Treatment FAQ

what are the definitive treatment for pregnant mothers with hypertension

by Hailie Nienow Published 2 years ago Updated 2 years ago

Intravenous (IV) labetalol and hydralazine have long been considered first-line medications for the management of acute-onset, severe hypertension in pregnant women and women in the postpartum period. Available evidence suggests that oral nifedipine also may be considered as a first-line therapy.Jun 22, 2022

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How to manage hypertension in pregnancy effectively?

Women can suffer from various types of high blood pressure in pregnancy, some of them being:

  • Preeclampsia: A complication in pregnancy that is characterized with very high blood pressure. ...
  • Chronic hypertension: Present before conception or during the first 20 weeks of pregnancy.
  • Chronic hypertension with superimposed preeclampsia: This condition occurs in pregnant women who are already suffering from chronic blood pressure.

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Is it safe to use an antihypertensive in pregnancy?

The choice of antihypertensive drugs also is discussed; methyldopa, labetalol, and nifedipine, among others, appear safe for use in pregnancy, whereas angiotensin converting enzyme inhibitors and angiotensin receptor blockers should be avoided.

How do you treat hypertension in pregnancy?

For the pregnant parent:

  • Weekly evaluations of your platelet count, serum creatinine, and liver enzyme levels
  • Weekly assessment of protein in the urine (indicating preeclampsia)
  • Regular blood-pressure checks, either by a doctor or at home (after receiving medical guidance and the proper supplies)

What hypertension medications can you use during pregnancy?

Medicines to avoid during pregnancy

  • Angiotensin converting enzyme inhibitors. Angiotensin converting enzyme (ACE) inhibitors interfere with the body’s production of a chemical that causes the arteries to constrict.
  • Diuretics. Diuretics such as furosemide (Lasix) and hydrochlorothiazide (Microzide) should be avoided during pregnancy.
  • Propranolol. ...

What is the treatment of hypertension during pregnancy?

There are a wide variety of agents available for use, and orally administered antihypertensive agents can be used in standard doses in pregnancy (Table 2). First-line agents for nonsevere hypertension are methyldopa and labetalol, with nifedipine as second line, followed by others in third line.

Which of the following would be the definitive treatment for pregnancy induced hypertension?

The only definitive therapy for preeclampsia is delivery. When urgent control of BP is necessary, or when delivery is expected within the next 48 hours, intravenous agents, such as labetalol or hydralazine, are the drugs of choice.

What is the most commonly used medication for hypertension during pregnancy?

For the initial treatment of high blood pressure in pregnancy, the three most commonly used medications are labetalol (Normodyne, Trandate), nifedipine (Procardia, Adalat) and methyldopa (Aldomet), and these are recommended above all other medications.

What is the first line treatment for preeclampsia?

2. Hydralazine and labetalol are the two “first line” agents used for hypertension in preeclampsia. Hydralazine is an arteriolar dilator that reduces blood pressure but may cause tachycardia.

Which is the drug of choice for severe preeclampsia?

The drug of choice for the prevention and control of maternal seizures in patients with severe preeclampsia or eclampsia during the peripartum period is i.v. magnesium sulfate. Its mechanism of action for the treatment of eclampsia is not well understood.

Which drug is given during hypertension?

The first are called dihydropyridine CCBs and include amlodipine (Norvasc), felodipine (Plendil), nifedipine (Procardia), and nicardipine (Cardene). The second, termed nondihydropyridine CCBs include two drugs, diltiazem (Dilacor, Cardizem, Cartia, and Tiazac), and verapamil (Calan, Covera, Isoptin, Verelan).

Which hypertensive drug is not safe in pregnancy?

The choice of antihypertensive drugs also is discussed; methyldopa, labetalol, and nifedipine, among others, appear safe for use in pregnancy, whereas angiotensin converting enzyme inhibitors and angiotensin receptor blockers should be avoided.

Which antihypertensive drug is contraindicated in pregnancy?

Both labetalol and methyldopa are considered safe for use in pregnant women,12,13 while angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARB) are contraindicated during all trimesters of pregnancy based on their potential teratogenic and fetotoxic effects,1 though this is ...

What is the best medication for hypertension during pregnancy?

Drug treatment of hypertension in pregnancy. According to NHBPEP methyldopa, labetalol, beta blockers (other than atenolol), slow release nifedipine, and a diuretic in pre-existing hypertension are considered as appropriate treatment [1].

What is the most common medical condition during pregnancy?

Similar to the non-pregnant population, hypertension is the most common medical disorder encountered during pregnancy and is estimated to occur in about 6–8% of pregnancies [1]. A recent report highlighted hypertensive disorders as one of the major causes of pregnancy-related maternal deaths in the United States, ...

How much aspirin is safe for preterm birth?

Doses up to 75 mg appear to be safe.

What is the best way to measure BP?

BP can be measured using a mercury sphygmomanometer, calibrated aneroid device, or an automated BP device (valida ted for use in preeclampsia). (II-2A) Automated BP machines may underestimate BP in women with preeclampsia, and comparison of readings using mercury sphygmomanometry or an aneroid device is recommended.

Is nocturnal hypertension associated with preeclampsia?

Nocturnal hypertension is higher in women with preeclampsia than in those with gestational hypertension and is associated with more maternal and fetal complications. The predictive accuracy of ABPM remains low; ambulatory pulse pressure and daytime DBP have been shown to be predictive of birth weight.

Is hypertension a condition in pregnancy?

