Symptoms
With treatment, the average life expectancy of someone with the disease is just 10 years less than the average man’s. In the 1960s, the average lifespan for a boy with hemophilia was just 11 years old.
Causes
The best way to treat hemophilia is to replace the missing blood clotting factor so that the blood can clot properly. This is typically done by injecting treatment products, called clotting factor concentrates, into a person’s vein. Clinicians typically prescribe treatment products for episodic care or prophylactic care.
Complications
If left untreated, the bleeding can cause permanent damage. There’s currently no cure for hemophilia, but patients can be treated with an intravenous clotting factor.
What is the life expectancy of someone with hemophilia?
Some people develop hemophilia with no family history of the disorder. This is called acquired hemophilia. Acquired hemophilia is a variety of the condition that occurs when a person's immune system attacks clotting factor 8 or 9 in the blood.
What is the best way to treat hemophilia?
What happens if hemophilia is left untreated?
Can you have hemophilia with no family history?
What happens if hemophilia is not treated?
Left untreated, frequent internal bleeding can cause arthritis or destruction of the joint. Infection. If the clotting factors used to treat hemophilia come from human blood, there's an increased risk of viral infections such as hepatitis C. Because of donor screening techniques, the risk is low.
What is the life expectancy with without treatment of hemophilia?
Without appropriate treatment, many hemophiliacs will die before adulthood. With treatment, the average life expectancy of someone with the disease is just 10 years less than the average man's. In the 1960s, the average lifespan for a boy with hemophilia was just 11 years old.
How long does someone with hemophilia live?
Estimated median life expectancy of patients with hemophilia was 77 years, 6 years lower than the median life expectancy of the general Dutch male population (83 years).
Can hemophilia lead to death?
Hemophilia can result in: Bleeding within joints that can lead to chronic joint disease and pain. Bleeding in the head and sometimes in the brain which can cause long term problems, such as seizures and paralysis. Death can occur if the bleeding cannot be stopped or if it occurs in a vital organ such as the brain.
Does hemophilia get worse with age?
Many of the complications of hemophilia, including intracranial hemorrhage, joint disease, and inhibitor development, increase with increasing age.
Can you live normally with hemophilia?
Fact: With several medical advancements, people haemophilia lead a near normal life expectancy. With prophylaxis treatment (infusing a small amount of factor VIII into one's system on a regular, prescribed dosage), a haemophilia patient can enjoy a normal, active lifestyle.
Why is hemophilia painful?
Acute pain in haemophilia In haemophilia, bleeding episodes in joints and muscles cause acute pain. Therefore, pain can initially serve as an early warning sign of active joint (or other) bleeds [6,10].
Can someone with hemophilia have a child?
A family may have children with the hemophilia gene and children without it. It is also possible for all the children in the family to inherit the normal gene or all to inherit the hemophilia gene.
What is a major cause of death in patients who have hemophilia?
AIDS remains the most common cause of death in patients with severe hemophilia.
What is the leading cause of death in hemophiliacs?
The leading associated cause of 418 deaths of haemophilia as underlying cause was hemorrhage (52.6%), half of which intracranial hemorrhage.
How long does hemophilia last?
Life expectancy in hemophilia varies, depending on whether patients receive appropriate treatment. Many patients still die before adulthood due to inadequate treatment. With proper treatment, life expectancy is only about 10 years less than healthy men. Overall, the death rate for people with hemophilia is about twice that ...
What is hemophilia news?
Hemophilia News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you ...
What is the most serious complication of hemophilia?
The most important life-threatening complications of the disease are bleeding in the skull and hemorrhages in soft tissue around airways or other internal organs. About 10 percent of those with severe hemophilia have bleeding in the skull, and 30 percent with the condition die. There is an up to 8 percent risk that a person with ...
Why did the death rate of hemophilia spike in the 1980s?
The hemophilia death rate spiked in the 1980s from the impact of the human immunodeficiency virus (HIV) and therapy-associated hepatitis infections. Today, the mortality rate of men with hemophilia is still twice that of healthy men. Although joint deterioration remains a chronic complication in hemophilia, prompt and proper treatment can greatly ...
Can hemophilia cause joint pain?
People with hemophilia can also develop chronic, debilitating joint disease .
How long does a hemophiliac live?
Without appropriate treatment, many hemophiliacs will die before adulthood. With treatment, the average life expectancy of someone with the disease is just 10 years less than the average man’s. In the 1960s, the average lifespan for a boy with hemophilia was just 11 years old. Treatment and comprehensive care have both increased ...
How severe is hemophilia?
The severity of a person’s hemophilia depends on the amount of clotting factor they have in their blood. Generally speaking, the disease is considered mild, moderate or severe, although around 70 percent of people living with the disease have the severe form.
What is the most life threatening bleed?
The most life-threatening is intracranial bleeding. It’s estimated that around 10 percent of hemophilia patients will suffer some form of bleeding in the skull and this accounts for around a third of all hemophilia deaths.
