
- Take a blood test. If you might have syphilis, your doctor will order a blood test. ...
- Determine stage. Your doctor will determine the stage of infection by reviewing information from your exam and asking you questions.
- Treat and cure. To cure syphilis, you need to receive the right antibiotic. ...
- Follow-up with your doctor. While treatment can cure you, follow-up appointments are necessary. Some people need more than one shot of penicillin.
- Partner notification. You should tell your partner (s) that you were diagnosed with syphilis. This is important so that they can be tested and, if necessary, treated.
- Prevent repeat infections. When you start having sex again, use latex condoms and/or dental dams to prevent getting syphilis again or other sexually transmitted diseases.
How long does it take before you can treat syphilis?
In adults and adolescents with late syphilis or unknown stage of syphilis, the WHO STI guideline suggests benzathine penicillin G 2.4 million units intramuscularly once weekly for three consecutive weeks over procaine penicillin 1.2 million units once daily for 20 days. Conditional recommendation, very low quality evidence
How long it will take to recover from syphilis?
Apr 03, 2020 · Syphilis affects your nervous system: Penicillin given through an IV (intravenous) infusion, with treatment given once a week for two weeks. To treat syphilis with penicillin, you need a shot or IV infusion. Taking penicillin pills cannot cure you. You should not have sex for at least 1 week after treatment and until all symptoms have gone away.
Does syphilis go away on its own?
Apr 07, 2005 · How is syphilis treated? An intramuscular injection of penicillin G is the preferred treatment. Generally, a single shot of long-acting benzathine penicillin G will cure a person of primary, secondary, or early latent syphilis. Late latent and tertiary syphilis are treated with three doses of penicillin G given at one-week intervals. 3
What is the treatment for the early stages of syphilis?
Apr 24, 2021 · Primary syphilis treatment A single intramuscular injection of penicillin can be used to treat syphilis. Patients who are allergic to penicillin may receive an oral antibiotic called doxycycline for 14 days. Secondary syphilis treatment

What is the fastest treatment for syphilis?
What is the treatment for syphilis? A single injection of long-acting Benzathine penicillin G can cure the early stages of syphilis. This includes primary, secondary, or early latent syphilis.
Can syphilis be cured?
Is there a cure for syphilis? Yes, syphilis is curable with the right antibiotics from your healthcare provider. However, treatment might not undo any damage the infection can cause.
What is the official treatment of syphilis?
Penicillin G, administered parenterally, is the preferred drug for treating patients in all stages of syphilis. The preparation used (i.e., benzathine, aqueous procaine, or aqueous crystalline), dosage, and length of treatment depend on the stage and clinical manifestations of the disease.
How long does it take to cure syphilis?
After treatment, wait at least 10 days and until all sores are healed before you have any sexual contact. Even if you use a condom, you and your partner or partners can still spread the infection.
Which antibiotics treat syphilis?
When diagnosed and treated in its early stages, syphilis is easy to cure. The preferred treatment at all stages is penicillin, an antibiotic medication that can kill the organism that causes syphilis.Sep 25, 2021
What syphilis looks like?
a blotchy red rash that can appear anywhere on the body, but often develops on the palms of the hands or soles of the feet. small skin growths (similar to genital warts) – on women these often appear on the vulva and for both men and women they may appear around the anus. white patches in the mouth.
Can Amoxicillin 500mg treat syphilis?
Amoxycillin is thus a safe and effective oral agent for the treatment of all stages of syphilis in man.
How do you take azithromycin for syphilis?
Abstract. The efficacy of oral azithromycin (500 mg daily for 10 days or 500 mg on alternate days for 11 days) in 100 patients with seropositive syphilis was studied.
What are the signs of syphilis in a man?
A person with primary syphilis generally has a sore or sores at the original site of infection. These sores usually occur on or around the genitals, around the anus or in the rectum, or in or around the mouth. These sores are usually (but not always) firm, round, and painless.
Does syphilis go away without treatment?
The sores usually last about 3 to 6 weeks and then go away on their own — with or without treatment. But if you don't get treated, you still have syphilis, even if the sores are gone. You have to take medication to cure syphilis and stop it from moving to the next stage.
How long can you have syphilis without knowing?
Late latent syphilis is latent syphilis where infection occurs more than 12 months ago. Latent syphilis of unknown duration is when there is not enough evidence to confirm initial infection was within the previous 12 months. Latent syphilis can last for years.
What happens if syphilis is left untreated?
Left untreated, syphilis can cause tumors, blindness, and paralysis, damage the nervous system, brain and other organs, and may even kill you. If you are pregnant and have syphilis that is not treated, it can be passed to the baby during pregnancy or birth – called congenital syphilis.
What is the best treatment for syphilis?
The preferred treatment at all stages is penicillin, an antibiotic medication that can kill the organism that causes syphilis. If you're allergic to penicillin, your doctor may suggest another antibiotic or recommend penicillin desensitization. If you are diagnosed with primary, secondary or early-stage latent syphilis (by definition, ...
