The cost for arsenic trioxide intravenous solution (1 mg/mL) is around $158 for a supply of 10 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans. This arsenic trioxide price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
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Intravenous Solution.
| Quantity | Per unit | Price |
|---|---|---|
| 20 (2 x 10 milliliters) | $61.06 | $1,221.26 |
| 100 (10 x 10 milliliters) | $38.76 – $60.68 | $3,875.81 – $6,068.30 |
What is arsenic trioxide (ATO)?
3 rows · The cost for arsenic trioxide intravenous solution (1 mg/mL) is around $158 for a supply of 10 ...
What are the side effects of arsenic trioxide?
A) Inhalation is the most common exposure in arsenic workers. OSHA has set an "action level" of 5 mcg/m(3) of inorganic arsenic in the air over an 8-hour period. Initial treatment should be to remove the patient from the exposure and refer the patient to an occupational specialist for 24-hour urine collection.
How is arsenic trioxide used to treat leukaemia?
Mar 09, 2017 · Recently, a single dose of arsenic trioxide (As 2 O 3) has been found especially effective in treating acute promyelocytic leukemia (APL). Generally speaking, As 2 O 3 is a more effective treatment of APL than other, newer medications and has less severe adverse reactions and greater safety.
Where can I find FDA label information for arsenic trioxide?
Nov 19, 2020 · How to Take Arsenic Trioxide Arsenic trioxide is given by intravenous (into a vein) infusion. Your specific dose will depend on your body size. Your treatment schedule will depend upon where you are in your treatment course. Possible Side Effects There are a number of things you can do to manage the side effects of arsenic trioxide.
How much does treatment for acute promyelocytic leukemia cost?
The base-case results for first-line APL treatment are presented in Table 4, ordered from least expensive to most expensive. Total costs per patient ranged from $96,940 for the ATRA + AraC + additional chemotherapy regimen to $136,170 for the ATO + ATRA regimen.Aug 5, 2015
Can APL be completely cured?
Acute promyelocytic leukemia (APL) has become a curable disease by all-trans retinoic acid (ATRA)-based induction therapy followed by two or three courses of consolidation chemotherapy. Currently around 90% of newly diagnosed patients with APL achieve complete remission (CR) and over 70% of patients are curable.Jul 29, 2003
How is arsenic trioxide administered?
Arsenic trioxide comes as a solution (liquid) to be injected into a vein by a doctor or nurse in a medical office or clinic. Arsenic trioxide is usually injected over 1 to 2 hours, but it may be injected over as long as 4 hours if side effects are experienced during the infusion.Aug 15, 2019
How long does arsenic trioxide stay in your system?
You have arsenic trioxide as a drip into the bloodstream. The drip lasts for between 1 and 2 hours. But if you have a reaction to the drip you may have it more slowly over 4 hours.
What is the most treatable leukemia?
While it is similar in many ways to the other subtypes, APL is distinctive and has a very specific treatment regime. Treatment outcomes for APL are very good, and it is considered the most curable type of leukemia.Nov 14, 2019
How long can you live with APL leukemia?
APL is now considered a highly curable disease, with 2-year event-free survival rates of 75–84%. Early mortality is common in APL and is frequently related to hemorrhagic complications. Prior to ATRA therapy, early death (ED) related to hemorrhage occurred in up to 26% of cases.
Does Ato cause hair loss?
It does not cause hair loss and is not myelosuppressive in patients with APL. Oncology nurses can play a major role in educating patients about this new drug, explaining its clinical benefits and side effects and the precautions that are necessary for its use.
What is the best treatment for acute promyelocytic leukemia?
The most important drugs for treating APL are non-chemo drugs called differentiating agents, like all-trans-retinoic acid (ATRA). Other treatments might include chemotherapy (chemo) and transfusions of platelets or other blood products.Aug 21, 2018
Is arsenic trioxide chemo?
ARSENIC TRIOXIDE (AR se nik trye OX ide) is a chemotherapy drug. It slows the growth of cancer cells. This medicine is used to treat acute promyelocytic leukemia (APL).
What is APL in cancer?
Acute promyelocytic leukemia (APL) in patients whose cancer has a certain type of chromosome mutation that affects the PML gene and RARA gene. It is used: In adults with newly diagnosed APL that is low risk. In patients whose disease has not gotten better or has relapsed after retinoid and anthracycline chemotherapy.
