What is the difference between first line and second line treatment?
Second-Line Treatment In contrast to first-line treatment, second-line treatment is usually a treatment which is chosen after first-line treatment has failed to achieve the goal (either it doesn't work or all, or it works for a period of time and then stops working), or has side effects requiring you to stop using that treatment.
What are second line medicines?
These are your medicines that are less commonly prescribed for a particular disease. But, they are available as options when first-line treatments alone are not working. What classifies a medicine as the second line? Again, I’m going to speculate using experience guided by common sense. This is just a guess.
What is first-line treatment?
First-line treatment or therapy simply refers to the initial, or first treatment recommended for a disease or illness. This may also be referred to as primary treatment, initial treatment, or induction therapy.
What is the second line of treatment for cancer?
Overview of Second-Line Treatment for Cancer. Second-line treatment is treatment for a disease or condition after the initial treatment ( first-line treatment) has failed. Second-line treatment may be used for a few different reasons: The first-line treatment doesn't work The first-line treatment worked but has since stopped working.
What is first line and second line treatment?
Second-line treatment is treatment for a disease or condition after the initial treatment (first-line treatment) has failed, stopped working, or has side effects that aren't tolerated. It's important to understand "lines of treatment" and how they differ from first line treatment and can play a role in clinical trials.
What is first line and second line?
At the core of any IT service desk is first line and second line. These are the levels that cover most issues raised by your user community, with the highest ticket volumes for IT related problems.
What is 1st line treatment?
THAYR-uh-pee) The first treatment given for a disease. It is often part of a standard set of treatments, such as surgery followed by chemotherapy and radiation. When used by itself, first-line therapy is the one accepted as the best treatment.
What is first second and third line of treatment?
Treatment that is given when both initial treatment (first-line therapy) and subsequent treatment (second-line therapy) don't work, or stop working.
What is 2L treatment?
2L was defined as treatment after progression/recurrence after 1L treat- ment, or recurrence with ≤ 12 months of neoadjuvant/adjuvant treatment. Analyses were conducted using descriptive statistics.
What is a second line medication?
Any therapeutic agent that is not the drug of choice, or the 1st normally used to treat a particular condition; in rheumatoid arthritis, 2nd-line agents are used when standard 'first-line' therapy–ie, anti-inflammatory agents and corticosteroids fail.
What are the lines of treatment?
“Lines of therapy” is the term used to describe the order in which different therapies are given to people as their disease progresses.
What is the first-line?
Definition of first-line : being the preferred, standard, or first choice first-line treatment of tuberculosis — compare second-line.
What is a first-line antibiotic?
Amoxicillin and penicillin V remain first-line therapy due to their reliable antibiotic activity against GAS. For penicillin-allergic patients, cephalexin, cefadroxil, clindamycin, or macrolides are recommended. GAS antibiotic resistance to azithromycin and clindamycin are increasingly common.
What is second-line antibiotics?
Antibiotics were classified as “first-line” (amoxicillin, TMP-SMX, or erythromycin) or “second-line” (clarithromycin, azithromycin, amoxicillin-clavulanate, cephalosporin, or fluoroquinolone).
What is a third line drug?
Third line therapy is usually defined as a regimen for an individual who has developed resistance to at least one drug in all three classes of anti-HIV therapies [nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors] or has failed ...
What are the two methods of treatment?
Types of Treatment MethodsTargeted Therapies: A targeted therapy is designed to treat only the cancer cells and minimize damage to normal, healthy cells. ... Chemotherapy: ... Surgery: ... Radiation Therapies: ... Biological Therapy: ... Hormonal Therapy:
How to indent a line in Word?
Setting an Indent style 1 Select the text where you want to add a hanging indent. 2 Go to Home > Paragraph dialog launcher > Indents and Spacing. 3 Under Special, select one of the following indent styles:#N#Hanging#N#First Line#N#None#N#On Hanging and First Line indents, you can adjust the depth of the indent with the By field. 4 Select OK.
How many paragraph indent styles are there?
Less. There are essentially two paragraph indent styles, Hanging and First Line indents. The indent styles are applied to a paragraph where sentences are typed to the end without pressing the Enter key. When you press the Enter key, it starts a new paragraph, and the indent style over again. If you need to start another line within ...
