What does a complete response to treatment mean?
Complete response to treatment (CR) is the term used for the absence of all detectable cancer after your treatment is complete. Complete response doesn't necessarily mean that you are cured, but it is the best result that can be reported. It means the cancerous tumor is now gone and there is no evidence of disease.
What is a partial response to treatment?
After treatment completion, an individual is generally assessed for response after a period of time to allow maximal regression of the tumor. At the end of that period if there is some disease remaining but a reduction of disease by 30% or more on clinical examination or x-rays and scans – it is called partial response (or partial regression).
What is ‘patient response?
• Short definition: ‘Patient response’ is the documentation of the patient’s preferences and responses to physician’s requests within the clinical record.
How do I respond to a client who is taking things for granted?
You can have several of these types of responses within one response to the client, such as: “you are tired of being taken for granted.” (Feeling and content reflection). See the workbook for more details.
What is it called when there is no residual disease?
At the end of that period if there is no residual disease that can be identified on clinical examination by the doctor, or on X-rays and scans, or even by lab tests for the disease or its markers—it is called complete response (or complete regression).
How is pre-surgical treatment assessed?
Pre-surgical treatment is assessed for pathologic complete response by examining the breast tissue removed in surgery. If no cancer is found in the tissue, the patient is said to have pathological complete response.
What does CR mean in cancer?
Complete response to treatment (CR) is the term used for the absence of all detectable cancer after your treatment is complete. Complete response doesn't necessarily mean that you are cured, but it is the best result that can be reported. It means the cancerous tumor is now gone and there is no evidence of disease.
Is a complete response a cure?
Complete response (CR) does not imply cure. 1 Some people with a complete response may have a tumor recurrence later. But it definitely is a good thing to have a complete response—. it is the best starting point for a cure. For some types of cancers, seeing a complete response is a good indication of a cure.
Is seeing a complete response good?
For some types of cancers, seeing a complete response is a good indication of a cure. For other cancers, the rate of cure is lower after seeing a complete response. Ask your doctor to explain to you what the term means in the case of cancers similar to yours. Your doctor will know what it is likely to mean for patients with your condition who had ...
What is individual variation in drug response?
Individual variation in drug response. Prescribers have numerous sources of guidance about how to use drugs appropriately (e.g. dose , route, frequency, duration) for many conditions. However, this advice is based on average dose–response data derived from observations in many individuals. They can never be certain about ...
What are extreme examples of drug therapy?
Extreme examples are: total non-responsiveness and. severe adverse effects. reported for virtually all drugs in smaller or larger patient subsets.
How do disease markers help in treatment decisions?
Along the way, disease markers gradually transform the traditional organ- and histology-based disease classification into one more relevant for treatment decisions . Therapies are also optimized by the consideration of the patient’s treatment objectives and drug preferences.
What are patient specific factors?
Patient-specific factors include his/her therapeutic objectives and drug preferences, contraindications such as age, pregnancy, or comorbidities, and the individual, usually hardly predictable profile of undesired drug effects. Responsiveness prediction based on (tumor) genotyping is used mainly in oncology and it is partly driven by high costs ...
How are therapies optimized?
Therapies are also optimized by the consideration of the patient’s treatment objectives and drug preferences. All therapies require optimization. The individual intensity and urgency is determined by the pharmacological and toxicological drug properties, by the course of the disease, and by patient-specific factors.
Why is variation in the drug concentrations achieved by equivalent doses important?
Variation in the drug concentrations achieved by equivalent doses is a much more important cause of the inter-individual variation in drug response encountered in clinical practice . There are many reasons why the absorption, metabolism and excretion of drugs might vary.
Can a doctor be certain of the dose response relationship?
They can never be certain about the actual dose–response relationships for the particular patients that they treat. They can never be certain that their choice will be effective or safe for their individual patient and must recognize the need to monitor the outcome of their prescription.
What does "complete response" mean?
Some of these include: Complete response means that cancer has responded to treatment and no evidence of cancer can be seen on imaging studies. Complete remission means all target lesions have disappeared.
What does partial response mean?
Partial response (PR) implies that further treatment will probably be required to attempt a cure. In some slow-growing tumors (including low-grade lymphomas) no further treatment may be immediately necessary until the disease starts increasing in size again.
What is progressive disease?
Progressive disease means that cancer has at least a 20% increase in the sum of diameters of target lesions, taking as reference the smallest sum on study (this includes the baseline sum if that is the smallest on study).
Is partial response good or bad?