What is hemophilia news?
Hemophilia News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
Can hemophilia be treated?
Treatment for people with hemophilia has improved dramatically over the past few decades. With access to clotting factor, many people can now prevent major bleeds and live a normal life.
Why are blood products safer for people with hemophilia?
Blood products became safer after the mid-1980s due to screening of donated blood for hepatitis and HIV. Adverse reaction to clotting factor treatment.
What are the symptoms of hemophilia?
Signs or symptoms of bleeding into the brain. An injury in which the bleeding won't stop. Swollen joints that are hot to the touch and painful to bend. If you have a family history of hemophilia, you may want to undergo genetic testing to see if you're a carrier of the disease before you start a family.
What happens if you don't have clotting factor?
If you have a severe deficiency of the clotting factor protein, the greater health concern is deep bleeding inside your body, especially in your knees, ankles and elbows. That internal bleeding can damage your organs and tissues, and may be life-threatening. Hemophilia is a genetic disorder.
How does hemophilia happen in boys?
This means that hemophilia almost always occurs in boys and is passed from mother to son through one of the mother's genes. Most women with the defective gene are simply carriers and experience no signs or symptoms of hemophilia.
Why does hemophilia bleed?
If you have hemophilia, you might bleed for a longer time after an injury than you would if your blood clotted properly.
What is the most common type of hemophilia?
The most common type is hemophilia A, associated with a low level of factor 8 The next most common type is hemophilia B, associated with a low level of factor 9.
Where is the faulty gene located in hemophilia?
Hemophilia inheritance. In the most common types of hemophilia, the faulty gene is located on the X chromosome. Everyone has two sex chromosomes, one from each parent. A female inherits an X chromosome from her mother and an X chromosome from her father.
What is hemophilia in medical terms?
Table of Contents. Hemophilia is a bleeding disorder in which blood does not clot properly. Blood contains many proteins, called clotting factors, that can help to stop bleeding after injury or surgery.
What is the factor of hemophilia?
People with hemophilia have low amounts of either factor VIII (eight) or factor IX (nine), key factors responsible for normal blood clotting. A person’s genes provide the instructions on how to make proteins, such as factor VIII and factor IX. In people with hemophilia, there is a mutation (difference from normal) in either the gene for ...
What is the chance of a daughter having a hemophilia allele?
Each daughter has a 1 in 2 (50%) chance of getting her mother’s hemophilia allele and being heterozygous. Overall, there is a 1 in 4 (25%) chance for each pregnancy that the baby will be a son with hemophilia and a 1 in 4 (25%) chance that the baby will be a heterozygous daughter.
Is hemophilia inherited from a parent?
It almost always is inherited (passed down) from a parent to a child. Both hemophilia A and B are inherited in the same way, because both the genes for factor VIII and factor IX are located on the X chromosome (chromosomes are structures within the body’s cells that contain the genes).
Can a son have hemophilia without the allele?
Without the hemophilia allele, the sons will not have hemophilia and can’t pass it down to their children. Overall, there is a 1 in 2 (50%) chance that the child will be a son who does not have hemophilia and a 1 in 2 (50%) chance that the child will be a daughter who is heterozygous (a carrier). This is true if the mother does not have ...
Can hemophilia be hidden in a family?
Hemophilia may be hidden in a family for many generations if it passes only through females who do not have bleeding symptoms. If a mother is heterozygous (a carrier) for hemophilia and the father does not have hemophilia, each son has a 1 in 2 (50%) chance of getting his mother’s hemophilia allele and having hemophilia.
How to treat hemophilia A?
Your doctor can treat hemophilia A with a prescription hormone. This hormone is called desmopressin, which they can give as an injection into your vein. This medication works by stimulating the factors responsible for the process of blood clotting.
What is hemophilia C?
Hemophilia C is a mild form of the disease that’s caused by a deficiency of factor XI. People with this rare type of hemophilia often don’t experience spontaneous bleeding. Hemorrhaging typically occurs after trauma or surgery. Hemophilia is an inherited genetic condition.
Can hemophilia go away?
Though treatment can help improve and prevent symptoms, there is currently no cure for hemophilia. You will need regular treatment to ensure your blood clots normally.
What are the three forms of hemophilia?
The three forms of hemophilia are hemophilia A, B, and C. Hemophilia A is the most common type of hemophilia, and it’s caused by a deficiency in factor VIII. According to the National Heart, Lung, and Blood Institute (NHLBI) Hemophilia B, which is also called Christmas disease, is caused by a deficiency of factor IX.
Why are hemophilia A and B more common in males than females?
Hemophilia A and B are more common in males than females because of genetic transmission.
Can hemophilia cause swollen joints?
People with hemophilia bleed easily, and the blood takes a longer time to clot. People with hemophilia can experience spontaneous or internal bleeding and often have painful, swollen joints due to bleeding into the joints. This rare but serious condition can have life-threatening complications.
Is hemophilia inherited?
