Treatment FAQ

what happens when the hep c treatment fails

by Prof. Hal Ullrich I Published 2 years ago Updated 2 years ago
image

Untreated hepatitis

Hepatitis

Inflammatory condition of the liver.

C can have serious health effects on the heart, including congestive heart failure. Hepatitis

Hepatitis

Inflammatory condition of the liver.

C can affect the blood vessels that carry blood to and from the heart and lungs. This damage can lead to high blood pressure and, eventually, heart failure.

Full Answer

What happens if Hepatitis C goes untreated?

This damage can lead to high blood pressure and, eventually, heart failure. Those with untreated hepatitis C may experience a burning, prickling sensation, or numbness. This happens when nerves attached to more than one body part are affected.

How long can you live with hepatitis C after a transplant?

The only effective treatment for people with end-stage liver disease is a liver transplant. Chronic hepatitis C virus is the most frequent cause of liver transplantation in the United States. Most people who receive a liver transplant for hepatitis C survive for at least five years after their transplant,...

Can hepatitis C be cured?

There’s Reason for Hope With Hepatitis C. Yet “new treatments for hepatitis C have been revolutionary,” explains Singh. “Over 95 percent of patients can be cured with three months of treatment.” Newer antiviral drugs can clear the virus even in people who have had no luck on earlier medications.

How long does it take for hepatitis C to progress?

The hepatitis C virus slowly damages the liver over many years, often progressing from inflammation to permanent, irreversible scarring (cirrhosis). Often, people have no signs or symptoms of liver disease or have only mild symptoms for years or even decades until they develop cirrhosis.

image

How long can you live with hep C treatment?

The prognosis of chronic HCV is typically very good, and as treatment continues to improve, it will only get better. Most people with chronic HCV can live a normal life, providing that doctors are able to diagnose it before any liver damage or other complications occur.

What is the success rate of hep C treatment?

Hepatitis C treatment can cure more than 90 percent of hepatitis C cases, but testing is a critical first step. It's estimated 40 percent of people with hepatitis C in the U.S. from 2015-2018 were unaware of their infection.

What are the symptoms of end stage hep C?

Symptoms of end-stage liver disease may include:Easy bleeding or bruising.Persistent or recurring yellowing of your skin and eyes (jaundice)Intense itching.Abdominal pain.Loss of appetite.Nausea.Swelling due to fluid buildup in your abdomen and legs.Problems with concentration and memory.

Can you get hep C treatment twice?

Having had hep C once does not make you immune from getting it again. You can be reinfected with hep C whether you clear the virus by successful treatment (called a sustained virologic response, or SVR) or by spontaneously clearing it on your own.

When is hep C not curable?

Is there a cure? Though there is no vaccine for Hepatitis C, treatments can reduce the viral load to undetectable levels which is considered cured or in remission. The virus is considered cured when it is not detected in your blood 12 weeks after treatment is completed.

Can chronic hep C be cured?

Today, chronic HCV is usually curable with oral medications taken every day for two to six months. Still, about half of people with HCV don't know they're infected, mainly because they have no symptoms, which can take decades to appear.

What happens when your liver shuts down?

Acute liver failure often causes complications, including: Excessive fluid in the brain (cerebral edema). Too much fluid causes pressure to build up in your brain, which can lead to disorientation, severe mental confusion and seizures. Bleeding and bleeding disorders.

Does End Stage Liver Disease mean death?

End-stage liver disease (ESLD) is a commonly reported cause of death in the United States and has become a focus of palliative care research [2].

Can Stage 4 Hep C be cured?

With new hepatitis C drugs, the disease is curable in 90% or more of cases. By the time the disease reaches end stage, it can't be reversed. You can take medicine to control symptoms like fatigue, pain, and itching. If your liver stops working, the only option is to have a liver transplant.

How does hep C come back after treatment?

Relapses usually occur in the first few months after blood testing to confirm that the virus is no longer detectable. Sometimes, however, a relapse becomes evident much later. Although the exact cause of relapse is unknown, the remote possibility that the infection may return is further reason not to drink.

