what are 2 treatment plans for hemophilia

Medication

What Are the Treatments for Hemophilia?

• Monitoring. ...
• Acquiring a blood-borne disease: In the past, people receiving clotting factor from donated blood ran the risk of contracting a blood-borne disease.
• Changes to the immune system: Your immune system may begin to recognize the administered clotting factor as foreign and then destroy it.

Therapy

There is no cure for haemophilia A, but there are treatments to control the bleeding and decrease pain when it does occur. These include: -Take medications that help stop bleeding by increasing the number of platelets in your body.

Self-care

The best way to treat hemophilia is to replace the missing blood clotting factor so that the blood can clot properly. This is typically done by injecting treatment products, called clotting factor concentrates, into a person’s vein. Clinicians typically prescribe treatment products for episodic care or prophylactic care.

Nutrition

Treatment of Hemophilia. The best way to treat hemophilia is to replace the missing blood clotting factor so that the blood can clot properly. This is typically done by injecting treatment products, called clotting factor concentrates, into a person’s vein. Clinicians typically prescribe treatment products for episodic care or prophylactic care.

How do you cure hemophilia?

Are there any cures for hemophilia?

Can you cure hemophilia?

How to cure hemophilia?

What is the treatment of choice for hemophilia?

The main treatment for hemophilia is called replacement therapy. Concentrates of clotting factor VIII (for hemophilia A) or clotting factor IX (for hemophilia B) are slowly dripped or injected into a vein. These infusions help replace the clotting factor that's missing or low.

Are there treatments available for hemophilia?

People with haemophilia A can be treated on-demand with injections of octocog alfa or a medicine called desmopressin. Desmopressin is a synthetic hormone. It works by stimulating the production of clotting factor VIII (8) and is usually given by injection.

What is the mainstay of treatment for hemophilia?

Replacement of the congenitally deficient factor VIII or IX through plasma-derived or recombinant concentrates is the mainstay of treatment for hemophilia.

How is hemophilia diagnosed and treated?

Diagnosis includes screening tests and clotting factor tests. Screening tests are blood tests that show if the blood is clotting properly. Clotting factor tests, also called factor assays, are required to diagnose a bleeding disorder. This blood test shows the type of hemophilia and the severity.

How is hemophilia treated with gene therapy?

Gene therapy offers the potential for a cure for patients with hemophilia by establishing continuous endogenous expression of factor VIII or factor IX (FIX) following transfer of a functional gene to replace the hemophilic patient's own defective gene.

How do you treat hemophilia with inhibitors?

About Inhibitors People with hemophilia, and many with VWD type 3, use treatment products called clotting factor concentrates (“factor”). These treatment products improve blood clotting, and they are used to stop or prevent a bleeding episode.

How do you stop bleeding from hemophilia?

First, control the bleeding: Apply pressure with sterile gauze, a bandage, or a clean cloth. Place another bandage over the first if blood soaks through the bandage, and continue to apply pressure. Raise the injured body part to slow bleeding.

How can hemophilia be prevented?

At this time, there is no way to prevent hemophilia in someone who inherits a defective gene and thus produces too little clotting factor. If hemophilia runs in your family, you can be tested to see whether you carry the defective gene and receive counseling about your chance for having children with hemophilia.

How to treat bleeding disorders?

Treatment Options for Bleeding Disorders 1 Standard half-life therapies: Standard half-life therapies are used to treat hemophilia A and B, some types of von Willebrand disease, and some rare factor disorders. Dosing can be anywhere from three times a week to every day, depending on the person. 2 Extended half-life (EHL) therapies: EHL contains a molecule that has been modified in some way to delay the breaking down of factor in the body. This results in higher levels of factor in the body lasting for longer, resulting in less frequent infusions. How long the factor is effective in the body depends on the person. Extended half-life therapies are mostly used to treat hemophilia A and B. 3 Bypassing agents are used to treat bleeds in people with hemophilia with inhibitors. These treatments contain other factors that can stimulate the formation of a clot and stop bleeding.

What is extended half life therapy?

Extended half-life therapies are mostly used to treat hemophilia A and B. Bypassing agents are used to treat bleeds in people with hemophilia with inhibitors. These treatments contain other factors that can stimulate the formation of a clot and stop bleeding.

What is EHL therapy?

Extended half-life (EHL) therapies: EHL contains a molecule that has been modified in some way to delay the breaking down of factor in the body. This results in higher levels of factor in the body lasting for longer, resulting in less frequent infusions. How long the factor is effective in the body depends on the person.

What is non factor replacement therapy?

Non-factor replacement therapies include: Emicizumab (Hemlibra) is a therapy used to treat hemophilia A, to prevent bleeding episodes in people both with and without inhibitors. It is known as a factor VIII (8) mimetic because it mimics, or imitates, the way factor VIII (8) works.

How to prevent hemophilia?

Lifestyle and home remedies. To avoid excessive bleeding and protect your joints: Exercise regularly. Activities such as swimming, bicycle riding and walking can build up muscles while protecting joints. Contact sports — such as football, hockey or wrestling — are not safe for people with hemophilia.

How to help a child with hemophilia?

To help you and your child cope with hemophilia: Get a medical alert bracelet. This bracelet lets medical personnel know that you or your child has hemophilia, and the type of clotting factor that's best in case of an emergency. Talk with a counselor.

