what are treatment combinations

Treatments are combined for several reasons:

• One treatment may be more effective at a certain stage of cancer than another.
• One treatment may enhance the effectiveness of another synergy.
• One treatment alone may not affect the tumor.

Full Answer

What are the benefits of combination treatments?

Combining two or more types of treatments - such as surgery, radiation, and chemotherapy - may be more effective than a single therapy alone. Under certain conditions, combination therapy not only can achieve a greater likelihood of cure than a single approach, but can do so with less damage to vital organs and tissues.

What is an example of combination therapy?

Another form of combination therapy is the use of multifunctional molecules—single agents that combine >1 activity or >1 target. An example of this is rasagiline, a monoamine oxidase (MAO) B inhibitor used to treat Parkinson’s disease, which, in addition to MAO B inhibition, has neuroprotective effects and effects on amyloid processing [27, 28].

What is'pharmaceutical combination therapy'?

'Pharmaceutical' combination therapy may be achieved by prescribing/administering separate drugs, or, where available, dosage forms that contain more than one active ingredient (such as fixed-dose combinations).

Should we combine therapeutic agents?

However, a combination of ≥2 agents that target separate pathways presents an opportunity for treating the disease that may offer synergistic effects, and there are very few of these in trials. Combining therapeutic agents may allow for lower doses of the individual agents, reducing costs and side effects.

What is an example of a combination therapy?

Tuberculosis treatment is a classic example of combination therapy [1]. After the discovery of Streptomycin in 1944, improvement in the effectiveness of therapy was observed with the addition of Isoniazid, the first oral mycobactericidal drug in 1952 and Rifamycins in 1957.

What is combination drug treatment?

Combination drug therapy is defined as the use of 2 or more pharmacologic agents administered separately or in a fixed-dose combination of 2 or more active ingredients in a single-dosage formulation.

What treatments or combination of treatments are most effective?

Research generally shows that psychotherapy is more effective than medications, and that adding medications does not significantly improve outcomes from psychotherapy alone.

What is combination chemotherapy?

Combination chemotherapy is the use of more than one medication at a time to treat cancer. Since chemotherapy drugs affect cancer cells at different points in the cell cycle, using a combination of drugs increases the chance that all of the cancer cells will be eliminated.

Why is drug combinations used?

The use of drugs in combination can produce a synergistic effect if each of the drugs impinges on a different target or signaling pathway that results in reduction of required drug concentrations for each individual drug. Therefore, use of drug combinations could increase the success rate of drug repurposing screens.

Why is combination therapy?

The rationale for combination therapy is to use drugs that work by different mechanisms, thereby decreasing the likelihood that resistant cancer cells will develop. When drugs with different effects are combined, each drug can be used at its optimal dose, without intolerable side effects.

What is the best combination of antidepressants?

Bupropion, citalopram, escitalopram, and sertraline were better tolerated than the other antidepressants. Escitalopram and sertraline were found to have the best combination of efficacy and acceptability. Efficacy results.

Which form of therapy is most easily combined with medication management?

CBT is the most well-studied form of psychotherapy for depression and has been shown to be effective when used alone or in combination with medication. Patients receiving CBT work collaboratively with their therapists to learn specific skills to solve their problems and manage their emotions.

What do you think is the most effective treatment for depression medication psychotherapy or combination of both explain?

Because cognitive therapy and behavioral therapy work well together to treat depression and anxiety disorders, the two are often combined in an approach called cognitive behavioral therapy (CBT). CBT focuses on addressing both the negative thought patterns and the behaviors that contribute to depression.

What are the side effects of combination therapy?

The most common side-effects of combined chemohormonal therapy were gastro-intestinal (nausea, vomiting, rarely diarrhoea) in 43 patients (57.3%), followed by alopecia in 23 patients (30.6%), myelosuppression in 12 patients (16%), extravasation and thrombophlebitis in 7 patients (9.3%), and mucositis and oral erythema ...

Why is combination therapy better than monotherapy?

On the other hand, several factors argue in favour of combination therapy: a broader antibiotic spectrum, in vitro data showing synergy of antibiotic combinations2, lower efficacy of colistin monotherapy compared to betalactam monotherapy62, lower risk of resistance development (e.g. against colistin)1, lower doses and ...

