What are the guidelines for chemotherapy dosage adjustment?
GuideLines for Chemotherapy Dosage Adjustment Adjust if Function Impaired Adjust if Function Impaired Hepatic Renal Alemtuzumab No No Arsenic trioxide Yes Yes Asparaginase (E coli) +/- +/- 73 more rows ...
What is the dosage regimen?
The dosage regimen is the modality of drug administration that is chosen to reach the therapeutic objective. This depends on the drug used, the condition to be treated, and the patient’s characteristics. The decisions defining dosage regimen are about:
Should we use fixed dose guidelines for cancer treatment?
Consideration should be given to using fixed dose guidelines independent of body surface area and based on drug elimination capability, both as a starting dose and for dose adjustment, which may have accuracy, safety and financial advantages. British Journal of Cancer(2002) 86, 1297–1302.
How long should a treatment regimen be in duration?
When a treatment regimen is 21 days in duration, the regimen will be repeated on the twenty-second, forty-third, sixty-fourth…, etc. days following treatment initiation. Administration duration should be clearly indicated. If a drug is to be administered on more than one day per cycle, each cycle day should be explicitly identified.
How long can a drug be administered?
An exception to this rule applies to drug products with extended stability, where a drug is administered from a single container for greater than 24 hours. In such cases, treatment plans and prescribers’ orders should specify the amount of drug that is administered during each 24-hour interval.
What is a contiguous treatment day?
Contiguous treatment days — Treatment plans should specify the total number of days a drug is administered and the cycle day that treatment commences. Include parenthetically the cycle days on which treatment occurs. Non-contiguous days — Treatment plans should specify the cycle days on which each dose should be given.
What is a CTEP protocol?
All protocols sponsored by the Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute (NCI), are reviewed for safety and scientific integrity. Cancer Therapy Evaluation Program (CTEP) staff have developed standardized guidelines to express chemotherapy regimens in a uniform, clear and consistent manner. The intention of the guidelines is to minimize undue risks to patients on DCTD sponsored investigational clinical trials. DCTD-sponsored protocols will not be approved unless they comply with the Guidelines for Treatment Regimen Expression and Nomenclature. CTEP will screen all protocol related documents to assure compliance with the treatment regimen guidelines. These guidelines should be used in all facets of protocol development including Letters of Intent (LOIs), Concept Reviews, protocols, protocol amendments, protocol related publications and any other protocol related correspondence.
How long is a drug stable?
Drug products stable for ≥ 24 hours — (Containers are prepared for multiple days): Express the dose as the amount of drug administered per day and indicate the number of days for which it is administered. Include the total dose (as a function of BSA, weight, etc., when appropriate) in parentheses.
How often should drug containers be changed?
Drug containers should be changed at least daily unless extended stability and sterility data are available. In protocol descriptions and orders for treatment, ...
Should details be omitted in a protocol?
No detail (no matter how minor) should be omitted ; however, avoid unnecessary redundancy. Delete extraneous information that may confuse readers ( e.g., protocols that use only injectable drugs products should not include information for a tablet formulation).
What is the usual dosage regimen?
For most drugs, a usual dosage regimen is proposed by the manufacturer and approved by registration authorities. This regimen should suit the average patients needs. As a principle, individualization of the dosing regimen should be considered systematically, leading in selected cases to apply unusual dosing decisions in order to tailor the treatment to a patient condition. For example, the standard regimen must be adapted to the patient's characteristics (e.g. weight and age) and to the presence of comorbidity that affects the drug's pharmacokinetics (e.g. renal failure, liver disease).
What is the objective of drug therapy?
The objective of drug therapy is to bring plasma concentration within the therapeutic window. The dosage regimen is the modality of drug administration that is chosen to reach the therapeutic objective. This depends on the drug used, the condition to be treated, and the patient’s characteristics. The decisions defining dosage regimen are about:
When we write dosage orders for drugs in the apothecary system, do we have to follow a certain
When we write dosage orders for drugs in the apothecary system, we have to follow a certain set of rules that were traditionally used with apothecary abbreviations so that we minimize the chances that they could be confused with metric measurements. These rules are:
Why do we need to know how to write prescriptions?
