
Adjuvant treatment: Because it may be easier for melanoma in the head or neck to spread, patients often receive another treatment after surgery. Called adjuvant therapy, this treatment helps to reduce the risk of the cancer returning. Radiation therapy or interferon may be given as adjuvant therapy.
How is melanoma of the head and neck treated?
Melanoma of the Head and Neck Treatment Surgical resection with wide margins and often sentinel lymph node biopsy is required for melanoma that has not spread. Thin tumors, up to 1 millimeter thick, can be resected with 1-centimeter (half an inch) margins around the tumor.
What are the treatment options for melanoma?
Treatment 1 Surgical removal of melanomas. Superficial melanoma can be removed with a surgery called a wide excision. ... 2 Lymphatic mapping and sentinel node biopsy. You may need to have a sentinel node biopsy during your surgery. ... 3 Reconstruction of your wound site. ... 4 After your surgery. ...
How does melanoma spread to the head and neck?
The anatomy of the head and neck is complex. In these areas, we have more blood vessels and many lymph nodes. Because melanoma cells can spread through the blood and lymph, it may be easier for melanoma to spread when this cancer begins in the head, neck, or scalp.
How is mucosal melanoma diagnosed and treated?
To diagnose mucosal melanoma, a doctor will likely take a biopsy of the suspected tissue and perform further testing, such as MRI, CT, and PET scans. The most effective treatment for mucosal melanoma is surgery to remove the melanoma, followed by chemotherapy and radiation therapy.

How is skin cancer on the neck treated?
Skin cancer of the head and neck treatment They require a multimodality approach to treatment, with formal surgical resection and adjuvant radiation or chemotherapy. Melanoma is more likely to spread, and aggressive surgical resection with wide margins is required, in addition to radiation and/or chemotherapy.
Can melanoma spread to the neck?
The anatomy of the head and neck is complex. In these areas, we have more blood vessels and many lymph nodes. Because melanoma cells can spread through the blood and lymph, it may be easier for melanoma to spread when this cancer begins in the head, neck, or scalp.
Is melanoma common on the neck?
In the United States, during 2010, approximately 68,000 new cases of malignant melanoma were diagnosed with 8700 deaths from melanoma. Approximately 30% of melanomas are located within the head and neck. Recently, increases in incidence have been noted at 5% per year and mortality at 2% per year.
What is the survival rate for melanoma in the lymph nodes?
If a sentinel node biopsy yields findings of melanoma in the lymph nodes, the 5-year survival is approximately 75%. Stage IIA: The 5-year relative survival rate is approximately 85%. If a sentinel node biopsy yields findings of melanoma in the lymph nodes, the 5-year survival is approximately 65%.
What stage is melanoma in lymph nodes?
Stage 3 is part of the number staging system. It generally means that cancer cells have spread to the lymph nodes close to where the melanoma started (the primary tumour). Or it has spread to an area between the primary tumour and the nearby lymph nodes.
Is melanoma in the lymph nodes curable?
Melanoma cells can spread from the primary tumor through the bloodstream and lymphatic system to form new tumors. Melanoma, the most aggressive form of skin cancer, is often incurable once the cancer has spread from the original site of the tumor to distant organs and tissues.
How long does melanoma take to spread?
Melanoma can grow very quickly. It can become life-threatening in as little as 6 weeks and, if untreated, it can spread to other parts of the body. Melanoma can appear on skin not normally exposed to the sun. Nodular melanoma is a highly dangerous form of melanoma that looks different from common melanomas.
How do you know if melanoma has spread?
If your melanoma has spread to other areas, you may have: Hardened lumps under your skin. Swollen or painful lymph nodes. Trouble breathing, or a cough that doesn't go away.
Is melanoma hard to cure?
Melanoma is usually curable when detected and treated early. Once melanoma has spread deeper into the skin or other parts of the body, it becomes more difficult to treat and can be deadly. The estimated five-year survival rate for U.S. patients whose melanoma is detected early is about 99 percent.
How is melanoma in lymph nodes treated?
Immunotherapy is often recommended after surgery for melanoma that has spread to the lymph nodes or to other areas of the body. When melanoma can't be removed completely with surgery, immunotherapy treatments might be injected directly into the melanoma. Targeted therapy.
Do you have to have chemo for melanoma?
Chemotherapy doesn't work as well against melanoma as it does for some other types of cancer. Doctors are more likely to use newer drugs called targeted cancer drugs or immunotherapy first to treat melanoma.
How long does it take for melanoma to spread to lymph nodes?
How fast does melanoma spread and grow to local lymph nodes and other organs? “Melanoma can grow extremely quickly and can become life-threatening in as little as six weeks,” noted Dr. Duncanson.
How to tell if you have melanoma in your neck?
