Treatment FAQ

how to treatment corynebacterium xerosis

by Clay Bailey Published 3 years ago Updated 2 years ago
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Strains of C. xerosis responsible for these infections were found to be susceptible to penicillin, erythromycin, and most of the usual antibiotics used against gram-positive
gram-positive
Eubacterium is a genus of Gram-positive bacteria in the family Eubacteriaceae. These bacteria are characterised by a rigid cell wall. They may either be motile or nonmotile. If motile, they have a flagellum. A typical flagellum consists of a basal body, filament, and hook.
https://en.wikipedia.org › wiki › Eubacterium
organisms
[6].

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What is Corynebacterium xerosis?

Corynebacterium xerosisis a commensal organism found in skin and mucous membranes of humans. It is considered an unusual pathogen, and it is rarely found in human and animal clinical samples.

Can Corynebacterium cause disease?

Infections caused by Corynebacterium species found on the skin Coryneform bacteria of multiple species are part of the microflora of healthy human skin but some of these bacterial species can cause disease under specific conditions. The four species discussed in this paragraph are occasionally associated with human disease.

Which antibiotics are used to treat Corynebacterium infections?

It recommends the usage of benzylpenicillin, ciprofloxacin, moxifloxacin, gentamicin, vancomycin, clindamycin, tetracycline, linezolid, and rifampicin.47 Molecular identification Molecular identification systems for Corynebacteriumspecies have been outlined.

What are the treatment options for xerosis?

irritants, and adequate moisturization are the key treatment modalities for xerosis. Topical steroids may be necessary if more conservative measures fail. Pharmacists can assist by educating seniors about useful product categories.

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What is the treatment for Corynebacterium?

Diphtheroids. Antibiotics are the treatment of choice for nondiphtherial corynebacteria infections. Many species and groups are sensitive to various antibiotics, including penicillins, macrolide antibiotics, rifampin, and fluoroquinolones.

What does Corynebacterium Xerosis cause?

Corynebacterium xerosis has been reported as a rare but serious cause of bacteremia, septicemia, pneumonia, septic arthritis, vertebral osteomyelitis, meningitis and, most commonly, endocarditis in adults.

What does Corynebacterium Xerosis look like?

C. xerosis grows in colonies of 0.2–1.0 mm in diameter, brown-yellowish in colour, slightly dry in appearance and non-haemolytic when cultured in blood agar. Microscopically, C. xerosis is irregularly stained, pleomorphic Gram positive rods presenting club-like ends.

Is Corynebacterium Xerosis normal flora?

Corynebacterium xerosis is a Gram-positive bacillus seen as normal flora of the skin. It is usually a commensal of the conjunctival sac.

Does Corynebacterium Xerosis have a capsule?

They are non-motile and not acid-fast. Capsules: No.

Is Corynebacterium Xerosis aerobic?

Structure and Physiology. This bacteria is a Gram positive, rod shaped aerobe.

Where does Corynebacterium come from?

Habitat. Corynebacterium species occur commonly in nature in soil, water, plants, and food products. The nondiphtheiroid Corynebacterium species can even be found in the mucosa and normal skin flora of humans and animals.

How do you test for Corynebacterium?

Basic tests for Corynebacteria identification include Gram staining and cell morphology, size, pigmentation, odour and haemolysis of colonies, CAMP reaction, lipophilia, motility and biochemical tests such as catalase and pyrazinamidase production, nitrate reduction, urea hydrolysis, esculin hydrolysis, acid production ...

Is Corynebacterium Xerosis motile?

Distinctive features for the identification of C. xerosis include negative reactions for hemolysis, urease, and motility, and positive reactions for catalase, glucose, sucrose and nitrate reduction.

Does ceftriaxone cover Corynebacterium?

Based on CLSI M45 breakpoint criteria for Corynebacterium, highest resistance rates were observed for ciprofloxacin (73.7%), followed by trimethoprim/sulfamethoxazole (71.6%), erythromycin (65.5%) and ceftriaxone (63.6%; Table 2).

Does levofloxacin cover Corynebacterium?

In conclusion, levofloxacin was the most active of the six fluoroquinolones evaluated against coryneform bacteria isolated from clinical samples and could therefore be a promising treatment option in this setting.

Does linezolid treat Corynebacterium?

Linezolid also showed activity against Corynebacterium spp., Nocardia spp., Bacteroides fragilis, Moraxella catarrhalis and Listeria monocytogenes. However, oxazolidinones are not well suited for tackling Gram-negative pathogens, which are intrinsically resistant to these agents.

