When should thrombocytopenia be corrected?
People with mild thrombocytopenia might not need treatment. For people who do need treatment for thrombocytopenia, treatment depends on its cause and how severe it is. If your thrombocytopenia is caused by an underlying condition or a medication, addressing that cause might cure it.
When should I start steroids with ITP?
We suggest: Treatment be administered to for newly diagnosed patients with a platelet count <30 × 109/l (grade 2C); Longer courses of steroids are preferred over shorter courses of corticosteroids or IVIg as first-line treatment (grade 2B);
What is the first-line treatment for ITP?
The standard initial treatment for ITP is oral corticosteroids to increase platelet counts. Intravenous immunoglobulin or anti-D immunoglobulin can also increase platelet counts and are particularly useful for stimulating rapid platelet increases before planned procedures.
Should ITP be treated?
Children usually improve without treatment. Most adults with ITP will eventually need treatment, as the condition often becomes severe or long term (chronic). Treatment may include a number of approaches, such as medications to boost your platelet count or surgery to remove your spleen (splenectomy).
How long should I take steroids for low platelets?
If your platelet count is within the goal range after four weeks, the dose of prednisone will typically be decreased slowly (tapered) over four to six weeks with the goal of ultimately stopping it completely.
How quickly does dexamethasone increase platelets?
A good initial response to high-dose dexamethasone occurred in 106 of the 125 patients (85 percent): the platelet count increased by at least 20,000 per cubic millimeter by the third day of treatment, and the mean platelet count was 101,400±53,200 per cubic millimeter (range, 50,000 to 260,000 per cubic millimeter) one ...
When is ITP transfuse platelets?
The 2010 international consensus guidelines on the diagnosis and management of ITP (Blood, 2010) recommends that platelet transfusions be reserved for use when an urgent restoration in platelet count is needed, such as for patients who are bleeding and those preparing for surgery.
When should I use IVIG in ITP?
IVIg is generally recommended for ITP patients under critical bleeding condition, as an emergency rescue procedure, and even for those not responding to GCs or cannot tolerate glucocorticoids (6,23,33).
How is ITP 2021 treated?
In adults with newly diagnosed ITP, the ASH guideline panel recommends against a prolonged course (>6 weeks) of prednisone in favor of a short course (≤6 weeks) and suggests either prednisone (0.5 - 2.0 mg/kg/day) or dexamethasone (40 mg/day for 4 days) as the type of corticosteroid for initial therapy1 .
What happens if ITP is not treated?
The specific symptoms of ITP are affected by your platelet count: The lower your count, the more likely you are to have spontaneous and unexpected bleeding, both internally and externally. Without treatment to correct platelet counts, bleeding can become severe and life threatening.
How long does it take to cure ITP?
ITP may be acute and resolve in less than 6 months, or chronic and last longer than 6 months. Treatment options include a variety of medications that can reduce the destruction of platelets or increase their production. In some cases, surgery to remove the spleen is necessary.
Can ITP resolve itself?
Acute ITP usually goes away on its own without treatment. But chronic ITP can come back after you treat it, sometimes frequently. The doctor who treats your ITP will monitor you for signs that your disease has come back.
Diagnosis
Treatment
- People with mild immune thrombocytopenia may need nothing more than regular monitoring and platelet checks. Children usually improve without treatment. Most adults with ITPwill eventually need treatment, as the condition often becomes severe or long term (chronic). Treatment may include a number of approaches, such as medications to boost your plat...
Clinical Trials
- Explore Mayo Clinic studiestesting new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.
Lifestyle and Home Remedies
- If you have immune thrombocytopenia, try to: 1. Avoid contact sports.Depending on your risk of bleeding, head impacts during sports like boxing, martial arts and football could cause bleeding in your brain. Talk to your doctor about what activities are safe for you. 2. Watch for signs of infection.If you've had your spleen removed, be alert for any signs of infection, including fever, a…
Preparing For Your Appointment
- Because a low platelet count may not cause symptoms, the problem is often discovered when you have a blood test for another reason. To diagnose immune thrombocytopenia, your doctor is likely to order further blood tests that require drawing a small amount of blood from a vein in an arm. He or she may also refer you to a specialist in blood diseases (hematologist).