Why are drugs studied?
Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.
Is a syringe a substitute for medical advice?
It is not a substitute for medical advice. The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. Please see your health care professional for more information about your specific medical condition and the use of this drug.
What are the side effects of a syringe?
Less common, but important side effects can include: 1 Allergic Reactions : In some cases, patients can have an allergic reaction to this medication. Signs of a reaction can include: shortness of breath or difficulty breathing, chest pain, rash, flushing or itching or a decrease in blood pressure. If you notice any changes in how you feel during the infusion, let your nurse know immediately. 2 Secondary Cancers: A secondary cancer is one that develops as a result of cancer treatment for another cancer. This is quite rare, but you should be aware of the risk. In most cases, a secondary cancer related to chemotherapy is a blood cancer (leukemia, lymphoma). This can occur years after treatment. This is most often associated with repeated treatments or high doses. Your provider will monitor your labs closely. Consider having a complete blood count with differential checked annually by your healthcare provider if you received high risk therapies. 3 Liver Toxicity: This medication can cause liver toxicity, which your oncology care team may monitor for using blood tests called liver function tests. Notify your healthcare provider if you notice yellowing of the skin or eyes, your urine appears dark or brown, or you have pain in your abdomen, as these can be signs of liver toxicity.
How to tell if you have a reaction to a syringe?
Signs of a reaction can include: shortness of breath or difficulty breathing, chest pain, rash, flushing or itching or a decrease in blood pressure. If you notice any changes in how you feel during the infusion, let your nurse know immediately.
What foods can help with diarrhea?
Also, try eating low-fiber, bland foods, such as white rice and boiled or baked chicken. Avoid raw fruits, vegetables, whole grain breads, cereals and seeds. Soluble fiber is found in some foods and absorbs fluid, which can help relieve diarrhea.
How to help nausea and vomiting from oncology?
Talk to your oncology care team so they can prescribe medications to help you manage nausea and vomiting. In addition, dietary changes may help. Avoid things that may worsen the symptoms, such as heavy or greasy/fatty, spicy or acidic foods (lemons, tomatoes, oranges). Try saltines, or ginger ale to lessen symptoms.
Can you take electrolytes with a blood test?
This medication can affect the normal levels of electrolytes in your body. Your levels will be monitored using blood tests. If your levels become too low, your care team may prescribe specific electrolytes to be given by IV or taken by mouth. Do not take any supplements without first consulting with your care team.
How to manage fatigue after cancer treatment?
While on cancer treatment, and for a period after, you may need to adjust your schedule to manage fatigue. Plan times to rest during the day and conserve energy for more important activities . Exercise can help combat fatigue; a simple daily walk with a friend can help.
Can chemo cause cancer?
In most cases, a secondary cancer related to chemotherapy is a blood cancer (leukemia, lymphoma). This can occur years after treatment. This is most often associated with repeated treatments or high doses. Your provider will monitor your labs closely.
What are the side effects of arsenic trioxide?
Numbness or tingling of hands or feet. Chills (see flu-like symptoms) Anxiety . Shivering or a sudden feeling of cold. Increase in the number of white blood cells in the blood. These side effects are less common side effects (occurring in about 10-29%) of patients receiving arsenic trioxide: Constipation. Chest pain.
How does arsenic trioxide work?
How Arsenic Trioxide Works: Arsenic is a naturally occurring element widely distributed in the earth's crust. In the environment, arsenic is combined with oxygen, chlorine, and sulfur to form inorganic arsenic compounds. Arsenic in animals and plants combines with carbon and hydrogen to form organic arsenic compounds.
What is the generic name for Trisenox?
Arsenic trioxide is the generic name for the trade name drug Trisenox®. In some cases, health care professionals may use the trade name Trisenox® when referring to the generic drug name Arsenic Trioxide.
Can arsenic be destroyed?
Arsenic cannot be destroyed in the environment; it can only change its form. Arsenic in the air will settle to the ground or is washed out of the air by rain. Many arsenic compounds can dissolve in water. Fish and shellfish can accumulate arsenic, but this arsenic is mostly in a form that is not harmful.
Is arsenic poisonous to humans?