What is first line treatment?
First-line treatment or therapy simply refers to the initial, or first treatment recommended for a disease or illness. This may also be referred to as primary treatment, initial treatment, or induction therapy. With many conditions, including cancer, there are many possible treatments that could be effective.
What is the difference between first line and second line?
In contrast, second-line treatments are used when the first-line treatment failed to improve a cancer, or if it worked for a while and then the cancer progressed, and tend to be less effective.
What is alternative treatment?
In this setting, therapies such as acupuncture, meditation, massage, and yoga are used in an integrative fashion—that is, they are used along with traditional treatments such as chemotherapy. These complementary treatments may help some people cope with the side effects of cancer and cancer treatments.
What is the first line of treatment for lung cancer?
First-line treatment is usually the standard treatment (the "gold standard") given when someone is diagnosed with a particular disease or condition , such as lung cancer. In other words, it is likely the treatment most oncologists would first choose in treating someone. That said, there are no general "rules" stating which treatment has to absolutely come first, and in addition to that, it's important to work with your oncologist to choose the treatment that is best for you as an individual. Only you can be your own advocate and select the treatments which offer you the best outcome while minimizing the side effects you are willing to tolerate.
Is neoadjuvant therapy considered a first line treatment?
Neoadjuvant therapy, chemotherapy given before surgery to reduce the size of a tumor, or adjuvant therapy, given after surgery to reduce the risk of recurrence, are considered components of first-line therapy in this setting. First-Line vs. Second-Line Treatment. In contrast to first-line treatment, second-line treatment is usually ...
Who is Lynne Eldrige?
Lynne Eldrige, MD, is a lung cancer physician, patient advocate, and award-winning author of "Avoiding Cancer One Day at a Time.". Douglas A. Nelson, MD, is a board-certified oncologist and hematologist who previously served for 13 years as a physician in the US Air Force. First-line treatment or therapy simply refers to the initial, ...
Is second line treatment the same as first line?
In contrast to first-line treatment, second-line treatment is usually a treatment which is chosen after first-line treatment has failed to achieve the goal (either it doesn't work or all, or it works for a period of time and then stops working), or has side effects requiring you to stop using that treatment. Second-line treatments are often inferior to first-line treatments but not always. For example, with metastatic breast cancer, second-line therapy tends not to control the cancer for as long a period of time as first-line therapy. In some cases, there are two treatments (or more) that may offer very similar results (and have similar side effects), and second-line treatment may be equally effective to first-line therapy.
What is second line treatment?
Second-line treatment is treatment for a disease or condition after the initial treatment ( first-line treatment) has failed, stopped working, or has side effects that aren't tolerated. It's important to understand "lines of treatment" and how they differ from first line treatment and can play a role in clinical trials.
Why do we use second line therapy?
Second-line or further lines of therapy (third-line, fourth-line, seventh-line, etc.) may be used for a few different reasons: The first-line treatment worked but has since stopped working. The first-line treatment has side effects that are not tolerated.
What is the importance of defining lines of treatment?
An example of the importance of defining lines of treatment is a 2019 study that compared different second-line treatments for lung cancer. Since there are a number of different options, and many studies look at the effectiveness of first line therapies, this can give important information to oncologists.
Why is understanding the line of treatment important?
Understanding line of treatment becomes very important when looking at clinical trials for cancer. Some clinical trials require that people have no previous treatments, whereas others are designed for people who have had inadequate results with a previous treatment.
Is first line treatment more effective than present treatment?
The first-line treatment has side effects that are not tolerated. A new treatment becomes available that appears to be more effective than the present treatment. With survival rates improving for many cancers, and the number of available treatments increase, some people receive many lines of therapy.
Is second line therapy better than first line?
In some cases a person will have a better response to a second line therapy than they did to first line treatment. Second-line treatments are available for most cancers, but the likelihood of effective options can vary with the type and stage of your cancer.
Is breast cancer a first line treatment?
First line treatment can include more than one treatment method. For example, if a woman has surgery followed by chemotherapy and radiation for breast cancer, the combination of therapies is still considered first line therapy.
Rewriting Your First Lines
It sounds contrary to what I just said, but try not to worry about the first lines in your first draft.
