What is the role of GCSF in chemotherapy?
Outside pregnancy, the addition of G-CSF to chemotherapy improves overall survival, as it minimizes treatment delays and allows dose-dense chemotherapy regimens leading to an increased disease control [19].
What does G-CSF stand for?
Granulocyte Colony Stimulating Factor (G-CSF) Induced splenic infarction in breast cancer patient treated with dose-dense chemotherapy regimen. Case Rep Oncol Med. 2019;2019:8174986.
Is G-CSF used on the NHS?
This type of G-CSF is not commonly used in the NHS. Growth factors are proteins made in the body. Some of them make the bone marrow produce blood cells. G-CSF is a type of growth factor that makes the bone marrow produce white blood cells to reduce the risk of infection after some types of cancer treatment.
What is GCSF bone marrow used for?
Bone marrow is a spongy material inside bones. It is where blood cells are made. G-CSF is used in two ways. It is given: during treatment with chemotherapy, to stimulate the bone marrow to make white blood cells. These cells are called neutrophils.
Why is G-CSF given?
G-CSF injections are a synthetic version of this naturally occurring growth factor. G-CSF injections are given before you donate your stem cells to boost your white cells and to release stem cells into the bloodstream ready to collect. G-CSF is also given to some patients receiving treatment for cancer.
Why is G-CSF given 24 hours after chemo?
G-CSFs are administered between 24-72 hours after receiving chemotherapy. The reason for this minimum 24-hour delay is to allow the body time to metabolize and excrete the cytotoxic drugs.
What is the most common side effect of G-CSF?
What side effects may I notice from receiving this medicine?allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue.back pain.dizziness or feeling faint.fever.pain, redness, or irritation at site where injected.pinpoint red spots on the skin.shortness of breath or breathing problems.More items...
When do you give G-CSF after chemo?
G-CSF is usually started 24 hours or more after your chemotherapy finishes. You usually have it daily. Your doctor or pharmacist will tell you how many injections you need. Some types of G-CSF stay in the body for longer.
How long does it take for G-CSF to work?
This usually takes 5 to 7 days, although it can be longer. If you are having G-CSF before a stem cell transplant, you usually have your first dose 4 to 6 days before your stem cells are going to be collected.
Why does G-CSF cause bone pain?
There are four main causes of G-CSF related bone pain: bone marrow quantitative and qualitative expansion, peripheral nociceptor sensitization to nociceptive stimuli, modulation of immune function and direct effect on bone metabolism.
What is the shot given after chemo?
CSFs include Neupogen (filgrastim), Neulasta (pegfilgrastim), and Leukine and Prokine (sargramostim). They are usually given as shots 24 hours after a chemotherapy treatment.
Where do you inject G-CSF?
You usually have injections under the skin (subcutaneous injection) into the stomach, thigh or top of your arm. You might have stinging or a dull ache for a short time after this type of injection but they don't usually hurt much. The skin in the area may go red and itchy for a while.
Can G-CSF cause leukemia?
G-CSF use has been associated with later development of myelodysplastic syndromes/acute myelogenous leukemia (MDS/AML) in several clinical circumstances.
When do you stop G-CSF?
Autologous transplants - Stop the G-CSF after 2 consecutive days of neutrophils >1.0 x 109/l. Note: Longer-acting Pegylated G-CSF is not approved for use in this setting.
How can I increase my white blood cells after chemo?
The only treatment that has been proved to increase the number of white blood cells after chemotherapy is an injectable medicine that stimulates the bone marrow to make white blood cells faster.
What stimulates bone marrow to produce more platelets?
Thrombopoietin (TPO) is a protein made in the liver. It is a natural stimulator of platelet production in the bone marrow.
What is G-CSF treatment?
People undergoing leukapheresis. Trusted Source. — a procedure that collects stem cells from the blood — may also require G-CSF treatment. G-CSF moves hematopoietic stem cells, which will go on to form blood cells, from the bone marrow into the bloodstream.
