Precautions
After reconstitution with Sterile Water for Injection, USP, NebuPent (pentamidine isethionate) is administered by inhalation via the Respirgard® II nebulizer [Marquest, Englewood, CO] (see DOSAGE AND ADMINISTRATION).
How is nebupent administered?
Dosage The recommended adult dosage of NebuPent (pentamidine isethionate) for the prevention of Pneumocystis jiroveci pneumonia is 300 mg once every four weeks administered via the Respirgard® II nebulizer. The dose should be delivered until the nebulizer chamber is empty (approximately 30 to 45 minutes).
What is the recommended dosage of nebupent for adults?
While using Nebupent, you may need frequent blood tests. Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).
What kind of tests will I need to take while using nebupent?
DRUG INTERACTIONS. Because the nephrotoxic effects may be additive, the concomitant or sequential use of NebuPent (pentamidine isethionate) and other nephrotoxic drugs such as aminoglycosides, amphotericin B, cisplatin, foscarnet, or vancomycin should be closely monitored and avoided, if possible.
Can nebupent be taken with aminoglycosides?
How do you administer Nebupent?
The recommended adult dosage of NebuPent (pentamidine isethionate) for the prevention of Pneumocystis jiroveci pneumonia is 300 mg once every four weeks administered via the Respirgard® II nebulizer. The dose should be delivered until the nebulizer chamber is empty (approximately 30 to 45 minutes).
How do you take pentamidine?
Adults and children 5 years of age and older—300 milligrams (mg) by oral inhalation once every four weeks. Children younger than 5 years of age—Use and dose must be determined by your doctor.
How do you give the pentamidine IV?
How to use Pentamidine 300 Mg Solution For Injection Antiprotozoal Agents. This medication is given by injection into a vein or muscle as directed by your doctor, usually once a day. If it is given by injection into a vein, it is slowly injected over 1 to 2 hours.
How do we deliver pentamidine treatments?
Inhaled pentamidine is administered via the Respirgard II Nebulizer, which utilizes a series of one-way valves and a filter to minimize the release of aerosol droplets into the air. Aerosolized pentamidine may be potentially toxic, necessitating use of this special nebulization system.
Why is pentamidine given?
Pentamidine is used to try to prevent Pneumocystis carinii pneumonia (PCP), a very serious type of pneumonia. This type of pneumonia occurs commonly in patients whose immune systems are not working normally, such as patients with acquired immune deficiency syndrome (AIDS).
Can pentamidine be given at home?
Aerosolized pentamidine appears to be better tolerated and is considered an alternative treatment for PCP in both hospital and community settings. This report describes our experience with 34 patients with AIDS who received aerosolized pentamidine at home.
What is Nebupent used for?
Nebupent is an antifungal medication that fights infections caused by fungus. Nebupent is used to prevent and treat pneumonia caused by Pneumocystis jiroveci (carinii).
How long does IV pentamidine last?
Pentamidine is given intravenously or inhaled as an aerosol for P. jirovecii pneumonia. It can be given by deep intramuscular injection for leishmaniasis or trypanosomiasis. Pentamidine is metabolised in the liver and has a very long half-life (10–14 days).
Can you use IV pentamidine for inhalation?
For the prevention of PCP, pentamidine is given by inhalation. This involves breathing in the drug through a device called a nebulizer. The nebulizer converts the drug into a mist that then coats your lungs. The usual dose for inhalation is 300 mg given once every 4 weeks on a regular basis.
What is pentamidine nebuliser?
Nebulised pentamidine is a medicine given to children to prevent a type of chest infection called Pneumocystis Jiroveci pneumonia. You may hear the doctors and nurses referring to this as 'PCP' as it was previously called Pneumocystis Carinii pneumonia.
What is aerosolized treatment?
Aerosol therapy is a technique of administering medication directly into the airway and lungs. An aerosol is a suspension of liquid and/or solid particles, usually administered by a medical device like an inhaler.
How do you Nebulize a patient on a ventilator?
Place the medicine in the nebulizer chamber. Screw the cap onto the chamber. Unhook the ventilator tubing and insert the T-piece into the ventilator tubing on the inhalation side. Insert the nebulizer cup into the T-piece that is now in line with the ventilator circuit.
What is nebu pent?
