What are the in vitro tests for canine osteosarcoma (OSA)?
Nov 26, 2014 · Osteosarcoma (OSA) is the most common type of bone tumors in dogs, which has high metastasis ability. 80 % of dogs with OSA die due to lung metastasis. As a result its treatment is a challenge for veterinary practitioners. The authors discuss the etiology, pathogenesis and the possible risk factors of OSA.
Are fucoidan nanoparticles effective for osteosarcoma treatment?
Osteosarcoma (OSA) is the most common type of bone tumors in dogs, which has high metastasis ability. 80 % of dogs with OSA die due to lung metastasis. As a result its treatment is a challenge for veterinary practitioners. The authors discuss the etiology, pathogenesis and the possible risk factors of OSA.
What is the prognosis of osteosarcoma in dogs?
What kind of bone tumor does a German Shepherd have?
What is the most common bone tumor in dogs?
Osteosarcoma (OSA) is the most common type of bone tumors in dogs, which has high metastasis ability. 80 % of dogs with OSA die due to lung metastasis. As a result its treatment is a challenge for veterinary practitioners. The authors discuss the etiology, pathogenesis and the possible risk factors of OSA. The article focuses on literature review and the study of recent advances in OSA treatment. The authors describe therapies which have significantly prolonged the lives of dogs, as well as those that have proven to be ineffective. Advantages and disadvantages of limb amputation and limb-sparing surgery have been described. Authors present also the results of both single agent’s therapies with the most commonly used drugs as cisplatin, carboplatin and doxorubicin and compare them to the results obtained using combined chemotherapy. The use of nanotechnology as a new approach in OSA treatment in order to avoid multidrug resistance and reduce negative side effects of cytostatic drugs is presented. The main reasons of the therapies failure are also provided in this article.
Is doxorubicin as effective as cisplatin?
It is believed that doxorubicin used in OSA treatment is as effective as cisplatin or carboplatin. One of the first researches on doxorubicin’s effectiveness was conducted in 1995. Berg and associates ( 1995) compared the results of 35 dogs with appendicular OSA treated with 5 doses of doxorubicin (30 mg/m2 of body surface, i.v., every 2 weeks) and limb amputation (after second or third dose) with a historical control group of 162 dogs who were treated with amputation alone. The median survival time for dogs receiving adjunctive therapy was 366 days, which was significantly longer than for the control group (138 days). Similar results were presented by Moore et al. (Moore et al. 2007 ), whose study included 303 dogs with appendicular OSA. The way of doxorubicin administration was similar to the one in the previous report. Doxorubicin demonstrated efficacy in the slowing of metastasis in dogs with appendicular OSA with a 1-, 2-, and 3-year median survival time of 35, 17, and 9 % respectively (Moore et al. 2007 ). The results obtained are similar to those with carboplatin as the adjunctive method of treatment, which indicates that both drugs may be used to prolong patients’ lives, however, neither of them inhibits metastasis.
Is radiation therapy palliative?
Radiation therapy is considered to be a palliative method of treatment. The intent is to provide pain relief and prolong patients’ lives. However, it is not easily accessible and requires a general anesthesia of the patient. Studies performed by Oblak et al. (Oblak et al. 2012) proved that combined therapy including surgery, chemotherapy and radiotherapy is nowadays the most effective way of treatment. Fifty dogs were included in the study and median survival times between those that received palliative radiation therapy alone, and in combination with chemotherapy, pamidronate, or both were compared. Median survival times were the longest for dogs receiving radiotherapy together with chemotherapy (307 days) and the shortest in dogs receiving radiotherapy and pamidronate (69 days). Chemotherapy in addition to radiotherapy gave satisfying results, while enriching radiotherapy with pamidronate was ineffective (Oblak et al. 2012 ).
Author information
1. Kansas State University College of Veterinary Medicine, Mosier Hall, 1800 Denison Avenue, Manhattan, KS 66506-5606, USA.
Abstract
Osteosarcoma (OSA) is the most common primary bone tumor diagnosed in dogs. Our understanding of the risk factors and genetic changes in canine OSA patients is growing, but specific, innovative therapeutic strategies are slow in coming.
Similar Articles
To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.