Treatment FAQ

how long is zoloft treatment

by Frederique Runolfsson Published 3 years ago Updated 2 years ago
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In general, you should stay on your medication for at least four to nine months, and if you've struggled with depression three or more times, you should wait at least two years. 4 Talk to your mental health professional about whether or not it's a good time to discontinue your medication.

How long should I be on Zoloft for?

Your doctor will advise you how long to take sertraline for, as it depends on why you are taking it. For depression it might be six months, for OCD it might be 12 months and for other anxiety related conditions such as PTSD and panic disorder it might be up to 18 months.

Is Zoloft a long-term medication?

Since Zoloft is a long-term medication, there is no inherent danger in taking it for months or even years. However, since it's a mind-altering drug, it can cause dependence. When a person becomes unable to feel normal or get through the day without taking Zoloft, they've become dependent on the medication.Oct 4, 2021

How long should Zoloft be taken for anxiety?

Some patients report feeling better after their first few weeks on Zoloft, but on average it takes 6-8 weeks on the medication to experience significant improvement.Sep 7, 2021

Can you stay on Zoloft for years?

SSRIs are generally considered safe to take long-term, says Maurizio Fava, executive vice chair of the department of psychiatry at Massachusetts General Hospital.Aug 28, 2019

Can you stay on sertraline forever?

Clinical trials of sertraline show that it's safe to use for the long-term, with many cases of people using sertraline for years at a time. Your healthcare provider will advise you about how long you should continue using sertraline or other medication to treat your depression or anxiety.Dec 22, 2021

Does your brain go back to normal after antidepressants?

In time, the brain readjusts and people should experience a return to their normal state. If depressive symptoms do arise and gradually worsen, it's best to consult a psychiatrist or doctor, if they don't improve within a few weeks or if they become severe.Sep 28, 2020

Is it hard to get off Zoloft?

Be aware that there are not any hard and fast rules for tapering off Zoloft. One person may do it within a short amount of time, while another may take longer. Some may even need to use liquid Zoloft or split their pills in half in order to taper in even smaller increments.

What is better than Zoloft for anxiety?

A 2014 study published in International Clinical Psychopharmacology suggested that Lexapro may be more effective and better tolerated than Zoloft or Paxil. Lexapro has different binding site interactions which may lead to better efficacy and tolerability.Dec 2, 2019

Does Zoloft permanently change the brain?

Some research has suggested this type of drug aids in neuroplasticity. In other words, these drugs can affect how our minds organize and form synaptic connections. Other researchers believe this type of medication has no long-term effects on our brains once the individual stops using the drug.Dec 27, 2021

Does taking antidepressants shorten your life?

The analysis found that in the general population, those taking antidepressants had a 33 percent higher risk of dying prematurely than people who were not taking the drugs. Additionally, antidepressant users were 14 percent more likely to have an adverse cardiovascular event, such as a stroke or a heart attack.Sep 19, 2017

What are the long term side effects of Zoloft?

To date, there are no known problems associated with long term use of sertraline. It is a safe and effective medication when used as directed.

How long does it take for brain to return to normal after SSRI?

The process of healing the brain takes quite a bit longer than recovery from the acute symptoms. In fact, our best estimates are that it takes 6 to 9 months after you are no longer symptomatically depressed for your brain to entirely recover cognitive function and resilience.Jun 15, 2017

How Long Does It Take For Zoloft to Work – Or “Kick In”?

It depends on the user. Although Zoloft starts working immediately in terms of exerting a neurophysiologic effect, it may take weeks for the medica...

Why Zoloft Might Work Immediately (Possible Reasons)

Included below is a list of explanations as to why Zoloft may start working immediately (within the first day or week of treatment). Possible reaso...

Why Zoloft Might Take A Longer Time to Start Working (Possible Reasons)

If Zoloft doesn’t work as quick as you were expecting, below are some potential reasons as to why it might take a longer duration to “kick in.” Pos...

Variables That Influence The Onset of Zoloft’S Action

There are likely multiple variables that influence the length of time it takes for Zoloft to start working OR a person to notice Zoloft working. Va...

How Long Did Zoloft Take to “Kick In” For Me?

Years ago when I was prescribed Zoloft by a psychiatrist, I initiated treatment at the lowest therapeutic dose (50 mg) and titrated upwards to high...

How Long Did It Take For Zoloft to Work For You?

If you’ve used Zoloft, also known as sertraline, how long did it take for the medication to “work”? More specifically, how long did it take for you...

When will you start feeling the effects of Zoloft?

The length of time it takes for Zoloft to work varies from person to person, but in general, people start feeling better in at least six weeks on average. For some people, it may take as soon as one to two weeks to start feeling some of the benefits of Zoloft but it could be much longer for others.

What To Do If Zoloft Is Not Working Anymore?

If you find that Zoloft is not working for you anymore, it is important to take note of the following advice to avoid serious consequences such as drug overdose or harmful side effects.

How long does it take for Zoloft to work?

