The goal of this project is to evaluate the therapeutic potential of pioglitazone (PIO) to target underlying mechanisms that promote muscle fatigue in patients with breast cancer. This represents an off-label use of this compound, both in terms of the patient population and the clinical phenotype targeted.
When should I take pioglitazone?
May 21, 2020 · changes in your vision; or. sudden unusual pain in your hand, arm, or foot. Some people taking pioglitazone have had bladder cancer, but it is not clear if pioglitazone was the actual cause. Common side effects may include: headache; muscle pain; or. cold symptoms such as stuffy nose, sinus pain, sneezing, sore throat.
When to take pioglitazone?
Pioglitazone was associated with increased incidence of melanoma and non-Hodgkin lymphoma and decreased risk of renal cancer in one cohort study. These findings need to be re-evaluated on a prospective basis. There is no convincing evidence that pioglitazone increases or decreases the risk of cancer in other sites.
What is a substitute for pioglitazone?
Mar 02, 2022 · Actos. Brand Names: Canada. ... bladder cancer, or type 1 diabetes. If the patient is a child. Do not give this drug to a child. ... to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications ...
What are the side effects of pioglitazone?
Dec 15, 2016 · The U.S. Food and Drug Administration (FDA) announced that use of pioglitazone (Actos) for the treatment of type 2 diabetes may increase bladder cancer risk. The group has accordingly updated ...
What does the medication pioglitazone do?
Why would a doctor prescribe pioglitazone?
Does pioglitazone reduce mortality?
What is the mode of action of pioglitazone?
Pioglitazone selectively stimulates the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) and to a lesser extent PPAR-α. It modulates the transcription of the genes involved in the control of glucose and lipid metabolism in the muscle, adipose tissue, and the liver.
What are the adverse effects of pioglitazone?
- swelling (edema), when used in combination with sulfonylurea or insulin.
- low blood sugar (hypoglycemia)
- upper respiratory infection.
- headache.
- heart failure.
- sinus infection.
- fracture of bone.
- sore throat (pharyngitis)
Does pioglitazone affect the kidneys?
How long does pioglitazone stay in your system?
Is Actos hard on kidneys?
What are SGLT2 inhibitor drugs?
Does pioglitazone cause heart failure?
What are the drug interactions with pioglitazone?
| Drug | Interaction |
|---|---|
| Integrate drug-drug interactions in your software | |
| Bromocriptine | The risk or severity of hypoglycemia can be increased when Pioglitazone is combined with Bromocriptine. |
| Budesonide | The risk or severity of hyperglycemia can be increased when Budesonide is combined with Pioglitazone. |
Where is pioglitazone absorbed?
Before Taking This Medicine
You should not use this medicine if you are allergic to pioglitazone, or if you have severe or uncontrolled heart failure, active bladder cancer, o...
How Should I Take Pioglitazone?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
What Happens If I Overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. You may have signs of low blood sugar, such as extreme weakness, b...
Pioglitazone Side Effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.St...
Pioglitazone Dosing Information
Usual Adult Dose for Diabetes Type 2:-Patients without congestive heart failure: Initial dose: 15 mg or 30 mg orally once a day-Patients with conge...
What Other Drugs Will Affect Pioglitazone?
Tell your doctor if you use insulin. Taking pioglitazone while you are using insulin may increase your risk of serious heart problems.Tell your doc...
Brand Names: Canada
ACCEL Pioglitazone [DSC]; ACH-Pioglitazone; ACT Pioglitazone; Actos [DSC]; APO-Pioglitazone; DOM-Pioglitazone [DSC]; JAMP-Pioglitazone; MINT-Pioglitazone; MYLAN-Pioglitazone [DSC]; PMS-Pioglitazone; PRO-Pioglitazone; RAN-Pioglitazone; SANDOZ Pioglitazone; TEVA-Pioglitazone [DSC]; VAN-Pioglitazone [DSC]
Warning
This drug may cause or make heart failure worse. Tell your doctor if you have had heart failure. Do not take this drug if you have moderate to severe heart failure or any signs of heart failure. You will be watched closely while starting this drug and if your dose is raised.
What is this drug used for?
It is used to lower blood sugar in patients with high blood sugar (diabetes).
What do I need to tell my doctor BEFORE I take this drug?
If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
What are some things I need to know or do while I take this drug?
Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
What are some other side effects of this drug?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
What is pioglitazone used for?
Expand Section. Pioglitazone is used with a diet and exercise program and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Pioglitazone is in a class of medications called thiazolidinediones.
Can pioglitazone be used for diabetes?
Pioglitazone is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may develop if high blood sugar is not treated). Over time, people who have diabetes and high blood sugar can develop serious ...
Can pioglitazone cause heart failure?
Pioglitazone and other similar medications for diabetes may cause or worsen heart failure (condition in which the heart is unable to pump enough blood to the other parts of the body). Before you start to take pioglitazone, tell your doctor if you have or have ever had heart failure, especially if your heart failure is so severe ...
