Treatment FAQ

what bloodwork is needed for trt treatment

by Prof. Angel Harvey Published 3 years ago Updated 2 years ago
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Before undergoing testosterone replacement therapy (TRT), it's vital to obtain a number of blood tests. The main blood tests to measure are total and free testosterone, hematocrit, PSA, estradiol, HDL cholesterol and others.

If your doctor prescribes TRT, you should have regular check-ups. Your doctor should follow- up with blood tests for testosterone level, PSA and hematocrit. (PSA is a test for prostate issues including prostate cancer. Hematocrit tests your red blood cell count.)

Full Answer

What blood tests are done before testosterone replacement therapy (TRT)?

Before undergoing testosterone replacement therapy (TRT), it's vital to obtain a number of blood tests. The main blood tests to measure are total and free testosterone, hematocrit, PSA, estradiol, HDL cholesterol and others.

Why do I need to have blood work done before TRT?

This allows us to assess the quantitative values of your testosterone (and possibly other associated assays). It's essential to have blood work done before and during TRT to ensure your red blood cell counts, blood lipids, prostate-specific antigen, and other relevant biomarkers are in a healthy range.

What tests will my doctor check during TRT?

At the same time, your doctor will check your red blood cell levels. Within 1 to 2 years of TRT, your doctor will measure your bone density if you had osteoporosis when treatment began. Your doctor will evaluate your prostate cancer risk at the start of treatment and may do more tests at the 3- and 6-month marks, and then annually.

Can TRT cause cracks in blood vessels?

TRT can increase water retention, sodium uptake and hematocrit is some men, factors that can increase blood pressure. If your blood pressure rises too much, it can place excess strain on your blood vessels and potentially cause a crack.

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How often should you get bloodwork on TRT?

In general, a blood draw every two to three months is typically recommended for TRT patients experiencing polycythemia. It's important not to overdraw blood, because doing so can lead to anemia, iron deficiency, and other conditions.

When do I need a TRT blood test?

Your doctor might suggest a blood test for testosterone if:you are having problems conceiving a child – both men and women can be tested.you are a man with a low sex drive.you are a man with problems getting an erection.you are a woman with masculine features, such as a lot of body hair or a low voice.More items...

What test is best for TRT?

The Advanced TRT (Testosterone Replacement Therapy) Blood Test is a venous blood test (which means it must be taken from a vein in your arm) which measures important markers in your blood to help you monitor and manage your testosterone replacement therapy.

How much test do you take for TRT?

Comparison of testosterone replacement therapy preparationsTestosterone formulationInitial dosingIM testosterone cypionate50–400 mg every 2–4 weeksIM testosterone enanthate50–400 mg every 2–4 weeksIM testosterone undecanoate750 mg once, 750 mg 4 weeks later, then 750 mg every 10 weeks9 more rows•Jul 10, 2016

How much does TRT bloodwork cost?

Blood And Lab Work Quality hormone specialists specialize their treatments to your exact needs, so you'll need to undergo a range of blood tests. These can cost upwards of $1,500 without financial help from your insurer.

How much does TRT blood work cost?

Blood and Lab Work A full, 8-hormone panel can cost as much as $800; some labs quote as much as $1,500 for a comprehensive range of tests that aren't covered by insurance. Performing at-home testing is a considerably more affordable option. However, it can still be expensive, running anywhere from $80 to $350.

Is hCG necessary on TRT?

You won't need hCG to raise your testosterone levels because we'll give you an adequate dose to get you to optimal levels. However, you'll want to add hCG in case you want to maintain a healthy sperm count and/or prevent testicular atrophy.

What should I check before starting TRT?

According to Endocrine Society guidelines, men with a PSA level >4 ng/ml or with a high risk of prostate cancer and a PSA level >3 ng/ml are recommended to be referred to a urologist prior to initiation of testosterone therapy.

What blood tests check for testosterone?

Complete Blood Count (CBC), Comprehensive Metabolic Panel - 14 tests, Testosterone Free Direct with Total Testosterone, Dehydroepiandrosterone (DHEA) Sulfate, Estradiol, Hemoglobin A1c, C-Reactive Protein (CRP), Fibrinogen, Homocyst(e)ine Plasma, Thyroid-stimulating Hormone (TSH), Lipid Panel With Total Cholesterol:HDL ...

Does TRT shorten your life?