Lower levels of arsenic can cause nausea and vomiting, decreased red and white blood cells, abnormal heart rhythm, and numbness and tingling in the hands and feet. Organic arsenic compounds are less toxic than inorganic arsenic.
Does arsenic trioxide cause leukemia?
The mechanism of action of arsenic trioxide is not well understood. There is speculation that it causes death of leukemia cells via morphological changes and DNA fragmentation. Arsenic Trioxide also damages or degrades the fusion protein promyelocytic leukemia (PML) - retinoic acid receptor (RAR) alpha.
How to treat a sore in the mouth?
To help treat/prevent mouth sores, use a soft toothbrush, and rinse three times a day with 1/2 to 1 teaspoon of baking soda and/or 1/2 to 1 teaspoon of salt mixed with 8 ounces of water. Use an electric razor and a soft toothbrush to minimize bleeding. Avoid contact sport or activities that could cause injury.
How long does arsenic trioxide last?
Or if your treatment has come back (relapsed) or not gone away (refractory). You have it for 5 days a week with a 2 day break, for 4 to 5 weeks.
How long can you stay off live shots?
Don’t have immunisations with live vaccines while you’re having treatment and for up to 12 months afterwards. The length of time depends on the treatment you are having. Ask your doctor or pharmacist how long you should avoid live vaccinations.
What are the effects of a syringe?
Each of these effects happens in between 1 and 10 out of 100 people (1 and 10%). You might have one or more of them. They include: 1 increased risk of getting an infection 2 breathlessness and looking pale due to a low number of red blood cells carry oxygen around your blood 3 bruising, bleeding gums or nosebleeds due to a low number of platelets in your blood 4 fluid around the heart or lungs 5 weight gain 6 kidney changes - you will have regular blood tests to check this 7 eye changes such as blurred vision 8 low blood pressure 9 seizures 10 herpes virus 11 chills 12 tummy (abdominal) pain 13 bone and joint pain 14 high number of white blood cells in your blood (leucocytosis) 15 a build up of a substance called ketones in the blood and urine (ketoacidosis) 16 inflammation of the blood vessels 17 chest pain 18 bleeding in the lung 19 reddening of the skin 20 swollen face (oedema) 21 sudden sharp, stabbing or burning pain in the chest when you take a breath in or breathe out
Why do you have to have a blood test?
You have regular blood tests to check for any changes in the way your liver is working. Less commonly your blood might show high levels of bilirubin in the blood. You have regular blood tests to check for any changes in the levels of chemicals produced by the liver.
What do they check before and during a chemo treatment?
You have blood tests before and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.
How long does a central line last?
It stays in while you’re having treatment, which may be for a few months. Find out about central lines.
Can you get numbness in your fingers after a syringe?
Numbness or tingling in fingers or toes is often temporary and can improve after you finish treatment. Tell your doctor if you're finding it difficult to walk or complete fiddly tasks such as doing up buttons.
What is arsenic trioxide used for?
What is arsenic trioxide? Arsenic trioxide is used to treat a cancer of the blood and bone marrow called acute promyelocytic (pro-MYE-loe-SIT-ik) leukemia , or APL. Arsenic trioxide is sometimes given in combination with another medicine called tretinoin.
How long does it take for arsenic trioxide to kill you?
This condition may occur within 1 days to 2 months after you start taking arsenic trioxide.
Is arsenic trioxide a cancer drug?
Arsenic trioxide is given as an infusion into a vein. A healthcare provider will give you this injection. You may need frequent medical tests to be sure arsenic trioxide is not causing harmful effects. Your cancer treatments may be delayed based on the results.
Can you delay treatment for cancer?
Your cancer treatments may be delayed based on the results. You may be given other medications to help prevent serious side effects or allergic reaction. Keep using these medicines for as long as your doctor has prescribed. You must remain under the care of a doctor while you are using arsenic trioxide.
Can arsenic trioxide cause heart problems?
Arsenic trioxide can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.
What are the symptoms of a rash?
fever, cough, trouble breathing; dizziness; rash; decreased urination; rapid weight gain; or. swelling in your arms or legs. Also call your doctor right away if you have: fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);
Can low potassium cause leg cramps?
low potassium --leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling. trouble sleeping. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