Hypertension in pregnancy includes a range of conditions, most notably preeclampsia, a form of hypertension unique to pregnancy that occurs de novo or may be superimposed on chronic hypertension. The other forms, chronic and gestational hypertension, usually have more benign courses [1].

Is methyldopa safe for pregnancy?

Methyldopa has a long history of use in pregnancy and does not appear teratogenic [27]. Methyldopa has a record of safety in pregnancy, as established by follow-up studies in the 1980’s of children exposed to the drug in utero [31].

What to do if you have high blood pressure while pregnant?

If you have high-blood pressure during pregnancy, ACOG recommends regular prenatal check-ups for both you and your baby. Doctors are likely to perform the following tests to monitor your gestational hypertension:

What is the goal of gestational hypertension?

The main goal of treatment is to prevent the development of more serious conditions.

Why is early delivery important?

In cases of serious problems, like eclampsia, early delivery is usually attempted to avoid the development of potentially life-threatening complications. 1.

Why is it important to treat pregnancy?

The main goal of treatment is to prevent the development of more serious conditions. Pregnant parents can develop seizures or placental abruption, while their babies can be harmed by fetal growth restriction, pre-term delivery, or stillbirth. 1.

Can hypertension cause hospitalization?

If your hypertension has become severe enough to put you or your baby's health at immediate risk, or getting to regular check-ups is hard, your doctor might recommend hospitalization during certain phases of pregnancy to ensure that you and your child are well cared for. 1.

Can pregnancy cause hypertension?

There are several strategies to treat hypertension that develops during pregnancy. These strategies are similar to those used to treat preeclampia, which is when a pregnant person has gestational hypertension as well as increased levels of protein in their urine. Up to half of people with gestational hypertension go on to develop preeclampsia or symptoms consistent with it. 1

Which blood pressure medication slows down heart rate?

Labetalol: a beta-blocker, which helps to slow your heart rate. Hydralazine: a vasodilator, which relaxes blood vessels to promote blood flow. Nifedipine: a calcium-channel blocker, which also eases the blood vessels to prevent the heart from needing to pump so hard 1.

What is gestational hypertension?

Gestational hypertension. Hypertension occurring in the second half of pregnancy in a previously normotensive woman, without significant proteinuria or other features of pre-eclampsia, is termed gestational or pregnancy induced hypertension. It complicates 6–7% of pregnancies7and resolves post partum.

When does blood pressure drop during pregnancy?

This reduction in blood pressure primarily affects the diastolic pressure and a drop of 10 mm Hg is usual by 13–20 weeks gestation.1Blood pressure continues to fall until 22–24 weeks when a nadir is reached. After this, there is a gradual increase in blood pressure until term when pre-pregnancy levels are attained.

What is the most common medical problem during pregnancy?

Hypertension is the most common medical problem encountered in pregnancy and remains an important cause of maternal, and fetal, morbidity and mortality. It complicates up to 15% of pregnancies and accounts for approximately a quarter of all antenatal admissions. The hypertensive disorders of pregnancy cover a spectrum of conditions, ...

What are the three types of hypertension?

There are three types of hypertensive disorders: chronic hyper tension. gestational hypertension. pre-eclampsia. Chronic hypertension. Chronic hypertension complicates 3–5% of pregnancies4although this figure may rise, with the trend for women to postpone childbirth into their 30s and 40s.

How much is the risk of superimposed pre-eclampsia?

The risk of superimposed pre-eclampsia is 15–26%,8but this risk is influenced by the gestation at which the hypertension develops. When gestational hypertension is diagnosed after 36 weeks of pregnancy, the risk falls to 10%.8With gestational hypertension, blood pressure usually normalises by six weeks post partum. Pre-eclampsia and eclampsia.

What is the pathogenesis of pre-eclampsia?

The pathogenesis and manifestations of pre-eclampsia can be considered in a two stage model. The primary stage involves abnormal placentation. In the first trimester, in a healthy pregnancy, the trophoblast invades the uterine decidua and reaches the inner layer of the myometrium.

Which condition is the most common cause of maternal death in the UK?

The hypertensive disorders of pregnancy cover a spectrum of conditions, of which pre-eclampsia poses the greatest potential risk and remains one of the most common causes of maternal death in the UK.

What is the leading cause of maternal illness and death worldwide?

Known officially as hypertensive disorders of pregnancy, preeclampsia and gestational hypertension are among the leading causes of maternal illness and death worldwide, and for women who experience them, a host of future cardiovascular maladies for themselves and, perhaps, their children awaits. In a study. external link.

Can pregnant women take antihypertensive medication?

Up to 6% of pregnant women in the United States suffer from chronic hypertension, but current guidelines from the American College of Obstetricians and Gynecologists (ACOG) recommend not giving anti-hypertensive medication to those with high blood pressure in the mild range—or less than 160/105 mmHg. In the CHAP trial, one group of women is ...

Is it safe to treat diabetes after pregnancy?

It would be advisable that health care providers who treat women after pregnancy and through older age make themselves aware of the increased risk for diabetes, high cholesterol, and hypertension, and know that those risks emerge shortly after pregnancy and persist across decades, Stuart says.

Can you treat hypertension while pregnant?

Chronic hypertension in pregnancy: To treat or not to treat? If a woman is pregnant and chronic high blood pressure is seriously high, doctors typically don’t debate what to do. They treat it—and fast—mainly to minimize the risk for strokes and other potentially deadly cardiovascular events.

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