Treatment FAQ

how soon after a positive breast cancer biopsy does treatment have to begin

by Litzy Powlowski Published 3 years ago Updated 2 years ago
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In general, the sooner you can receive treatment, the better. However, this does not mean you need to rush into treatment the same day you receive a diagnosis. Your physician may recommend receiving treatment within a month or two of the diagnosis.

Waiting between 31 and 90 days to first treatment after diagnosis with breast cancer may be beneficial for doctors and patients who want a more extensive diagnostic plan and additional time to make decisions, according to the results of a new study.Feb 22, 2020

Full Answer

When does a doctor recommend a biopsy for breast cancer?

A doctor may recommend a biopsy if there is a lump or mass in the breast, an irregularity on a mammogram, bleeding from the nipple, or other symptoms of a health problem in the area. There are different types of breast biopsy, and the type a doctor recommends may depend on factors such as the size or location of a lump.

What happens after a biopsy for breast cancer?

If you have a biopsy resulting in a cancer diagnosis, the pathology report will help you and your doctor talk about the next steps. You will likely be referred to a breast cancer specialist, and you may need more scans, lab tests, or surgery.

When should chemotherapy start after breast cancer surgery?

Ideally, it would seem that chemotherapy should be started if at all possible within 30 days of surgery, especially for those who have high risk tumors. There is little research looking at the optimal time until treatment for metastatic breast cancer, though it appears that waiting more than 12 weeks has been linked with lower survival.

When should I go to the ER after a breast biopsy?

After a breast biopsy, a person should receive emergency medical care if they experience any concerning symptoms, such as shortness of breath, chest pain, or signs of a blood clot in the leg. These signs can include pain, swelling, or color changes in the leg area.

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What is the next step after a positive breast biopsy?

After the biopsy procedure, the breast tissue is sent to a lab, where a doctor who specializes in analyzing blood and body tissue (pathologist) examines the sample using a microscope and special procedures. The pathologist prepares a pathology report that is sent to your doctor, who will share the results with you.

How soon after breast cancer diagnosis does chemo start?

The NICE guideline on early and locally advanced breast cancer recommends: “Start adjuvant chemotherapy or radiotherapy as soon as clinically possible within 31 days of completion of surgery in patients with early breast cancer having these treatments”. This is in line with the findings of the study.

How long after cancer diagnosis do you have surgery?

But these studies strongly suggest that it also makes sense to have surgery within 30 days of diagnosis and to start chemotherapy within 90 days of surgery, especially if you've been diagnosed with stage I or stage II triple-negative disease.

What happens after a positive breast cancer diagnosis?

Once your doctor has diagnosed your breast cancer, he or she works to establish the extent (stage) of your cancer. Your cancer's stage helps determine your prognosis and the best treatment options. Complete information about your cancer's stage may not be available until after you undergo breast cancer surgery.

At what stage of breast cancer is chemotherapy used?

Most women with breast cancer in stages I, II, or III will get some kind of systemic therapy as part of their treatment. This might include: Chemotherapy.

Do you need chemo for Stage 1 breast cancer?

Chemotherapy. Chemotherapy is not usually offered for stage 1 breast tumours. It may be offered after surgery (called adjuvant therapy) for these tumours if there is a high risk that the cancer will come back (recur). Find out more about the risk of breast cancer recurrence and adjuvant therapy.

How quickly is breast cancer surgery scheduled?

Lumpectomies are typically performed within the first month or so after a diagnosis, while mastectomies may take a little longer to get on the surgical schedule. If whole breast radiation (the most common type) is needed post-surgery, that can add about four to six weeks to the treatment timeline.

What is the first step in treating breast cancer?

Surgery. Surgery is usually the first step in treating early breast cancer. You may have mastectomy (the entire breast is removed) or lumpectomy (only the tumor and some surrounding tissue are removed).

At what stage of breast cancer the breast is removed?

Larger tumors in later stages can spread to muscle, skin and lymph nodes around the breast. Surgery for stage three and stage four cancer generally requires removing the entire breast and nearby tissue affected by the cancer.

How long do you see an oncologist after breast cancer?

Once your initial breast cancer treatment ends, you will need to see your oncologist every three or four months during the first two or three years. Then, you can visit your doctor once or twice a year. After that, these visits will depend on the type of cancer you have had.

