The total dose is 300 mg/kg, given as 3 separate doses, administered over a total of 21 hrs. Dose preparation is weight based: 5 to 20 kg: Loading Dose: 150 mg/kg in 3 mL/kg diluent, infused over 1 hour
How much acetylcysteine do you put in a nebulizer?
Nebulized into a tent. You will need to use enough acetylcysteine (10% or 20%) to maintain a heavy mist in the tent for the length of time your doctor prescribes. You may use as much as 300 mL of acetylcysteine during a single treatment.
How much acetylcysteine can I use in one treatment?
You may use as much as 300 mL of acetylcysteine during a single treatment. It has not been confirmed that this drug is safe and effective for use in children younger than 18 years.
How much acetylcysteine should I take before a bronchoscopy?
Adults and children—1 to 2 mL of a 20% solution or 2 to 4 mL of a 10% solution used for inhalation or placed directly into the trachea two or three times before the test. If you miss a dose of acetylcysteine, take it as soon as possible.
How is acetylcysteine given in a hospital?
It is usually given by inhalation but may be given in other ways in a hospital. Acetylcysteine is used for certain lung conditions when increased amounts of mucus make breathing difficult. Acetylcysteine liquefies (thins) or dissolves mucus so that it may be coughed up. Sometimes the mucus may have to be removed by suction.
Can you Nebulize acetylcysteine?
Acetylcysteine comes as a solution (liquid) and concentrated solution to inhale by mouth using a nebulizer (machine that turns medication into a mist that can be inhaled). When using a nebulizer, it is usually used 3 to 4 times a day.
Can you Nebulize Mucomyst?
MUCOMYST may be administered using conventional nebulizers made of plastic or glass.
What is acetylcysteine 200 mg used for?
Acetylcysteine 200 mg Powder is used to treat: breathing difficulties caused by too much mucus in the lungs and airways or the mucus being too thick and sticky to cough up easily.
What is acetylcysteine 100 mg used for?
When inhaled by mouth, acetylcysteine is used to help thin and loosen mucus in the airways due to certain lung diseases (such as emphysema, bronchitis, cystic fibrosis, pneumonia). This effect helps you to clear the mucus from your lungs so that you can breathe easier.
Can you mix acetylcysteine and albuterol?
Interactions between your drugs No interactions were found between acetylcysteine and albuterol.
How do I give Mucomyst Neb?
Nebulization - Face Mask, Mouthpiece, Tracheostomy: When nebulized into a face mask, mouthpiece, or tracheostomy, 1 to 10 mL of the 20% solution or 2 to 20 mL of the 10% solution may be given every 2 to 6 hours; the recommended dose for most patients is 3 to 5 mL of the 20% solution or 6 to 10 mL of the 10% solution ...
Is acetylcysteine good for Covid?
N-acetylcysteine (NAC) has been used in clinical practice to treat critically ill septic patients, and more recently for COVID-19 patients. NAC has antioxidant, anti-inflammatory and immune-modulating characteristics that may prove beneficial in the treatment and prevention of SARS-Cov-2.
Can I take acetylcysteine 600 mg twice a day?
Our findings show that in Chinese patients with moderate-to-severe COPD, long-term use of N-acetylcysteine 600 mg twice daily can prevent exacerbations, especially in disease of moderate severity. Future studies are needed to explore efficacy in patients with mild COPD (GOLD I).
How do you take 600 mg acetylcysteine?
Swallow the capsule with a drink of water. The capsule should be taken after food. In patients with impaired kidney or liver function there is insufficient data on whether dosage adjustments are required.
Is acetylcysteine a bronchodilator?
Is acetylcysteine a bronchodilator? Acetylcysteine is not a bronchodilator because it does not relax your airway. Most people who take acetylcysteine will also be need to take a bronchodilator like albuterol or ipratropium.
Is acetylcysteine good for asthma?
Acetylcysteine inhalation solution is used to help break up thick, sticky mucus that can form in your airways if you have certain diseases. These diseases include bronchitis, pneumonia, emphysema, asthma, cystic fibrosis, and tuberculosis.
Can NAC worsen asthma?
Asthma—Acetylcysteine may make the condition worse.
How much mucus is in a nebulizer?
To thin or dissolve mucus in lung diseases: Adults and children—. 3 to 5 milliliters (mL) of a 20% solution or 6 to 10 mL of a 10% solution used in a nebulizer three or four times a day. The medicine is inhaled through a face mask, mouthpiece, or tracheostomy.
