What client would be most likely to benefit from treatment with filgrastim (Neupogen)? A client who has recently undergone bone marrow transplant to treat leukemia The action of immune stimulants ultimately results in the development of flu-like symptoms as adverse effects. True
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What is filgrastim used to treat?
What client would be most likely to benefit from treatment with filgrastim (Neupogen)? A client who has recently undergone bone marrow transplant to treat leukemia The nurse closely monitors a client who is receiving anakinra and etanercept for:
Does filgrastim act as a growth factor for tumor cells?
Jan 13, 2021 · Patients with severe chronic neutropenia: pain, decreased red blood cells, nose bleed, diarrhea, reduced sensation, and hair loss. These are not all the possible side effects of NEUPOGEN. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the pharmacokinetics of filgrastim?
What client would be most likely to benefit from treatment with filgrastim (Neupogen)? A client who has recently undergone bone marrow transplant to treat leukemia. A client is being treated for malignant melonoma and has been prescribed interferon alfa-2b. The client has complex medical history and the medication regimen includes aspirin ...
How many patients received Neupogen 30 mcg/kg/day?
Contraindication. NEUPOGEN ® is contraindicated in patients with a history of serious allergic reactions to human granulocyte colony-stimulating factors (G-CSFs), such as filgrastim or pegfilgrastim; Splenic Rupture. Splenic rupture, including fatal cases, can occur following the administration of NEUPOGEN ®; Evaluate patients who report left upper abdominal or shoulder …
What clients are likely to benefit from treatment with interferons?
What conditions do interferons treat?Chronic hepatitis C, hairy cell leukemia, Kaposi sarcoma caused by AIDS, chronic myelogenous leukemia (CML)Chronic hepatitis, lymphoma, and malignant melanoma.Genital warts.Aug 30, 2020
Which is the most likely indication for the use of immunosuppressant agents?
The most common indications include transplant rejection prophylaxis and the treatment of autoimmune disorders such as lupus, psoriasis, and rheumatoid arthritis. It is common practice to use a combination of different immunosuppressive drugs to maximize their immunosuppressive effect and minimize their side effects.Nov 4, 2021
Which are examples of adverse effects of immune suppressants select all that apply?
Use of T- and B-cell suppressors may result to these adverse effects:Increased risk for infection and development of neoplasms.CNS: headache, tremors.CV: hypertension.Respiratory: pulmonary edema.GI: hepatotoxicity, GI upset, diarrhea.GU: renal toxicity, renal dysfunction.Feb 11, 2021
Which agent would be classified as an immune stimulant?
Immune stimulants include interferons, interleukins, and colony-stimulating factors (utilized to stimulate bone marrow to produce more white blood cells especially for patients at serious risk for infection).Feb 11, 2021
What is immunosuppression therapy?
(IH-myoo-noh-suh-PREH-siv THAYR-uh-pee) Treatment that lowers the activity of the body's immune system. This reduces its ability to fight infections and other diseases, such as cancer. Immunosuppressive therapy may be used to keep a person from rejecting a bone marrow or organ transplant.
What do immunosuppressants increase the likelihood of?
Everyone who takes immunosuppressive drugs is at risk of developing skin cancer and this risk increases with time. For instance, twenty years after organ transplantation, more than half of all transplant patients will have had a skin cancer.
What is the most common side effect of immunosuppressive medications?
The most significant side effect of immunosuppressant drugs is an increased risk of infection. Other, less serious side effects can include loss of appetite, nausea, vomiting, increased hair growth, and hand trembling. These effects typically subside as the body adjusts to the immunosuppressant drugs.Mar 15, 2018
Which potential problem is of most concern for the patient receiving immunosuppressant medications?
The main safety concern with their use is the risk of infections. Certain infections can be prevented or their impact minimized.
How do immunosuppressants stay healthy?
Here are nine tips to stay healthy while on immunosuppressant medications.Maintain good hygiene. ... Limit contact with sick people. ... Care for open wounds. ... Don't touch your face. ... Practice safe food preparation. ... Plan ahead for traveling. ... Take care of yourself. ... Talk to your doctor.More items...•May 21, 2018
Which medications suppress the immune system?
Other medicines which suppress the immune system include:Azathioprine.Mycophenolate mofetil.Monoclonal antibodies - of which there are many ending in "mab", such as bevacizumab, rituximab and trastuzumab.Anti-TNF drugs such as etanercept, infliximab, adalimumab, certolizumab and golimumab. ... Methotrexate.Ciclosporin.More items...•May 24, 2021
What does an immune stimulant do?
Immunostimulants (immunostimulators) are drugs that stimulate the immune system by increasing the activity of any of its components. The immune system is a complex network of cells, tissues, and organs. Together, they help the body fight infections and diseases.Jul 27, 2021
Which drugs cause immunosuppression?
Who gets drug-induced immunosuppression?Azathioprine.Ciclosporin.Mycophenolate mofetil.Cyclophosphamide.Systemic corticosteroids, such as prednisone.
How long after bone marrow transplant can you take neuogen?
The recommended dosage of NEUPOGEN following bone marrow transplantation ( BMT) is 10 mcg/kg/day given as an intravenous infusion no longer than 24 hours. Administer the first dose of NEUPOGEN at least 24 hours after cytotoxic chemotherapy and at least 24 hours after bone marrow infusion. Monitor CBCs and platelet counts frequently following marrow transplantation.
What is G-CSF?
G-CSF is a substance produced by the body. It stimulates the growth of neutrophils, a type of white blood cell important in the body's fight against infection. Acute Radiation Syndrome: The effectiveness of NEUPOGEN for this use was only studied in animals, because it could not be studied in people.
Can filgrastim be absorbed into milk?
There is published literature documenting transfer of filgrastim into human milk. There are a few case reports describing the use of filgrastim in breastfeeding mothers with no adverse effects noted in the infants. There are no data on the effects of filgrastim on milk production. Other filgrastim products are secreted poorly into breast milk, and filgrastim products are not absorbed orally by neonates. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for NEUPOGEN and any potential adverse effects on the breastfed child from NEUPOGEN or from the underlying maternal condition.
What is the name of the large blood vessel that transports blood from the heart to the body?
Inflammation of the aorta (aortitis). Inflammation of the aorta (the large blood vessel which transports blood from the heart to the body) has been reported in patients who received NEUPOGEN. Symptoms may include fever, abdominal pain, feeling tired, and back pain.
Can adverse reaction rates be directly compared with rates in the clinical trials of another drug?
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.
What is capillary leak syndrome?
Capillary leak syndrome (CLS) has been reported after G-CSF administration, including NEUPOGEN, and is characterized by hypotension, hypoalbuminemia, edema and hemoconcentration. Episodes vary in frequency, severity and may be life-threatening if treatment is delayed. Patients who develop symptoms of capillary leak syndrome should be closely monitored and receive standard symptomatic treatment, which may include a need for intensive care.
Is filgrastim immunogenic?
As with all therapeutic proteins, there is a potential for immunogenicity. The detection of antibody formation is highly dependent on the sensitivity and specificity of the assay, and the observed incidence of antibody (including neutralizing antibody) positivity in an assay may be influenced by several factors, including assay methodology, sample handling, timing of sample collection, concomitant medications, and underlying disease. For these reasons, comparison of the incidence of antibodies to filgrastim in the studies described below with the incidence of antibodies in other studies or to other products may be misleading.