Which medications is used for PCP prophylaxis?
The agent most commonly used for prophylaxis is trimethoprim/sulfamethoxazole (TMP/SMX). Other agents that have activity against Pneumocystis jirovecii include dapsone, pentamidine, atovaquone, pyrimethamine, sulfadoxine, and clindamycin and primaquine in combination.
When do you start steroids in PCP?
In adults, it is recommended to start the corticosteroid treatment as early as possible but within 72 hours after starting the PCP‐specific therapy.
How is PJP treated?
Treatment of PJP - General Considerations While officially classified as a fungal pneumonia, P jiroveci pneumonia (PJP) does not respond to antifungal treatment. The treatment of choice is TMP-SMX, with second-line agents including pentamidine, dapsone (often in combination with pyrimethamine), or atovaquone.
What is the recommended first line treatment for pneumocystis pneumonia?
Treating Disease. TMP-SMX is the treatment of choice for PCP (AI).
When should I take steroids during pregnancy?
A single course of corticosteroids is recommended for pregnant women between 24 0/7 weeks and 33 6/7 weeks of gestation, and may be considered for pregnant women starting at 23 0/7 weeks of gestation, who are at risk of preterm delivery within 7 days 1 11 13.
Why does bactrim treat Pneumocystis?
The mainstay of treatment is trimethoprim-sulfamethoxazole (Bactrim, Septra), given intravenously or orally (Table 5). Trimethoprim-sulfamethoxazole sequentially inhibits two enzymes in folate metabolism essential for DNA synthesis: dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS).