Treatment FAQ

how much hydroxychloroquine for covid treatment

by Kaley Wiegand II Published 2 years ago Updated 2 years ago
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In an open-label trial, Mitja et al. randomized 307 nonhospitalized people who were recently confirmed to have COVID-19 to receive hydroxychloroquine or no antiviral treatment. Patients in the hydroxychloroquine arm received hydroxychloroquine 800 mg on Day 1 followed by 400 mg daily for an additional 6 days.Jul 8, 2021

What are some of the medications that I can take to reduce the symptoms of COVID-19?

Acetaminophen (Tylenol), ibuprofen (Advil, Motrin) and naproxen (Aleve) can all be used for pain relief from COVID-19 if they are taken in the recommended doses and approved by your doctor.

What is the first drug that was approved by the FDA to treat COVID-19?

Remdesivir is the first drug approved by the FDA for treatment of hospitalized COVID patients over the age of 12.

What is the pill Paxlovid used for in COVID-19?

Paxlovid is an oral antiviral pill that can be taken at home to help keep high-risk patients from getting so sick that they need to be hospitalized. So, if you test positive for the coronavirus and a health care provider writes you a prescription, you can take pills at home and lower your risk of going to the hospital.

What is the latest medication for COVID-19?

Paxlovid is the latest COVID-19 treatment that's been all over the news. The drug was granted an emergency use authorization (EUA) by the Food and Drug Administration (FDA) in December for anyone ages 12 and older who weighs at least 88 pounds, and is at high risk for severe disease.

What is Remdesivir?

Remdesivir is in a class of medications called antivirals. It works by stopping the virus from spreading in the body.

When was the COVID-19 treatment Paxlovid approved by the FDA?

FDA authorized Paxlovid (nirmatrelvir and ritonavir) in December 2021 for the treatment of mild-to-moderate COVID-19 in adults and pediatric patients (12 years of age and older weighing at least 40 kg) with positive results of direct SARS-CoV-2 viral testing who are also at high risk for progression to severe COVID-19

What is the Paxlovid COVID-19 rebound?

Paxlovid is the leading oral medication for preventing severe cases of COVID-19 in high-risk individuals. However, symptoms returned in some patients after treatment was completed, prompting the Centers for Disease Control and Prevention (CDC) to issue a health advisory on this so-called “COVID-19 rebound.”

Can COVID-19 symptoms rebound after using Paxlovid?

Study finds few COVID-19 patients get rebound symptoms after Paxlovid treatment.

How often can you take the COVID-19 treatment Paxlovid?

How often do I take Paxlovid? You take three Paxlovid pills twice daily for five days for a full course that adds up to 30 pills. It helps that the pills are packaged in a “dose card,” basically a medication blister pack that allows you to punch out the pills as needed.

What are some treatments for COVID-19?

Remdesivir (Veklury; Gilead) was the first drug approved by the FDA for treating the SARS-CoV-2 virus. It is indicated for treatment of COVID-19 disease in hospitalized adults and children aged 12 years and older who weigh at least 40 kg. The broad-spectrum antiviral is a nucleotide analog prodrug.

Is Remdesivir approved to treat COVID-19?

Remdesivir is a nucleotide analogue prodrug that is approved to treat COVID-19 in certain patients.

What are some medications that are safe to take with the COVID-19 vaccine?

Taking one of the following medications is not, on its own, a reason to avoid getting your COVID-19 vaccination:• Over-the-counter medications (non-prescription)• Non-steroidal anti-inflammatory drugs (NSAIDs) (naproxen, ibuprofen, aspirin, etc.)• Acetaminophen (Tylenol, etc.)

Side Effects

  • In some people, HCQ may cause gastrointestinal problems, such as nausea, vomiting, upset stomach, cramps, or diarrhea. These may occur for the first few days a person takes the drug while the body adjusts to the medication. Loss of appetite, tiredness, weakness, or headache are uncommon side effects and typically go away over time.
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  • Plaquenil is associated with potential side effects, one of which is particularly worrisome to people who have been prescribed the drug. Safe use helps to minimize undesirable side effects. Plaquenil is generally well-tolerated, but side effects are possible. Common side effects linked to Plaquenil include nausea and diarrhea. Taking the medication with food eases nausea for most …
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  • Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. It is imperative that patients and physicians are aware of and watch for this drugs ocular side effects. And before treatment is initiated with hydroxychloroquine, a complete ophthalmic examination should be performed to d…
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  • Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect. 1. Disturbances of the gut such as diarrhoea, nausea, vomitin…
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Treatment

