the probability of contracting HIV after potential exposure, either occupational (through a work-related accident) or non-occupational (for example, during unprotected sex, rape, or the use of contaminated injection supplies).
Is taking PEP for 14 days effective?
The longer you wait, the greater the chance that PEP won't work. PEP usually isn't given more than 72 hours (3 days) after exposure as studies show it is unlikely to be effective.
What Steps Do I Need to Follow For Pep Therapy?
Your healthcare provider will set your device to the amount of pressure needed. He will tell you to repeat these steps at least 5 times to make 1 c...
How Do I Clean My Pep device?
Clean mucus and moisture out of your device after every use. A more complete cleaning depends on the type of device you use. Ask your healthcare pr...
When Should I Contact My Healthcare Provider?
1. You are not able to move mucus after several cycles. 2. You have questions or concerns about your condition or care.
What is PEP?
PEP (post-exposure prophylaxis) means taking medicine to prevent HIV after a possible exposure. PEP Must Be Started Within 72 Hours of Possible Exp...
How well does PEP work?
If taken within 72 hours after possible exposure, PEP is highly effective in preventing HIV. But to be safe, you should take other actions to prote...
Are there any side effects?
PEP is safe but may cause side effects like nausea in some people. In almost all cases, these side effects can be treated and aren’t life-threatening.
How to start a PEP?
Guidelines recommend the following baseline screening before initiating PEP: 1 HIV rapid test at baseline. If baseline rapid test indicates existing HIV infection, PEP should not be started. However, if rapid HIV baseline test is not available, there should be no delay in starting PEP. Oral HIV tests are not recommended for use among persons being evaluated for PEP. 2 Pregnancy test (if a woman is of reproductive age, not using highly effective contraception, eg IUDs or other long-active reversible contraceptives (LARCs), oral contraceptives, or properly used condoms, and with vaginal exposure to semen). 3 Serum liver enzymes 4 BUN/creatinine 5 STI screening#N#Persons being evaluated for PEP because of a sexual encounter should have STI-specific nucleic acid amplification (NAAT testing) for chlamydia and gonorrhea, and a blood test for syphilis 6 Hepatitis B testing, including hepatitis B surface antigen, surface antibody, and core antibody 7 Hepatitis C (HCV) antibody
What tests are needed for PEP?
BUN/creatinine. STI screening. Persons being evaluated for PEP because of a sexual encounter should have STI-specific nucleic acid amplification (NAAT testing) for chlamydia and gonorrhea, and a blood test for syphilis. Hepatitis B testing, including hepatitis B surface antigen, surface antibody, and core antibody.
What is a pregnancy test?
Pregnancy test (if a woman is of reproductive age, not using highly effective contraception, eg IUDs or other long-active reversible contraceptives (LARCs), oral contraceptives, or properly used condoms, and with vaginal exposure to semen). Serum liver enzymes. BUN/creatinine.
Can you start a PEP if you have HIV?
If baseline rapid test indicates existing HIV infection, PEP should not be started. However, if rapid HIV baseline test is not available, there should be no delay in starting PEP. Oral HIV tests are not recommended for use among persons being evaluated for PEP.
Is PEP effective for HIV?
PEP is only indicated for potentially exposed people without HIV infection. PEP is unlikely to be effective in people who have been exposed more than 72 hours before seeking medical assistance. PEP should be provided only for infrequent exposures.
Is HIV prevention a side effect?
In almost all cases, the benefits of HIV prevention outweigh any other risks posed by the medication. In a meta-analysis of 24 PEP-related studies, including 23 cohort studies and 1 randomized clinical trial, nausea, vomiting, diarrhea and fatigue were the most commonly reported side effects.
Who prescribes PEP?
Emergency medicine physicians are among the most frequent prescribers of PEP, given the need for immediate treatment after exposure. Clinicians working in ambulatory care practices can also ensure that their non-HIV-infected patients who report risk behavior are aware of PEP, and know how to access it.
How does PEP therapy work?
Some PEP therapy devices use vibrations, or oscillations, to help loosen mucus. As you breathe out, the pressure and vibrations in your airways work together to help loosen mucus. PEP therapy also helps air get into the small airways deep in your lungs.
What is PEP therapy?
PEP (positive expiratory pressure) therapy helps open and move mucus out of your lungs. You breathe into a small handheld device that has a valve. You breathe out against a set amount of pressure. The pressure helps hold your airways open. It also allows air to get behind and loosen mucus.
How to bring up mucus?
