What is the best treatment for malaria in pregnancy?
Uncomplicated malaria in pregnancy Currently, quinine and clindamycin is the recommended treatment for women in the first trimester of pregnancy31. In many places, clindamycin is unavailable, and quinine monotherapy is prescribed.
What malaria drug is safe during pregnancy?
The Centers for Disease Control and Prevention (CDC) now recommends the antimalarial drug mefloquine for pregnant women both as a malaria treatment option and as an option to prevent malaria infection for all trimesters.
What is the first line treatment for malaria in pregnancy?
Artesunate is first-line anti-malarial drug recommended for treatment of complicated (severe) malaria in all trimesters of pregnancy by international guidelines [1, 56], based on evidence from various studies [17, 18, 28].
When should malaria be treated during pregnancy?
The National malaria control program,6,7 recommends two doses of IPT-SP during normal pregnancy; the first dose to be administered at quickening, which ensures that the woman is in the second trimester, and the second dose given at least one month from the first.
Is artemether and lumefantrine safe in pregnancy?
Strong evidence now demonstrates that artemether-lumefantrine (AL) (Coartem) is effective and safe in the treatment of malaria in pregnancy.
Is IV artesunate safe in pregnancy?
In two studies comparing intravenous quinine with intravenous artesunate, intravenous artesunate was more efficacious and safe for use in pregnant women. No studies detected an increased risk of miscarriage, stillbirth, or congenital anomalies associated with first trimester exposure to artesunate.
Is artemether injection safe in pregnancy first trimester?
Artemether / lumefantrine Pregnancy Warnings This drug should not be used during the first trimester of pregnancy unless there are no alternatives; this drug should be considered during the second and third trimesters of pregnancy only if the benefit to the mother outweighs the risk to the fetus.
When is Fansidar given in pregnancy?
For SP to be safe and well tolerated, the doses of IPTp-SP should be administered from the earliest second trimester (14 weeks of gestation) to delivery, with each dose given at one-month interval [10,11,12].
Why is Fansidar given in pregnancy?
All pregnant women accessing services at health care facilities in Uganda receive at least three doses of Fansidar from the second trimester to reduce malaria episodes, maternal and fetal anemia, placental parasitemia, low birth weight, and mortality.
Is artesunate safe in early pregnancy?
Artesunate and other antimalarials also appear to be effective and safe in the first trimester of pregnancy, when development of malaria carries a high risk of miscarriage. Use of tafenoquine to prevent relapse of P vivax malaria during pregnancy is not recommended.
Is Fansidar safe in pregnancy?
Use of Fansidar in pregnancy is justified because the benefit to the mother and fetus outweighs the risks. Pregnant women using the drug should also take folic acid supplementation.
Is ciprofloxacin safe in pregnancy?
Ciprofloxacin (Cipro) and levofloxacin are also types of antibiotics. These drugs could cause problems with the baby's muscle and skeletal growth as well as joint pain and potential nerve damage in the mother.