What is G-CSF drug?
G-CSF drugs are a type of protein called glycoproteins. They target hematopoietic cells stored in the bone marrow. G-CSF promotes the growth and development of these cells into different types of blood cells, including white blood cells.
What are the risks of G-CSF?
The manufacturers also warn of several health risks of using G-CSF drugs. These include: 1 ruptured spleen, which causes significant blood loss and can be fatal 2 acute respiratory distress syndrome, a lung condition that causes fluid to leak into the lungs 3 serious allergic reactions, which can include anaphylactic shock 4 sickle cell crisis, a condition that occurs in people with sickle cell disease, causing moderate-to-severe pain and swelling of the hands and feet 5 glomerulonephritis, or inflammation of the glomeruli of the kidneys, which reduces the function of these organs and causes fluid buildup and hypertension 6 myelodysplastic syndrome and acute myeloid leukemia, which are forms of blood cancer
What do doctors check for when taking G-CSF?
Doctors will monitor people receiving G-CSF for fever and check their level of white blood cells. These are two factors that researchers have tested when studying the efficacy of G-CSF.
What is G-CSF injection?
G-CSF drugs are a type of protein called glycoproteins.
Can you use Granix for G-CSF?
Uses of G-CSF. Doctors can prescribe G-CSF drugs for different uses, although these vary depending on the specific drug. Doctors prescribe Granix for people 1 month and older to lower the duration of severe neutropenia in people with certain types of cancer who are taking drugs that lower white blood cell levels.
Is Filgrastim a biologic?
Filgrastim is a biologic drug that comes in the form of a sterile solution for injection. The cost may depend on the purchasing pharmacy and whether the person has health insurance. As the drug is available in biosimilar forms, people can ask their pharmacist which biosimilar is cheapest.
What is G-CSF?
G-CSF (Granulocyte-colony stimulating factor) Granulocyte-colony stimulating factor (G-CSF) is a type of drug called a growth factor. This helps your body make more white blood cells. On this page.
Why is G-CSF used after a stem cell transplant?
G-CSF may also be used after a stem cell transplant to help speed up the recovery of the new stem cells in the bone marrow.
What is the purpose of neutrophils in chemo?
During treatment with chemotherapy to stimulate the bone marrow to make white blood cells, called neutrophils. These blood cells help to fight infection. Before a stem cell transplant to encourage stem cells to be released from the bone marrow into the blood. The stem cells can then be collected for use in a stem cell transplant.
How long does G-CSF stay in your system?
With chemotherapy. G-CSF is usually started 24 hours or more after chemotherapy finishes and given daily. Your doctor or pharmacist will tell you how many injections you need. Some types of G-CSF stay in the body for longer.
How is G-CSF made?
G-CSF is made naturally in the body but can also be made as a drug in the laboratory. G-CSF stimulates the bone marrow to make more blood cells. Bone marrow is a spongy material inside bones. It is where blood cells are made. G-CSF is used in two ways. It is given:
How long does it take to get a G-CSF injection?
Some people may have G-CSF as a drip into a vein, which takes about 30 minutes. You will have this at the hospital or clinic. The levels of white blood cells in your body will be tested regularly with a blood test while you are having G-CSF injections.
What to do if you need to get G-CSF?
If you need medical treatment for any reason, always tell the doctors and nurses that you are having G-CSF. Give them the contact details for your cancer doctor so they can ask for advice.
What is a G-CSF?
G-CSF. A biosimilar is a biologic medical product that is almost an identical copy of an original medication that is manufactured by a different pharmaceutical company. Other Names: G-CSF, granulocyte-colony stimulating factor. Chemocare.com uses generic names in all descriptions of drugs.
How long after chemo can you take filgrastim?
The manufacturer recommends that the first dose of filgrastim be given no sooner than 24 hours after chemotherapy. Your doctor will discontinue therapy with filgrastim when your white blood cell count has reached acceptable levels.
