Precautions
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What is sofosbuvir and velpatasvir used for?
Sofosbuvir and velpatasvir combination is used with or without ribavirin to treat chronic hepatitis C genotype 1, 2, 3, 4, 5, or 6 infection (including with or without cirrhosis). This medicine is available only with your doctor's prescription.
What is sofosbuvir used to treat?
Sofosbuvir is used along with ribavirin (Copegus, Rebetol, Ribasphere, others) and sometimes another medication (peginterferon alfa [Pegasys]) to treat certain types of chronic hepatitis C (an ongoing viral infection that damages the liver) in adults.
What are ledipasvir and sofosbuvir tablets used for?
Ledipasvir and sofosbuvir combination is used with or without ribavirin to treat chronic hepatitis C infection in adults and children 3 years of age and older (including liver transplant patients, with or without cirrhosis). This medicine is available only with your doctor's prescription.
Which type of viral hepatitis is curable with sofosbuvir in about 90% of patients?
Some types of hepatitis C can be treated using more than 1 type of DAA. NHS-approved hepatitis C medicines include: sofosbuvir. a combination of ledipasvir and sofosbuvir.
What is the mode of action of sofosbuvir?
Sovaldi's mechanism of action The drug is a direct-acting antiviral agent and interferes with the HCV lifecycle, restraining viral replication. It can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator. The drug is available for oral use in the form of 400mg tablets.
What medicines should not be taken with Sofosbuvir and Velpatasvir?
Examples include efavirenz, rifamycins (such as rifampin, rifabutin), St. John's wort, tipranavir/ritonavir, drugs used to treat seizures (such as phenobarbital, carbamazepine, phenytoin, primidone), among others. Do not take this medication with other products that contain sofosbuvir.
When do you take Sofosbuvir and Ledipasvir?
The combination of ledipasvir and sofosbuvir comes as a tablet and pellets to take by mouth. It is usually taken with or without food once daily. Take ledipasvir and sofosbuvir at around the same time every day.
What is the difference between interferon and peginterferon?
Overview. Pegylated interferon, usually called peginterferon, is a chemically modified form of the standard interferon that treats hepatitis C and rarely hepatitis B. The difference between interferon and peginterferon is the PEG, which stands for a molecule called polyethylene glycol.
What is the brand name for Ledipasvir Sofosbuvir?
Harvoni (ledipasvir / sofosbuvir) is a combination medication containing two antiviral medications, ledipasvir and sofosbuvir (Sovaldi). It is a first-choice treatment option for hepatitis C for certain types of people.
What is the first line of treatment in hepatitis?
Currently, pegylated interferon alfa (PEG-IFN-a), entecavir (ETV), and tenofovir disoproxil fumarate (TDF) are the first-line agents in the treatment of hepatitis B disease.
What is the newest treatment for hep C?
Recent advances in antiviral treatment have led to the development of new highly effective drugs for the treatment of all types of hepatitis C. The new hepatitis C treatments are sofosbuvir with ledipasvir (Harvoni); sofosbuvir (Sovaldi); daclatasvir (Daklinza); and ribavirin (Ibavyr).
Why hepatitis D is called delta hepatitis?
History. Hepatitis D virus was first reported in 1977 as a nuclear antigen in patients infected with HBV who had severe liver disease. This nuclear antigen was then thought to be a hepatitis B antigen and was called the delta antigen.