
Medication
The recommended treatment for neurosyphilis, ocular syphilis, or otosyphilis is Aqueous crystalline penicillin G 18-24 million units per day, administered as 3-4 million units intravenously every 4 hours or continuous infusion, for 10-14 days. Treatment will prevent disease progression, but it might not repair damage already done.
Self-care
You can also be infected with syphilis for years and not notice any symptoms. But since syphilis doesn’t go away on its own, if you have signs or symptoms of syphilis, you should get tested for it, and treated if you have it. How Long Does Syphilis Last After Treatment?
Nutrition
These syphilis symptoms may come and go for up to 2 years. They include body rashes that last 2 – 6 weeks — often on the palms of your hands and the soles of your feet. There are lots of other symptoms, including mild fever, fatigue, sore throat, hair loss, weight loss, swollen glands, headache, and muscle pains.
How long does it take to treat and cure syphilis?
Yes. If you have syphilis in any stage, penicillin is the best treatment. The disease is usually cured by this treatment. In the case of penicillin allergies, your health care provider may prescribe a different medicine. How Long Should You Take Amoxicillin For Syphilis?
Does syphilis go away on its own?
How long can person live with syphilis?
Can syphilis be cured at any stage?

Is syphilis still contagious after treatment?
You are no longer contagious once treatment is completed. You will need to be evaluated three months after treatment, and then regularly during the first year of your diagnosis and treatment. This would include an exam and blood tests.
How long does it take to cure syphilis after penicillin shot?
If you had syphilis for more than one year, you need three shots—one shot a week for three weeks. If you're allergic to penicillin, be sure to tell your doctor. If you have an advanced case of syphilis, you may need stronger treatment. You may get shots of penicillin every day for 10 days.
How do you know when syphilis is gone?
Blood. Blood tests can confirm the presence of antibodies that the body produces to fight infection. The antibodies to the syphilis-causing bacteria remain in your body for years, so the test can be used to determine a current or past infection.
How quickly does penicillin shot work?
You should begin to feel better during the first few days of treatment with penicillin G injection. If your symptoms do not improve or get worse, call your doctor. Use penicillin G injection for as long as your doctor tells you that you should, even if you feel better.
How Do People Get Syphilis?
Syphilis is transmitted from person to person by direct contact with a syphilitic sore, known as a chancre. Chancres can occur on or around the ext...
How Quickly Do Symptoms Appear After Infection?
The average time between acquisition of syphilis and the start of the first symptom is 21 days, but can range from 10 to 90 days.
What Are The Signs and Symptoms in Adults?
Syphilis has been called “The Great Pretender”, as its symptoms can look like many other diseases. However, syphilis typically follows a progressio...
How Does Syphilis Affect A Pregnant Woman and Her Baby?
When a pregnant woman has syphilis, the infection can be transmitted to her unborn baby. All pregnant women should be tested for syphilis at the fi...
How Is Syphilis Diagnosed?
The definitive method for diagnosing syphilis is visualizing the Treponema pallidum bacterium via darkfield microscopy. This technique is rarely pe...
What Is The Link Between Syphilis and HIV?
In the United States, approximately half of men who have sex with men (MSM) with primary and secondary (P&S) syphilis were also living with HIV(htt...
What Is The Treatment For Syphilis?
For detailed treatment recommendations, please refer to the 2015 CDC STD Treatment Guidelines(https://www.cdc.gov/std/tg2015/syphilis.htm). The rec...
Who Should Be Tested For Syphilis?
Any person with signs or symptoms suggestive of syphilis should be tested for syphilis. Also, anyone with an oral, anal, or vaginal sex partner who...
How Can Syphilis Be Prevented?
Correct and consistent use of latex condoms can reduce the risk of syphilis when the infected area or site of potential exposure is protected. Howe...
How long does it take for tertiary syphilis to appear?
Tertiary syphilis is rare and develops in a subset of untreated syphilis infections;, it can appear 10–30 years after infection was first acquired, and it can be fatal. Tertiary syphilis can affect multiple organ systems, including the brain, nerves, eyes, heart, blood vessels, liver, bones, and joints.
How is syphilis transmitted?
Syphilis is transmitted from person to person by direct contact with a syphilitic sore, known as a chancre. Chancres can occur on or around the external genitals, in the vagina, around the anus , or in the rectum, or in or around the mouth. Transmission of syphilis can occur during vaginal, anal, or oral sex.