The cardiovascular issues associated with TRT have been clarified by recent studies showing that therapy associated with clear increases in serum testosterone levels to the normal range is associated with reduced all-cause mortality.

Does TRT change your face?

Your eyes and face will begin to develop a more angular, male appearance as facial fat decreases and shifts. Please note that it's not likely your bone structure will change, though some people in their late teens or early twenties may see some subtle bone changes.

Is it better to inject testosterone once or twice a week?

Twice per week is preferred for the balance of testosterone delivery. What's the best place to inject testosterone? This is really about personal preference; where it's the least painful and easiest for you to inject.

How to Know if You Need TRT

The first thing doctors actually measure before you get on testosterone replacement is your total and free testosterone blood levels to find out if you have low testosterone. They will also ask you a few questions to see if you have low testosterone or hypogonadal symptoms.

Follow Up Lab Tests After Starting TRT

Once you get on testosterone replacement, your doctor will have you come back either at week six or eight to run another blood test to see if your dosage needs to be adjusted and/or you may require other medications to monitor or to modulate or change levels like estradiol, hematocrit, etc. The first one obviously is testosterone total and free.

Avoiding or Lowering High Hematocrit on TRT

Hematocrit is the proportion of red blood cells in the blood. Testosterone tends to increase red blood cells. Some men don't have that issue, but most men at least have a two to a three-point increase in hematocrit after starting TRT.

Avoiding Low Ferritin and Iron

When your hematocrit is over 53, and you donate blood frequently than every three months, you can deplete your iron stores which makes you tired, depressed, and with no libido. Blood donations should not be happening that frequently because you'll lose iron.

Monitoring the PSA Test on Testosterone

High PSA, prostate-specific antigen, is the only contraindication for testosterone replacement therapy if it is 4 or above. Obviously, physicians get very concerned that a man with higher PSA may have prostatic cancer, although it could be caused by an infection of your prostate (prostatitis) that could be easily treatable with an antibiotic.

Monitoring Estradiol Test on Testosterone

Estradiol (E2) is a very important hormone for men. We need it because estradiol is actually linked to bone health, cognitive functioning, cardiovascular health, even sex drive, and decreased fat mass. Having very low estradiol of under 20 pg/mL is actually not good for you since it can decrease bone density and cause other issues.

Avoiding High Blood Pressure and Water Retention on TRT

Some men on testosterone replacement therapy tend to have increased blood pressure related to water retention. There are some central nervous system effects that increase blood pressure and heart rate. These men can gain considerable weight during the first weeks of TRT. Most lose most of that weight after a few weeks of therapy.

Why is it important to have blood work done before and during TRT?

It's essential to have blood work done before and during TRT to ensure your red blood cell counts, blood lipids, prostate-specific antigen, and other relevant biomarkers are in a healthy range.

What is TRT protocol?

TRT is a life-changing protocol for many males, and the research backing its benefits is unambiguous. Hopefully, this guide gave you a better idea of what to expect on TRT and how you can go about starting the process to restore your testosterone levels to a healthy range.

Why do men need testosterone?

From an evolutionary perspective, men needed higher testosterone to give them that ‘alpha male’ drive for hunting and protecting family.

How long does it take for testosterone injections to work?

(Your muscle might twitch slightly but it’s not a painful sensation for most people, more so a reflex.) The entire injection process generally takes no more than 15 seconds.

How long does it take for low T to go down?

Depending on the form of testosterone used, many men notice a reduction of low T symptoms within as little as one month on TRT. For some, it may take longer before improvements in health and well-being become apparent.

Is TRT good for health?

It’s key to remember that TRT is a long-term solution to an otherwise long-term health problem. Research suggests that the short-term benefits of TRT may include a heightened sense of vitality, increased libido, enhanced energy levels, more restful sleep, and other positive changes. [2] .

Can you have low T with blood work?

It’s important to note that while you may exhibit several (or all) of these symptoms, you should confirm that you have low T with proper blood work . A trained physician at Gameday Men’s Health can help order the appropriate lab tests and guide you through the process of restoring your testosterone to healthy levels.

What is the blood test for testosterone?

This testosterone blood test measures the total amount testosterone that is bound to proteins in the blood as well as testosterone that is not bound (free testosterone), providing a complete analysis of all testosterone levels. Approximately two-thirds of testosterone circulates in the blood bound to SHBG and less than one-third is bound to albumin.

