Median concentration of CA-125 after first-line therapy was 10 U/ml. Increasing CA-125 concentration by > 5 U/ml, 3 and 6 months after the treatment was associated with higher risk of relapse (HR = 7.6, p < 0.0001 and HR = 5.29, p < 0.0001 respectively). 5-year survival rate was significantly lower in patients with increased CA-125 by 5 U/ml, 3 and 6 months after therapy (56.79% vs 0 and 50.62% vs 15.55%).
Does the CA125 level change during treatment?
As a result, CA125 levels and changes in CA125 levels during treatment have been extensively investigated.
Can a ca 125 spike after chemotherapy be an early prognostic parameter?
If CA 125 increases within days after chemotherapy, the increase may be caused by death of the cancer cells. It was therefore speculated if a CA 125 spike may serve as an early prognostic parameter.
Does your CA level fluctuate?
Yes, it fluctuates, even within normal range. Just finished taking antibiotics for UTI, had new bloods and found antibiotics drove CA down by 60%! An infection of any kind can make your CA rise. Tesla You may also like...
Does CA-125 fluctuations in ovarian cancer patients with complete response mean anything?
Even minor increase in CA-125 concentration is associated with patients’ anxiety and difficult interpretation and counselling for clinicians. The aim of this study was to evaluate the significance of CA-125 fluctuations within reference level in patients who suffered from ovarian cancer with complete response after first-line treatment.
Is it normal for CA-125 to fluctuate?
So, CA 125 values can and do fluctuate. Major treatment decisions, such as changing or discontinuing treatment, depend on multiple factors that you and your physician will consider. The trend in your CA 125 values is only one of these factors.
How much should CA-125 go down after chemo?
Therefore, half-life=ln 2×(t2-t1)/ln C1/C2. C1 was the CA125 value before the first treatment, and C2 was the value at which CA125 decreased to <35 U/mL for the first time. If the CA125 level never decreased to <35 U/mL within three months of starting chemotherapy, the lowest value during that period was selected.
What causes CA-125 to fluctuate?
Conditions that can cause an increase in CA 125 include many that aren't cancerous, such as menstruation and uterine fibroids. Certain cancers may also cause an increased level of CA 125 , including ovarian, endometrial, peritoneal and fallopian tube cancers.
How fast does CA-125 increase?
The average time from serum CA125 increase to detection of a recurrent lesion by physical or imaging examination was about 3 months. It is not recommend chemotherapy when patients serum CA125 increased alone after post-treatment.
Does CA 125 rise after treatment finishes?
Conclusions. Increase of CA-125 serum concentration by > 5 U/ml within the normal range 3 and 6 months after the end of treatment in patients who achieved complete remission is independent poor prognostic factor and significantly raises the risk of OC recurrence and risk of death.
Can CA 125 levels go down?
If testing shows your CA-125 levels have gone down, it usually means the cancer is responding to treatment. If your levels go up or stay the same, it may mean the cancer is not responding to treatment. If you have finished your treatment for ovarian cancer, high CA-125 levels may mean your cancer has come back.
How often should CA-125 be checked?
It's typically ordered every two to four months for the first two years following the completion of cancer treatment. After this period, the test is ordered every six months for three years and then once per year. Some doctors may recommend the CA-125 blood test to women with a strong family history of ovarian cancer.
Can Covid increase CA-125?
Recently, one retrospective study found that among all admitted patients with coronavirus disease 2019 (COVID-19) infection, increases in CA 125 and other cancer biomarkers were associated with severe COVID-19 infection (Wei et al., 2020).
How accurate is CA-125 blood test?
Results: Using a CA125 cutoff of 30 U/mL, an overall sensitivity of 94.8% (96.6% specificity) was obtained when comparing malignancies versus healthy postmenopausal controls, whereas a cutoff of 65 U/mL provided a sensitivity of 83.9% (99.6% specificity).
Can CA-125 go up during chemo?
The present investigation was inspired by studies describing a paradoxical increase of tumor markers (CEA, CA 125, and CA 15-3) in the days after chemotherapy of women with breast cancer. If CA 125 increases within days after chemotherapy, the increase may be caused by death of the cancer cells.
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The Ovarian Cancer Support Community connects patients, families, friends and caregivers for support and inspiration. This community is sponsored by the Ovarian Cancer Research Alliance, an Inspire trusted partner.
About this Community
The Ovarian Cancer Support Community connects patients, families, friends and caregivers for support and inspiration. This community is sponsored by the Ovarian Cancer Research Alliance, an Inspire trusted partner.
How long before appointment for CA 125?
CA-125 assay was performed up to 14 days before appointment. Laboratory tests were performed with electrochemiluminescence immunoassay using the cobas e 601 analyzer (Roche Diagnostics) according to manufacturer’s protocol [ 20 ]. Based on CA-125 changes in concentration after end of the treatment, 3 groups of patients were established:
What is CA 125?
CA-125 is a tumor marker of ovarian cancer that plays a significant role in making clinical decisions. Many studies assessed the importance of a single CA-125 measurement [ 7, 8, 9, 10, 11, 12, 13 ], while number of studies that analyzed the multiple evaluation of this marker is limited. Conducting such studies is challenging, as they long term follow up, large number of variables and due to difficulties in interpretation of the data. A further effort is related to the need of use of complex mathematical and statistical models. On the other hand, multiple measurements of tumor marker concentration yield additional information that cannot be obtained in a single assay. Such model can be used in screening, assessment of treatment effectiveness, prediction of relapse and overall survival.
How long does it take for OC to recur?
Based on this classification (not only) second-line chemotherapy is made. While detection of OC recurrence is made more than 12 months after the end of treatment , increase of CA-125 concentration within the normal range in the first months after treatment may indicate resistance to platinum-based chemotherapy.
Is CA 125 normal after first line?
In clinical practice alterations in CA-125 concentration within normal range in patients with ovarian cancer after first-line treatment are common. Even minor increase in CA-125 concentration is associated with patients’ anxiety and difficult interpretation and counselling for clinicians. The aim of this study was to evaluate the significance of CA-125 fluctuations within reference level in patients who suffered from ovarian cancer with complete response after first-line treatment.
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