Cough and bring up mucus:#N#Remove the mouthpiece from your mouth or the mask from your face.#N#Do 2 to 3 huff coughs. Take a deep breath in. Use your stomach muscles to breathe out 3 quick, forceful breaths. Make a ha, ha, ha sound.#N#Then cough hard to bring up mucus. Spit the mucus out. Do not swallow the mucus.#N#You may need to rest for 1 to 2 minutes.#N#Repeat the cycle for up to 30 minutes. 1 Remove the mouthpiece from your mouth or the mask from your face. 2 Do 2 to 3 huff coughs. Take a deep breath in. Use your stomach muscles to breathe out 3 quick, forceful breaths. Make a ha, ha, ha sound. 3 Then cough hard to bring up mucus. Spit the mucus out. Do not swallow the mucus. 4 You may need to rest for 1 to 2 minutes. 5 Repeat the cycle for up to 30 minutes.
How to keep mouthpiece in?
You may be able to keep the mouthpiece in, or your mask on, as you repeat. Take a deep breath in through your nose. Cough and bring up mucus: Remove the mouthpiece from your mouth or the mask from your face. Do 2 to 3 huff coughs. Take a deep breath in. Use your stomach muscles to breathe out 3 quick, forceful breaths.
How to keep your nose and mouth flat?
While you hold your breath, place the mouthpiece in your mouth or the mask over your mouth and nose. Breathe out at a steady rate for 4 to 6 seconds or as long as you can. Keep your cheeks as flat as possible. You may have to use your fingers to hold your cheeks down. Try not to cough.
How to stop air from moving?
Sit up with your back straight and your chin slightly up. This position allows your throat to be open so air can move easily without blockage. You may need to put your elbows on a table . This may keep you from slouching and blocking air from moving freely. Take a deep breath and hold it for 2 to 3 seconds.
Can you use bleach to clean a medical device?
Ask your healthcare provider for information on cleaning your specific device. Never use bleach to clean any device.
What is a PEP?
PEP is for Emergency Situations 1 PEP is given after a possible exposure to HIV. 2 PEP is not a substitute for regular use of other HIV prevention. 3 PEP is not the right choice for people who may be exposed to HIV frequently. 4 If you are at ongoing risk for HIV, such as through repeated exposures to HIV, talk to your health care provider about PrEP (pre-exposure prophylaxis).
What is PEP for HIV?
PEP is given after a possible exposure to HIV. PEP is not a substitute for regular use of other HIV prevention. PEP is not the right choice for people who may be exposed to HIV frequently. If you are at ongoing risk for HIV, such as through repeated exposures to HIV, talk to your health care provider about PrEP (pre-exposure prophylaxis).
How long does it take to get a PEP?
PEP Must Be Started Within 72 Hours of Possible Exposure to HIV. Talk right away (within 72 hours) to your health care provider, an emergency room doctor, or an urgent care provider about PEP if you think you’ve recently been exposed to HIV: during sex (for example, if the condom broke),
Is PEP safe for HIV?
PEP is safe but may cause side effects like nausea in some people. In almost all cases, these side effects can be treated and aren’t life-threatening. YouTube. Centers for Disease Control and Prevention (CDC) 538K subscribers. HIV Prevention – Let’s Talk About PEP. Watch later. Share. Info.
Can you use condoms while taking PEP?
But to be safe, you should take other actions to protect your partners while you are taking PEP. This includes always using condoms with sexual partners and not sharing needles, syringes, or other equipment to inject drugs.
New (September 17, 2018)
Guidance for Non-HIV-Specialized Providers Caring for Persons with HIV Who Have been Displaced by Disasters (such as a Hurricane) external icon
Update (May 23, 2018)
Interim Statement Regarding Potential Fetal Harm from Exposure to Dolutegravir – Implications for HIV Post-exposure Prophylaxis (PEP). Please see attached PDF pdf icon [PDF – 104 KB].
Resources for Consumers
Basic PEP Q&As – learn the basics about PEP and if it’s right for you.
Resources for Providers
Visit the Prescribe HIV Prevention website to learn about using PrEP and PEP to reduce new HIV infections.
How to start PEP after being exposed to HIV?
If you were exposed to HIV in the last 3 days and want PEP, see a nurse or doctor or go to the emergency room immediately . Timing is really important. You must start PEP as soon as you can after being exposed to HIV for it to work. PEP is for emergencies. It can’t take the place of proven, ongoing ways to prevent HIV — like using condoms, ...
What happens if you inject drugs?
If you inject drugs, don’t share needles or works. This helps protect you from being exposed to HIV again. And it lowers the chances of giving HIV to others if you do have it. If you develop symptoms like a fever or rash while using PEP, talk with your doctor. These may be signs of the beginning stages of HIV.
What is a PEP?
PEP is for people who may have been exposed to HIV in the last 3 days. PEP might be right for you if: You shared needles or works (like cotton, cookers, or water) with someone who may have HIV. If you were exposed to HIV in the last 3 days and want PEP, see a nurse or doctor or go to the emergency room immediately.