What happens if breast biopsy comes back cancerous?

If you have a biopsy resulting in a cancer diagnosis, the pathology report will help you and your doctor talk about the next steps. You will likely be referred to a breast cancer specialist, and you may need more scans, lab tests, or surgery.

What stage of breast cancer is invasive ductal carcinoma?

Generally, the stage of invasive ductal carcinoma is described as a number on a scale of I through IV. Stages I, II, and III describe early-stage cancers, and stage IV describes cancers that have spread outside the breast to other parts of the body, such as the bones or liver.

How soon should you start chemo after diagnosis?

Cancer treatment should start very soon after diagnosis, but for most cancers, it won't hurt to wait a few weeks to begin treatment. This gives the person with cancer time to talk about all their treatment options with the cancer care team, family, and friends, and then decide what's best for them.

How long after cancer surgery does chemotherapy start?

It is usually accepted that adjuvant chemotherapy should begin within 8 weeks after surgery, and most clinical trials mandate that it should be started within 6 to 8 weeks after surgery.

What is a 21 day chemo cycle?

Each cycle of TC takes 21 days (3 weeks). On the first day of each cycle, you will have docetaxel and cyclophosphamide. You will then have no chemotherapy for the next 20 days. At the end of the 21 days, you will start your second cycle of TC.

Does Stage 2 breast cancer require chemo?

If you've been diagnosed with stage 2 breast cancer, the outlook is very good. You are more likely to have chemotherapy and/or radiation therapy than if your tumor was stage 1, but these tumors are still very treatable.

How long does it take to get a biopsy report?

Ask for a copy of your initial biopsy report that will be available in 2-3 days.

How long does it take to find breast cancer?

Finding your breast cancer (1 – 3 weeks) Most small breast cancers are found on screening mammography and possibly by ultrasound or maybe a breast MRI. You may have detected your own breast lump and sought further help from your physician.

How long does it take to get a lumpectomy?

The average time from the date of cancer diagnosis to the day of lumpectomy surgery is about 32 days. The average time to mastectomy surgery is about 40 days.

What is the hardest part of breast cancer?

Making good decisions is the most difficult part of having breast cancer. You will feel pressed for time to learn everything and start your treatment as soon as possible. Time is usually on your side. You must work with your team to learn everything about your cancer and treatment options.

How long does it take to get a breast radiation?

Whole breast radiation is the most common type and takes 4 to 6 weeks.

What is the first treatment for breast cancer?

Surgery is usually the first treatment for early-stage breast cancer.

How long does it take to get a mammogram?

The time to schedule a mammogram, have it performed, return for further breast imaging and then get the results can take days to weeks. Always ask to have your tests and appointments scheduled as soon as possible.

How long does it take to get chemo after breast cancer surgery?

This study didn’t use the SEER database or NCDB. Instead it examined a total of 24,843 patients from the California Cancer Registry diagnosed with stage I to III breast cancer between January 1, 2005 and December 31, 2010 treated with adjuvant chemotherapy. Time to chemotherapy was defined as the number of days between the last surgery for breast cancer and the first dose of chemotherapy, and delayed time to chemotherapy was defined as 91 or more days. Overall, the authors found no evidence of adverse effects when patients started chemotherapy between 31-60 or 61-90 days after their surgery as compared to patients who started their chemotherapy in 30 days. However, for patients who started their chemotherapy 91+ days after their surgery the results weren’t so good. These patients experienced worse overall survival (hazard ratio [HR], 1.34; 95% CI, 1.15-1.57) and worse breast cancer–specific survival (HR, 1.27; 95% CI, 1.05-1.53). The authors then did a subgroup analysis examining different subtypes of cancer to subtype, longer time-to-chemotherapy was associated with worse OS in the subgroups one would predict. Specifically patients with triple-negative breast cancer had worse overall survival (HR, 1.53; 95%CI, 1.17-2.00) and worse breast cancer–specific survival (HR, 1.53; 95%CI 1.17-2.07). This finding intuitively makes sense because it is patients whose tumors are estrogen receptor-negative for whom there is the greatest benefit due to adjuvant chemotherapy.