Sometimes the first sign of head and neck melanoma is an enlarged lymph node in the neck. Normal moles in the head and neck often resemble each other. Any mole that is new or looks different from the others should be evaluated. Regular self-examination will help you determine if a mole is new or changing. Mucosal melanoma of the head and neck most ...
How is melanoma diagnosed?
Diagnosis is made by clinical exam and a biopsy. Melanoma is diagnosed by the presence of abnormal melanocytes. Melanoma of the skin is staged based on how deeply it invades the skin layers and whether or not it has spread.
How deep is a melanoma?
Thick melanomas (greater than 4 millimeters deep) are associated with a higher risk of spread to other organs, which is evaluated by pretreatment imaging. When enlarged lymph nodes are detected on clinical exam, a fine needle aspiration biopsy is performed to determine whether melanoma is present in nodes.
What does it mean when you have a mole in your neck?
If you have a preexisting mole, any change in the characteristics of this spot — such as a raised or irregular border, irregular shape, change in color, increase in size, itching or bleeding — is a warning sign of melanoma. Sometimes the first sign of head and neck melanoma is an enlarged lymph node in the neck.
Why is melanoma the least common form of skin cancer?
Melanoma is the least common form of skin cancer, but it is responsible for more deaths per year than all other skin cancers combined . Melanoma is also more likely than other skin cancers to spread, and may be harder to control.
What does E mean in melanoma?
E=Evolving: A lesion that changes in size, color, shape or texture is suspicious for melanoma. Melanomas may also have the appearance of a wart, crusty spot, ulcer, mole or sore. It may or may not bleed or be painful.
When is neck dissection performed?
When enlarged lymph nodes are present, a neck dissection is performed at the time of surgery. If distant spread is detected during the workup — that is, melanoma has spread to other organs — immunotherapy and sometimes radiation therapy are used for treatment.
What is the treatment for melanoma in the neck?
Adjuvant treatment: Because it may be easier for melanoma in the head or neck to spread, patients often receive another treatment after surgery. Called adjuvant therapy , this treatment helps to reduce the risk of the cancer returning. Radiation therapy or interferon may be given as adjuvant therapy. Some patients join a research study and receive ...
What to do if you have melanoma on your neck?
Because melanoma on the head or neck can be aggressive, it’s important to keep all of your follow-up appointments. During these appointments, you will have a thorough cancer check-up. You may also have testing, such as a MRI or another type of scan and blood tests.
How to treat melanoma early?
For this reason, treatment tends to be more aggressive. Your treatment plan may include: Surgery to remove the cancer: Treatment for melanoma that begins anywhere on the body usually starts with surgery to remove the melanoma. If you have an early melanoma, your dermatologist can often perform this surgery in the office.
How to prevent skin cancer?
You can reduce your risk of getting melanoma or another skin cancer by: 1 Wearing sun-protective clothes, such as a long-sleeved shirt, pants, and a wide-brimmed hat, along with UV-protective sunglasses. 2 Staying in the shade while outdoors. 3 Planning outdoor activities so that you avoid being outdoors between 10:00 a.m. and 2:00 p.m., when the sun’s rays are the strongest. 4 Applying a broad-spectrum sunscreen with SPF 30 or higher to all skin that clothing won’t cover, even when it’s cloudy or cold outside. 5 Using sunscreen every day, even when you’ll be outside for a short time, such as when you go to work or run errands. 6 Avoiding tanning, both indoors and outside.
Why is it easier for melanoma to spread?
In these areas, we have more blood vessels and many lymph nodes. Because melanoma cells can spread through the blood and lymph, it may be easier for melanoma to spread when this cancer begins in the head, neck, or scalp.
What happens when melanoma develops on the head?
When melanoma, the most serious skin cancer, develops on the head or neck, it can behave differently than on other parts of the body. As a result, you may: Have more aggressive treatment. Require frequent follow-up appointments.
How to get rid of skin cancer early?
See a board-certified dermatologist. Teaming up with a board-certified dermatologist will help you get the treatment you need. Your dermatolog ist will give you full-body skin exams, which can help find skin cancer as early as possible.
How to treat early stage melanoma?
Treatment for early-stage melanomas usually includes surgery to remove the melanoma. A very thin melanoma may be removed entirely during the biopsy and require no further treatment. Otherwise, your surgeon will remove the cancer as well as a border of normal skin and a layer of tissue beneath the skin.
How to cope with melanoma?
Here are some ideas to help you cope: Learn enough about melanoma to make decisions about your care. Ask your doctor about your cancer, including your treatment options and, if you like, your prognosis. As you learn more about cancer, you may become more confident in making treatment decisions. Keep friends and family close.
How to treat melanoma that has spread beyond the skin?
Treating melanomas that have spread beyond the skin. If melanoma has spread beyond the skin, treatment options may include: Surgery to remove affected lymph nodes. If melanoma has spread to nearby lymph nodes, your surgeon may remove the affected nodes.