How to diagnose syphilis?
Syphilis can be diagnosed by testing samples of: Blood. Blood tests can confirm the presence of antibodies that the body produces to fight infection. The antibodies to the syphilis-causing bacteria remain in your body for years, so the test can be used to determine a current or past infection. Cerebrospinal fluid.
How long does a Jarisch Herxheimer reaction last?
Signs and symptoms include a fever, chills, nausea, achy pain and a headache. This reaction usually doesn't last more than one day.
How to prevent HIV infection?
Avoid sexual contact with new partners until the treatment is completed and blood tests indicate the infection has been cured. Notify your sex partners so that they can be tested and get treatment if necessary. Be tested for HIV infection.
Can you take penicillin while pregnant?
Women who are allergic to penicillin can undergo a desensitization process that may allow them to take penicillin. Even if you're treated for syphilis during your pregnancy, your newborn child should be tested for congenital syphilis and if infected, receive antibiotic treatment.
What to do if you have syphilis?
If you might have syphilis, your doctor will order a blood test. If this blood test is positive, the lab typically performs a second test on your blood to confirm that you have syphilis. If you have syphilis, you need treatment.
What are the symptoms of syphilis?
About 10% of people treated for syphilis feel sick within a few hours. They may develop one or more of the following: 1 Fever 2 Chills 3 Flushing 4 Achy muscles 5 Racing heart 6 Headache 7 Rash
How long does it take to get penicillin for syphilis?
Here’s how you may get the antibiotic: Early stage: One shot of penicillin. Late stage: Three shots of penicillin, with one shot given each week for three weeks. Syphilis affects your nervous system: Penicillin given through an IV (intravenous) infusion, with treatment given once a week for two weeks. To treat syphilis with penicillin, you need ...
How long after syphilis treatment can you have sex?
To treat syphilis with penicillin, you need a shot or IV infusion. Taking penicillin pills cannot cure you. You should not have sex for at least 1 week after treatment and until all symptoms have gone away.
Can you take penicillin while pregnant?
These antibiotics can be less effective at treating syphilis. If you are pregnant and allergic to penicillin, you must treat with penicillin. It’s the only antibiotic that can treat both mother and baby. A method called “desensitization” is used so that you can be safely treated with penicillin.
Can syphilis cause HIV?
People who have had syphilis have a higher risk of developing an HIV infection. If the syphilis was caught in a late stage, it may have affected your body in other ways. You may need other medical tests. People also need follow-up syphilis blood tests to make sure the syphilis treatment worked.
What to do if you are allergic to penicillin?
If you are allergic to penicillin, tell your doctor before you get your first shot or IV of penicillin. Some people can be treated with another antibiotic, such as doxycycline or tetracycline. If your doctor decides to treat you with one of these antibiotics, you will need several follow-up appointments.
What is the best treatment for syphilis?
Syphilis is typically treated with penicillin, the same drug used to treat the infection since 1943. While the bacterial disease can be treated with other types of antibiotics, there are circumstances where penicillin is the only choice. The partner of an infected individual may also be presumptively treated to safeguard against infection.
How long does it take for a syphilis test to be performed?
1. In terms of treatment, most doctors treat any sexual partner as a confirmed infection, since it can take up to 90 days to get an accurate test result.
Can gonorrhea be treated with penicillin?
As a result, gonorrhea is today treated with a combination of the injectable and oral antibiotics. Thus far, there have been no indications of this happening with syphilis and penicillin.
How long does ceftriaxone last?
People with neurosyphilis can be treated with a 10- to 14-day course of ceftriaxone delivered by intramuscular injection or intravenous infusion. 5.
Does penicillin help with syphilis?
While penicillin G is considered extremely effective in clearing a syphilis infection, some people may require additional treatments if follow-up tests do now show the anticipated drop in the volume (titer) of syphilis antibodies.
Primary syphilis treatment
It is recommended that patients have a single injection of penicillin or a 10-14 day course of antibiotics in tablet form.
Secondary syphilis treatment
It is recommended that patients have a single injection of penicillin or a 10-14 day course of antibiotics in tablet form.
Latent syphilis treatment
In early-latent stages, i.e. less than one year, it is recommended that patients have a single injection of penicillin or a 10-14 day course of antibiotics in tablet form.
Tertiary syphilis treatment
In the tertiary stages, patients may require further and more advanced treatments involving three doses of penicillin or a 28 day course of antibiotics in tablet form. Additional treatment for health complications that may occur during the tertiary stages may also be necessary during the tertiary stages.
How do you treat syphilis?
Penicillin is the most common treatment for syphilis in either injection or tablet form.
How long does it take to cure syphilis?
The length of time it takes to cure syphilis will depend on the stage of syphilis you are being treated for.
Can syphilis go away on its own?
Syphilis does not go away on its own. Though the symptoms of syphilis may heal over time, the infection can remain dormant in the body for years and even decades.
What is the cause of syphilis?