What is a recombinant clotting factor?

Similar products, called recombinant clotting factors, are manufactured in a laboratory and aren't made from human blood. Other therapies may include: Desmopressin. In some forms of mild hemophilia, this hormone can stimulate your body to release more clotting factor.

How to stop bleeding under the skin?

For small areas of bleeding beneath the skin, use an ice pack. Ice pops can be used to slow down minor bleeding in the mouth. Vaccinations. Although blood products are screened, it's still possible for people who rely on them to contract diseases.

What is the best way to prevent clots from breaking down?

It can be injected slowly into a vein or provided as a nasal spray. Clot-preserving medications. These medications help prevent clots from breaking down. Fibrin sealants. These medications can be applied directly to wound sites to promote clotting and healing. Fibrin sealants are especially useful in dental therapy.

How to treat internal bleeding?

If internal bleeding has caused severe damage, you may need surgery. First aid for minor cuts. Using pressure and a bandage will generally take care of the bleeding. For small areas of bleeding beneath the skin, use an ice pack.

When is hemophilia diagnosed?

Depending on the severity of the deficiency, hemophilia symptoms can first arise at various ages. Severe cases of hemophilia usually are diagnosed within the first year of life.

How to treat hemophilia A?

This is done by infusing (giving medication into a vein) a FVIII product into the affected person. When you infuse, FVIII concentrate, the FVIII is immediately available in the bloodstream, and your body can use it to stop or prevent the bleeding.

When did cloning of FVIII and FIX occur?

In the early 1980s, the cloning of FVIII and FIX and subsequent expression of functional proteins occurred. This was during the “bad blood” era (when many individuals with hemophilia being treated with plasma-derived clotting factor were infected with HIV and/or HCV). This led to the development and commercialization of recombinant clotting factors. These initial products were manufactured using Chinese hamster ovary cells or baby mouse kidney cells. Manufacturers injected these cells with the factor gene so that large amounts of the factor protein could be produced. Since the proteins are extracted from animal cells, they are not at risk for containing human viruses. Some factor concentrate products are stabilized using human albumin, while others are stabilized using sucrose. This was life-changing for many with hemophilia, allowing for prophylactic (or preventive) treatment. Some companies are now using human embryonic kidney (HEK) cells to grow the factor.

What is a broviac catheter?

BROVIAC® catheters and HICKMAN® catheters (often referred to as “broviacs”) are similar to a PICC line. However, A BROVIAC® catheter is placed directly into a central vein and threaded to a position just above the heart. It is tunneled under the skin and brought out away from the site where it enters the vein to theoretically prevent bacteria from gaining access to the central portion of the catheter. BROVIAC® catheters contain a “cuff” that is under the skin. As the skin grows into this “cuff,” the catheter becomes more stable, reducing the chance of it becoming pulled out. Like the PICC line, his device is easy to use and does not require sticks into the person’s skin. The difference is that these catheters can last for a prolonged period of time. The most common long-term complications of this type of central line are infection, movement that takes the catheter out of the proper position, and damage to the catheter.

Can you infuse FVIII into bloodstream?

All FVIII products need to be infused directly into the bloodstream. There are several ways to infuse FVIII, and each has its advantages and disadvantages. These include peripheral infusion (accessing a vein with a butterfly needle), port-a-catheter (also called a port), a peripherally inserted central catheter (PICC) line, or a BROVIAC® or HICKMAN® catheter.

Does hemophilia have an inhibitor?

While anyone with a bleeding disorder can develop an inhibitor to clotting factor, those with hemophilia A develop inhibitors more often than the other bleeding disorders. Inhibitors are antibodies that the immune system develops because it perceives the infused FVIII as a foreign substance that needs to be destroyed. Antibodies are proteins that eat up the FVIII before it has time to stop the bleeding.

What is the treatment for hemophilia?

There are two main categories of treatment for hemophilia: preventive therapy or prophylaxis and on-demand treatment. The type of treatment you receive will be prescribed by doctors at the IHTC with input from you and your family.

Why is it important to follow a prescribed treatment for bleeding?

Regardless of which type of treatment you or your child receive, it is very important that you follow that prescribed treatment in order to have the best outcome and avoid long-term complications related to bleeding.

How does a doctor measure factor VIII?

To do so, your doctor measures factor VIII levels using blood samples taken after one or more of your regular treatment infusions over time. Then, your doctor will measure factor VIII levels in each sample to generate your PK profile.

Does hemophilia have the same PK?

The aim of hemophilia A treatment is to continuously maintain factor VIII at high enough levels with regular infusions to reduce the frequency of bleeding episodes – but specific treatment details vary from person to person. No two people have the same PK profile , which is why it’s important to speak with your doctor about conducting PK testing.

Comprehensive Care

For patients with hemophilia, von Willebrand disease or another inherited bleeding disorder optimal comprehensive care includes at least one visit per year to a hemophilia treatment center.

Home self-infusion

Home self-infusion is the ability to receive antihemophilic factor at home through intravenous infusion by the patient, a family member, or a home health nurse thereby avoiding the emergency room whenever possible. Education and training in self-infusion are available to all patients and their families.

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