For the same reason, a partial response could be particularly good or particularly bad. It all depends not only on your specific cancer but on the molecular profile of your specific cancer. If you are searching for information on your cancer keep this in mind.
Sunday, October 03, 2010
In clinical trials, the efficacy endpoints are often measured as continuous variables. The hypothesis tests are used to determine whether or not there are statistically significant differences between one group vs. another group. This is desired by the statisticians.
Individual response vs. group response
In clinical trials, the efficacy endpoints are often measured as continuous variables. The hypothesis tests are used to determine whether or not there are statistically significant differences between one group vs. another group. This is desired by the statisticians.
What is patient response?
A ‘Patient Response’ is much like a medical test result. You can think of a patient response as being much like a medical test report that comes back into the record for the clinician to use in making a better diagnosis or treatment plan.
How does patient response improve patient care?
Patient response can improve the doctor-patient relationship and care outcomes by promoting empathy. With patient response, the doctor gets to learn the patient’s perspective in a short time, and the patient gets the satisfaction of knowing his voice was heard. Both enjoy the rewards of improved medical outcomes.
What is Dr. Jones' practice?
Dr Jones runs a thriving cardiology practice. Apart from being a very competent doctor and an expert in his field, there’s an all-important ingredient in his formula for success – Patient Response. Dr Jones’ team uses EMRs ( electronic medical records) which are accessible to the patient through a patient portal; and ensures that appropriate feedback is obtained after every consultation. Patients are proactively asked if they have any concerns about their treatment plan; and regular emails are sent to ensure that patients are coping well . This active involvement of patients in their treatment is what truly sets him apart from many other well-meaning doctors.
What is a pre-visit summary?
1. Pre-visit summaries. Pre-visit summaries are patient responses to a set of questions sent to a patient in advance of a visit. The questions are specific to the reason for the visit and interactively probe the patient’s symptoms, concerns, level of knowledge, and expectations for the visit.
How long did it take for information therapy to become mainstream?
It took less than 10 years from the publication of Information Therapy to the publishing of the Meaningful Use rules that took information prescriptions mainstream. And now that information therapy has paved the way for patient response, its road can be travelled far more quickly.
Is it enough to inform a patient?
While informing patients is a key step in unlocking the patient’s potential, one-way information—by itself—is not enough. Until the physician can see, in the clinical record, the patient’s response to a query or decision aid, there is little chance that the patient’s voice will be heard.
What does it mean to acknowledge someone is using the silent treatment?
Acknowledge that someone is using the silent treatment. For example, a person can say, “I notice that you are not responding to me.” This lays the foundation for two people to engage with each other more effectively.
What is silent treatment?
Summary. The silent treatment is a refusal to communicate verbally with another person. People who use the silent treatment may even refuse to acknowledge the presence of the other person. People use the silent treatment in many types of relationship, including romantic relationships. It can sometimes be a form of emotional abuse.
Why is silent treatment important?
for healthy relationships. Using the silent treatment prevents people from resolving their conflicts in a helpful way. When one partner wants to talk about a problem but the other withdraws, it can cause negative emotions such as anger and distress.
How does silent treatment affect relationships?
How it affects relationships. In most cases, using the silent treatment is not a productive way to deal with a disagreement. Research indicates that both men and women use the silent treatment in relationships. However, clear and direct communication is essential. for healthy relationships.
What are the types of emotional abuse?
demanding access to their phone, email account, and other digital information. deciding what they wear, eat, or drink.
What to do if someone feels they are in danger?
If a person feels that they or their family are in immediate danger, they must call 911. If they are not in immediate danger, a person who believes that their partner is abusive should consider whether or not they wish to stay in the relationship. It will help someone in an abusive relationship to:
How to deal with a person who is abusive?
Avoid becoming defensive or going into problem-solving mode. Try to stay present and listen empathically. If the person responds in a threatening or abusive way, it is important to remove oneself from the situation until they calm down. Talk to a doctor, therapist, or trusted friend for help.
Assessing Complete Response to Treatment
Does It Mean You're Cured?
- Complete response (CR) does not imply cure.1 Some people with a complete response may have a tumor recurrence later. But it definitely is a good thing to have a complete response— it is the best starting point for a cure. For some types of cancers, seeing a complete response is a good indication of a cure. For other cancers, the rate of cure is lower after seeing a complete respons…
Pathologic Complete Response
- When you see complete response reported for clinical trials and other research, the studies may use another term called pathologic complete response. Pathologic complete response refers to a situation in which some form of therapy is given prior to surgery for cancer (such as chemotherapy, radiation, etc), and then once the patient undergoes surger...