Syphilis is a sexually transmitted disease (STD) caused by the bacterium Treponema pallidum. Syphilis can cause serious health sequelae if not adequately treated.
How is syphilis transmitted?
Syphilis is transmitted from person to person by direct contact with a syphilitic sore, known as a chancre. Chancres can occur on or around the external genitals, in the vagina, around the anus , or in the rectum, or in or around the mouth. Transmission of syphilis can occur during vaginal, anal, or oral sex.
What is a detailed fact sheet?
Detailed fact sheets are intended for physicians and individuals with specific questions about sexually transmitted diseases. Detailed fact sheets include specific testing and treatment recommendations as well as citations so the reader can research the topic more in depth.
What is the name of the disease that causes headaches, paralysis, and dementia?
Syphilis can invade the nervous system at any stage of infection, and causes a wide range of symptoms, including headache, altered behavior, difficulty coordinating muscle movements, paralysis, sensory deficits, and dementia. 3 This invasion of the nervous system is called “neurosyphilis.
What is the primary stage of syphilis?
Primary Stage. The appearance of a single chancre marks the primary (first) stage of syphilis symptoms, but there may be multiple sores. The chancre is usually (but not always) firm, round, and painless. It appears at the location where syphilis entered the body.
How long does a chancre last?
These painless chancres can occur in locations that make them difficult to notice (e.g., the vagina or anus). The chancre lasts 3 to 6 weeks and heals regardless of whether a person is treated or not. However, if the infected person does not receive adequate treatment, the infection progresses to the secondary stage.
When should a woman be screened for syphilis?
All women should be screened at their first prenatal visit. For patients who belong to communities and populations with high prevalence of syphilis and for patients at high risk, blood tests should also be performed during the third trimester (at 28–32 weeks) and at delivery.
What is the best treatment for syphilis?
Penicillin G administered intramuscularly (IM) or intravenously (IV) is the preferred drug for treating all stages of syphilis. The preparation used (i.e. benzathine, aqueous procaine or aqueous crystalline), dosage and length of treatment depend on the stage and clinical signs of the disease.
How is syphilis transmitted?
It is transmitted through sexual contact, but can also be transmitted from mother to fetus during pregnancy. Syphilis is divided into three stages; primary, secondary and latent or tertiary syphilis. Stages are determined by clinical findings, which are used to provide guidance for treatment and follow-up. Syphilis affecting the central nervous system (CNS) can occur during any stage of syphilis.
What is latent syphilis?
Latent syphilis is defined as seroreactivity without other evidence primary, secondary or tertiary disease. Early latent, latent and late latent syphilis overlap the primary, secondary and tertiary stages of syphilis based on length of time of infection and visible symptoms.
How many types of serologic tests are needed for syphilis?
Two types of serologic tests are required to diagnosis syphilis, nontreponemal and treponemal. Use of only one type is insufficient since when used alone, each type of tests has major limitations.

Nontreponemal Tests and Traditional Algorithm
Treponemal Tests and Reverse Sequence Algorithm
- The majority of patients who have reactive treponemal tests will have reactive tests for the remainder of their lives, regardless of adequate treatment or disease activity. However, 15%–25% of patients treated during the primary stage revert to being serologically nonreactive after 2–3 years (570). Treponemal antibody titers do not predict treatmen...
Cerebrospinal Fluid Evaluation
- Further testing with CSF evaluation is warranted for persons with clinical signs of neurosyphilis (e.g., cranial nerve dysfunction, meningitis, stroke, acute or chronic altered mental status, or loss of vibration sense). All patients with ocular symptoms and reactive syphilis serology need a full ocular examination, including cranial nerve evaluation. If cranial nerve dysfunction is present, a …
Diagnosis
- Tests
Syphilis can be diagnosed by testing samples of: 1. Blood.Blood tests can confirm the presence of antibodies that the body produces to fight infection. The antibodies to the syphilis-causing bacteria remain in your body for years, so the test can be used to determine a current or past inf…
Treatment
- Medication
When diagnosed and treated in its early stages, syphilis is easy to cure. The preferred treatment at all stages is penicillin, an antibiotic medication that can kill the organism that causes syphilis. If you're allergic to penicillin, your doctor may suggest another antibiotic or recommend penicillin d… - Treatment follow-up
After you're treated for syphilis, your doctor will ask you to: 1. Have periodic blood tests and exams to make sure you're responding to the usual dosage of penicillin. Your specific follow-up will depend on the stage of syphilis you're diagnosed with. 2. Avoid sexual contact with new part…
Clinical Trials
- Explore Mayo Clinic studiestesting new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.
Coping and Support
- Finding out you have syphilis can be extremely upsetting. You might experience anger if you feel you've been betrayed, or shame if you think you've infected others. However, hold off placing blame. Don't assume that your partner has been unfaithful to you. One (or both) of you may have been infected by a past partner.
Preparing For Your Appointment
- Most people don't feel comfortable sharing the details of their sexual experiences, but the doctor's office is one place where you have to provide this information so that you can get the right care.