Can leuprolide be used for infertility?
^^ I believe the question is referring to the drug 'leuprolide'.#N#Leuprolide is a GnRH analog, and if given continuously it will result in initially an increase in FSH and LH (and testosterone), but eventually the GnRH receptors downregulate, and testosterone levels fall.#N#*Leuprolide can also be used in infertility, however here the use is pulsatile*#N#Alternately, 'flutamide' can also be used, which is an androgen receptor blocker.#N#Note with flutamide FSH and LH values will be high (due to decreased negative feedback)#N#With leuprolide FSH and LH levels will be low (due to GnRH receptor downregulation).#N#Also.. flutamide and leuprolide are often used together in conjunction, with flutamide given first to counteract the initial testosterone surge with leuprolide.#N#Off the top of my head.. kaplan pharm videos (with lionel raymon) discuss this very well, also conrad fisher in kaplan physio endocrine talked about this.
Can flutamide be used for prostate cancer?
if you can find flutamide/leuprolide in your notes, then it was discussed. The sole purpose of these drugs is to help prostate cancer patients. And their mechanism of action relies on the basic principle that prostate cancers can be androgen sensitive.