What happens if PEP doesn't work?
If PEP doesn’t work, you may have symptoms of the first stage of an HIV infection, like a fever or rash. If you have these symptoms while you’re on PEP, or within a month after finishing PEP, call your nurse or doctor.
What is PEP in HIV?
What is PrEP? What is PEP? YouTube. PEP stands for post exposure prophylaxis. PEP is a series of pills you can start taking very soon after you’ve been exposed to HIV that lowers your chances of getting it . But you have to start PEP within 72 hours, or 3 days, after you were exposed to HIV, or it won’t work.
What happens before you get PEP?
Before you get PEP, the nurse or doctor will talk with you about what happened, to decide whether PEP is right for you. They’ll give you a blood test for HIV (if you already have HIV, you won’t be able to use PEP). You’ll also be tested for Hepatitis B.
How long after PEP can you get a test?
You need to visit your nurse or doctor for follow-up testing after you finish PEP. You’ll get another HIV test 4-6 weeks after you were first exposed to HIV, and then you’ll be tested again 3 months later. Depending on your situation, your doctor may recommend another HIV test 6 months later.
What is PEP in HIV?
What Is PEP? PEP is a way to help prevent the transmission of HIV in an HIV-negative person who may have been recently exposed to the virus. PEP consists of taking three HIV antiviral drugs for 28 days after exposure to the virus.
How long does it take to take raltegravir?
Raltegravir or dolutegravir. Ideally, the medication should be started immediately, within one–two hours of exposure . A PEP supply of three–five days is usually first given for emergency use, followed by the rest of the 28-day dose. PEP should not be confused with PrEP, which involves taking two HIV medications on an ongoing basis, before, during, ...
How long after exposure to HIV can you get a repeat test?
Counseling. Repeat HIV testing will be obtained 30 days and 90 days after exposure. Testing should be performed using a fourth-generation HIV test. If a fourth-generation test is unavailable, an older test may be used along with more frequent follow-up appointments to limit the possibility of a false-negative result.
How long does it take to get a repeat HIV test?
Repeat HIV testing should be obtained at six weeks, 12 weeks, and six months minimum. Sometimes these repeat tests are in addition to testing at 30 days and 90 days. If you test positive or develop symptoms of acute retroviral syndrome, an HIV viral load may be obtained.
How long does it take to get a follow up test for PEP?
Follow-up Tests. If you are on PEP, a healthcare professional will ask you to schedule a follow-up appointment within 72 hours. Your appointment will include: HIV testing. Lab monitoring for drug toxicity. Counseling. Repeat HIV testing will be obtained 30 days and 90 days after exposure.
Is PEP 100% effective?
PEP is not 100% effective, so there are times when the drug will not prevent you from acquiring the virus. The following symptoms may signal the acute phase of HIV infection: 3. If you experience any of these symptoms while on PEP, contact a healthcare professional immediately.
Is PEP the same as PrEP?
PEP should not be confused with PrEP, which involve s taking two HIV medications on an ongoing basis, before, during, and after possible exposure to HIV. 2. Preventing HIV With PrEP.
How many cases of HIV are there after PEP?
In 40 cases, HIV infection was attributed to ongoing risk behaviour after completing PEP. Among these 40 are 35 cases in which seroconversion occurred more than six months after starting PEP. These HIV transmissions are unlikely to be due to a failure of PEP. 8 cases are considered to represent potential PEP failures.
What is PEP in HIV?
Post-exposure prophylaxis (PEP) is a four-week course of medication that may block HIV infection after exposure to the virus. You can read an overview of PEP here. PEP should not be confused with pre-exposure prophylaxis (PrEP), which involves taking medicine on an ongoing basis, before possible exposure to HIV.
How effective is PEP?
PEP is most effective when it is started soon after exposure to HIV, when doses are not missed and when people complete the 28-day course. The most common cause of HIV infection in people who take PEP is ongoing risk behaviour. Post-exposure prophylaxis (PEP) is a four-week course of medication that may block HIV infection after exposure to ...
How many studies have been published on PEP?
The six studies, from the United States, Australia, the Netherlands and Brazil had been published since 2004. The latest news and research on PEP.
When is PEP due for review?
Next review date. This page was last reviewed in April 2019. It is due for review in April 2022.
Paying for PEP After a Sexual Assault
You may qualify for partial or total reimbursement for medicines and clinical care costs.
Paying for PEP After an Exposure at Work
Your workplace health insurance or workers’ compensation will usually pay for PEP.
Paying for PEP for Another Reason
If you cannot get insurance coverage, your health care provider can apply for free PEP medicines through the medication assistance programs run by the manufacturers.
