JERUSALEM, Israel and HACKENSACK, N.J.,, July 18, 2019 (GLOBE NEWSWIRE) — BrainsWay Ltd. (NASDAQ: BWAY, TASE: BWAY), a global leader in the advanced non-invasive treatment of brain disorders, today announced the publication of a third-party study which demonstrated that Deep Transcranial Magnetic Stimulation (Deep TMS™) plus standard medication was significantly more effective at reducing depression levels among Major Depressive Disorder (MDD) patients compared with standard medication alone.
Full Answer
Which is better NeuroStar vs BrainsWay?
On average, technicians reported feeling that both the Magstim and NeuroStar devices were significantly easier to use than the Brainsway Deep TMS H-Coil device. Additionally, they found the former two devices to be more reliable and better tolerated.
How is rTMS different from TMS?
In transcranial magnetic stimulation (TMS), an electromagnetic coil placed against the scalp creates a magnetic field that stimulates certain areas of the brain. During an rTMS session, an electromagnetic coil is placed against your scalp near your forehead.
Which is more effective ECT or TMS?
We found that ECT (P<0.0001) was more effective than TMS (P<0.012) (not statistically significant in group effect) in TRD patients. However, ECT patients reported a higher percentage of side effects (P<0.01) and the TMS treatment scored better in terms of patient preference.
How does BrainsWay TMS work?
Deep TMS treatment utilizes BrainsWay's patented H-coil technology to regulate brain activity and improve patients' mental health and well-being. During the procedure, a helmet holding the H-coil is fitted over the patient's head before sending magnetic pulses to targeted areas of the brain.
What is the best transcranial magnetic stimulation?
NeuroStar is a great quality machine, and in general, they have the most recognition among patients and practitioners alike, thanks to commercials like these where individuals are told to “ask for NeuroStar by name.” NeuroStar is the first of many Surface TMS machines, meaning that they stimulate the outer cortex of ...
What is the best TMS Therapy?
Transcranial Magnetic Stimulation has proven to be an incredible breakthrough treatment for patients suffering from major depression, severe anxiety, or other mental health conditions. When it comes to TMS mental health treatments, patients typically have a choice between two popular options, NeuroStar and Brainsway.
Why is TMS better than ECT?
Unlike ECT, however, TMS does not involve the application of direct electrical currents to a patient's head. TMS is designed to activate the brain's healing process more gently by magnetically stimulating a very discrete part of the brain while avoiding global seizures and cognitive dysfunction.
What is a disadvantage of TMS?
Facial twitching during the treatment. Skin redness at site of coil placement. Anxiety before and during treatment. Mild discomfort (usually dissipates by end of first treatment).
What is the success rate of TMS therapy?
Does TMS work? Approximately 50% to 60% of people with depression who have tried and failed to receive benefit from medications experience a clinically meaningful response with TMS. About one-third of these individuals experience a full remission, meaning that their symptoms go away completely.
Is Deep TMS better than rTMS?
While Traditional rTMS has a narrower range of activation, Deep TMS manages to safely reach deeper brain structures directly, which contributes to its higher level of efficacy. Various studies have shown that both Deep TMS and Traditional rTMS are safe and effective courses of treatment.
Can TMS make you worse?
While TMS does not worsen symptoms for patients who are correctly diagnosed with a condition that TMS is known to treat (such as depression, anxiety, OCD, and PTSD), TMS may possibly worsen symptoms for patients with conditions that TMS are not know to treat, such as schizophrenia or bipolar disorder.
How long does it take for TMS to start working?
Some patients start to feel the benefits of TMS treatment within the first 2 weeks of treatment. Others don't notice the effects until several weeks into treatment. Younger people may experience the benefits of TMS faster than older people because their brains adapt faster to changes.
Brain Implants for Depression
Electrode implants are not new to clinical medicine. Open-loop DBS involves manual adjustment of stimulation of brain structures every few months and has been used to treat epilepsy and Parkinson’s disease.
Closed-Loop DBS for Persistent Depression Symptoms
Closed-loop DBS utilizes a brain implant for depression treatment. First, an individual’s brain is mapped, locating regions associated with the most intense depression symptoms, as well as with consistent, sustained improvement of symptoms.
