To apply Zirgan: Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper as you squeeze out a drop into this pocket, the close your eyes for 1 or 2 minutes. Use only the number of drops your doctor has prescribed.
How is Zirgan used to treat keratitis?
How to Use Zirgan. Zirgan is for topical ophthalmic use only. The recommended dosing for Zirgan is one drop five times per day until the corneal ulcer heals (usually about 7-8 days), and then one drop three times per day for seven days. In addition to Zirgan applied to the eye, the patient is often treated with high doses of oral Valtrex or acyclovir.
How do you use Zirgan gel for corneal ulcers?
One drop in the affected eye 5 times per day (approximately every 3 hours while awake) until the corneal ulcer heals. Followed by 1 drop 3 times per day for 7 days. ZIRGAN is supplied as 5 grams of a topical ophthalmic gel containing 0.15% of ganciclovir in a polycoated aluminum tube 1. NDC number: 24208-535-35.
How do I use Zirgan?
Sep 03, 2019 · ZIRGAN (ganciclovir ophthalmic gel) 0.15% is indicated for the treatment of acute herpetic keratitis (dendritic ulcers). 2 DOSAGE AND ADMINISTRATION The recommended dosing regimen for ZIRGAN is 1 drop in the affected eye 5 times per day (approximately every 3 hours while awake) until the corneal ulcer heals, and then 1 drop 3 times per day for 7 days.
How long can you use Zirgan gel?
DOSING. ZIRGAN is applied 5 times per day until your eye ulcer heals; then the gel is applied 3 times per day for 7 days. Follow your doctor's instructions. STORAGE. Store ZIRGAN at room temperature (15°C-25°C or 59°F-77°F). Do not freeze. CONTACT YOUR DOCTOR. If pain develops, or if redness, itching, or swelling becomes worse, contact your doctor.
How do I apply ZIRGAN to my eye?
To apply Zirgan:Tilt your head back slightly and pull down your lower eyelid to create a small pocket. ... Use only the number of drops your doctor has prescribed.Gently press your finger to the inside corner of the eye (near your nose) for about 1 minute to keep the liquid from draining into your tear duct.Aug 5, 2021
How long does it take for ZIRGAN to work?
How quickly does Zirgan (ganciclovir) work? Most people with herpes infection of the eye usually have to take Zirgan (ganciclovir) for about 7 days for the ulcers to heal. Make sure to go to your follow-up appointments to make sure that your infection is going away properly.
What does ZIRGAN do for the eye?
INDICATION. ZIRGAN is used to treat eye ulcers caused by a herpes virus.
Does ZIRGAN need to be refrigerated?
In addition, Zirgan doesn't require refrigeration, and it has a shelf life of 18 months. Eyecare practitioners in Europe have been prescribing the drug, known overseas as Virgan, for the successful treatment of herpetic viral infections for more than a decade.Jul 1, 2010
Can keratitis heal on its own?
If your keratitis is caused by an injury, it usually clears up on its own as your eye heals. You may get an antibiotic ointment to help with symptoms and prevent infection. Infections are treated with prescription eye drops and sometimes antibiotics or antiviral medicine.
Is keratitis serious?
With prompt attention, mild to moderate cases of keratitis can usually be effectively treated without loss of vision. If left untreated, or if an infection is severe, keratitis can lead to serious complications that may permanently damage your vision.Aug 28, 2020
Does ZIRGAN cause blurry vision?
SIDE EFFECTS: Temporary blurred vision after you apply this medication and mild eye irritation/redness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Can acyclovir treat eye infections?
Ophthalmic acyclovir is used to treat an infection of the eye caused by herpes simplex virus. Acyclovir is in a class of antiviral medications called synthetic nucleoside analogues. It works by stopping the spread of the herpes virus in the eye.Jun 15, 2019
Is ZIRGAN a drop?
The recommended dosing regimen for ZIRGAN is 1 drop in the affected eye 5 times per day (approximately every 3 hours while awake) until the corneal ulcer heals, and then 1 drop 3 times per day for 7 days.
How long should I take Zylet?
Use eye drops before eye ointments to allow the eye drops to enter the eye. Do not use this medication more often than prescribed or for longer than 2 weeks unless directed by your doctor.
Is bepreve used for pink eye?
Dosing information Use: For the treatment of itching associated with allergic conjunctivitis. Use: For the treatment of itching associated with allergic conjunctivitis.Mar 24, 2022
How is dendritic ulcer treated?
The current treatment is with an antiviral medication called Ganciclovir. This is given as an eye ointment 5 times a day for 7-10 days. Depending on your ulcer, different treatment durations and occasionally different medications will be needed. Antiviral tablets might also be given in some cases.Sep 17, 2019
Does ganciclovir affect fertility?
Ganciclovir caused decreased fertility in male mice and hypospermatogenesis in mice and dogs following daily oral or intravenous administration of doses ranging from 0.2 to 10 mg/kg (30x to 1,600x the human ocular dose). Close.
Is ganciclovir teratogenic?