How to treat xerosis?

In general, there is a twofold approach to the treatment of xerosis: (1) minimizing irritation and (2) moisturization. 2 Patients should be instructed to limit bathing, especially in soapy baths that strip oil from skin and leave it chapped. 2 While some experts recommend bathing once daily in warm water and mild soap, others suggest bathing only every other day and supplementing with sponge baths of the axillae and anogenital areas, since these areas are rarely affected by xerosis. 1,2 Patting the skin dry instead of rubbing can also help. Detergents, rubbing alcohol, and skin care products that contain alcohol and other drying agents should be avoided if possible. Irritating materials (e.g., wool) should not be placed next to the skin. 1

What is the best treatment for xerosis?

irritants, and adequate moisturization are the key treatment modalities for xerosis. Topical steroids may be necessary if more conservative measures fail. Pharmacists can assist by educating seniors about useful product categories. Pharmacists may also appropriately recommend effective treatments that are commensurate with a patient's aesthetic preferences and cost constraints.

What is xerosis diagnosis?

The differential diagnosis of xerosis includes atopic eczema, autosomal dominant ichthyosis, nummular eczema, and stasis dermatitis, as outlined in table 2. Inherited ichthyoses, characterized by excessive accumulation of scales on the surface of the skin, are classified according to clinical features such as age at onset (e.g., birth, infancy, or childhood), type of scale (e.g., fine, large and dark, large and coarse, thick and warty), associated clinical findings (e.g., corneal opacities, ectropion, blisters) and genetic features (e.g., autosomal dominant, X-linked, autosomal recessive). In these cases, it is recommended that genetic counseling and treatment guidance be sought through consultation with a dermatologist. 3

What causes xerosis of the stratum corneum?

While the exact cause of xerosis is unknown, the condition is related to altered lipid composition of the stratum corneum, in addition to other changes in epidermal differentiation. 1 It appears as though xerosis does not occur as a result of decreased water in the skin, but rather is the result of abnormal keritinization and desquamation. 2.

What is the condition of the skin that is dry and rough?

Staten Island, New York. US Pharm. 2006;4:28-32. Dryness of the skin, known as xerosis, or xeroderma, is a common condition in the elderly. As people age, the outer layer of skin loses water, causing the surface to become dry and rough. 1 Incidence of xerosis increases with age, and prevalence of the condition in the United States may increase, ...

Where does xerosis appear?

1,3 Xerosis may occasionally appear on the face, as well. 2 Clinically, the skin appears tessellated (mosaic-like) with dull scales and mild erythema.

Why does my stratum corneum lose water?

1 The stratum corneum loses excessive water under the condition of low humidity, which dries the surface and makes the skin shiny and less pliable.

What antibiotics are used to treat C. urealyticum?

The majority of C. urealyticumstrains are highly resistant to a large number of antibiotics, including aminoglycosides, B-lactams, and macrolides although teicoplanin and vancomycin remain universally active against these isolates.3

Where is C. urealyticum isolated?

C. urealyticumis isolated from the groin of elderly patients receiving broad spectrum antibiotics with relative frequency, thus providing an ideal environment that may favor colonization of urinary catheters with subsequent infection of bladder mucosa particularly in the setting of co-morbidities (trauma, tumor, or inflammation).1

What is C. urealyticum?

urealyticumis an opportunistic nosocomial pathogen mainly causing acute cystitis, pyelonephritis, alkaline encrusted cystitis, and encrusted pyelitis and may also cause bacteremia preferential in patients with chronic urological diseases.2

How many rrn operons does the C. urealyticumDSM7109 have?

urealyticumchromosome.19The C. urealyticumDSM7109 chromosome has three rrn operons on the leading strands, one on the right and two on the left replichore. This is different from C. jeikeium, which contains three rrn operons on the leading strand of the right replichore, indicating the occurrence of structural rearrangements in the chromosome of C. urealyticumDSM7109.20

When was C. urealyticum first discovered?