See Some Plays
The best rule I ever heard for how much backstory or information to give the reader is to share whatever the reader needs to understand at that very moment.
First Line Looks Matter
The appearance of your first page and first lines affects how likely a reader is to keep reading.
Convey Your Genre
Finally, your first lines also should hint at or clearly signal your genre.
What is the first line of Pride and Prejudice?
And here is Jane Austen exhibiting her slyly satirical wit in the first line of Pride and Prejudice: It is a truth universally acknowledged, that a single man in possession of a good fortune must be in want of a wife. Of course he must.
Who wrote the opening line of The Little Prince?
Here’s the opening line from The Little Prince by Antoine de Saint-Exupéry: Once when I was six years old I saw a magnificent picture in a book, called True Stories from Nature, about the primeval forest. It was a picture of a boa constrictor in the act of swallowing an animal. Here is a copy of the drawing.
Why is it so hard to write a script without a logline?
This is because a screenplay logline contains the foundational DNA the whole movie is built on: its struggle between all the major characters and essence of what’s at stake.
What is a logline in a movie?
Here’s a quick logline definition: A logline is simply the script’s core conflict summed up in one or two sentences. By “core conflict” we mean the struggle between protagonist and antagonist that indicates to the reader what’s at stake—the reason why they should watch this movie.
What Makes A Drug Second-Line?
- These are your medicines that are less commonly prescribed for a particular disease. But, they are available as options when first-line treatments alone are not working.
What Causes A Drug to Change First-Line Or Second-Line Status?
- Or what causes first-line medicines to become the second-line? What causes second-line drugs to become first-line? Once again, I’m going to make an educated guess here. 1. Studies show it’s not as beneficial as once thought. Muscarinicsare a good example here. Atrovent was once-upon-a-time considered a first-line asthma medicine. It fit all the qualifications of one. But, subsequent …
What to Make of this?
- So, these are just some examples of what makes a drug first-line or second-line? There may be other reasons overlooked here. Still, this should give you a pretty good idea of why that Advair inhaler is first-line and why Singular is second-line.
Understanding First-Line Treatment
Questions to Ask
- When you and your healthcare provider consider a first-line treatment or first-line treatments, think through these questions. 1. Clarify the type and stage and molecular profile of your tumor. Is there any further testing that should be done? (If you've been diagnosed with advanced cancer, ask about the molecular profile of your tumor, and if this hasn't been done, ask why not). 2. What is y…
Alternative and Complementary Treatments
- It's important when talking about treatment to clarify what is meant by "alternative treatments." Most people now use the phrase alternative treatments to refer to complementary treatments that are offered by some cancer centers. In this setting, therapies such as acupuncture, meditation, massage, and yoga are used in an integrative fashion—that is, they are used along with tradition…
Lines of Treatment
Significance
- Since discussing second-line treatment usually means that first-line treatment failed, you are likely feeling a whole host of cancer emotions, similar to when you were first diagnosed. Some people say that it feels like starting all over—but with less energy this time. Usually, first-line treatments are chosen because they have the greatest benefit and/or the fewest side effects. Yet all people …
The Option of Clinical Trials
- Understanding line of treatment becomes very important when looking at clinical trialsfor cancer. Some clinical trials require that people have no previous treatments, whereas others are designed for people who have had inadequate results with a previous treatment. For example, one clinical trial may require the treatment to be used as a first line therapy, whereas another may only be en…
Questions to Ask About Second-Line Treatments
- Since the failure of a first treatment can leave you feeling overwhelmed and anxious, having a list of questions to ask your healthcare provider (as well as a friend to attend the visit with you) can be very helpful. 1. How effective is the second-line treatment, and how does it compare to the treatment you had previously? 2. What are the possible ...
Example
- An example of the importance of defining lines of treatment is a 2019 study that compared different second-line treatments for lung cancer. Since there are a number of different options, and many studies look at the effectiveness of first line therapies, this can give important information to oncologists. For example, the second line chemotherapy drug Taxotere (docetax…
Coping
- Thinking about and making decisions about second-line treatment can be heartwrenching. It's hard enough the first time around, but at this point many people are exhausted and it's easy to get discouraged. Reach out to people in your support network, and don't be afraid to share your fears. Certainly, not every friend will be comfortable with this, but choose at least a friend or two with …