Why do we need a CBC test?

A complete blood count (CBC) test can be ordered to help evaluate your overall health by measuring the number of red blood cells, white blood cells, and platelets, among other things. These cells manage very important tasks for you, like carrying oxygen throughout the body and defending it from infections.

What is the test for estradiol?

The estradiol ultrasensitive test is used to measure ranges of the hormone estradiol in the blood that are lower than the levels of the standard estradiol test. This type of estradiol test is recommended for when increased sensitivity to estradiol is expected and/or appropriate, as in situations with men. Estradiol is a form of estrogen, and men undergoing testosterone therapy may experience elevated levels of estradiol. In men, small amounts of estradiol is released by the testes to prevent sperm from dying prematurely. Testing estradiol levels may be useful in the evaluation of males for gynecomastia (also known as man boobs).

How long do you have to fast for a test?

Fasting Instructions: Fasting is required for this lab test. You should not consume food or beverages other than water for at least 8 hours prior to visiting the lab. If you choose not to fast, it may affect your results. Our Testosterone Maintenance / Therapy Panel is used to evaluate important levels within the blood that can be affected ...

How much testosterone is in albumin?

Approximately two-thirds of testosterone circulates in the blood bound to SHBG and less than one-third is bound to albumin. A small percent (less than 4 percent) circulates in the blood as free testosterone.

Why do you need to do a TRT blood test?

You may need to do the test several times because T levels are affected by various factors, such as: diet. level of fitness. time of day the test is done. certain medications, like anticonvulsants and steroids.

What is TRT used for?

TRT is traditionally used to treat hypogonadism, which occurs when your testes (also called gonads) don’t produce enough testosterone. There are two types of hypogonadism: Primary hypogonadism. Low T results from issues with your gonads. They’re getting signals from your brain to make T but can’t produce them.

What is TRT therapy?

TRT is an acronym for testosterone replacement therapy , sometimes called androgen replacement therapy. It’s primarily used to treat low testosterone (T) levels, which can occur with age or as a result of a medical condition. But it’s becoming increasingly popular for non-medical uses, including:

How much does TRT cost?

Generally, you can expect to pay anywhere from $20 to $1,000 per month.

How does TRT work?

TRT works to make up for T that isn’t being produced by your testes. If you have true hypogonadism, TRT can: improve your sexual function. boost your sperm count and volume. increase levels of other hormones that interact with T, including prolactin. TRT can also help to balance unusual T levels caused by:

When was the last time T supplements were reviewed?

Last medically reviewed on January 28, 2019.

Is TRT considered doping?

Plus, using TRT to gain a competitive edge in a sport is considered “doping” by many professional organizations, and most consider it grounds for termination from the sport. Instead, consider trying some alternative methods for boosting T. Here are eight tips to get you started.

Who is testosterone replacement therapy for, and how does it work

Doctors prescribe TRT to males with hypogonadism. To receive a definitive diagnosis, blood tests must show that a person has low testosterone levels, which the American Urological Association notes as being below 300 nanograms per deciliter (ng/dl).

Injectable

Injectable testosterone is an inexpensive and common form of TRT. A person can receive short-acting treatment, which involves a shot every 1 or 2 weeks, or long-acting treatment, in which the second shot is 4 weeks after the first, and all others are 10 weeks apart. The dosage and frequency of the treatment may vary depending on the person.

Topical (transdermal)

People usually apply gels and creams on a daily basis. Gradual absorption causes more stable testosterone levels in the blood.

Cheek or buccal patches

A person places a buccal patch above the upper teeth, and it releases testosterone over 12 hours. In comparison with oral medications, patches may be less toxic to the liver. However, these patches can cause headaches and gum and mouth irritation.

Testosterone implants or pellets

Testosterone pellets are small plastic pellets that doctors implant under the skin. The implant goes into a person’s upper hip or buttock. The pellets dissolve slowly and can deliver TRT for 3–6 months.

Oral testosterone

Oral testosterone is a less common type of TRT that is more expensive and less practical. Its long-term use can potentially cause liver damage.

Intranasal

A person applies nasal testosterone gel to the inside of the nose. They will need to do this three times a day at intervals of 6–8 hours, preferably at the same times every day. Some common reactions to this treatment include headaches, nosebleeds, a runny nose, and nasal discomfort.

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