The name C. urealyticumwas first proposed in 1986 to describe the formation of bladder stones in vivo in an animal model by urealytic bacteria of the CDC coryneform group D2 (old name of C. urealyticum).3

What are the characteristics of C. urealyticum?

urealyticumwas originally characterized based on its biochemical properties, including failure to produce acid from carbohydrates and the ability to hydrolyze urea.12,13The cell wall peptidoglycan of C. urealyticumcontains meso-diaminopimelic acid. Arabinose and galactose are the major cell wall sugars. Tuberculostearic acid and short-chain mycolic acids are present resembling mycobacterium tuberculosis.2The degree of relatedness of C. urealyticumto other Corynebacteriumspecies can be determined by using DNA–DNA hybridization studies2,14and 16S ribosomal ribonucleic acid (rRNA) sequence analysis. A 16S rDNA sequence-based phylogenetic tree of the species belonging to the genus is shown in Figure 1.15,16Studies were done using a small-subunit rRNA sequence data and observed a close phylogenetic relationship between C. urealyticumand C. jeikeium.2However, the difference between them is that C. jeikeiumis non-urealytic and produces acid from glucose among others.17,18

What is the family of C. urealyticumbelongs?

C. urealyticumbelongs to the family Corynebacteriaceae and the genus Corynebacterium(Table 1).10According to Funke et al,11medically relevant species in the genus Corynebacteriumare classified into the following:

How to tell if you have xerosis cutis?

Symptoms of xerosis cutis include: skin that is dry, itchy, and scaly, especially on the arms and legs. skin that feels tight, especially after bathing. white, flaky skin. red or pink irritated skin.

Why is xerosis cutis worse in the winter?

Xerosis cutis is worse during the cold winter months when the air is very dry and there is low humidity. Older people are more susceptible to developing the condition than younger people. As we age, our sweat glands and sebaceous glands are less active, mostly due to changes in hormones. This makes xerosis cutis a common problem.

What to use for itchy skin?

Look for creams that contain the ingredients lactic acid, urea, or a combination of both. A topical steroid medication, such as 1 percent hydrocortisone cream, can also be used if the skin is very itchy. Ask a pharmacist to recommend a moisturizing cream or product that will work for you.

Can lotions cause xerosis cutis?

Note that products marked “lotion” instead of “cream” contain less oil. Water-based lotions may irritate xerosis cutis instead of healing your skin or soothing symptoms. Other treatment methods include: avoiding forced heat.

Can aloe vera be used for xerosis?

One study. Trusted Source. even recommends avoiding aloe vera in the treatment of xerosis, as it can make skin more sensitive.

Is xerosis cutis a symptom of thyroid?

Xerosis cutis can be a symptom of other conditions, including: ringworm. thyroid issues. psoriasis. Therefore, it’s important not to ignore xerosis cutis. If itching or discomfort persists after treatment, bring the symptoms to the attention of a medical professional.

Where is Corynebacterium xerosis isolated from?

Identification and molecular characterization of Corynebacterium xerosis isolated from a sheep cutaneous abscess: first case report in Mexico

Is Corynebacterium xerosis a pathogen?

Corynebacterium xerosisis a commensal organism found in skin and mucous membranes of humans. It is considered an unusual pathogen, and it is rarely found in human and animal clinical samples. Here we describe the isolation of C. xerosisfrom a 4-months-old Pelifolk lamb located in Tesistán, central western Mexico. This microorganism should be considered for differential diagnosis in cutaneous abscessed lesions in sheep, as it represents a zoonotic risk factor for human infection in sheep farms.

What are the characteristics of Corynebacterium xerosis?

The corynebacterium are the rod shaped bacilli and sometimes they are a slight curved in shape. This curve does not thick ends and thin inner round (comma type shape). This genera, has a gram positive result. It is usually found in a commensal relationship with the skin of human. As it consider the skin as it's host tissues. It usually attacks the conjuctival sac of eye. It is present single or sometimes in pairs. It is present in the shape of v or y.

How are corynebacterium xerosis arranged?

There is a specific way of their joining. They are arranged in a Chinese manner or in the form of V palisade. It may also have arrangement of 2 and 4 palisade. It is usually found in the normal Flora of skin in human. Corynebacterium xerosis may also appear elliptical. Throughout their life cycle, they are polymorphic, which means they keep changing their shapes and structure. They may vary in length and thickness.

Who discovered corynebacterium xerosis?

Collins and Cummins were the two scientists who in 1986 described the main features of corynebacterium xerosis. These are when pass through gram staining process, results in positive gram staining. These are gram positive in nature. Not only corynebacterium xerosis but the whole genus corynebacterium is gram positive. These are not spore forming bacteria. Even the catalyzation process of corynebacterium xerosis gives positive result. Some other features we're described about its shape that they are rod shaped bacilli and sometimes appear in a slight curved form.

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