What is the most serious complication of osteoporosis?
Compression fractures Bone fractures, particularly in the spine or hip, are the most serious complications of osteoporosis. Hip fractures often are caused by a fall and can result in disability and even an increased risk of death within the first year after the injury.
What is treatment failure in osteoporosis?
Treatment failure is defined as 'An overall decline in BMD in the order of 5% or more in at least two serial BMD measurements at the lumbar spine or 4% at the proximal femur. Sequential measurement of markers of bone turnover should use the same assay.
How many years can Reclast be given?
After 3 to 5 years, your healthcare provider may stop your Reclast prescription and prescribe a different osteoporosis treatment. That's because studies of Reclast are only based on 3 years of treatment.
Is severe osteoporosis a death sentence?
A diagnosis of osteopenia or osteoporosis is not a death sentence. Rather, it's a warning that you have to pay more attention to your lifestyle habits and your surroundings. For women don't die from osteoporosis; instead, they die from complications related to the fractures that occur with severe osteoporosis.
What is the monoclonal antibody used for the treatment of osteoporosis?
Denosumab. Denosumab, also known as AMG 162, is a fully human monoclonal antibody that binds to RANKL with high affinity, mimicking the effects of OPG on RANKL. Therefore, denosumab can block the differentiation of osteoclasts, resulting in inhibition of osteoclast-mediated bone resorption.
What are the negative side effects of Reclast?
Common side effects of Reclast include:nausea,tiredness,flu-like symptoms (e.g., fever, chills, muscle/joint aches),cough,dizziness,headache,vision problems,diarrhea,More items...
What are the dangers of Reclast for osteoporosis?
There are concerns about the long-term safety of bisphosphonates (such as Reclast) as long-term use has been associated with atypical femur fractures, osteonecrosis of the jaw, and esophageal cancer. The risk of osteonecrosis of the jaw is greater in those who have received chemotherapy, radiation, or steroids.
How many infusions of Reclast are recommended?
The recommended regimen is a 5 mg infusion given once every 2 years intravenously over no less than 15 minutes. Patients must be adequately supplemented with calcium and vitamin D if dietary intake is not sufficient. Postmenopausal women require an average of 1200 mg calcium and 800-1000 IU vitamin D daily.
What is the life expectancy of someone with severe osteoporosis?
This excess risk is more pronounced in the first few years on treatment. The average life expectancy of osteoporosis patients is in excess of 15 years in women younger than 75 years and in men younger than 60 years, highlighting the importance of developing tools for long-term management.
What is end stage osteoporosis?
The fourth stage of osteopenia and osteoporosis Without any intervention, osteoporosis can progress to stage four. During this stage the effects of significant bone loss become visible. Softening of the bones and accumulated fragility fractures, especially in the spine, results in deformity.
What organs are affected by osteoporosis?
Osteoporosis is a bone disease that causes your bones to be weak and more likely to break. Organs affected by osteoporosis include the ovaries and thyroid gland.