what are some treatment options for polypharmacology

What's new in Polypharmacology studies?

To consider both outcomes separately, polypharmacology can be divided into two types: therapeutic polypharmacology and adverse polypharmacology (Table 2). Therapeutic polypharmacology includes the concept of treating multigenic, complex diseases by targeting multiple targets with one or more drugs, in order to effectively reset the regulatory network …

How can Polypharmacology be used for drug repurposing?

Targeted Polypharmacology: Discovery of a Highly Potent Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-10/-13 Inhibitor ... -8, -9, -12, and -14 enable this compound to decipher disease causing MMP networks and to generate new treatment options through targeted polypharmacology. Publication types Research Support, Non-U.S. Gov't

Are there adverse effects of polypharmacological treatments?

Apart from bariatric surgery, treatment options to decrease body weight are often underwhelming. Innovative pharmacological options are required to cope with the global "diabesity" pandemic. Objectives: Particular novel pharmacological approaches are discussed, with a special focus on polyagonist-based pharmacotherapies.

What are polypharmacological phenomena?

Mar 10, 2022 · However, it is now more frequently used to treat erectile dysfunction. [ 32] Certainly, kinase inhibitors are the elephant in the room regarding polypharmacology research. As a …

How is polypharmacy treated?

What are the tools available to help decrease polypharmacy?

What is the nurses role in preventing polypharmacy?

What are the four types of polypharmacy?

How do you Deprescribe medication?

What is the medication Appropriateness Index?

What nursing actions should the nurse take to administer medication safely?

What is medication reconciliation and when should it be done?

How does medication reconciliation allow for a reduction of polypharmacy?

What is polypharmacy in medicine?

What are medication interactions?

How many medications is polypharmacy?

How does polypharmacology help?

Polypharmacological approaches help to increase the efficiency of drug action when developed with individual molecules that hit a useful set of multiple targets [6,7,53]. A single drug can act on multiple targets of a single disease pathway, or multiple targets associated with multiple disease pathways.

What are the advantages of polypharmacology?

A major advantage offered by the early application of polypharmacology is that it facilitates early decision making. Early decisions proactively address downstream complications, which stand to save financial losses and time. The ICH regulatory guidelines, ICH S7A guidelines require “secondary PD studies” to investigate the effects of a substance not related to its desired therapeutic target. Polypharmacology belongs under this category and this study is undertaken to inform the selection and design of safe drug compounds and for its application in the interpretation of in vivo safety pharmacology and toxicology studies. Understanding of the pharmacological safety properties of a drug could help the pharmaceutical company to outcompete the existing therapies for a disease, while offering advantage over its competitors and, most importantly, the promise of overall safety to the patients.

What is the difference between on-target pharmacology and polypharmacology?

Polypharmacology refers to the specific binding of a drug to more than one target, while on-target pharmacology is the biological activity of a drug after binding to a specific target;

What is polypharmacology in drug discovery?

Polypharmacology is a term that is used to describe compounds that interact with multiple targets. A recurring issue in drug discovery is drug compounds acting on multiple targets; this has been termed as being “blind” to other connected processes.

How to improve therapeutic index of antibodies?

One strategy to potentially improve the therapeutic index of antibodies is to engage multiple targets simultaneously, thereby using polypharmacology as a mechanism to better treat a disease. The first antibody treatment ever used, serum therapy, used this approach in a crude manner. Intravenous immunoglobulin (IVIG), which uses purified serum IgGs from donors, is an improvement to the serum therapy approach in wide use today. Additionally, there are now at least nine clinical candidates in which the therapeutic consists of multiple IgGs. Several antibodies have been demonstrated to engage multiple targets using a single combining site, perhaps the most interesting of which is ustekinumab (Stelara®), which targets the p40 subunit shared by IL-12 and IL-23. Finally, while a wide variety of bispecific IgGs or antibody fragments containing multiple combining sites have been tested since the early 1980s, only recently have the bispecific technologies been good enough to result in clinical candidates that have a significant chance of being marketed. The most advanced of these is blinatumomab (AMG-103) (CD19 x CD3 BiTE), which is currently in Phase II clinical trials for the treatment of acute lymphoblastic leukemia (ALL).

Is target specific monotherapy bad for cancer?

In cancer, a general drawback of target-specific monotherapy therefore derives from the fact that a single genetic alteration conferring target resistance to an individual tumor cell can eventually lead to relapse, as exemplified by the clonal selection for drug-resistant BCR–ABL alleles during imatinib therapy.

Is polypharmacology a future?

Polypharmacology certainly has the potential to play a larger role in the development of drugs in the future, although it is essential that appropriate care is taken to reap the benefits of multiple drug actions while minimizing the associated risks. It is expected that in the near future, there will be more research in this area, ...

Is polypharmacology a single drug?

However, there is some concern about the adverse effects that may be observed with polypharmacological treatments. Polypharmacology refers to a single drug that acts on multiple targets, which may be associated with a single disease pathway or several different disease pathways.

Why is polypharmacology bad?

However, polypharmacology has the potential to cause problems when it is not used correctly, or insufficient information is known about the activity of the drug. This is primarily a result of adverse effects that result from secondary drug targets.

What is polypharmacology in medicine?

Polypharmacology is the design or use of pharmaceutical agents that act on multiple targets or disease pathways. Despite scientific advancements and an increase of global R&D spending, drugs are frequently withdrawn from markets. This is primarily due to their side effects or toxicities.

What is the role of polypharmacology in drug development?

Polypharmacology remains to be one of the major challenges in drug development, and it opens novel avenues to rationally design the next generation of more effective but less toxic therapeutic agents. Polypharmacology suggests that more effective drugs can be developed by specifically modulating multiple targets.

What is the design or use of pharmaceutical agents that act on multiple targets or disease pathways?

Polypharmacology. Polypharmacology is the design or use of pharmaceutical agents that act on multiple targets or disease pathways. Despite scientific advancements and an increase of global R&D spending, drugs are frequently withdrawn from markets. This is primarily due to their side effects or toxicities.

Should polypharmacology be studied early?

Study polypharmacology earlier in drug discovery, say researchers. Polypharmacology—the ability of a drug to affect more than one protein —should be studied early in the drug discovery pathway, and constantly monitored as the chemical structure is optimized in the design of the clinical candidate, leading researchers believe. ...

Who is the lead author of the study "The Polypharmacology of a Drug"?

Study lead author Dr. Albert Antolin, Sir Henry Wellcome Postdoctoral Fellow at the Institute of Cancer Research, London, said, "The polypharmacology of a drug can influence the effects it has on cells, and the way it operates as a treatment. We found, to our surprise, that the polypharmacology of drug candidates created to target ...

What is the ability of a drug to affect more than one protein?

Polypharmacology —the ability of a drug to affect more than one protein—should be studied early in the drug discovery pathway, and constantly monitored as the chemical structure is optimized in the design of the clinical candidate, leading researchers believe. New research demonstrates the importance of assessing polypharmacology from ...