hypogonadotropic hypogonadism treatment in females how long

Medication

Hypogonadotropic Hypogonadism. Definition. Hypogonadism is a condition in which the male testes or the female ovaries produce little or no sex hormones. Hypogonadotropic hypogonadism (HH) is a form of hypogonadism that is due to a problem with the pituitary gland or hypothalamus.

Therapy

Unless it is acquired from a treatable condition, in Hypogonadotropic Hypogonadism, the issues of the condition, such as hormone levels, restoring fertility, and others could be managed. If the treatment is stopped, the symptoms may resurface due to a decrease in hormones.

Nutrition

The diagnosis of Hypogonadotropic Hypogonadism includes hormone tests. This includes checking sex hormone levels, usually done through a blood test. In addition, to confirm these symptoms are not due to any other condition, a thyroid test may be carried out.

What does hypogonadotropic mean in medical terms?

Young women with HH are at risk for bone loss and fracture. Congenital hypogonadism may be particularly detrimental to the skeleton because it may lead to failure to achieve peak bone mass, in addition to loss of established bone mass.

Can hypogonadism be treated or is it treatable?

How is hypogonadotropic hypogonadism diagnosed?

What is the prognosis of congenital hypogonadism (HH)?

How long does it take to treat hypogonadism?

Response times can be as long as 1–2 years for the combination, and success is higher in men with testicular volumes >8 cc and later onset of hypogonadism 22.

How is female hypogonadotropic hypogonadism treated?

A female with hypogonadotropic hypogonadism is usually presented with two treatment options - combined gonadal hormone replacement or pulsatile gonadotropin releasing hormone. When a patient incurs a contraindication to hormonal therapy, the management of their endocrine disorder becomes much more challenging.

Can hypogonadotropic hypogonadism be cured?

Unless it's caused by a treatable condition, hypogonadism is a chronic condition that may require lifelong treatment. Your sex hormone level may decrease if you stop treatment. Seeking support through therapy or support groups can help you before, during, and after treatment.

How do you manage hypogonadotropic hypogonadism?

Male hypogonadotropic hypogonadism (MHH), a disorder associated with infertility, is treated with testosterone replacement therapy (TRT) and/or gonadotropins replacement therapy (GRT) (TRT and GRT, together with HRT hormone replacement therapy).

When does a woman need hormone replacement therapy?

Hormone replacement therapy is medication that contains female hormones. You take the medication to replace the estrogen that your body stops making during menopause. Hormone therapy is most often used to treat common menopausal symptoms, including hot flashes and vaginal discomfort.

What causes hypogonadotropic hypogonadism in females?

HH is caused by a lack of hormones that normally stimulate the ovaries or testes. These hormones include gonadotropin-releasing hormone (GnRH), follicle stimulating hormone (FSH) and luteinizing hormone (LH).

Does hypogonadism go away?

Unless it's caused by a treatable condition, hypogonadism is a chronic condition that may require lifelong treatment. Your sex hormone level may decrease if you stop treatment. Seeking support through therapy or support groups can help you before, during, and after treatment.

Can a woman have hypogonadism?

Hypogonadism in females describes the inadequate function of the ovaries, with impaired production of germ cells (eggs) and sex hormones (oestrogen and progesterone). Primary hypogonadism refers to a condition of the ovaries (primary ovarian insufficiency/hypergonadotropic hypogonadism).

Is it possible to reverse hypogonadism?

It is believed that lifelong hormone therapy is required to maintain sexual function and secondary sexual characteristics in men with idiopathic hypogonadotropic hypogonadism. However, rare cases of spontaneous reversal of this condition later in life have been reported.

Can you get pregnant with hypogonadism?

It's possible for women with hypogonadism to become pregnant, but it may be difficult without the proper treatment. Hypogonadism that occurs in adult females can often cause infertility. If it's untreated, these cases of hypogonadism may prevent a woman from being able to become pregnant.

How common is hypogonadotropic hypogonadism?

The incidence of congenital hypogonadotropic hypogonadism is approximately 1-10:100,000 live births, and approximately 2/3 and 1/3 of cases are caused by Kallmann syndrome (KS) and idiopathic hypogonadotropic hypogonadism, respectively.