How long does it take to start chemo for breast cancer?

Most patients with breast cancer start adjuvant chemotherapy within 30 to 40 days of surgery. It is thought that chemotherapy administration delayed beyond this time can decrease the benefit provided by cytotoxic systemic therapies. Possible explanations for these effects include accelerated growth of micrometastases after resection of the primary tumor, increased tumor angiogenesis, or development of primary resistance. The optimal time of chemotherapy administration for patients with breast cancer is not precisely defined. Furthermore, it is possible that the time to chemotherapy (TTC) has a different effect according to tumor subtype, tumor stage, and tumor grade. Administration of combination systemic chemotherapy within 120 days of diagnosis in women younger than 70 years with T1cN0M0 or stage II or III hormone receptor–negative breast cancer is considered a quality metric by the Centers for Medicare & Medicaid Services. This metric will now be reported by 11 cancer hospitals as part of the Prospective Payments System-Exempt Cancer Hospital Reporting Program.

What is adjuvant chemotherapy?

Adjuvant chemotherapy is chemotherapy given after surgery with the intent of decreasing the chance of tumor recurrence. It is standard of care for many kinds of breast cancer. For instance, in two of the kinds of breast cancer with poorer prognosis, triple negative breast cancer [PDF] and HER2 (+) breast cancer, ...

Why wait a while for breast cancer?

When a patient with breast cancer comes in to see me, not infrequently I have to reassure her that she doesn’t need to be wheeled off to the operating room tomorrow , that it’s safe to wait a while. One reason, of course, is that it takes years for a cancer to grow from a single cell to a detectable mass. The big question, of course, is: What is “a while”? Two studies published online last month attempt to answer that question. One study (Bleicher et al) comes from Fox Chase Cancer Center and examines the effect of time to surgery on breast cancer outcomes; the other (Chavez-MacGregor et al) is from the M.D. Anderson Cancer Center and examines the effect of time to chemotherapy on outcome. Both find a detrimental effect due to delays in treatment.

Is it safe to delay chemo for breast cancer?

I realize that these two studies are about as close to “Well, duh!” studies as there are. Of course, delaying surgery for breast cancer is not a good thing. Of course, delaying chemotherapy when it’s indicated is also not a good thing. These are results that are not unexpected. However, these studies are still very important because they give us estimates of how much of a delay is safe and at what point delaying care starts to have a measurable impact on patient outcomes. Putting the results of these studies together suggests that it’s best to do surgery within about 60 days in patients not needing chemotherapy first, and that for patients with disease lacking the estrogen and progesterone receptor it’s best to start chemotherapy within 90 days of surgery.

Is it possible to have chemotherapy for breast cancer?

Furthermore, it is possible that the time to chemotherapy (TTC) has a different effect according to tumor subtype, tumor stage, and tumor grade .

Is inflammatory breast cancer treated first with chemotherapy?

Patients with inflammatory breast cancer were excluded, which makes sense because inflammatory cancer is generally treated first with chemotherapy. The SEER-Medicare cohort included 94,544 patients 66 years or older diagnosed between 1992 and 2009, while the NCDB cohort included 115,970 patients 18 years or older diagnosed between 2003 and 2005.

How long does it take to get breast cancer surgery?

They then looked at wait times to surgery and survival rates at five different intervals: a wait of less than 30 days, a wait time of 31 to 60 days, a wait time of 61 to 90 days, a wait time of 91 to 120 days, and a wait time of 121 to 180 days.

How long after surgery can you start chemo?

Ideally, it would seem that chemotherapy should be started if at all possible within 30 days of surgery, especially for those who have high risk tumors.

How long can you delay breast cancer?

Delaying for a lengthy period of time can be dangerous, with studies finding that those who delay over six months are twice as likely to die from the disease. This is important to keep in mind for those who have breast lumps they are "observing" without a clear diagnosis. Any breast lump needs to be explained.

How soon after a diagnosis can you have surgery?

For women who are young (defined as 15 to 39), a 2013 study in JAMA Surgery suggested that young women should have surgery no more than six weeks after diagnosis and preferably earlier. This study of close to 9,000 women found 5-year survival rates as follows: 4 

Does triple negative tumor grow faster?