Hemophilia is an inherited genetic condition , meaning it is passed down through families. It’s caused by a defect in the gene that determines how the body makes factors VIII, IX, or XI. These genes are located on the X chromosome, making hemophilia an X-linked recessive disease.
How old are people with hemophilia?
Among all males with hemophilia, just over 4 in 10 have the severe form of the disorder. The average age of persons with hemophilia in the United States is 23.5 years. Compared to the distribution of race and ethnicity in the U.S. population, white race is more common, Hispanic ethnicity is equally common, while black race ...
Why is hemophilia decreasing among black people?
The reason for the decreased prevalence of hemophilia among people of black race is not known.
Why is there a large variation in the prevalence of hemophilia between states?
A number of observations from this study need further investigation: The large variation in the prevalence of hemophilia between states is thought to be due primarily to the hereditary (passed down from one’s parents) nature of hemophilia and known migratory patterns (when people with hemophilia moved between states) early in U.S. history.
Why does hemophilia not clot?
Hemophilia is an inherited bleeding disorder in which the blood does not clot properly due to a lack or decrease in a protein called clotting factor. The two most common types of hemophilia are hemophilia A, which is due to a lack of clotting factor VIII (8) ...
What are the two most common types of hemophilia?
The two most common types of hemophilia are hemophilia A , which is due to a lack of clotting factor VIII (8) and hemophilia B, which is due to a lack of clotting factor IX (9). Either type can lead to spontaneous bleeding into muscles, organs, and joints as well as prolonged bleeding following injuries or surgery.
Where is hemophilia most prevalent?
Hemophilia prevalence varies widely across the United States and is highest in Midwestern and Northeastern states. The estimated incidence of hemophilia among U.S. births is 1 birth per 5,617 male births for hemophilia A and 1 birth per 19,283 male births for hemophilia B. Among all males with hemophilia, just over 4 in 10 have the severe form ...
Do people with hemophilia use HTCs?
Future Directions. More work is needed to get a better estimate of how many people living with hemophilia do not utilize HTCs for their care. It would also be important to know whether the health of this group differs from the health of people with hemophilia who are cared for in the HTCs.
Which organ is most suitable for hemophilia?
The most suitable organ for this is the liver. “At present, all of the hemophilia gene therapy trials are using a virus called AAV (adeno-associated virus) to get the gene into the body,” Dr. Jonathan Ducore, director of the Hemophilia Treatment Center at the University of California Davis told Healthline.
What percentage of patients with hemophilia A have factor VIII deficiency?
This happens in up to 30 percent or more of patients with severe hemophilia A (factor VIII deficiency). These inhibitors require alternative but less effective treatments and lead to poorer outcomes for patients.”.
How old do you have to be to get gene therapy?
Researchers don’t yet know whether young people can be treated with gene therapy as current trials require all patients to be 18 years or older. “There are questions about administering these viruses to younger children with growing livers. We don’t know if the liver is the best organ to target for the gene therapy.
What is the cause of hemophilia?
Hemophilia is caused by a decrease in one of the blood clotting factors, either factor VIII or factor IX. The disorder can cause uncontrolled and spontaneous bleeding without an obvious injury. The level of bleeding risk is dependent on the level of clotting factor decrease.
How long does a woman's menstrual cycle last?
Girls and young women can experience heavy menstrual bleeding lasting more than seven days as well as hemorrhaging after childbirth. Radford received a diagnosis at 7 months old when a small contusion on her head turned into a large bump.
What is the disease that prevents blood from clotting?
I was in excruciating pain,” Radford told Healthline. in the United States living with hemophilia , a genetic bleeding disorder that prevents blood from clotting normally. For many with hemophilia, daily life consists of trying to avoid cuts and bruises.
When can infants start getting treatment?
Treatment for infants can begin at 1 year of age or earlier. Parents must learn how to administer treatments that can be as frequent as every second day. “This comes at a tremendous cost to patients, families, and health systems.
How long can a child live with hemophilia?
With careful management, many children with hemophilia can live relatively healthy lives with a normal lifespan.
How is hemophilia treated?
Your child's healthcare provider will refer you to a hematologist, an expert in blood disorders. Your child’s health care provider will figure out the best treatment based on:
What is hemophilia?
Hemophilia is an inherited bleeding disorder. Children with hemophilia can’t stop bleeding because they don’t have enough clotting factor in their blood. Clotting factors are needed for blood to clot. Blood clots to prevent excessive bleeding.
What are the symptoms of hemophilia?
The most common symptom of this disorder is heavy, uncontrollable bleeding.
How is hemophilia in children diagnosed?
he diagnosis of hemophilia is based on your family history, your child's medical history, and a physical exam. Blood tests include:
How many chromosomes does hemophilia have?
They are passed on from parents to children through a gene on the X chromosome. Females have two X chromosomes, while males have one X and one Y chromosome.
What is the cause of hemophilia B?
Hemophilia B. This is caused by a deficiency of factor IX. This is also called Christmas disease or factor IX deficiency.