Can you use acetylcysteine more than once?
Use acetylcysteine only as directed. Do not use more of it and do not use it more often than your doctor ordered. To do so may increase the chance of side effects. If you are using this medicine at home, make sure you understand exactly how to use it. If you have any questions about this, check with your doctor.
How much acetylcysteine is in a glass vial?
Acetylcysteine is available in rubber stoppered glass vials containing 4, 10, or 30 mL. The 20% solution may be diluted to a lesser concentration with either Sodium Chloride Injection, Sodium Chloride Inhalation Solution, Sterile Water for Injection, or Sterile Water for Inhalation. The 10% solution may be used undiluted.
When three fourths of the initial volume of acetylcysteine solution has been ne
When three fourths of the initial volume of acetylcysteine solution has been nebulized, a quantity of Sterile Water for Injection, USP (approximately equal to the volume of solution remaining) should be added to the nebulizer. This obviates any concentration of the agent in the residual solvent remaining after prolonged nebulization.
What happens if you cough with acetylcysteine?
After proper administration of acetylcysteine, an increased volume of liquified bronchial secretions may occur. When cough is inadequate, the open airway must be maintained open by mechanical suction if necessary. When there is a mechanical block due to foreign body or local accumulation, the airway should be cleared by endotracheal aspiration, with or without bronchoscopy. Asthmatics under treatment with acetylcysteine should be watched carefully. Most patients with bronchospasm are quickly relieved by the use of a bronchodilator given by nebulization. If bronchospasm progresses, the medication should be discontinued immediately.
How long does it take for acetaminophen to be absorbed?
(Antidotal) Acetaminophen is rapidly absorbed from the upper gastrointestinal tract with peak plasma levels occurring between 30 and 60 minutes after therapeutic doses and usually within 4 hours following an overdose. The parent compound, which is nontoxic, is extensively metabolized in the liver to form principally the sulfate and glucuronide conjugates which are also nontoxic and are rapidly excreted in the urine. A small fraction of an ingested dose is metabolized in the liver by the cytochrome P-450 mixed function oxidase enzyme system to form a reactive, potentially toxic, intermediate metabolite which preferentially conjugates with hepatic glutathione to form the nontoxic cysteine and mercapturic acid derivatives which are then excreted by the kidney. Therapeutic doses of acetaminophen do not saturate the glucuronide and sulfate conjugation pathways and do not result in the formation of sufficient reactive metabolite to deplete glutathione stores. However, following ingestion of a large overdose (150 mg/kg or greater) the glucuronide and sulfate conjugation pathways are saturated resulting in a larger fraction of the drug being metabolized via the P-450 pathway. The increased formation of reactive metabolite may deplete the hepatic stores of glutathione with subsequent binding of the metabolite to protein molecules within the hepatocyte resulting in cellular necrosis.
What is the chemical name for acetylcysteine?
The compound is a white crystalline powder with the molecular formula C 5 H 9 NO 3 S, a molecular weight of 163.2, and chemical name of N-acetyl-L-cysteine. Acetylcysteine has the following structural formula:
Does acetylcysteine have a mucolytic effect?
The mucolytic activity of acetylcysteine is unaltered by the presence of DNA, and increases with increasing pH.
Does acetylcysteine deacetylate?
Acetylcysteine undergoes rapid deacetylation in vivo to yield cysteine or oxidation to yield diacetylcystine. Occasionally, patients exposed to the inhalation of an acetylcysteine aerosol respond with the development of increased airways obstruction of varying and unpredictable severity.