Does cirrhosis improve after hep C treatment?

Hepatitis C virus (HCV)-related liver fibrosis improves significantly in the majority of people with pre-treatment advanced fibrosis or cirrhosis after treatment resulting in a sustained virological response, Swedish investigators report in the Journal of Viral Hepatitis.

Can hep C go into remission?

The virus spreads mainly through intravenous drug use. Untreated hepatitis C can lead to serious liver problems, including cirrhosis and cancer. The good news is that the virus can go into remission with the right treatment. Doctors refer to remission as a sustained virological response (SVR).

Can HCV be resistant to DAA?

Some of these mutations inadvertently allow HCV the ability to resist the effect of one or more DAAs. Thus it is possible that in a small proportion of people who have never been treated there might be low levels of HCV circulating that possess the ability to resist a DAA.

Is there a path forward after HCV treatment failure?

There is no simple path forward after HCV treatment failure because the reasons for such an outcome can differ from one patient to another. The Spanish researchers suggest that the following issues be considered by physicians in cases of possible re-treatment:

Tricky Symptoms to Spot

Yellowing of the skin and dark urine can be signs of this curable infection. Here’s what to look for and why a simple blood test can make all the difference in preventing liver damage.

Complications of a Scarred Liver

Without treatment, this viral infection can lead to permanent damage of the liver. Learn about cirrhosis and its symptoms.

How You Can Stay Healthy

Hepatitis C is a curable infection, but it’s important to take care of your physical and mental health while taking your medication.

How It Affects Your Liver

Take an inside look at how the hepatitis C virus slowly damages your liver over time.

What if It Goes Untreated?

Hepatitis C is curable, but if left untreated, it can lead to a host of serious complications affecting your whole body.

How the Cure Works

Medication can cure your hep C in a matter of weeks. Find out how it works to heal you.

Hep C and Relationships: What to Know

You can enjoy a healthy relationship while you have hep C. Learn what steps you need to take to make it happen.

What are the health problems associated with hepatitis C?

Skin problems. Blood pressure issues. Heart issues. Nerve problems. Joint and muscle issues. Blood sugar issues. Takeaway. Hepatitis C is a bloodborne virus that causes inflammation of the liver. More than 3 million people are living with hepatitis C in the United States.

Why does hepatitis C cause nerve damage?

This happens when nerves attached to more than one body part are affected. Nerve problems brought on by hepatitis C are thought to be related to inflammation of the blood vessel walls caused by the presence of abnormal proteins in the blood, says Houghton.

What is the only treatment for total hepatitis C?

But the only current treatment for total hepatitis C–related liver failure is a liver transplant . Scientists are quickly working to develop new treatments for liver failure, such as: Artificial liver support devices that can do the work a failing liver can no longer do.

What are the symptoms of cirrhosis?

Cirrhosis can do a lot of damage to the liver without ever being detected, and it can cause conditions such as: 1 yellowing of the skin and the whites of the eyes (jaundice) 2 chronic bruising and bleeding 3 gallstones 4 fluid buildup in the abdomen (ascites) 5 painful swelling of legs and feet (edema) 6 enlargement of the spleen (splenomegaly) 7 an increase of blood pressure in the portal venous system of the body (portal hypertension) 8 poisoning of the brain through the inability to process ammonia in the liver (hepatic encephalopathy) 9 chronic weakening of bone density (bone disease)

How is hepatitis C transmitted?

Today, hepatitis C is usually transmitted by sharing needles or other equipment to inject drugs. These are just a few of the serious long-term effects of untreated hepatitis C:

What are the causes of hepatitis C pain?

Joint and muscle issues. Joint and muscle problems impact 40 to 80 percent of people with hepatitis C, says Houghton. Joint problems include inflammation that is similar to rheumatoid arthritis — leading to painful hand and knee joints. Muscles and joints in other parts of the body can become painful and swollen, as well.