As noted, tumors that were triple negative or HER2 positive grew much faster. This was also linked to an increase in stage based on size between diagnosis and surgery, with 18 percent of triple-negative tumors increasing (higher tumor size) versus only 2 to 3 percent of estrogen receptor positive tumors changing. Since stage is linked with survival rates, this study also supports earlier surgery, especially for people with triple negative or HER2 positive tumors. 5 

Is it better to wait 30 days after breast cancer surgery?

The conclusion was the same as above—earlier surgery (ideally within 30 days) is better.

Can a mastectomie be done for breast cancer?

Newer procedures such as nipple-sparing/skin-sparing mastectomies are a great option for some women, but not all surgeons do these procedures. For young women with breast cancer, time to see a fertility specialist to talk about fertility preservation.

What to do if you are doubtful about your breast biopsy results?

When in doubt about your breast biopsy results, it’s best to speak with your oncologist.

What is a breast biopsy?

A breast biopsy involves taking a small sample of breast tissue so it can be examined under a microscope.

What percentage of breast biopsy results are benign?

The main result from a breast biopsy is whether the tissue sample contained cancer cells. Research from 2019 suggests that about 75 percent of breast biopsies performed in the United States come back with a benign (noncancerous) result.

What to do if pathology indicates breast cancer?

If the pathology report indicates breast cancer, it’s likely your next step will be to visit with a breast cancer specialist , such as a breast surgeon or oncologist.

What does it mean when a her2 positive test is positive?

Overexpression of HER2 can make breast cancer grow and spread faster. But a positive result means that your treatment can include drugs that target HER2.

What happens if you test positive for hormone receptors?

If your cancer tests positive for these hormone receptors (HR), the cancer is using hormones to fuel growth. This is important because it means you can benefit from hormone therapy.

What does it mean when a cancer sample is malignant?

A malignant result means that cancer cells were found in the sample. Your report will provide additional information about the cancer.

How long does it take for a biopsy to be done?

The pathology report, which can take one or two weeks to complete, is sent to the patient’s doctor.

How many women do not have breast cancer after a breast biopsy?

The good news is that 80% of women who have a breast biopsy do not have breast cancer.

What is the difference between a core biopsy and a stereotactic biopsy?

During an ultrasound-guided core needle biopsy, the patient lies down while the doctor holds the ultrasound against the breast to direct the needle. On the other hand, during a stereotactic-guided core-needle biopsy, the doctor uses x-ray equipment and a computer to guide the needle. Typically, the patient is positioned lying on the stomach on a special table that has an opening for the breast, and the breast is compressed, similar to a mammogram.

What is core needle biopsy?

What is a core-needle biopsy? Core needle biopsy is the procedure to remove a small amount of suspicious tissue from the breast with a larger “core” (meaning “hollow”) needle. It is usually performed while the patient is under local anesthesia, meaning the breast is numbed.

What does it mean when you find a lump in your breast?

Myth: Finding a lump in your breast means you have breast cancer. Myth: Men do not get breast cancer; it affects women only. Myth: A mammogram can cause breast cancer to spread. Myth: If you have a family history of breast cancer, you are likely to develop breast cancer, too. Myth: Breast cancer is contagious.

What is a biopsy of breast?

A breast biopsy is a test that removes tissue or sometimes fluid from the suspicious area. The removed cells are examined under a microscope and further tested to check for the presence of breast cancer. A biopsy is the only diagnostic procedure that can definitely determine if the suspicious area is cancerous.

What is a close margin on a biopsy?

A close margin means that the space between the cancerous tissue and surrounding normal tissue is less than about 3 millimeters (0.118 inch). If you have a biopsy resulting in a cancer diagnosis, the pathology report will help you and your doctor talk about the next steps.

What is the role of a pathologist after a biopsy?

After a biopsy, your health care team completes several steps before the pathologist makes a diagnosis. A pathologist is a doctor who specializes in reading laboratory tests and looking at cells, tissues, and organs to diagnose disease.

What is a biopsy specimen?

The tissue sample removed during a biopsy is called a specimen. The medical staff who perform your biopsy place the specimen in a container with a fluid to preserve it. They label the container with your name and other details. A pathologist then describes how it looks to the naked eye. This includes the color, size, and other features. This is called a gross or macroscopic examination. The gross description includes the following information: 1 The label written by the doctor who took the specimen 2 Visual features 3 Size 4 What was done to the specimen

What is the tissue sample called when you take a biopsy?