Usual Adult Dose for Acetaminophen Overdose
Injectable: The total dose is 300 mg/kg, given as 3 separate doses, administered over a total of 21 hrs. Dose preparation is weight based: 5 to 20 kg: Loading Dose: 150 mg/kg in 3 mL/kg diluent, infused over 1 hour Second Dose: 50 mg/kg in 7 mL/kg diluent, infused over 4 hours Third Dose: 100 mg/kg in 14 mL/kg diluent, infused over 16 hours 21 to 40 kg: Loading Dose: 150 mg/kg in 100 mL diluent, infused over 1 hour Second Dose: 50 mg/kg in 250 mL diluent, infused over 4 hours Third Dose: 100 mg/kg in 500 mL diluent, infused over 16 hours 41 to 100 kg: Loading Dose: 150 mg/kg in 200 mL diluent, infused over 1 hour Second Dose: 50 mg/kg in 500 mL diluent, infused over 4 hours Third Dose: 100 mg/kg in 1,000 mL diluent, infused over 16 hours Over 100 kg: Loading Dose: 15,000 mg in 200 mL diluent, infused over 1 hour Second Dose: 5,000 mg in 500 mL diluent, infused over 4 hours Third Dose: 10,000 mg in 1,000 mL diluent, infused over 16 hours Compatible diluents: 5% Dextrose in Water, 0.45% Sodium Chloride Injection, and Sterile Water for Injection Comments: -Limited information is available regarding dosing patients weighing more than 100 kg; there are no specific studies. -The critical ingestion to treatment interval is 0 to 8 hours for maximal protection against severe hepatic injury. -Efficacy diminishes progressively after 8 hours. -Initiating treatment 15 to 24 hours post-ingestion yields limited efficacy, but does not appear to worsen the patient's condition and it should not be withheld, as reported ingestion time may not be correct. -Determine serum acetaminophen level at least 4 hours after ingestion of suspected overdose to determine the need for treatment with acetylcysteine. -If patient presents after 4 hours post-ingestion, determine the serum acetaminophen level immediately. -Administer within 8 hours from acetaminophen ingestion for maximal protection against hepatic injury for patients whose serum acetaminophen levels fall above the "possible" toxicity line on the Rumack-Matthew nomogram (line connecting 150 mcg/mL at 4 hours with 37.5 mcg/mL at 12 hours); the manufacturer product information should be consulted. -Administer immediately if time of ingestion is unknown, or serum acetaminophen level is not available/cannot be interpreted/is not available within 8 hours of ingestion. -Administer immediately if 24 hours or less have elapsed from the reported time of overdose, regardless of the ingested quantity reported. Use: Antidote for Acute Ingestion or Repeated Supratherapeutic Ingestion (RSI) acetaminophen overdose, to prevent or lessen hepatic injury after ingestion of a potentially hepatotoxic quantity of acetaminophen. ---- Oral administration of 20% solution for inhalation: Loading Dose: 140 mg/kg body weight, orally, once as a loading dose (see preparation instructions below) Maintenance Dose: 70 mg/kg body weight, orally, 4 hours after the loading dose and every 4 hours for 17 total doses, unless repeated acetaminophen assays reveal nontoxic levels (see preparation instructions below) Dose preparation is weight based: 100 to 109 kg/220 to 240 lb: Loading dose: 15 g (75 mL) in 225 mL diluent; total volume: 300 mL Maintenance Dose: 7.5 g (37 mL) in 113 mL diluent; total volume: 150 mL 90 to 99 kg/198 to 218 lb: Loading dose: 14 g (70 mL) in 210 mL diluent; total volume: 280 mL Maintenance Dose: 7 g (35 mL) in 105 mL diluent; total volume: 140 mL 80 to 89 kg/176 to 196 lb: Loading dose: 13 g (65 mL) in 195 mL) in 210 mL diluent; total volume: 260 mL Maintenance Dose: 6.5 g (33 mL) in 97 mL diluent; total volume: 130 mL 70 to 79 kg/154 to 174 lb: Loading dose: 11 g (55 mL) in 165 mL) in 210 mL diluent; total volume: 220 mL Maintenance Dose: 5.5 g (28 mL) in 82 mL diluent; total volume: 110 mL 60 to 69 kg/132 to 152 lb: Loading dose: 10 g (50 mL) in 150 mL) in 210 mL diluent; total volume: 200 mL Maintenance Dose: 5 g (25 mL) in 75 mL diluent; total volume: 100 mL 50 to 59 kg/110 to 130 lb: Loading dose: 8 g (40 mL) in 120 mL) in 210 mL diluent; total volume: 160 mL Maintenance Dose: 4 g (20 mL) in 60 mL diluent; total volume: 80 mL 40 to 49 kg/88 to 108 lb: Loading dose: 7 g (35 mL) in 105 mL) in 210 mL diluent; total volume: 140 mL Maintenance Dose: 3.5 g (18 mL) in 52 mL diluent; total volume: 70 mL 30 to 39 kg/66 to 86 lb: Loading dose: 6 g (30 mL) in 90 mL) in 210 mL diluent; total volume: 120 mL Maintenance Dose: 3 g (15 mL) in 45 mL diluent; total volume: 60 mL 20 to 29 kg/44 to 64 lb: Loading dose: 4 g (20 mL) in 60 mL) in 210 mL diluent; total volume: 80 mL Maintenance Dose: 2 g (10 mL) in 30 mL diluent; total volume: 40 mL Less than 20 kg (usually patients younger than 6 years), must calculate diluent volume: Loading dose: 140 g/kg Maintenance Dose: 70 g/kg -Add 3 mL of diluent to each 1 mL (200 mg) of 20% acetylcysteine solution -Do not decrease the proportion of diluent. Diluents: Dilute in diet cola or other diet soft drink; if giving via g-tube or Miller-Abbott tube, may dilute with water. Comments: -Administer immediately if 24 hours or less from ingestion of an overdose, regardless of the quantity of acetaminophen reported to have been ingested.