What is the trade name for filgrastim?
Neupogen, Granix and Zarxio are trade names for filgrastim. Granulocyte - colony stimulating factor (G-CSF) is another name for filgrastim. In some cases, health care professionals may use the trade name Neupogen, Granix or Zarxio when referring to the generic drug name filgrastim. Drug type: Filgrastim is a biologic response modifier.
How is filgrastim given?
How Filgrastim Is Given: Filgrastim may be given subcutaneous (the layer between the skin and muscle) injection or infused into a vein ( intravenous, IV). Filgrastim is generally given on a daily basis. The number of days you receive filgrastim will be prescribed by your doctor.
What is Filgrastim used for?
What Filgrastim Is Used For: Filgrastim is used to stimulate the production of granulocytes (a type of white blood cell) in patients undergoing therapy that will cause low white blood cell counts. This medication is used to prevent infection and neutropenic (low white blood cells) fevers caused by chemotherapy. Filgrastim is a support medication.
What is the function of a growth factor that stimulates the production, maturation, and activation of neutrophil
Filgrastim is a growth factor that stimulates the production, maturation, and activation of neutrophils (a type of white blood cell). Filgrastim also stimulates the release of neutrophils from the bone marrow.
Is Filgrastim a support medication?
Filgrastim side effects may be quite manageable. There are many options to minimize or prevent the side effects of filgrastim. Filgrastim is a support medication .
What is G-CSF in cancer?
Case reports suggest that tumors expressi …. Granulocyte colony-stimulating factor (G-CSF) is a cytokine most well-known for maturation and mobilization of bone marrow neutrophils. Although it is used therapeutically to treat chemotherapy induced neutropenia, it is also highly expressed in some tumors. Case reports suggest that tumors expressi ….
What is G-CSF in tumors?
G-CSF in tumors: Aggressiveness, tumor microenvironment and immune cell regulation. Granulocyte colony-stimulating factor (G-CSF) is a cytokine most well-known for maturation and mobilization of bone marrow neutrophils. Although it is used therapeutically to treat chemotherapy induced neutropenia, it is also highly expressed in some tumors.
What is G-CSF?
Granulocyte colony-stimulating factor (G-CSF) is a cytokine most well-known for maturation and mobilization of bone marrow neutrophils. Although it is used therapeutically to treat chemotherapy induced neutropenia, it is also highly expressed in some tumors. Case reports suggest that tumors expressing high levels of G-CSF are aggressive, ...
Abstract
Granulocyte-colony-stimulating factor (G-CSF) is a member of the hematopoietic growth factor family that primarily affects the neutrophil lineage. G-CSF serves as a powerful mobilizer of peripheral blood stem cells and recombinant human G-CSF (rhG-CSF) has been used to treat granulocytopenia and neutropenia after chemotherapy for cancer patients.
Acknowledgements
The authors of the present study would like to thank Professor Daya Luo (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Nanchang University), who made valuable suggestions regarding this manuscript.
Funding
The present review was supported by grants from the National Natural Science Foundation of China (grant no. 81760509) and the Natural Science Foundation of Jiangxi Province of China (grant no. 20181BAB205043).
Authors' contributions
LL and YL wrote the manuscript, prepared the figures and repeatedly revised the paper. CZ collected the articles regarding G-CSF expression. XX and XY reviewed drafts of the paper. All authors read and approved the final manuscript.
What is G-CSF in cancer treatment?
The use of Granulocyte colony-stimulating factor (G-CSF) can be indicated for dose dense chemotherapy in high risk breast cancer patients or for the treatment or prevention ...
Can you use G-CSF while pregnant?
However, as evidence is still scarce, physicians are still reluctant to the use of G-CSF during pregnancy. In this series, the International Network of Cancer, Infertility and Pregnancy (INCIP) reports on 42 pregnant patients who received G-CSF during oncological treatment.