What is palliative chemotherapy?

Clarification regarding the term palliative chemotherapy is critical: palliative chemotherapy is defined as chemotherapy that is given in the non-curative setting to optimize symptom control, improve quality of life (QoL) and, ideally, to improve survival.

Why is monotherapy used?

Normally, monotherapy is selected because a single medication is adequate to treat the medical condition. However, monotherapies may also be used because of unwanted side effects or dangerous drug interactions.

What is polytherapy in medicine?

For polytherapy in the sense of 4 or more medications at once, see Polypharmacy. Combination therapy or polytherapy is therapy that uses more than one medication or modality . Typically, the term refers to using multiple therapies to treat a single disease, and often all the therapies are pharmaceutical ...

What is monotherapy in epilepsy?

Retrieved 2008-04-02. Monotherapy: The treatment of epilepsy with a single medication rather than a combination. Monotherapy has advantages over combining medications in many patients, including absence of drug-drug interactions, fewer side effects, simpler dosing, and lower cost.

What are the benefits of combination therapy?

One major benefit of combination therapies is that they reduce development of drug resistance since a pathogen or tumor is less likely to have resistance to multiple drugs simultaneously. Artemisinin -based monotherapies for malaria are ...

Why are combination therapies needed?

In a recent study about solid cancers, Martin Nowak, Bert Vogelstein, and colleagues showed that in most clinical cases, combination therapies are needed to avoid the evolution of resistance to targeted drugs.

Is combination therapy cheaper than monotherapy?

Combination therapy may seem costlier than monotherapy in the short term, but when it is used appropriately, it causes significant savings: lower treatment failure rate, lower case-fatality ratios, fewer side-effects than monotherapy, slower development of resistance, and thus less money needed for the development of new drugs.

Is combination therapy safe for oncology?

Combination therapy has gained momentum in oncology in recent years, with various studies demonstrating higher response rates with combinations of drugs compared to monotherapies, and the FDA recently approving therapeutic combination regimens that demonstrated superior safety and efficacy to mono therapies.

How does angiotensin help lower blood pressure?

They help lower blood pressure by inhibiting the production of angiotensin in the body. Angiotensin is a hormone that causes blood vessels to constrict which can lead to increased blood pressure. Angiotensin II receptor blockers (ARBs): The ARBs block the effects of angiotensin.

What is resistant hypertension?

Resistant hypertension means blood pressure that stays high despite treatment with three different types of blood pressure medications. It's thought that about 30% of people with high blood pressure have resistant hypertension.

What are the risk factors for resistant hypertension?

Other studies suggest that people with resistant hypertension have associated risks factors such as diabetes, obstructive sleep apnea, enlargement of the heart chambers, and or chronic kidney disease.

What is combination therapy for high blood pressure?

Combination treatment means another class of blood pressure medication is added to the first drug to increase effectiveness. Many people with mild high blood pressure respond to one medication. It may take a few tries to find the most effective drug. However, sometimes one drug cannot control high blood pressure.

Is white coat hypertension resistant?

These scenarios are not synonymous. Sometimes, "white coat" hypertension is mistaken for resistant hypertension. With "white coat" hypertension, the patient may have a rise in blood pressure at the doctor's office but not at home. The doctor may recommend 24-hour blood pressure monitoring to exclude "white coat" hypertension.

Can you use thiazide alone?

Sometimes, using lower doses of one or more drugs in combination can minimize side effects. Thiazide diuretics may be used alone to treat hypertension. Low-dose diuretics, though, can also be used with other medications such as beta-blockers. When used in a drug combination, the diuretic has fewer side effects.

Can a diuretic be used in combination with a blood pressure medication?

When used in a drug combination, the diuretic has fewer side effects. It also boosts the blood-pressure-lowering effect of the other medication. Diuretics are added to other blood pressure medications. For instance, if the person with high blood pressure also retains fluid, a diuretic may be added.

What is the best treatment for MDD?

Therefore, many researchers and doctors believe the first and best approach to treating MDD is combination treatments . Still, many doctors will begin treatment with a single antidepressant medication. Before making a decision about the medication, give it time to work.

How long does it take for a med to work after a trial?

If the medication isn’t working as desired after a trial period — usually about 6 to 8 weeks — your doctor may wish to change medications or add a medication to see whether the combination helps. Last medically reviewed on February 4, 2021.

What is combination medicine?

Combination drug therapy is a type of treatment that many doctors and psychiatrists have been increasingly using during the past decade.

Can atypical antipsychotics be used with SSRIs?

Antipsychotics. Research suggests there may be some benefit in treating persistent symptoms in people taking SSRIs with atypical antipsychotics, such as aripiprazole. Some possible side effects associated with these medications include: Carefully consider the pros and cons of antipsychotics with your doctor.

Is bupropion a combination medication?

Atypical antidepressants. On its own, bupropion is very effective at treating MDD, but it may also be used with other medications for depression that’s difficult to treat. In fact, bupropion is one of the most commonly used combination therapy medications. It’s often used with selective serotonin reuptake inhibitors ...

Does mirtazapine cause weight gain?

For people experiencing loss of appetite and insomnia, mirtazapine may be an option. Its most common side effects are weight gain and sedation. However, mirtazapine hasn’t been studied in depth as a combination medication.

Can methylphenidate be used alone?

Many clinicians find that supplementing antidepressants with low doses of stimulants, such as methylphenidate, may help improve depression that doesn’t respond to treatment that well.

What is the best treatment for acne?

The combination of benzoyl peroxide and clindamycin is another option. Again, because clindamycin is an antibiotic, it helps reduce acne-causing bacteria. Benzoyl peroxide is helpful in treating inflamed pimples, as well as non-inflamed blackheads and breakouts. Acanya isn’t the only combination medication that contains these specific ingredients.

What is combination acne medicine?

What Are Combination Acne Medications? Combination acne medications are prescription treatments that combine two acne-fighting ingredients. For example, you can get benzoyl peroxide and a topical antibiotic in one medication or tretinoin and an antibiotic.

Why do people stick to acne treatment?

Some studies have shown that people are more likely to stick with treatment when using combo medications, most likely because they streamline acne treatment . Another big benefit of combination acne medications is that using different acne treatment ingredients together can boost the effectiveness of each.

Why do people like combo medications?

A lot of people really like these types of medications because they’re very easy to use . Instead of applying several different creams to your skin, you save a step and need just one application with combo medications.

Is benzoyl peroxide a topical retinoid?

Epiduo: Yes, benzoyl peroxide is a popular acne treatment. Here, it’s blended with the retinoid-like compound adapalene. You may know this acne-fighting ingredient by the brand name Differin . Adapalene is not technically a topical retinoid, but it works in the same way.

Is Benzaclin a combination of clindamycin and benzoyl peroxid

You can find the clindamycin/benzoyl combination in these medications too: BenzaClin (clindamycin 1% and benzoyl peroxide 5%) Duac (clindamycin 1% and benzoyl peroxide 5%) Onexton (clindamycin 1.2% and benzoyl peroxide 3.75%) Epiduo: Yes, benzoyl peroxide is a popular acne treatment. Here, it’s blended with the retinoid-like compound adapalene.

Can you use two different acne treatments?

Long term, you'll get better results—and clearer skin—when using multiple acne treatments. To be clear, combination treatments aren't necessarily any more effective than using two separate treatments. You can get the same type of results using, for example, a benzoyl peroxide lotion plus a separate clindamycin gel.

Short-Acting Vs. Long-Acting COPD Medications

There are two main categories of COPD medications: short-acting and long-acting. Short-acting drugs only stay in your system for three or four hours at most and provide immediate relief from symptoms; sometimes they’re referred to as “rescue” medications.

Benefits of Combination Treatment

Managing COPD can be a challenge, and remembering to take your medications as prescribed can be difficult. Each COPD medication is available as a single therapy, but combining them can make adherence much easier.

Overview

Uses

Conditions treated with combination therapy include tuberculosis, leprosy, cancer, malaria, and HIV/AIDS. One major benefit of combination therapies is that they reduce development of drug resistance since a pathogen or tumor is less likely to have resistance to multiple drugs simultaneously. Artemisinin-based monotherapies for malaria are explicitly discouraged to avoid the problem of developing resistance to the newer treatment.

Contrast to monotherapy

See also

External links