Zoloft (sertraline) has a half-life of 24 to 26 hours, which means that it will take a person roughly a day for the drug’s presence to reduce to half the amount. In another 24 hours, the amount in a person’s body will decrease to 25% or half of the remaining amount.

How long does Zoloft stay in your system?

Zoloft has a half-life of 24-26 hours. Approximately 44% of Zoloft can be found in a person’s urine and feces nine days after ingestion. Your dosage and individual physiology factors affect how long Zoloft stays in your system.

How does Zoloft affect the brain?

Many physicians believe that SSRIs work by blocking serotonin (which is responsible for mood regulation) from being reabsorbed into the body’s neurons.

How many mg of Zoloft can you take?

Dosages for Zoloft (sertraline) range between 50 mg and 200 mg. If you miss a dose of Zoloft (sertraline), do not take two doses the next time because this can have adverse consequences. Avoid drinking alcohol, using illegal drugs or taking any other type of antidepressant medication while taking Zoloft (sertraline).

What causes Zoloft to leave one person's body faster than another?

Some of these factors include age, genetics and sex. For example, the medication tends to leave the systems of younger patients faster.

How long does it take for Zoloft to show up in urine?

Statistics reveal that 44% of a Zoloft (sertraline) is found in a person’s urine within nine days post-ingestion, with a similar 44% being recovered in feces. This can present difficulties during drug tests because Zoloft (sertraline) can show up as benzodiazepine in drug tests.

What is a syringe used for?

While the medication is most commonly used to treat manic-depressive disorder, it is also used to treat obsessive-compulsive disorder, post-traumatic stress disorders and social phobia. The medication is also used for “off-label” conditions including binge-eating disorders and bulimia nervosa.

How Zoloft Works

Zoloft is the brand name for the antidepressant sertraline, which comes as a tablet or liquid medication. Specifically, Zoloft is a selective serotonin reuptake inhibitor (SSRI).

How Long Does It Take for Zoloft to Kick In?

It usually takes about two to six weeks for Zoloft to kick in. Like most antidepressants, sertraline can cause side effects. After a week or two, these Zoloft side effects may occur:

How Long Does Sertraline Stay In Your System?

If you’re wondering, “How long does Zoloft stay in your system?” the first thing you have to consider is Zoloft’s half-life. A drug’s half-life refers to the amount of time it takes half of the drug to leave a person’s system.

How long does it take for Zoloft to work?

If you are suffering from depression, you could feel some improvement in your energy, sleep, and mood in about 1 to 2 weeks. This is usually a sign that the drug is indeed working.

What is the name of the drug that increases serotonin levels?

Zoloft , which is a brand name of the generic drug Sertraline, belongs to the selective serotonin reuptake inhibitor (SSRI) class of drugs. The drug works by increasing the serotonin levels in the brain. Serotonin is the key hormone that is responsible for regulating mood, happiness, and overall well-being. YouTube. Anaheim Lighthouse.

Is Zoloft a recreational drug?

While Zoloft is considered to have a lower risk of abuse, there are still cases wherein Zoloft is being abused or taken as a recreational drug. For a person with a Zoloft prescription or those who have access to the drug (medicine cabinets at home, family members with a Zoloft prescription), it might be easier to try abusing whatever drug is available rather than looking for other prescription meds like opioids or benzos.

Does Zoloft help with anxiety?

Because Zoloft improves the serotonin levels in the brain, it could help boost your mood, energy, appetite, and sleep. It could also lessen your feelings of anxiety, fear, unwanted thoughts, and panic attacks. Eventually, it could help you regain your interest in the things you normally do day-to-day.

Can Zoloft cause a drug overdose?

This, however, could quicken your body’s tolerance to the drug, and instead of it working effectively, taking too much of the drug could lead to a drug overdose.

Is Zoloft a benzodiazepine?

Zoloft is often prescribed as the first line of treatment for depression. Unlike drugs like benzodiazepines, it is considered to have lower abuse potential. Aside from depression, the drug is also prescribed to treat other conditions such as anxiety, PTSD (post-traumatic stress disorder), obsessive-compulsive disorder, panic attacks, ...

Can you mix Zoloft with alcohol?

What’s more alarming is that some people mix Zoloft with other substances like alcohol or opioids in an attempt to intensify the drug’s effects. Mixing Zoloft with other substances or taking too much of the drug could lead to risky side effects and it could even result in an overdose.

How much Zoloft is available?

Zoloft is available in 25 mg, 50 mg, and 100 mg tablets and a 20 mg/ml oral solution. Check your prescription and consult your doctor to make sure you're taking the correct dose for you. For people with social anxiety disorder, a typical tablet dosage of Zoloft starts at 25 mg, with an increase to 50 mg after one week.

What is Zoloft used for?

Zoloft ( sertraline hydrochloride) is a prescription medication approved for the treatment of social anxiety disorder, a mental health condition marked by an irrational fear of being watched, judged, or of embarrassing or humiliating yourself.

What happens if you take too much Zoloft?

If you have taken too much Zoloft, get help right away before the drug has a chance to cause unpleasant or dangerous symptoms. The risk of a fatal overdose of Zoloft is low. Symptoms of an overdose include dizziness, drowsiness, nausea, vomiting, increased or slow heart rate, and coma. 5

Can you take Zoloft twice a day?