How long does it take for pioglitazone to work?
Pioglitazone controls type 2 diabetes but does not cure it. It may take 2 weeks for your blood sugar to decrease and 2 to 3 months for you to feel the full effect of pioglitazone. Continue to take pioglitazone even if you feel well. Do not stop taking pioglitazone without talking to your doctor.
Does pioglitazone affect blood sugar?
Expand Section. This medication may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms. Pioglitazone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: headache. muscle pain.
Does pioglitazone cause fractures?
In clinical studies, more women who took pioglitazone developed fractures (broken bones), especially of the hands, upper arms, or feet, than women who did not take pioglitazone. Men who took pioglitazone did not have a greater risk of developing fractures than men who did not take the medication.
What is the phone number to call for poison control?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
What is pioglitazone used for?
Pioglitazone is a diabetes drug (thiazolidinedione-type, also called "glitazones") used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes.
Does pioglitazone cause heart failure?
Pioglitazone may rarely cause or worsen a certain heart problem ( heart failure ). Tell your doctor right away if you notice any symptoms of heart failure, including: shortness of breath, swelling ankles /feet, unusual tiredness, unusual/ sudden weight gain.
Does a syringe have side effects?
Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: new/worsening vision problems (such as blurred vision ), bone fracture, reddish-colored urine, urgent need to urinate, pain while urinating.
Can you take pioglitazone with metformin?
Proper control of diabetes may also lessen your risk of a heart attack or stroke .Pioglitazone is used either alone or in combination with other diabetes medications (such as metformin or a sulfonylurea such as glyburide ).Talk to your doctor about the risks and benefits of pioglitazone.
How to prevent low blood sugar?
To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal.
How to raise blood sugar?
If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda.
Can drug interactions change your medication?
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.
What is pioglitazone used for?
Pioglitazone is a prescription drug indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus in multiple clinical settings. Pioglitazone exerts its antihyperglycemic effect only in the presence of endogenous insulin.
Is pioglitazone good for diabetics?
Pioglitazone exerts its antihyperglycemic effect only in the presence of endogenous insulin. Pioglitazone should not be used to treat type 1 diabetes or diabetic ketoacidosis, as it would not be effective in these settings. Pioglitazone is available under the following different brand names: Actos. Dosages of Pioglitazone: Tablet.
What are the side effects of pioglitazone?
yellowing of skin or eyes ( jaundice) cold symptoms ( stuffy nose, sneezing, cough) back pain. tooth problems. Rare side effects of pioglitazone include: liver failure. This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.
Does pioglitazone cause bladder cancer?
Bladder cancer. Pioglitazone may be linked to an increased risk of bladder cancer. Do not prescribe for patients with active bladder cancer. Consider benefit: risk ratio before prescribing in patients with a history of bladder cancer.
Can thiazolidinedione cause fluid retention?
Thiazolidinediones, which are peroxisome proliferator-activated receptor ( PPAR) gamma agonists, can cause dose-related fluid retention, particularly when used in combination with insulin. Risk of low blood sugar (hypoglycemia), in combination with insulin or other oral agents.
Can you stop taking a medicine before checking with your doctor?
Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
Medical uses
- Pioglitazone is used with a diet and exercise program and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Pioglitazone is in a class of medications called thiazolidinediones. It works by increasing the body's sensiti...
Administration
- Pioglitazone comes as a tablet to take by mouth. It is usually taken once daily with or without meals. Take pioglitazone at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take pioglitazone exactly as directed. Do not take more or less of it or take it more …
Results
- Pioglitazone controls type 2 diabetes but does not cure it. It may take 2 weeks for your blood sugar to decrease and 2 to 3 months for you to feel the full effect of pioglitazone. Continue to take pioglitazone even if you feel well. Do not stop taking pioglitazone without talking to your doctor.
Diet
- Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. It is important to eat a healthy diet, exercise regularly, and lose weight if necessary. This will help to control your diabetes and help pioglitazone work more effectively.
Interactions
- Alcohol may cause a decrease in blood sugar. Ask your doctor about the safe use of alcoholic beverages while you are taking pioglitazone.
Adverse effects
- You should know that pioglitazone may cause liver problems. Stop taking pioglitazone and call your doctor right away if you have nausea, vomiting, loss of appetite, pain in the upper right part of the stomach, flu-like symptoms, dark urine, yellowing of the skin or eyes, unusual bleeding or bruising, or lack of energy.
Risks
- In clinical studies, more people who took pioglitazone for more than one year developed bladder cancer than people who did not take pioglitazone Talk to your doctor about the risk of taking this medication. In clinical studies, more women who took pioglitazone developed fractures (broken bones), especially of the hands, upper arms, or feet, than women who did not take pioglitazone. …
Prevention
- Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat, light, and moisture (not in the bathroom). Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toi…
Preparation
- It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.