Traditional and Deep Transcranial Magnetic Stimulation (TMS)
Transcranial magnetic stimulation (TMS) is a noninvasive treatment utilizing magnetic pulses to impact the neural activity of specific brain structures associated with depression symptoms. These pulses are delivered by a technician using a handheld device during 20-40-minute treatment sessions, over a period of several weeks.
Technological Treatments for Depression
Technological depression treatments are helping individuals who may have lost hope find symptom relief. While effective DBS interventions are still in the earliest stages of exploration, TMS treatments are more widely available. And both approaches are defining the next generation of innovative depression treatment.
What is deep TMS?
Deep TMS: Deep Transcranial Magnetic Stimulation is a noninvasive treatment that utilizes magnetic pulses to safely and effectively regulate the neural activity of target brain structures. FDA-clearance to treat anxious depression was granted in 2021. Deep TMS has many advantages over traditional treatment options – no systemic side effects common to medication, no anesthesia or recovery period, and proven efficacy for treatment-resistant patients.
How long does TMS last?
BrainsWay’s Deep TMS for anxious depression involves 30 to 36 sessions over 9 to 12 weeks, with each session lasting approximately 20 minutes. The course of treatment includes an acute period with daily sessions over four weeks, followed by twice per week continuation sessions.
How to prevent anxiety and depression?
Lifestyle Changes to Protect Against Anxious Depression: Stress-reduction habits such as improved sleep habits, better diet, and frequent exercise may be beneficial in reducing symptoms of anxious depression. In addition, avoidance of alcohol, drugs, and tobacco is valuable as they may worsen symptoms and can negatively impact other treatment with therapy, medication, or Deep TMS. Lastly, social support groups can provide an effective network to mitigate anxiety and depression.
Does Deep TMS reduce anxiety?
Further analysis from additional studies, including real world clinical data and a head-to-head study of Deep TMS with medication vs. medication alone, corroborate the statistically significant reduction in anxiety comorbid with depression. When analyzing data from 3 randomized controlled studies on Deep TMS, favorable outcomes were demonstrated when compared to both sham or medication as standard of care. Using the Cohen’s d statistical method, Deep TMS demonstrated effect sizes ranging from 0.34 (when compared to sham) to 0.90 (when compared to medication), and an overall weighted, pooled effect size of 0.55.
Is Deep TMS a non-medical treatment?
Current treatment options for anxiety comorbid with depression are similar to those for anxiety disorders and non-anxious major depressive disorder. Deep TMS offers a new non-medication, noninvasive option that addresses some of the limitations of traditional treatment methods.
Is Deep TMS effective?
Multiple peer-reviewed clinical studies have found Deep TMS to be a highly effective treatment in treating anxiety comorbid with depression. In a multicenter, double-blind controlled study, Deep TMS showed significant reductions in anxiety symptoms through the acute course of TMS treatments and retained improvement through 16 weeks.
Does ECT help with anxiety?
ECT: Electroconvulsive therapy induces a brief set of seizures that stimulate the brain’s neural activity. ECT has been found to help alleviate severe depression, but it’s impact on anxiety is debated with some studies showing limited improvement and others showing exacerbation of symptoms. ECT requires full sedation under anesthesia and presents potential side effects such as nausea, confusion, and short-term memory loss.
What is deep TMS?
Deep TMS was FDA-cleared to treat depression in 2013. It uses its own, patented H-Coil technology held inside a cushioned helmet that is fitte d onto the patient’s head. Deep TMS’s unique technology and apparatus allow it to reach wider areas of the brain simultaneously, in addition to reaching deeper brain regions directly. As a result, Deep TMS is able to avoid the targeting issues that traditional TMS sometimes contends with.
How Does Transcranial Magnetic Stimulation Work?
It utilizes electromagnetic fields to regulate the neural activity of brain structures found to be associated with depression, particularly the bilateral prefrontal cortex. TMS is a noninvasive treatment which does not necessitate the use of anesthesia, normally does not cause any significant or long-lasting side effects, and can be incorporated into the patient’s daily routine.
How do SSRIs work?
SSRIs work within the synaptic cleft to keep the neurotransmitter serotonin from being reabsorbed. This method of prolonging its activation was shown to offer significant symptom relief to patients battling depression. As a result, SSRIs became the go-to pharmacological treatment for depression and were granted the FDA seal of approval for treating this condition.