Usual Adult Dose for Diagnostic Bronchograms
Nebulized into a face mask, mouth piece, or tracheostomy: Recommended dosage: 3 to 5 mL of 20% solution, or 6 to 10 mL of 10% solution, 3 to 4 times a day Dosage range: 1 to 10 mL of 20% solution, or 2 to 20 mL of 10% solution, every 2 to 6 hours Nebulization tent, Croupette: Recommended dose: The volume of 10% or 20% solution that will maintain a very heavy mist in the tent or Croupette for the desired period. -This requires very large solution volumes, as much as 300 mL in a single treatment period. -Intermittent or continuous prolonged administration periods, including overnight, may be desirable. -Nebulization into a tent or Croupette must be individualized. -Take into account the available equipment. Direct Instillation: Dose range: 1 to 2 mL of 10% to 20% solution, as often as every hour. -Routine tracheostomy care: 1 to 2 mL of 10% to 20% solution, every 1 to 4 hours, instilled into the tracheostomy -Percutaneous intratracheal catheter: 1 to 2 mL of 20% solution, or 2 to 4 mL of 10% solution, every 1 to 4 hours, via a syringe attached to the catheter -Direct pulmonary installation: 2 to 5 mL of 20% solution --Introduce directly into a particular segment of the bronchopulmonary tree by inserting (under local anesthesia and direct vision) a small plastic catheter into the trachea; instill using a syringe connected to the catheter. Diagnostic Bronchograms: Recommended dosing: 1 to 2 mL of the 20% solution, or 2 to 4 mL of the 10% solution, by nebulization or by instillation intratracheally, two or three times prior to the procedure. Comments: -The 20% solution may be diluted to a lesser concentration with either Sodium Chloride Injection, Sodium Chloride Inhalation Solution, Sterile Water for Injection, or Sterile Water for Inhalation. -The 10% solution may be used undiluted. -Use compressed tank gas (air) or an air compressor to provide pressure for nebulizing the solution. -Oxygen may also be used but should be used with the usual precautions in patients with severe respiratory disease and CO2 retention. Use: Adjuvant therapy for abnormal, viscid, or inspissated mucous secretions, such as in: Chronic bronchopulmonary disease (chronic emphysema or asthmatic bronchitis, emphysema with bronchitis, tuberculosis, bronchiectasis, or primary pulmonary amyloidosis) Acute bronchopulmonary disease (pneumonia, bronchitis, tracheobronchitis) Pulmonary complications of cystic fibrosis Tracheostomy care Pulmonary complications associated with surgery Use during anesthesia Post-traumatic chest conditions Atelectasis due to mucous obstruction Diagnostic bronchial studies (bronchograms, bronchospirometry, and bronchial wedge catheterization).