When was hepatitis C last reviewed?

If you think you may have hepatitis C or have been recently diagnosed, talk to your doctor so it can be treated early. Last medically reviewed on June 29, 2020.

What happens if you don't treat hepatitis C?

Although medication can cure hepatitis C, millions of people aren’t taking it. The problem: Left untreated, the virus can lead to serious health complications. There’s a reason the hepatitis C virus is called “the silent killer.”.

How many cases of hepatitis C have been identified?

The illness involves extremely fast bone turnover, which leads to severe, deep bone pain. Only people with hepatitis C develop this condition, and just 19 cases have been identified since 1992, according to a case study published in November 2016 in the journal Endocrinology, Diabetes and Metabolism Case Reports.

What percentage of people with hepatitis C have type 2 diabetes?

Type 2 diabetes Up to 33 percent of people with chronic hepatitis C also have type 2 diabetes, in part because the virus may cause insulin resistance, according to a review published in September 2015 in the journal Frontiers in Endocrinology.

How many people in the US have hepatitis C?

There’s a reason the hepatitis C virus is called “the silent killer.”. All too often, people don’t realize they’ve been infected. Out of the estimated 2.4 million people in the United States who have hepatitis C, more than half don’t know they have it, according to the U.S. Department of Health and Human Services.

What is RA in hepatitis?

Rheumatoid arthritis (RA) This inflammatory type of arthritis develops in some people with hepatitis C , causing symptoms that include pain, fatigue, swelling, and joint stiffness. These symptoms can even appear before people realize they have hepatitis C, according to the American College of Rheumatology.

Can diabetes cause cirrhosis?

The review also says that the virus may trigger diabetes, but having diabetes can also worsen hepatitis C, including increasing the risk of cirrhosis and liver cancer. It’s important to ask the doctors that treat your hepatitis C and diabetes to closely coordinate your treatment plan so you can manage both conditions.

Can hepatitis C cause liver cancer?

With hepatitis C, your risk of liver cancer also rises. Because hepatitis C symptoms are silent for so long, people sometimes see their doctor for a complication such as type 2 diabetes, only to discover later on that their condition was partly caused by hepatitis C, explains Dr. Singh. Here are a few other conditions that can be caused by ...

How long does hepatitis C last after liver transplant?

Most people who receive liver transplants for hepatitis C survive for at least five years after their transplants, but almost always hepatitis C virus returns.

What does it mean when you have end stage hepatitis C?

End-stage hepatitis C means the liver has been severely damaged by the hepatitis C virus. The hepatitis C virus slowly damages the liver over many years, often progressing from inflammation to permanent, irreversible scarring (cirrhosis). Often, people have no signs or symptoms of liver disease or have only mild symptoms for years ...

What happens when you have cirrhosis?

Cirrhosis usually progresses to the point where the liver loses most or all of its function — liver failure. In addition, people with cirrhosis may develop: 1 Bleeding of the digestive (gastrointestinal) tract due to enlarged veins in the tube that connects the throat and stomach (esophagus), a condition known as esophageal varices 2 Brain and nervous system damage due to the buildup of toxins in the bloodstream (hepatic encephalopathy)

Why does my liver swell?

Swelling due to fluid buildup in your abdomen and legs. Problems with concentration and memory. Cirrhosis usually progresses to the point where the liver loses most or all of its function — liver failure. In addition, people with cirrhosis may develop:

How to know if you have cirrhosis?

Once you have cirrhosis, treatment focuses on keeping the condition from worsening. It may be possible to stop or slow the damage. Symptoms of end-stage liver disease may include: Persistent or recurring yellowing of your skin and eyes (jaundice) Swelling due to fluid buildup in your abdomen and legs.

Does hepatitis C cure liver disease?

Newer, more-effective hepatitis C treatments can eliminate the virus in many people, reducing the risk of end-stage liver disease. With. Stacey A. Rizza, M.D.

image
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 1 2 3 4 5 6 7 8 9