What is the meaning of implications?
Treatment Implications. Using Neuroscience to Guide the Development of New Pharmacotherapies for Alcoholism. Suchitra Krishnan-Sarin, Ph.D., Stephanie O’Malley, ... Discussion of the treatment of withdrawal from alcohol, which involves a combination of pharmacologic therapy and nutritional and psychosocial support, is beyond the scope of this ...
What are the different types of implications?
Jul 13, 2020 · Nursing implications are the nursing-related consequences of something (a disease, a medication, a procedure). ie. not the medical side effects, but the things which may occur which are up to the nurse to resolve. To work out what they are, you need to understand about the disease, medication or procedure. What does implications of practice ...
What is the synonym of implication?
The biology of trauma: implications for treatment During the past 20 years, the development of brain imaging techniques and new biochemical approaches has led to increased understanding of the biological effects of psychological trauma. New hypotheses have been generated about brain development and the roots of antisocial behavior.
What is the implication of a statement?
implication: [noun] the act of implicating (see implicate) : the state of being implicated.
Kids Definition of implication
2 : a possible future effect or result Consider the implications of your actions.
Legal Definition of implication
What made you want to look up implication? Please tell us where you read or heard it (including the quote, if possible).
Prevalence of Anxiety in Autism Spectrum Disorders
Rachel Kent, Emily Simonoff, in Anxiety in Children and Adolescents with Autism Spectrum Disorder, 2017
Matching Patients to Alcoholism Treatment
The clinical implications of Project MATCH were described by the investigators in a 1998 publication as follows:
Metacognitive therapy for Alcohol Use Disorder: Theoretical foundations and treatment principles
Giovanni Mansueto, ... Marcantonio M. Spada, in The Handbook of Alcohol Use, 2021
Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating neurodegenerative diseases as metabolic diseases
Edward J. Calabrese, ... James Giordano, in International Review of Neurobiology, 2020
Foundations
Thomas G. O'Connor, ... Robert Plomin, in Comprehensive Clinical Psychology, 1998
Leukocyte Trafficking and Stress
S. Hong, ... P.J. Mills, in Encyclopedia of Stress (Second Edition), 2007
Clinical Implications of Network Principles 3–12
This chapter discusses the clinical implications of Principles 3–12. Principle 3 concerns how neural networks create psychological constructs; how mind emerges from brain. Principle 4 concerns memory reactivation as a basis of emotion-focused therapy and the use of medications to modify memory. Principle 5 concerns priming.
The discovery of recovery
Recovery is at the heart of the treatment themes in Britain’s national drug policies, featuring in the titles of both the English and the Scottish strategies ( The Road to Recovery ), while the Welsh strategy committed the nation to “focus our efforts on helping substance misusers to improve their health and maintain their recovery”.
Counsels of perfection or of necessity?
Though expressed as a process of ‘moving towards’, the implication that recovering from addiction entails developing lives more fulfilling than many who never had these problems was well represented by a definition from the US agency for substance ‘abuse’ and mental health.
Demands transformation of treatment
Having defined the desired ‘recovery’ outcome as far as we can, now we can work backwards to what that means for treatment. Logic dictates it should determine how to assess success and the inputs needed to achieve it.
Operationalising the objective
Recovery’s great utility is its elasticity, allowing it to act as an unarguably desirable objective under which disparate stakeholders can unite, even if in practice they interpret it differently, a role it plays in UK national strategies. But this also means it is too nebulous a concept to be used as a target or yardstick in itself.
On the ground?
A fundamental problem for services is that just as their remit is being extended to encompass recovery and the building of recovery capital, the resources available are being cut, in some areas, dramatically.
Issues
Among the issues raised by the recovery agenda are the fundamental one of whether we accept repeated and widespread post-treatment relapse as a sign of the intractability (or as US guidelines have it, the persistence of drug-induced brain dysfunction) of addiction, or a sign that treatment, commissioners and planners have failed truly to embrace the changes needed to reorientate to recovery.
Fda-Approved Treatments For Alcoholism
- Disulfiram
Disulfiram has been in use for the treatment of alcoholism since the 1940s. This medication produces an aversive effect by disrupting alcohol metabolism. When alcohol is consumed, it is converted to acetaldehyde, which is further broken down by aldehyde dehydrogenase. Disulfira… - Naltrexone
Naltrexone is available as an oral medication (Revia®) and in two injectable forms (Vivitrol® and Naltrel®). Its primary use is for the treatment of alcohol dependence, and it is well tolerated with primarily gastrointestinal side effects (O’Malley et al. 1992; Volpicelli et al. 1992). Naltrexone’s ef…
Other Promising Medications with Some Clinical Evidence of Efficacy
- Although the agents reviewed in this section are not FDA approved for treating alcoholism, they show promise for this purpose.
New Directions and Investigational Agents
- The agents reviewed below currently are under investigation and represent new directions for treating alcohol use. Unlike those reviewed above, the following agents have no clinical evidence of efficacy for treating alcoholism.
Summary
- Alcohol has a complex neuropharmacology and can affect many different brain neurotransmitter systems. Several pharmacological agents that interact with specific neurotransmitter systems affected by alcohol already have shown efficacy in the treatment of alcohol dependence and many exciting investigational agents are on the horizon. The development of these agents has b…
Acknowledgements
- This work was supported by the National Institute on Alcohol Abuse and Alcoholism Center grant P50AA12870 and K award K05AA014715.
Financial Disclosure
- Dr. Krystal has served as a consultant to the following pharmaceutical companies: Atlas Venture, Aventis Pharmaceuticals, Biomedisyn Corporation, Bristol-Meyers Squibb, Centre de Recherche Pierre Fabre, Cypress Bioscience, Eli Lilly, Fidelity Biosciences, Forest Laboratories, GlaxoSmithKline, Janssen Research Foundation, Merz Pharmaceuticals, Organon International (…
References
- Acheson, A.; Mahler, S.V.; Chi, H.; and de Wit, H. Differential effects of nicotine on alcohol consumption in men and women. Psychopharmacology 186(1):54–63, 2006. PMID: 16565827 Addolorato, G.; Caputo, F.; Capristo, E.; et al. Baclofen efficacy in reducing alcohol craving and intake: A preliminary double-blind randomized controlled study. Alcohol and Alcoholism 37(5):50…