Usual Adult Dose for Mucolytic
Nebulized into a face mask, mouth piece, or tracheostomy: Recommended dosage: 3 to 5 mL of 20% solution, or 6 to 10 mL of 10% solution, 3 to 4 times a day Dosage range: 1 to 10 mL of 20% solution, or 2 to 20 mL of 10% solution, every 2 to 6 hours Nebulization tent, Croupette: Recommended dose: The volume of 10% or 20% solution that will maintain a very heavy mist in the tent or Croupette for the desired period. -This requires very large solution volumes, as much as 300 mL in a single treatment period. -Intermittent or continuous prolonged administration periods, including overnight, may be desirable. -Nebulization into a tent or Croupette must be individualized. -Take into account the available equipment. Direct Instillation: Dose range: 1 to 2 mL of 10% to 20% solution, as often as every hour. -Routine tracheostomy care: 1 to 2 mL of 10% to 20% solution, every 1 to 4 hours, instilled into the tracheostomy -Percutaneous intratracheal catheter: 1 to 2 mL of 20% solution, or 2 to 4 mL of 10% solution, every 1 to 4 hours, via a syringe attached to the catheter -Direct pulmonary installation: 2 to 5 mL of 20% solution --Introduce directly into a particular segment of the bronchopulmonary tree by inserting (under local anesthesia and direct vision) a small plastic catheter into the trachea; instill using a syringe connected to the catheter. Diagnostic Bronchograms: Recommended dosing: 1 to 2 mL of the 20% solution, or 2 to 4 mL of the 10% solution, by nebulization or by instillation intratracheally, two or three times prior to the procedure. Comments: -The 20% solution may be diluted to a lesser concentration with either Sodium Chloride Injection, Sodium Chloride Inhalation Solution, Sterile Water for Injection, or Sterile Water for Inhalation. -The 10% solution may be used undiluted. -Use compressed tank gas (air) or an air compressor to provide pressure for nebulizing the solution. -Oxygen may also be used but should be used with the usual precautions in patients with severe respiratory disease and CO2 retention. Use: Adjuvant therapy for abnormal, viscid, or inspissated mucous secretions, such as in: Chronic bronchopulmonary disease (chronic emphysema or asthmatic bronchitis, emphysema with bronchitis, tuberculosis, bronchiectasis, or primary pulmonary amyloidosis) Acute bronchopulmonary disease (pneumonia, bronchitis, tracheobronchitis) Pulmonary complications of cystic fibrosis Tracheostomy care Pulmonary complications associated with surgery Use during anesthesia Post-traumatic chest conditions Atelectasis due to mucous obstruction Diagnostic bronchial studies (bronchograms, bronchospirometry, and bronchial wedge catheterization).
Usual Pediatric Dose for Acetaminophen Overdose
Injectable: The total dose is 300 mg/kg, given as 3 separate doses, administered over a total of 21 hrs. Dose preparation is weight based: 5 to 20 kg: Loading Dose: 150 mg/kg in 3 mL/kg diluent, infused over 1 hour Second Dose: 50 mg/kg in 7 mL/kg diluent, infused over 4 hours Third Dose: 100 mg/kg in 14 mL/kg diluent, infused over 16 hours 21 to 40 kg: Loading Dose: 150 mg/kg in 100 mL diluent, infused over 1 hour Second Dose: 50 mg/kg in 250 mL diluent, infused over 4 hours Third Dose: 100 mg/kg in 500 mL diluent, infused over 16 hours 41 to 100 kg: Loading Dose: 150 mg/kg in 200 mL diluent, infused over 1 hour Second Dose: 50 mg/kg in 500 mL diluent, infused over 4 hours Third Dose: 100 mg/kg in 1,000 mL diluent, infused over 16 hours Over 100 kg: Loading Dose: 15,000 mg in 200 mL diluent, infused over 1 hour Second Dose: 5,000 mg in 500 mL diluent, infused over 4 hours Third Dose: 10,000 mg in 1,000 mL diluent, infused over 16 hours Compatible diluents: 5% Dextrose in Water, 0.45% Sodium Chloride Injection, and Sterile Water for Injection Comments: -Limited information is available regarding dosing patients weighing more than 100 kg; there are no specific studies. -The critical ingestion