How do antidepressants work?
Antidepressants work by influencing the neural activity in the brain through a number of pathways shown to offer symptom reduction and mood elevation among patients battling depression.
What is the second generation of antidepressants?
The move to second-generation antidepressants began in the early 1980s, with a focus on what appeared to be a key neurotransmitter in mood elevation—serotonin. The medications in this generation work to prolong the activation period of this specific neurotransmitter, which was found to be roughly as efficacious as first-generation options but caused significantly less severe side effects. While there is some debate over what antidepressants fall within this group, it is universally accepted that selective serotonin reuptake inhibitors (SSRIs) should be considered a second-generation class of antidepressants, if not embody the entire category.
How many people are affected by depression?
Depression affects roughly one in 15 adults, or 6.7% of the adult population. 17.3 million adults (or 7.1%) of US adults are reported to have experienced one or more depressive episodes during their lives. Among individuals 18-29 years old, the prevalence of MDD is three times higher than among those 60 and older. Females tend to experience depression 1.5-to-3 times more than males, from the age of adolescence onward.
Do SNRIs work for depression?
As a result, SNRIs offer greater tolerability for roughly the same results. SNRIs typically work well for patients who do not have treatment-resistant depression.
When was transcranial magnetic stimulation first used?
Transcranial magnetic stimulation was first developed in 1985 as a medical device treatment option for various mental health conditions. The treatment utilizes electromagnetic fields to safely and effectively regulate the neural activity of brain structures found to be associated with the condition targeted. With depression, one of these structures is the bilateral prefrontal cortex.
How long does it take to diagnose major depressive disorder?
An MDD diagnosis can be considered after at least two weeks of symptomatology. Furthermore, MDD is not usually associated with instances of depression that continue beyond one year in children and two years in adults.
How does deep TMS work?
Deep TMS works by utilizing a magnetic field that manages to directly reach wider and deeper brain regions, regulating the neural activity of brain structures related to depression – specifically the dorsolateral prefrontal cortex (DLPFC). Repeated peer-reviewed studies have found Deep TMS to be a highly effective treatment ...
What is a standard rTMS?
Standard rTMS: Available to the public since 2008, Transcranial Magnetic Stimulation is a non-invasive treatment for depression. The procedure sends out electromagnetic pulses from a figure-8-shaped handheld device, used to regulate the neural activity of brain structures found to be involved in depression.
How many people are affected by depression?
Depression Demographics: According to the National Institute of Mental Health, Depression affects roughly one in 15 adults (6.7%). In the US, 17.3 million adults (7.1%) report experiencing one or more depressive episodes across their lifetime. Possible Causes for Depression: Several risk factors have been found to increase the chance ...
What is the best way to treat depression?
Psychotherapy: Psychotherapy, or talk therapy, refers to speaking with a mental health professional to better understand one’s experiences and increase their well-being. Forms of psychotherapy commonly used to treat depression include psychodynamics, cognitive-behavioral therapy (CBT) and interpersonal therapy (IPT). Support groups for patients and their primary care providers have also been shown to offer relief.
How to protect against MDD?
Lifestyle Changes to Protect Against MDD: While the above-mentioned factors are more stable fixtures, choosing to implement certain lifestyle changes can also help ward off depression. These include: adopting a Mediterranean diet rich with fruit, vegetables, olive oil and fish; participating in exercise to help release mood-elevating endorphins, strengthen self-worth and distract from depressive triggers; replenishing your energy levels through a good night’s sleep; and developing a balanced work-rest-play dynamic.
Is Deep TMS safe?
Deep TMS as a Safe Treatment for Depression. Deep TMS has not been shown to cause any substantial or lasting side effects. A 2007 study in Clinical Neurophysiology confirmed this, finding Deep TMS to be a well-tolerated treatment that does not cause any adverse side effects.
Is TMS invasive?
Deep TMS is also a non-invasive treatment that utilizes a magnetic field to safely and effectively regulate the neural activity of brain structures associated with depression, in addition to other forms of mental illness. Deep TMS does not require anesthesia or recovery, and can therefore be incorporated into an individual’s daily routine.