NebuPent (pentamidine isethionate) is indicated for the prevention of Pneumocystis jiroveci pneumonia (PJP) in high-risk, HIV-infected patients defined by one or both of the following criteria: a peripheral CD4+ (T4 helper/inducer) lymphocyte count less than or equal to 200/mm³.
How long is nebu pent stable?
After reconstitution with sterile water, the NebuPent (pentamidine isethionate) solution is stable for 48 hours in the original vial at room temperature if protected from light.
How does pentamidine isethionate interfere with microbial nuclear metabolism?
Studies suggest that the pentamidine isethionate interferes with microbial nuclear metabolism by inhibition of DNA, RNA, phospholipid and protein synthesis . However, the mode of action is not fully understood. Activity in vitro and in vivo.
Does nebu pent cause cough?
Inhalation of NebuPent (pentamidine isethionate) may induce bronchospasm or cough. This has been noted particularly in some patients who have a history of smoking or asthma. In clinical trials, cough and bronchospasm were the most frequently reported adverse experiences associated with NebuPent (pentamidine isethionate) administration (38% and 15%, respectively of patients receiving the 300 mg dose); however less than 1% of the doses were interrupted or terminated due to these effects. For the majority of patients, cough and bronchospasm were controlled by administration of an aerosolized bronchodilator (only 1% of patients withdrew from the study due to treatmentassociated cough or bronchospasm). In patients who experience bronchospasm or cough, administration of an inhaled bronchodilator prior to giving each NebuPent (pentamidine isethionate) dose may minimize recurrence of the symptoms.
Is pentamidine safe for pregnant women?
There are no adequate and well controlled studies of NebuPent (pentamidine isethionate) in pregnant women. A literature report indicated that intravenously administered pentamidine in pregnant rats at 4 mg/kg/day was embryolethal; teratogenicity was not observed in this study. It is unknown whether pentamidine administered via the aerosolized route crosses the placenta at clinically significant concentrations. It is not known whether NebuPent (pentamidine isethionate) can cause fetal harm when administered to a pregnant woman. NebuPent (pentamidine isethionate) should be given to a pregnant woman only if clearly needed.
Does nebupent affect PJP?
The use of NebuPent (pentamidine isethionate) may alter the clinical and radiographic features of PJP and could result in an atypical presentation, including but not limited to mild disease or focal infection.
Is nebu pent excreted in milk?
It is not known whether NebuPent (pentamidine isethionate) is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants from NebuPent (pentamidine isethionate) , a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Because many drugs are excreted in human milk, NebuPent (pentamidine isethionate) should not be given to a nursing mother unless the potential benefits are judged to outweigh the unknown risks.
How often should I take NebuPent?
The recommended adult dosage of NebuPent for the prevention of Pneumocystis jiroveci pneumonia is 300 mg once every four weeks administered via the Respirgard ® II nebulizer. The dose should be delivered until the nebulizer chamber is empty (approximately 30 to 45 minutes). The flow rate should be 5 to 7 liters per minute from a 40 ...
How long is NebuPent stable?
Freshly prepared solutions for aerosol use are recommended. After reconstitution with sterile water, the NebuPent solution is stable for 48 hours in the original vial at room temperature if protected from light.
How to use Nebupent Vial For Nebulizer
This medication is given by a health care professional as directed by your doctor, usually once every 4 weeks. It is given using a special machine called a nebulizer that changes the solution to a fine mist that you inhale. Each treatment usually takes 30 to 45 minutes.
Are you currently using Nebupent Vial For Nebulizer?
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Before taking Nebupent, tell your doctor
If you are allergic to Nebupent; any part of this medicine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
What are some things I need to know or do while I take Nebupent?
Tell all of your health care providers that you take Nebupent. This includes your doctors, nurses, pharmacists, and dentists.
How is Nebupent best taken?
Use Nebupent as ordered by your doctor. Read all information given to you. Follow all instructions closely.
What are the side effects of Nebupent that I need to call my doctor about immediately?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
What are some other side effects of Nebupent?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
If overdose is suspected
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Consumer information use and disclaimer
If your symptoms or health problems do not get better or if they become worse, call your doctor.
Proper Use
To help prevent the development or return of pneumocystis pneumonia, you must receive pentamidine inhalation on a regular basis, even if you are feeling well.
Dosing
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
Missed Dose
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