Is hypogonadotropic hypogonadism a rare disease?

Congenital hypogonadotropic hypogonadism (CHH, ORPHA174590) is a rare, genetic, endocrine disorder which is clinically characterized by incomplete/absent puberty and infertility as a result of a deficiency of gonadotropin releasing hormone.

What is the term for a condition in which the male testes or the female ovaries produce little or

Hypogonadism is a condition in which the male testes or the female ovaries produce little or no sex hormones. Hypogonadotropic hypogonadism (HH) is a form of hypogonadism that is due to a problem with the pituitary gland or hypothalamus.

What tests are done to check for hormones?

Tests that may be done include: Blood tests to measure hormone levels such as FSH, LH, and TSH, prolactin, testosterone and estradiol. LH response to GnRH. MRI of the pituitary gland/hypothalamus (to look for a tumor or other growth) Genetic testing. Blood tests to check for iron level.

What are the symptoms of puberty?

Symptoms. Children: Lack of development at puber ty (development may be very late or incomplete) In girls, a lack of breast development and menstrual periods. In boys, no development of sex characteristics, such as enlargement of the testes and penis, deepening of the voice, and facial hair.

Does hormone therapy help with puberty?

Outlook (Prognosis) The right hormone treatment will cause puberty to start in children and may restore fertility in adults. If the condition begins after puberty or in adulthood, symptoms will often improve with treatment.

What is hypogonadism in females?

Hypogonadism in females is due to disruption of any section of the hypothalamic –pituitary–ovarian axis pathway (figure 1). In a correctly functioning hypothalamic–pituitary–ovarian axis pathway: The hypothalamus produces gonadotrophin-releasing hormone (GnRH) at the onset of puberty.

What causes secondary hypogonadism?

Causes of acquired secondary hypogonadism can include: Intracranial space-occupying lesions (eg, tumours and cysts) Infiltrative disease (eg, sarcoidosis and haemochromatosis)

What is the cause of genitourinary discomfort?

Loss of elasticity, thickness, and moisture of vulval skin, resulting in genitourinary discomfort. Skin changes may also reflect the underlying cause of hypogonadism; for example, hyperpigmentation may be a sign of an autoimmune disease.

What are the symptoms of hypogonadism?

As mentioned earlier, it is caused by the lack of hormones responsible for sexual development in women. Here are some of the symptoms of HH: Insignificant breast growth. Lack of menses.

Does hypogonadism affect fertility?

Hypogonadotropic Hypogonadism has adverse effects on the daily functioning of women. Unless it is acquired from a treatable condition, in Hypogonadotropic Hypogonadism, the issues of the condition, such as hormone levels, restoring fertility, and others could be managed. If the treatment is stopped, the symptoms may resurface due ...

How is hypogonadism treated?

Hypogonadism is usually treated with hormone replacement therapy ( HRT). However, your course of treatment may differ depending on the exact cause of your condition. The symptoms of hypogonadism often improve significantly with the proper treatment.

What are the complications of hypogonadism in untreated adult males?

The complications of hypogonadism in untreated adult males include: infertility. erectile dysfunction. osteoporosis. decreased muscle mass and body hair. a low sex drive.

What hormones are needed to replace the hormones that the body no longer produces?

This treatment consists of taking medications containing the hormone that your body is lacking, such as testosterone, estrogen and progesterone, or pituitary hormones to replace the ones that the body no longer produces.

How to get testosterone out of your body?

Gel. You can rub a clear gel containing testosterone onto the skin of your shoulder, upper arm, or lower abdom en. After applying the gel, you must avoid bathing for several hours so your skin has time to absorb the testosterone properly.

What is secondary hypogonadism?

Secondary hypogonadism, also known as hypogonadotropic hypogonadism, is caused by a problem with the pituitary gland or hypothalamus. The hypothalamus and pituitary gland are located in the brain and help regulate various body functions, including the production of sex hormones.

How does testosterone help with sexual drive?

This treatment can: improve sexual drive and function . increase muscle strength. decrease bone loss. raise energy levels and feelings of well-being. In young boys and adolescent males, low doses of testosterone over time can be used to replace naturally occurring testosterone during puberty.