Looking at the tissue sample. The tissue sample removed during a biopsy is called a specimen. The medical staff who perform your biopsy place the specimen in a container with a fluid to preserve it. They label the container with your name and other details. A pathologist then describes how it looks to the naked eye.

How to examine tissue with a microscope?

They are then stained with various dyes, which show the parts of the cells. The pathologist or technician places the sections on a glass slide. Next, they place a thin cover called a cover slip on top to hold the specimen in place. The pat hologist will then look at the sections under a microscope.

How long does a specimen stay in a fixative?

To create a permanent section, the technician places the specimen in a fixative for several hours. A fixative is a substance that keeps the specimen “fixed” so that it does not change. The length of time the specimen stays in the fixative depends on its size. Formalin is the fixative used most often.

How long does it take to tell if a frozen section is cancerous?

The quality of a frozen section is often not as good as a permanent section. But the process is faster. It takes just a few minutes for the doctor to tell whether the tissue is cancerous.

Can patients review their pathology report?

Patients can review their pathology reports with their health care team. It helps to have some basic information about the technical words used in the report. Here are some words that may be used. Learn more about reading a pathology report.

What type of cancer needs to be treated right away?

You have a type of cancer that needs to be treated right away, like some leukemias, lymphomas, and certain other cancers that tend to be aggressive (grow and spread very fast). You have a tumor that's pressing on an organ or other vital part of the body, and treatment is needed to relieve the pressure.

Do you need to make adjustments before starting treatment?

You want more time to get a second opinion. It's important to know each person's case is different.

Can you wait to get lab results back?

You are waiting to get lab results back that will help decide what treatment option is best. You have already had surgery to remove a tumor, and you need time to recover before starting more treatment. You need to make adjustments at home, work, or for child care before starting treatment.

Does cancer need to be started right away?

Does cancer treatment always need to be started right away? Sometimes, it's important to start treatment as quickly as possible, but that's not always the case. Planning cancer treatment can be complex and might take some time, depending on the type and stage of your cancer.

How long does breast cancer treatment last?

Almost any cancer treatment can have side effects. Some might only last for a few days or weeks, but others might last a long time.

How long after cancer treatment do side effects show?

Some side effects might not even show up until years after you have finished treatment. Visits with your doctor are a good time for you to ask questions and talk about any changes or problems you notice or concerns you have. However, if you have additional concerns about your cancer, you do not have to wait until your next scheduled visit.

Why do you need a pelvic exam after breast cancer surgery?

Pelvic exams: If you are taking either of the hormone drugs tamoxifen or toremifene and still have your uterus, you should have pelvic exams every year because these drugs can increase your risk of uterine cancer.

Why aren't breast cancer tests included in follow up?

Other tests: Other tests such as blood tests and imaging tests (like bone scans and chest x-rays) are not a standard part of follow-up because they haven’t been shown to help a woman who's been treated for breast cancer live longer.

What factors affect follow up on breast cancer?

Your follow-up schedule can depend on many factors, including the type of breast cancer, how advanced it was when it was found, and how it was (or is being) treated.

What happens if cancer comes back?

If cancer does return, your treatment options will depend on where it comes back, what treatments you've had before, and your current health and preferences. For more information on how recurrent cancer is treated, see Treatment of Recurrent Breast Cancer .

What tests can be done to detect cancer?

If symptoms, exams, or tests suggest a possible recurrence of your cancer, imaging tests such as an x-ray, CT scan, PET scan, MRI scan, bone scan, and/or a biopsy may be done. If the cancer recurrence is confirmed, your doctor may also look for circulating tumor cells in the blood, or measure levels of blood tumor markers such as CA-15-3, CA 27-29, or CEA. The blood levels of tumor markers go up in some women if their cancer recurs or has spread to other parts of the body. If a tumor marker level is high, your doctor might use it to monitor the results of treatment. But tumor marker levels don’t go up in all women, so these tests aren't always helpful, and they aren't used to watch for cancer recurrence in women without any symptoms.

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