In order to write and read drug orders or prescriptions, we need to know how they should be written. Because it is so important to minimize the chance that someone might misread a drug order, there are specific units of measure, abbreviations, and rules for writing orders that must be used . In this section, we will learn what these rules are ...
What is the traditional system of measurement used in the medical profession in the West?
The traditional system of measurement used in the medical profession in the West has been the apothecary system, which has its roots in Latin. It is no longer commonly used because it contains script symbols that can be hard to read and because its units are much older and therefore more irregular, requiring more work to convert from one unit to another.
What does GTT stand for in drams?
The abbreviation gtt for drops seems strange because it does not share any of the same letters (this is because it comes from Latin), so be careful, and don't confuse the abbreviation gtt for drops with dr for drams!
What unit is used to measure the strength of a drug?
Most drug dosages are measured by weight in grams, milligrams or micrograms; however certain special drugs have other metric units that measure properties other than weight: International Units ( units ): International Units, often just referred to as Units, are used to measure the power or action of a drug.
When writing a decimal, should you always put a leading zero?
For example, to write one and one half milliliters, we should write 1.5 mL, not 1 1/2 mL. When writing decimals that are smaller than 1 , we should always put a leading zero before the decimal point.
How many units are in 1 ml of penicillin?
If one kind of penicillin is mixed so that 1 mL contains 200,000 U and another kind of penicillin is mixed so that 1 mL contains 1,000,000 Units, the second drug has five times more bacteria-fighting power than the first drug, even though one mL of each has the same volume.
How long does pyrazinamide last?
pyrazinamide (PZA) TB Regimens for Drug-Susceptible TB. Regimens for treating TB disease have an intensive phase of 2 months, followed by a continuation phase of either 4 or 7 months (total of 6 to 9 months for treatment). Drug Susceptible TB Disease Treatment Regimens. Regimens for treating TB disease have an intensive phase of 2 months, ...
How long does it take to treat TB?
TB disease can be treated by taking several drugs for 6 to 9 months. There are 10 drugs currently approved by the U.S. Food and Drug Administration (FDA) for treating TB. Of the approved drugs, the first-line anti-TB agents that form the core of treatment regimens are: isoniazid (INH) rifampin (RIF)
Can TB be treated?
It is very important that people who have TB disease are treated, finish the medicine, and take the drugs exactly as prescribed. If they stop taking the drugs too soon, they can become sick again; if they do not take the drugs correctly, the TB bacteria that are still alive may become resistant to those drugs.
How long does Valtrex last after hemodialysis?
Patients requiring hemodialysis should receive the recommended dose of VALTREX after hemodialysis. During hemodialysis, the half-life of acyclovir after administration of VALTREX is approximately 4 hours.
How long does Valtrex last?
The recommended dosage of VALTREX for treatment of herpes zoster is 1 gram 3 times daily for 7 days. Therapy should be initiated at the earliest sign or symptom of herpes zoster and is most effective when started within 48 hours of the onset of rash.
Can Valtrex be given without meals?
VALTREX may be given without regard to meals. Valacyclovir oral suspension (25 mg/mL or 50 mg/mL) may be prepared extemporaneously from 500-mg VALTREX tablets for use in pediatric patients for whom a solid dosage form is not appropriate [see Dosage and Administration ( 2.3 )].
Expression and Nomenclature
Introduction
Policy
General Guidelines
- The dosage regimen is the frequency at which the drug doses are given to maintain a steady-state serum concentration. Dosage Regimen means dose of drug and dosing interval. Simply, the schedule of doses of a therapeutic agent per unit of time . Dosage regimen is meant the systematized dosage schedule . In other words, the specific way a therapeutic...
Parenteral Administration
Oral Administration
Concomitant (Ancillary) Medications
Treatment Modifications