to treatment interval is 0 to 8 hours for maximal protection against severe hepatic injury. -Efficacy diminishes progressively after 8 hours. -Initiating treatment 15 to 24 hours post-ingestion yields limited efficacy, but does not appear to worsen the patient's condition and it should not be withheld, as reported ingestion time may not be correct. -Determine serum acetaminophen level at least 4 hours after ingestion of suspected overdose to determine the need for treatment with acetylcysteine. -If patient presents after 4 hours post-ingestion, determine the serum acetaminophen level immediately. -Administer within 8 hours from acetaminophen ingestion for maximal protection against hepatic injury for patients whose serum acetaminophen levels fall above the "possible" toxicity line on the Rumack-Matthew nomogram (line connecting 150 mcg/mL at 4 hours with 37.5 mcg/mL at 12 hours); the manufacturer product information should be consulted. -Administer immediately if time of ingestion is unknown, or serum acetaminophen level is not available/cannot be interpreted/is not available within 8 hours of ingestion. -Administer immediately if 24 hours or less have elapsed from the reported time of overdose, regardless of the ingested quantity reported. Use: Antidote for Acute Ingestion or Repeated Supratherapeutic Ingestion (RSI) acetaminophen overdose, to prevent or lessen hepatic injury after ingestion of a potentially hepatotoxic quantity of acetaminophen. ---- Oral administration of 20% solution for inhalation: Loading Dose: 140 mg/kg body weight, orally, once as a loading dose (see preparation instructions below) Maintenance Dose: 70 mg/kg body weight, orally, 4 hours after the loading dose and every 4 hours for 17 total doses, unless repeated acetaminophen assays reveal nontoxic levels (see preparation instructions below) Dose preparation is weight based: 100 to 109 kg/220 to 240 lb: Loading dose: 15 g (75 mL) in 225 mL diluent; total volume: 300 mL Maintenance Dose: 7.5 g (37 mL) in 113 mL diluent; total volume: 150 mL 90 to 99 kg/198 to 218 lb: Loading dose: 14 g (70 mL) in 210 mL diluent; total volume: 280 mL Maintenance Dose: 7 g (35 mL) in 105 mL diluent; total volume: 140 mL 80 to 89 kg/176 to 196 lb: Loading dose: 13 g (65 mL) in 195 mL) in 210 mL diluent; total volume: 260 mL Maintenance Dose: 6.5 g (33 mL) in 97 mL diluent; total volume: 130 mL 70 to 79 kg/154 to 174 lb: Loading dose: 11 g (55 mL) in 165 mL) in 210 mL diluent; total volume: 220 mL Maintenance Dose: 5.5 g (28 mL) in 82 mL diluent; total volume: 110 mL 60 to 69 kg/132 to 152 lb: Loading dose: 10 g (50 mL) in 150 mL) in 210 mL diluent; total volume: 200 mL Maintenance Dose: 5 g (25 mL) in 75 mL diluent; total volume: 100 mL 50 to 59 kg/110 to 130 lb: Loading dose: 8 g (40 mL) in 120 mL) in 210 mL diluent; total volume: 160 mL Maintenance Dose: 4 g (20 mL) in 60 mL diluent; total volume: 80 mL 40 to 49 kg/88 to 108 lb: Loading dose: 7 g (35 mL) in 105 mL) in 210 mL diluent; total volume: 140 mL Maintenance Dose: 3.5 g (18 mL) in 52 mL diluent; total volume: 70 mL 30 to 39 kg/66 to 86 lb: Loading dose: 6 g (30 mL) in 90 mL) in 210 mL diluent; total volume: 120 mL Maintenance Dose: 3 g (15 mL) in 45 mL diluent; total volume: 60 mL 20 to 29 kg/44 to 64 lb: Loading dose: 4 g (20 mL) in 60 mL) in 210 mL diluent; total volume: 80 mL Maintenance Dose: 2 g (10 mL) in 30 mL diluent; total volume: 40 mL Less than 20 kg (usually patients younger than 6 years), must calculate diluent volume: Loading dose: 140 g/kg Maintenance Dose: 70 g/kg -Add 3 mL of diluent to each 1 mL (200 mg) of 20% acetylcysteine solution -Do not decrease the proportion of diluent. Diluents: Dilute in diet cola or other diet soft drink; if giving via g-tube or Miller-Abbott tube, may dilute with water. Comments: -Administer immediately if 24 hours or less from ingestion of an overdose, regardless of the quantity of acetaminophen reported to have been ingested.
