Symptoms
Penicillamine: the treatment of first choice for patients with Wilson’s disease. Mov Disord. 1999;14:545–50. doi: 10.1002/1531-8257 (199907)14:4<545::AID-MDS1001>3.0.CO;2-U. [ PubMed] [ Google Scholar]
Causes
Wilson's disease is an inherited disorder in which there is too much copper in the body's tissues. The excess copper damages the liver and nervous system. The following list of medications are in some way related to, or used in the treatment of this condition. Activity ?
Prevention
Oral zinc sulphate as long-term treatment in Wilson’s disease (hepatolenticular degeneration) Eur Neurol. 1979; 18 :205–11. doi: 10.1159/000115077. [ PubMed] [ Google Scholar] [ Ref list]
Complications
Copper chelation in patients with Wilson’s disease. A comparison of penicillamine and triethylene tetramine dihydrochloride. Q J Med. 1973;42:441–52. doi: 10.1093/oxfordjournals.qjmed.a067346. [ PubMed] [ Google Scholar] 79.
Which medications are used in the treatment of Wilson’s disease?
What is Wilson's disease?
What is the long-term treatment for Wilson’s disease (hepatolenticular degeneration)?
Which chelating agents are used in Wilson’s disease?
What drugs overcome Wilson disease?
Zinc acetate (Galzin). This medication prevents your body from absorbing copper from the food you eat. It is typically used as maintenance therapy to prevent copper from building up again after treatment with penicillamine or trientine.
Why is there no cure for Wilson's disease?
Your body needs small amounts of copper from food to stay healthy. But a buildup of too much copper is serious. It can result in brain damage, liver failure, or death if it is not treated.
What is the gold standard for Wilson's disease?
There is no gold standard for the diagnosis of Wilson's disease, which is often delayed due to the non‐specific clinical features and the need for a combination of clinical and laboratory tests for diagnosis.
Which of the following chelating agents is used for the treatment of Wilson's disease?
The mainstay of therapy for Wilson disease is pharmacologic treatment with chelating agents such as D-penicillamine and trientine. Other agents include sodium dimercaptosuccinate, dimercaptosuccinic acid, zinc, and tetrathiomolybdate.
What is the safest treatment for Wilson's disease?
Penicillamine link (Cupramine, Depen) and trientine (Syprine) are two chelating agents used to treat Wilson disease. These medicines remove copper from the body. Penicillamine is more likely to cause side effects than trientine.
Which antidote is used in copper poisoning?
D-Penicillamine is the primary chelator used in copper toxicity, although EDTA (Ethylenediaminetetraacetic acid) and DMPS (dimercaptopropanesulfonic acid) may also be used for heavy metal toxicity with copper.
Can you reverse Wilson's disease?
Wilson's disease can develop into liver failure and brain damage if left untreated. Early treatment can help reverse neurological issues and liver damage. Treatment in a later stage may prevent further progress of the disease, but it won't always restore the damage.
What part of the brain is affected by Wilson's disease?
Abnormalities in the putamen, pons, midbrain, and thalamus are part of the neuroimaging spectrum of Wilson disease. There is a significant correlation between the site of brain injury and diagnosis lag time.
How long can you live with Wilson disease?
Usually, symptoms of Wilson's disease develop between 12 and 23 years of age, and untreated people may have a life expectancy of 40 years. However, early diagnosis, followed by proper treatment, may increase the life span.
Does chelation therapy work on copper?
Copper chelating agents are among the most promising tools to keep copper concentration at physiological levels. In this review, we focus on the most relevant compounds experimentally and clinically evaluated for their ability to counteract copper homeostasis deregulation.
What is trientine used for?
Trientine is used to treat Wilson's disease, a disease in which there is high levels of copper in the body in patients who are de-coppered and dependent to penicillamine. This medicine combines with excess copper in the body and may prevent your body from absorbing the copper in the foods you eat.
How can I lower my copper levels naturally?
Other great ways to support copper removal, according to Coates, include drinking filtered water and eating foods which can give you a good balance of copper and zinc, such as lamb, pork, poultry, soy milk, nuts, seeds, dried beans, and wheat germ.
Drugs used to treat Wilson's Disease
The following list of medications are in some way related to, or used in the treatment of this condition.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Baclofen
Baclofen is a derivative of gamma-aminobutyric acid (GABA), prescribed for severe chronic spasticity.
Clonazepam
Clonazepam is an anticonvulsant, muscle relaxant, prescribed for Lennox-Gastaut syndrome, panic disorder and seizures.
Dimercaprol
Dimercaprol is a chelating agent, indicated in the treatment of metal poisoning with metals such as arsenic, gold and mercury.
Levodopa
Levodopa is an antiparkinson agent, relieves some symptoms of Parkinson’s disease, including tremors, stiffness, and slowness of movement.
Penicillamine
Penicillamine is a chelating agent (remove heavy metals from the body), prescribed for Wilson disease (excess copper in the body), severe rheumatoid arthritis that has not responded to other treatments, and cystinuria (excess amino acids in the urine, which causes kidney stones).
Zinc Acetate
Zinc Acetate is a naturally occurring mineral, prescribed for Wilson disease.