Does testosterone increase liver function?

When used for an extended period, oral testosterone can increase your risk of liver problems , heart disease, and high cholesterol. Your doctor will monitor your blood counts and hormone levels during treatment, and they can make adjustments if necessary. This will help reduce the risks associated with HRT.

What are the clinical characteristics of hypogonadism?

The clinical characteristics of hypogonadotropic hypogonadism are androgen deficiency and a lack/delay/stop of pubertal sexual maturation. Low blood testosterone levels and low pituitary hormone levels confirm the hypogonadotropic hypogonadism diagnosis. A prolonged stimulated intravenous GnRH test can be useful.

What is a male hypogonadism?

Male hypogonadism is characterized by impaired testicular function, which can affect spermatogenesis and/or testosterone synthesis. Although it is a common endocrine disorder, the exact prevalence of this disease is unknown. Male hypogonadism can result from a primary testicular disorder or occur secondary to hypothalamic-pituitary dysfunction. ...

What is the most common form of hypogonadism in men?

Male hypogonadism can result from a primary testicular disorder or occur secondary to hypothalamic-pituitary dysfunction. Hypergonadotropic hypogonadism is also known as primary hypogonadism and is the most frequent form of hypogonadism found in adult men.

How many births are caused by hypogonadism?

The incidence of congenital hypogonadotropic hypogonadism is approximately 1-10:100,000 live births, and approximately 2/3 and 1/3 of cases are caused by Kallmann syndrome (KS) and idiopathic hypogonadotropic hypogonadism, respectively.

What is the most common congenital manifestation of hypogonadism?

Primary hypogonadism is characterized by low testosterone production and elevated levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (3). Klinefelter's syndrome is the most common congenital manifestation of primary hypogonadism and affects approximately one in every 500 men.

How many years of age do men have hypergonadism?

The acquired forms of hypergonadotropic hypogonadism include male aging, which affects approximately 4.1% of men between the ages of 40-49 years and 9.3% of men between the ages of 60-70 years, and exposure to gonadotoxic agents such as those used in chemotherapy and radiotherapy treatments.

Is hypogonadism a congenital disorder?

Impaired testicular function, i.e., hypogonadism, can result from a primary testicular disorder (hypergonadotropic) or occur secondary to hypothalamic-pituitary dysfunction (hypogonadotropic). Hypogonadotropic hypogonadism can be congenital or acquired. Congenital hypogonadotropic hypogonadism is divided into anosmic hypogonadotropic hypogonadism ...

What is hypogonadism in women?

Hypogonadotropic hypogonadism (HH) or secondary hypogonadism is defined as a clinical syndrome that results from gonadal failure due to abnormal pituitary gonadotropin levels. HH may result from either absent or inadequate hypothalamic GnRH secretion or failure of pituitary gonadotropin secretion. Several congenital and acquired causes, including functional and organic forms, have been associated with this condition. One important aspect of the HH diagnosis is that it may reflect the presence of a tumor of the hypothalamic pituitary region or even a systemic disease. On the other hand, functional forms of HH, characterized by a transient defect in GnRH secretion, are relatively common in women, in response to significant weight loss, exercise, or stress leading to hypothalamic amenorrhea. HH is typically characterized by low circulating sexual steroids associated with low or inappropriately normal gonadotropin levels. The precise and early diagnosis of HH can prevent negative physical and psychological sequelae, preserve normal peak bone mass, and restore the fertility in affected patients.

How long does it take for testosterone to reach normal levels?

Testosterone levels usually achieve normal range values by 6 months of continuous treatment in most patients, and spermatogenesis is attained in up to 80% of the cases. Another option for patients with partial pubertal development is to start with hCG alone for 6 months and subsequently add FSH if azoospermia persists.

Is IHH normal growth?

Patients with constitutional delay of puberty typically have delayed growth before puberty and delayed bone age, compatible with the height. In contrast, patients with congenital IHH have normal linear growth during childhood, and despite the absence of the pubertal growth spurt, short stature is not a common finding.

Definition

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Symptoms

Exams and Tests

Treatment

Outlook

Possible Complications

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