What is the primary stage of syphilis?
Primary Stage. The appearance of a single chancre marks the primary (first) stage of syphilis symptoms, but there may be multiple sores. The chancre is usually (but not always) firm, round, and painless. It appears at the location where syphilis entered the body.
How long does a chancre last?
These painless chancres can occur in locations that make them difficult to notice (e.g., the vagina or anus). The chancre lasts 3 to 6 weeks and heals regardless of whether a person is treated or not. However, if the infected person does not receive adequate treatment, the infection progresses to the secondary stage.
What are the symptoms of secondary syphilis?
Rashes associated with secondary syphilis can appear when the primary chancre is healing or several weeks after the chancre has healed. The rash usually does not cause itching. The characteristic rash of secondary syphilis may appear as rough, red, or reddish brown spots both on the palms of the hands and the bottoms of the feet. However, rashes with a different appearance may occur on other parts of the body, sometimes resembling rashes caused by other diseases. Sometimes rashes associated with secondary syphilis are so faint that they are not noticed. Large, raised, gray or white lesions, known as condyloma lata, may develop in warm, moist areas such as the mouth, underarm or groin region. In addition to rashes, symptoms of secondary syphilis may include fever, swollen lymph glands, sore throat, patchy hair loss, headaches, weight loss , muscle aches, and fatigue. The symptoms of secondary syphilis will go away with or without treatment. However, without treatment, the infection will progress to the latent and possibly tertiary stage of disease.
What is the cause of syphilis?
Syphilis is a sexually transmitted disease (STD) caused by the bacterium Treponema pallidum. Syphilis can cause serious health sequelae if not adequately treated.
Where do rashes occur in syphilis?
Large, raised, gray or white lesions, known as condyloma lata, may develop in warm, moist areas such as the mouth, underarm or groin region.
Nontreponemal Tests and Traditional Algorithm
False-positive nontreponemal test results can be associated with multiple medical conditions and factors unrelated to syphilis, including other infections (e.g., HIV), autoimmune conditions, vaccinations, injecting drug use, pregnancy, and older age ( 566, 569 ).
Treponemal Tests and Reverse Sequence Algorithm
The majority of patients who have reactive treponemal tests will have reactive tests for the remainder of their lives, regardless of adequate treatment or disease activity. However, 15%–25% of patients treated during the primary stage revert to being serologically nonreactive after 2–3 years ( 570 ).
Cerebrospinal Fluid Evaluation
Further testing with CSF evaluation is warranted for persons with clinical signs of neurosyphilis (e.g., cranial nerve dysfunction, meningitis, stroke, acute or chronic altered mental status, or loss of vibration sense).
Special Considerations
Parenteral penicillin G is the only therapy with documented efficacy for syphilis during pregnancy. Pregnant women with syphilis at any stage who report penicillin allergy should be desensitized and treated with penicillin (see Management of Persons Who Have a History of Penicillin Allergy).
Management of Sex Partners
Sexual transmission of T. pallidum is thought to occur only when mucocutaneous syphilitic lesions are present. Such manifestations are uncommon after the first year of infection.
What is the best treatment for syphilis?
Treatment for syphilis. After determining that you have syphilis, your doctor may give you a single injection of long-acting penicillin if you are still in the primary stages. If you are allergic to penicillin, your doctor may give you antibiotics like doxycycline, azithromycin, or ceftriaxone.
What is syphilis STD?
What is syphilis? Syphilis is a sexually transmitted disease (STD) and the treatment will depend on the stage at which you are diagnosed in. Syphilis is a common infection in people, especially adults, around the world. Consequently, it is important for you to know what it is, and what causes it. This will help you know how to treat it, ...
How long does it take for a chancre to disappear?
You may have one or more sores. The chancre disappears within three to six weeks.
How long does penicillin last in the hospital?
This medicine is usually given intravenously in a hospital for up to two weeks.
What are the symptoms of secondary syphilis?
After the early symptoms are gone, you will enter the secondary stage. You may start experiencing signs of secondary syphilis which include: A reddish brown rash. White patches in the mouth. Headaches, fever, tiredness, and other flu-like symptoms.
How many groups of people are affected by syphilis?
Symptoms are usually the same for men and women. They can be classified into three groups.
What blood test can be used to test for syphilis?