Usual Pediatric Dose for Diagnostic Bronchograms
Nebulized into a face mask, mouth piece, or tracheostomy: Recommended dosage: 3 to 5 mL of 20% solution, or 6 to 10 mL of 10% solution, 3 to 4 times a day Dosage range: 1 to 10 mL of 20% solution, or 2 to 20 mL of 10% solution, every 2 to 6 hours Nebulization tent, Croupette: Recommended dose: The volume of 10% or 20% solution that will maintain a very heavy mist in the tent or Croupette for the desired period. -This requires very large solution volumes, as much as 300 mL in a single treatment period. -Intermittent or continuous prolonged administration periods, including overnight, may be desirable. -Nebulization into a tent or Croupette must be individualized. -Take into account the available equipment. Direct Instillation: Dose range: 1 to 2 mL of 10% to 20% solution, as often as every hour. -Routine tracheostomy care: 1 to 2 mL of 10% to 20% solution, every 1 to 4 hours, instilled into the tracheostomy -Percutaneous intratracheal catheter: 1 to 2 mL of 20% solution, or 2 to 4 mL of 10% solution, every 1 to 4 hours, via a syringe attached to the catheter -Direct pulmonary installation: 2 to 5 mL of 20% solution --Introduce directly into a particular segment of the bronchopulmonary tree by inserting (under local anesthesia and direct vision) a small plastic catheter into the trachea; instill using a syringe connected to the catheter. Diagnostic Bronchograms: Recommended dosing: 1 to 2 mL of the 20% solution, or 2 to 4 mL of the 10% solution, by nebulization or by instillation intratracheally, two or three times prior to the procedure. Comments: -The 20% solution may be diluted to a lesser concentration with either Sodium Chloride Injection, Sodium Chloride Inhalation Solution, Sterile Water for Injection, or Sterile Water for Inhalation. -The 10% solution may be used undiluted. -Use compressed tank gas (air) or an air compressor to provide pressure for nebulizing the solution. -Oxygen may also be used but should be used with the usual precautions in patients with severe respiratory disease and CO2 retention. Use: Adjuvant therapy for abnormal, viscid, or inspissated mucous secretions, such as in: Chronic bronchopulmonary disease (chronic emphysema or asthmatic bronchitis, emphysema with bronchitis, tuberculosis, bronchiectasis, or primary pulmonary amyloidosis) Acute bronchopulmonary disease (pneumonia, bronchitis, tracheobronchitis) Pulmonary complications of cystic fibrosis Tracheostomy care Pulmonary complications associated with surgery Use during anesthesia Post-traumatic chest conditions Atelectasis due to mucous obstruction Diagnostic bronchial studies (bronchograms, bronchospirometry, and bronchial wedge catheterization).
Usual Pediatric Dose for Mucolytic
Nebulized into a face mask, mouth piece, or tracheostomy: Recommended dosage: 3 to 5 mL of 20% solution, or 6 to 10 mL of 10% solution, 3 to 4 times a day Dosage range: 1 to 10 mL of 20% solution, or 2 to 20 mL of 10% solution, every 2 to 6 hours Nebulization tent, Croupette: Recommended dose: The volume of 10% or 20% solution that will maintain a very heavy mist in the tent or Croupette for the desired period. -This requires very large solution volumes, as much as 300 mL in a single treatment period. -Intermittent or continuous prolonged administration periods, including overnight, may be desirable. -Nebulization into a tent or Croupette must be individualized. -Take into account the available equipment. Direct Instillation: Dose range: 1 to 2 mL of 10% to 20% solution, as often as every hour. -Routine tracheostomy care: 1 to 2 mL of 10% to 20% solution, every 1 to 4 hours, instilled into the tracheostomy -Percutaneous intratracheal catheter: 1 to 2 mL of 20% solution, or 2 to 4 mL of 10% solution, every 1 to 4 hours, via a syringe attached to the catheter -Direct pulmonary installation: 2 to 5 mL of 20% solution --Introduce directly into a particular segment of the bronchopulmonary tree by inserting (under local anesthesia and direct vision) a small plastic catheter into the trachea; instill using a syringe connected to the catheter. Diagnostic Bronchograms: Recommended dosing: 1 to 2 mL of the 20% solution, or 2 to 4 mL of the 10% solution, by nebulization or by instillation intratracheally, two or three times prior to the procedure. Comments: -The 20% solution may be diluted to a lesser concentration with either Sodium Chloride Injection, Sodium Chloride Inhalation Solution, Sterile Water for Injection, or Sterile Water for Inhalation. -The 10% solution may be used undiluted. -Use compressed tank gas (air) or an air compressor to provide pressure for nebulizing the solution. -Oxygen may also be used but should be used with the usual precautions in patients with severe respiratory disease and CO2 retention. Use: Adjuvant therapy for abnormal, viscid, or inspissated mucous secretions, such as in: Chronic bronchopulmonary disease (chronic emphysema or asthmatic bronchitis, emphysema with bronchitis, tuberculosis, bronchiectasis, or primary pulmonary amyloidosis) Acute bronchopulmonary disease (pneumonia, bronchitis, tracheobronchitis) Pulmonary complications of cystic fibrosis Tracheostomy care Pulmonary complications associated with surgery Use during anesthesia Post-traumatic chest conditions Atelectasis due to mucous obstruction Diagnostic bronchial studies (bronchograms, bronchospirometry, and bronchial wedge catheterization).
Liver Dose Adjustments
Data are not available to determine if dose adjustment is required. Published literature does not indicate a need for dose reduction.