  • For prevention or treatment of malaria in infants and children, the amount of hydroxychloroquine is based on the child's weight. Your doctor will calculate this amount and tell you how much hydroxychloroquine your child should receive.
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  • Baseline examination. At the initiation of treatment with hydroxychloroquine, the prescribing physician should refer the patient to an ophthalmologist. During the initial examination, it is recommended that the patient receive:
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Description

  • Hydroxychloroquine comes as a tablet to take by mouth. For prevention of malaria in adults, two tablets are usually taken once a week on exactly the same day of each week. The first dose is taken 1 to 2 weeks before traveling to an area where malaria is common, and then doses are continued for 8 weeks after exposure. For treatment of acute attacks of malaria in adults, four ta…
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Results

  • If you are taking hydroxychloroquine for symptoms of rheumatoid arthritis, your symptoms should improve within 6 months. If your rheumatoid arthritis symptoms do not improve, or if they worsen, stop taking the drug and call your doctor. Once you and your doctor are sure the drug works for you, do not stop taking hydroxychloroquine without talking to your doctor. Symptoms of rheuma…
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  • Plaquenil is a slow-acting drug. People who take Plaquenil may begin to notice improvement after one or two months. It may take up to six months before the full benefits of Plaquenil are realized.
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  • Toxicity: suspected and confirmed. Whenever you note abnormalities, obtain additional testing. Repeat visual fields promptly if you see central or parafoveal changes, even if these appear to be nonspecific. If these findings are reproducible, follow up with objective testing. If toxicity is suspected, perform more frequent and detailed examinations. Once toxicity is confirmed, the pr…
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Risks

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
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  • The aforementioned rare side effect that affects vision (hydroxychloroquine retinopathy), if caught early, may improve after discontinuation of Plaquenil. Since the side effect of vision loss is possible but rare, it is important for you to tell your doctor about any vision changes that you experience. Doctors generally recommend regular eye exams while on Plaquenil, so that early ch…
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  • It is critical to counsel patients about the benefits and limitations of screening, underscoring that it can catch toxicity at early stages and minimize vision loss but cannot necessarily prevent all toxicity and vision loss.
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Prevention

  • Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, t…
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  • If you are pregnant or considering becoming pregnant, discuss Plaquenil with your doctors. Though Plaquenil is generally regarded as safe during pregnancy, it is recommended that effective birth control is used throughout the course of Plaquenil treatment and for up to six months after treatment is stopped.
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  • Ongoing monitoring. Encourage the patient to obtain an annual ophthalmic examination as part of the screening process. Since toxicity is rare within the first five years of treatment, ancillary testing is not necessary unless abnormalities are noted on baseline examination. However, earlier, more frequent screening may be prudent for those at higher risk for toxicity. After five years of tr…
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Benefits

  • Research into the wide-ranging effects of hydroxychloroquine has revealed many important benefits in the treatment of lupus; it must be noted that these benefits may be less effective in people who smoke (Arthritis Care & Research 2010; 62:393–400). Benefits include: 1. Decrease in the number of disease flares. 2. Decrease in damage from disease over time. 3. Ability to delay …
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  • Plaquenil has been associated with additional beneficial properties in people with rheumatic disease. In people treated with Plaquenil as a disease-modifying antirheumatic drug, the drug was found to have other beneficial effects. Plaquenil was found to improve lipid profiles, control glucose and reduce the risk of diabetes mellitus, and lower the risk of thrombosis in certain peo…
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Use

  • For lupus erythematosus, one or two tablets are usually taken once or twice daily. For rheumatoid arthritis, one to three tablets are usually taken once a day. Hydroxychloroquine is used occasionally to treat porphyria cutanea tarda. Talk to your doctor about the possible risks of using this drug for your condition.
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Administration

  • Hydroxychloroquine can be taken with a glass of milk or a meal to decrease nausea. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take hydroxychloroquine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
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  • The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It's important to watch for possible side effects and toxicity. For people who weigh less than 80 kg, …
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History

  • The origin of antimalarials dates back to the 1630s in Peru. The bark from the \"fever tree' was found to contain the antimalarial compound, quinine. In 1820, chemists purified the quinine from the bark. Fast forward to 1951, when there was anecdotal evidence of improvement in lupus and rheumatoid arthritis by WWII Allied troops who were taking a synthetic form of quinine, called qu…
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