There are two types of blood tests to prove whether you have a syphilis infection: Nontreponemal tests detect damage to your cells caused by syphilis. Treponemal tests detect antibodies that your body creates to fight syphilis. Both types of tests are needed to confirm a positive diagnosis for syphilis.
How long does syphilis last?
This stage can last several years.
How to prevent syphilis?
The only way to prevent syphilis is to abstain from sex. If you are sexually active, you can reduce your risk of getting the infection by always using a condom or dental dam during sex. It’s important to use a condom properly to lower your chance of getting the infection.
How long does it take for a chancre to go away?
It goes away on its own in a few weeks or months. A chancre is small and usually painless, so you may not even know it’s there. Secondary syphilis: About one to six months after the chancre goes away, a rough, bumpy syphilis rash appears on the body, usually on your palms and soles (bottoms) of your feet.
What is the first symptom of syphilis?
Syphilis symptoms vary depending on the stage of the infection. In the first phase, a chancre (small, painless sore) develops on the genitals. During the second phase of syphilis, a pink, bumpy, rough rash appears on the body, usually on the palms of your hand or soles of your feet.
How many stages of syphilis are there?
If it isn’t treated, syphilis progresses in four stages. The infection causes different symptoms in each stage. In the first and second stages, people are very contagious and can easily pass the infection to their sex partners. The stages of syphilis are:
How does syphilis spread?
An infected person spreads the bacteria through vaginal, anal or oral sex. The bacteria enter the body through the anus, vagina, penis, mouth or broken skin. Syphilis is contagious. If you have syphilis and you have sex, you can infect your partner.
How many people get syphilis every year?
Syphilis cases have been increasing in recent years, especially among men who are gay and bisexual. About 80,000 people are diagnosed with syphilis every year. The infection is more common in men and appears more often in people in their early 20s.
How long does a syphilis sore last?
Sores are usually (but not always) firm, round, and painless. Because the sore is painless, it can easily go unnoticed. The sore usually lasts 3 to 6 weeks and heals regardless of whether or not you receive treatment. Even after the sore goes away, you must still receive treatment. This will stop your infection from moving to the secondary stage.
How to prevent syphilis?
If you are sexually active, you can do the following things to lower your chances of getting syphilis: 1 Being in a long-term mutually monogamous relationship with a partner who has been tested for syphilis and does not have syphilis; 2 Using latex condoms the right way every time you have sex. Condoms prevent transmission of syphilis by preventing contact with a sore. Sometimes sores occur in areas not covered by a condom. Contact with these sores can still transmit syphilis.
What are the symptoms of secondary syphilis?
Symptoms of secondary syphilis include skin rash, swollen lymph nodes, and fever. The signs and symptoms of primary and secondary syphilis can be mild, and they might not be noticed. During the latent stage, there are no signs or symptoms. Tertiary syphilis is associated with severe medical problems.
What is tertiary syphilis?
Tertiary syphilis is associated with severe medical problems. A doctor can usually diagnose tertiary syphilis with the help of multiple tests. It can affect the heart, brain, and other organs of the body.
How long does it take for a rash to show up on your feet?
The rash can show up when your primary sore is healing or several weeks after the sore has healed. The rash can look like rough, red, or reddish brown spots on the palms of your hands and/or the bottoms of your feet. The rash usually won’t itch and it is sometimes so faint that you won’t notice it.
How to avoid STDs?
The only way to avoid STDs is to not have vaginal, anal, or oral sex. If you are sexually active, you can do the following things to lower your chances of getting syphilis: Being in a long-term mutually monogamous relationship with a partner who has been tested for syphilis and does not have syphilis;
How long does a sore last after a scab?
Because the sore is painless, it can easily go unnoticed. The sore usually lasts 3 to 6 weeks and heals regardless of whether or not you receive treatment. Even after the sore goes away, you must still receive treatment. This will stop your infection from moving to the secondary stage.
How is syphilis transmitted?
Public health experience and historic studies illustrate that syphilis is highly transmissible during primary and secondary syphilis, and can be transmitted in a variety of ways including via sexual encounters, vertical transmission, parenteral exposures and occupational exposures.
Is syphilis a contact investigation?
Several studies have reported syphilis prevalence and incidence among individuals named in contact investigation studies, primarily in the era before prophylactic treatment of contacts became standard of care.

Nontreponemal Tests and Traditional Algorithm
Treponemal Tests and Reverse Sequence Algorithm
Cerebrospinal Fluid Evaluation