How it works
Acetylcysteine belongs to a class of drugs called mucolytics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
More common side effects
Some of the more common side effects that can occur with use of acetylcysteine include:
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
Allergy warning
Acetylcysteine can cause a severe allergic reaction. Symptoms can include:
Warning for people with asthma
After inhaling this drug, you’re at increased risk of wheezing, tightness in your chest, and trouble breathing. Make sure someone is with you when you take acetylcysteine.
Warnings for other groups
For pregnant women: Acetylcysteine is a category B pregnancy drug. That means two things:
Dosage for breaking up mucous in your airways
Nebulized into a face mask, mouth piece, or tracheostomy. The recommended dosage for most people is 3–5 mL of the 20% solution, or 6–10 mL of the 10% solution, three to four times per day. However, doses can range from 1–10 mL of the 20% solution or 2–20 mL of the 10% solution. These doses may be given every two to six hours.
What is NAC for bronchitis?
Treating lung conditions and excess mucus. For people with chronic lung conditions, such as bronchitis or cystic fibrosis, some doctors recommend NAC. It is available in an inhalable form that may help reduce excess mucus.
What is NAC treatment?
bipolar disorder. obsessive-compulsive disorder. schizophrenia. While research into NAC as a means of relieving psychiatric symptoms may be promising, most doctors would not recommend it as a sole treatment. Instead, a person should rely upon evidence-based treatments, such as therapy and medication, when applicable.
What are the benefits of NAC?
According to a 2011 review#N#Trusted Source#N#, NAC may also help alleviate symptoms of various psychiatric conditions, including: 1 bipolar disorder 2 obsessive-compulsive disorder 3 schizophrenia
How long does it take to administer acetaminophen?
Acetaminophen is an analgesic that can relieve aches, pains, and a fever. If a person experiences an overdose of this drug, administering NAC within 10 hours. Trusted Source.
Why do people take NAC?
People take it for various reasons, including to help treat medical issues ranging from psychological disorders to chronic lung conditions and to improve athletic performance.
Does NAC help with preterm birth?
According to the same 2017 review , NAC supplements may help reduce the risk of preterm birth. Infections such as bacterial vaginosis may increase the risk of preterm delivery, and the body’s inflammatory response may further raise the risk. Because NAC combats inflammation, the authors report, it may help counter this risk factor for preterm birth.
Does NAC help with inflammation?
Doctors believe that NAC may stimulate the synthesis of glutathione — a compound that helps fight free radicals, unstable atoms that can cause inflammation and damage. Keep reading to learn how NAC may benefit the body. We also describe risks, including side effects, associated with the supplement.
What is N-acetylcysteine?
N-acetylcysteine, or NAC, is the supplement form of the amino acid cysteine, which converts to glutathione, a powerful antioxidant. Supplemental NAC has been purported to treat a number of conditions. It appears to help relieve symptoms associated with respiratory disorders, particularly chronic bronchitis, and drug toxicity.
How much NAC should I take daily?
The University of Maryland Medical Center suggests starting with 500 mg daily and slowly increasing with your doctor's supervision.
Does NAC increase blood pressure?
NAC supplementation might increase the side effects associated with nitroglycerin and isosorbide, two medications commonly used to treat angina. Using NAC at the same time as the hypertension drugs ACE-inhibitors might cause blood pressure to drop too low. It might also strengthen the actions of immunosuppressant drugs too much.
Is NAC a good supplement?
Beth Israel reports NAC appears to be a generally safe supplement, but like any drug or supplement, side effects are a possibility in some people. Reported side effects include gastrointestinal upset, diarrhea, nausea, rash, vomiting and fatigue.
Does NAC raise homocysteine?
The University of Maryland Medical Center notes that supplementation could raise levels of homocysteine, an amino acid linked with a potentially increased risk of heart disease when present in high amounts. It recommends having your doctor monitor your levels while using NAC. Advertisement.
Does a saline solution help with bronchitis?
It appears to help relieve symptoms associated with respiratory disorders, particularly chronic bronchitis, and drug toxicity. Other purported uses have less backing behind them and require more research, including the treatment of cancer, HIV/AIDS, cataracts and macular degeneration and addiction.
Does NAC lower trace minerals?
The Beth Israel Deaconess Medical Center notes prolonged supplementation with NAC could decrease your levels of trace minerals, but that research looking at this action suggests this effect is minimal. If you plan on using NAC long-term, however, consider taking a standard multivitamin and mineral supplement.