What is the procedure to remove melanoma from lymph nodes?
If there's a risk that the cancer has spread to the lymph nodes, your doctor may recommend a procedure known as a sentinel node biopsy. During a sentinel node biopsy, a dye is injected in the area where your melanoma was removed. The dye flows to the nearby lymph nodes.
What is the stage of melanoma?
Melanoma is staged using the Roman numerals 0 through IV. At stage 0 and stage I, a melanoma is small and has a very successful treatment rate. But the higher the numeral, the lower the chances of a full recovery. By stage IV, the cancer has spread beyond your skin to other organs, such as your lungs or liver.
How does thickness affect melanoma?
The thickness of a melanoma helps doctors decide on a treatment plan. In general, the thicker the tumor, the more serious the disease. Thinner melanomas may only require surgery to remove the cancer and some normal tissue around it.
What is used to close the site of a biopsy?
During an excisional biopsy, the doctor removes an entire lump or an entire area of abnormal skin, including a portion of normal skin. Stitches are generally used to close the biopsy site after this procedure.
Where do melanomas occur?
Melanomas also commonly occur on the neck and face. The less common sites for melanomas include the eyes, mouth, genitals, and anal area. Although melanomas are far less common than the other types of skin cancers, they are more dangerous since they spread rapidly to other parts of the body ( metastasis ).
What is the first lymph node that a melanoma travels to?
Melanomas are rapidly spreading tumors. The first lymph node that a melanoma travels to is called the sentinel lymph node. A sentinel lymph node biopsy is a type of surgery in which a few lymph nodes nearest to the melanoma are removed and examined for the presence of melanoma cells.
What is the lymph node in melanoma?
The treatment of melanoma depends on the stage of the disease. Lymph nodes are small glands that are part of the lymphatic system. The lymphatic system is involved in the formations of the white blood cells or WBCs. It is also the site where lymph, a clear fluid containing the white blood cells, is filtered. When melanoma begins to spread, it often ...
Where does melanoma spread?
It is also the site where lymph, a clear fluid containing the white blood cells, is filtered. When melanoma begins to spread, it often first goes to the lymph node near the melanoma. The first lymph nodes that drain lymph fluid from the primary tumor are called sentinel lymph nodes. If the melanoma has spread to the lymph nodes, ...
Why do melanoma cells turn brown?
It develops when there is an uncontrolled growth of the cells that give the skin its tan or brown color (melanocytes). Usually, the melanoma tumors are brown or black since most melanoma cells can make melanin. Some melanomas, however, do not make melanin. Such melanoma tumors can appear pink, tan, or even white.
What Is Mucosal Melanoma?
Melanoma is cancer that develops in melanocytes, cells that produce melanin (pigment that produces color in the eyes, hair and skin). Although melanoma usually grows on the skin, it can also grow in mucosal membranes. This moist tissue lines cavities inside the body, such as the mouth, nose, sinuses and pelvic organs.
Mucosal Melanoma Care: The Penn Medicine Advantage
As part of the Abramson Cancer Center, the Tara Miller Melanoma Center provides exceptional care for people with mucosal melanoma. We offer:
Mucosal Melanoma Symptoms
The signs and symptoms of mucosal melanoma vary based on where the cancer is growing. Signs and symptoms that can occur in any area of mucosal melanoma include:
Risk Factors of Mucosal Melanoma
There are very few identified risk factors for mucosal melanoma. Mucosal melanoma, unlike melanoma skin cancer, is not linked to ultraviolet (UV) light exposure. Possible risk factors may differ according to the area where the disease is present.
Mucosal Melanoma Diagnosis and Treatment
Mucosal melanoma usually doesn’t show symptoms until its later stages, which makes it challenging to diagnose. That’s why it’s important to see doctors with experience in recognizing, diagnosing and treating mucosal melanoma.
Request an Appointment to Discuss Mucosal Melanoma with a Penn Expert
Call 800-789-7366 to schedule an appointment with one of our melanoma experts. You can also request an appointment using our online form.

Diagnosis
Treatment
- The best treatment for your melanoma depends on the size and stage of cancer, your overall health, and your personal preferences.
Clinical Trials
- Explore Mayo Clinic studiestesting new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.
Coping and Support
- A cancer diagnosis can change your life forever. Each person finds his or her own way of coping with the emotional and physical changes cancer brings. But when you're first diagnosed with cancer, sometimes it's difficult to know what to do next. Here are some ideas to help you cope: 1. Learn enough about melanoma to make decisions about your care.Ask your doctor about your c…
Preparing For Your Appointment
- Start by seeing your family doctor if you notice any skin changes that concern you. Depending on your situation and the outcome of any tests, you may be referred to a doctor who specializes in skin diseases (dermatologist) or to a doctor who specializes in cancer treatment (oncologist). Because appointments can be brief, and because there's often a lot to discuss, it's a good idea t…