Teratogenic Effects. Ganciclovir has been shown to be embryotoxic in rabbits and mice following intravenous administration and teratogenic in rabbits.
Can you wear contact lenses with herpetic keratitis?
Patients should not wear contact lenses if they have signs or symptoms of herpetic keratitis or during the course of therapy with ZIRGAN. Most common adverse reactions reported in patients were blurred vision (60%), eye irritation (20%), punctate keratitis (5%), and conjunctival hyperemia (5%).
DOSING
ZIRGAN is applied 5 times per day until your eye ulcer heals; then the gel is applied 3 times#N#per day for 7 days. Follow your doctor's instructions.
STORAGE
Store ZIRGAN at room temperature (15°C-25°C or 59°F-77°F). Do not freeze.
CONTACT YOUR DOCTOR
If pain develops, or if redness, itching, or swelling becomes worse, contact your doctor.
What are the side effects of Zirgan?
Zirgan side effects. Get emergency medical help if you have any of these signs of an allergic reaction to Zirgan: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as: eye pain, swelling, redness, or watering;
What is Zirgan used for?
It slows the growth and spread of the cytomegalovirus (CMV). Zirgan ophthalmic gel is used to treat eye ulcers caused by the herpes simplex virus. Zirgan is not a cure for CMV or herpes.
How to make a pocket in your eye?
Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper as you squeeze out a drop, then close your eye. Use only the number of drops your doctor has prescribed.
What does it mean when your eyes are itchy?
eye pain, swelling, redness, or watering; severe burning or itching of your eyes; vision changes, increased sensitivity to light; tunnel vision, problems with peripheral (side) vision; seeing flashes of light, halos around lights, or "floaters" in your vision; white patches on your eyes;
How to sterilize contact lenses?
Sterilize contact lenses according to the manufacturer's directions, and check with your doctor before you begin using them again. Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop into the pouch.
How to get a syringe out of your eye?
Hold the dropper directly over your eye and place one drop into the pouch. Look downward, gently close your eyes, and place one finger at the corner of your eye (near the nose). Apply gentle pressure for 1 to 2 minutes before opening your eyes. This will prevent the medication from draining out.
What to do if you miss a dose of a sulfate?
Consult your doctor for more details. Missed Dose. If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose.
Where to report side effects?
You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Precautions.
How to apply eye drops?
To apply eye medication, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface. Do not wear contact lenses while you have an eye infection or while using this medication.
Does ganciclovir cure herpes?
Ganciclovir is used to treat herpes infection of the eye. Although ganciclovir stops the growth of the virus, it is not a cure for the herpes infection. Herpes virus continues to live in the body even between outbreaks of infection.
Is First Databank copyrighted?
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
What causes corneal opacity?
Herpes simplex virus (HSV) infection of the eye is a major cause of corneal opacity in the US 1 and other developed countries. 2 Infection with either HSV-1 or HSV-2 is common. Data from the US National Health and Nutrition Examination Survey (NHANES) suggest an overall 58% seroprevalence rate for HSV-1—the predominant cause of herpes simplex keratitis 2 (HSK)—with rates in individual ethnic groups as high as 89%. 3 A three-month prospective epidemiological study conducted in France put the incidence of HSK at 31.5 cases per 100,000 per person-year. 4 Of these, 13.2 cases represented primary infections and 18.3 were recurrences. HSV infection is lifelong and recurrent, with the virus becoming latent in sensory nerves after the original outbreak. Estimates in the US indicate approximately 20,000 new cases of HSK each year with another 28,000 cases of recurrent disease. 5 The only currently available topical treatment for HSK in the US is trifluridine (TFT), a drug whose toxic effects highlight the need for more effective and less harmful treatments. This article will summarize HSV ocular infection and review current treatments approved both in the US and worldwide. It will also focus on efficacy and safety findings for ganciclovir 0.15% gel, an antiviral ophthalmic preparation available outside the US to treat HSK that is a promising new drug for the US market.
Is trifluridine a drug?
Trifluridine#N #Currently, TFT is the only drug marketed in the US for superficial herpetic keratitis. It is a thymidine analog activated by cell and viral thymidine kinase (TK) that is incorporated into both virus and host DNA. Although efficacious against superficial keratitis, 9 TFT affects healthy and infected cells alike. This lack of selectivity contributes to its epithelial toxicity, leading to superficial punctate keratitis (SPK) or filamentous keratitis, blepharitis, and cannicular punctal occlusion. In fact, prolonged TFT use (>21 days) is discouraged because it can lead to corneal epithelial dysplasia (considered a pre-cancerous condition), 10 conjunctival scarring, 11 and, potentially, anterior ocular ischemia. 12 Contact dermatitis has been reported in up to 10% of patients who use TFT. 13 Formulated as a 1% eye drop, TFT must be instilled nine times daily because of its short duration of action. Furthermore, penetration of the intact cornea is poor, 14 suggesting that treatment of deeper stromal herpetic disease may not be possible with TFT.