If you forget to take a daily dose, take it as soon as you remember. However, if it is close to the time of your next dose, skip the missed dose and take it at your regular time. Never take two doses of Zoloft at the same time. When travelling, store Zoloft in your carry-on baggage in case your luggage gets lost.

What are the side effects of Zoloft?

When first starting Zoloft, or when changing dosage, report any of the following side effects to your doctor immediately: Allergic reaction symptoms like hives, rash, difficulty swallowing or breathing, severe dizziness, and swelling of the face, mouth, throat, or tongue. Agitation.

Is Zoloft approved for the treatment of social anxiety disorder?

Have impaired liver or kidney function, heart disease, diabetes, or a history of seizures. Zoloft has not been approved for the treatment of social anxiety disorder in people under 18 years of age.

Is Zoloft safe for mental health?

Zoloft should be taken as directed unless your healthcare provider provides other guidance. To ensure Zoloft is safe for you, disclose to your doctor your mental health and family history as well all current or past prescription or over-the-counter medications, or any other substances that you are taking or plan to take.

How long does it take for Zoloft to work?

You will probably notice an improvement in some symptoms within the first 1-2 weeks of taking Zoloft. It could take up to 6-8 weeks to have the full benefits of the medication, depending on the reasons you take it. Do not stop taking Zoloft without consulting your prescriber, even when you start to feel better.

How often can you take Zoloft?

Side effects usually improve over the first week or two as you continue to take the medication. Zoloft is usually taken once per day and can be taken with or without food; be sure to follow your doctor’s instructions on how to take the medication. In addition, talk with your doctor about: What to do if you miss a dose.

How to avoid withdrawal symptoms from Zoloft?

To avoid Zoloft withdrawal symptoms, your doctor will usually prescribe a tapering at the end of the medication treatment. This means that they will slowly lower the dosage over time so that your body doesn’t experience abrupt discontinuation of the drug.

What does it mean when you stop taking Zoloft?

Zoloft Rebound. “Rebound” is also a type of withdrawal. It means that the symptoms for which you started taking Zoloft return after stopping the medication abruptly, but at a greater intensity than they were before you started the medication. These symptoms can include: Anxiety. Agitation. Insomnia. Depression.

What are the symptoms of Zoloft withdrawal?

Zoloft withdrawal symptoms can include: Irritability. Nausea. Dizziness. Vomiting. Nightmares. Headache. Paresthesia (tingling sensation on the skin) 1.

How long does Zoloft withdrawal last?

These symptoms could peak at 36-96 hours or later after stopping Zoloft and could last up to 6 weeks. 5. There are two withdrawal durations: acute and protracted. Acute withdrawal occurs immediately after discontinuation of Zoloft.

How long does it take for myoclonus to go away after stopping Zoloft?

Aggression. Hallucinations (seeing or hearing things that are not there) Decreased concentration. Ataxia (impaired coordination) Confusion. Myoclonus (sudden, brief involuntary muscular twitching or jerking) 5. These symptoms could peak at 36-96 hours or later after stopping Zoloft and could last up to 6 weeks. 5.

What are the guidelines for antidepressants?

Expert guidelines about antidepressants can be confusing. They depend on a variety of factors, including: 1 The type of prescription you take 2 Your dosage 3 The number of depressive episodes you’ve had 4 Your risk of relapse

What to do if you have side effects from one medication?

Brendel says that options for dealing with side effects include: Reducing the dosage of the medicine. Adding an additional medication that helps ease the side effects. Switching to another medication.

How to make antidepressants less effective?

Take depression medicine exactly as prescribed. Taking less medication or skipping doses will make an antidepressant less effective. If you experience troublesome side effects, be sure to tell your doctor right away. Don’t go off antidepressants on your own.

How do antidepressants work?

Antidepressants work by targeting certain chemicals in the brain called neurotransmitters. These chemicals affect mood and emotion. But exactly how antidepressants lessen depression is unclear. Experts have traditionally thought that they restore a chemical imbalance caused by being depressed.

What is the most commonly prescribed antidepressant?

Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressant medication. They tend to be well tolerated and effective. Serotonin and norepinephrine reuptake inhibitors (SNRIs) are a newer class of antidepressants and are similar to SSRIs.

What are the side effects of monamine oxidase inhibitors?

Monamine oxidase inhibitors (MAOIs) are also older antidepressants that are usually only prescribed for people who do not respond to other drugs for depression. They may also benefit people who have unusual symptoms such as excessive sleeping, hypochondria, or high levels of anxiety.

Why are tricyclics prescribed less often?

Tricyclics are an older class of depression medications that are prescribed less often because of more serious side effects. For example, people with heart disease, congestive heart failure, and arrhythmia should avoid them.

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How It Works

Upsides

Downsides

  • If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: 1. A headache, nausea, diarrhea, weight loss, insomnia, and sexual dysfunction. 2. May cause drowsiness, but not as likely as with some other antidepressants; however, caution should still be used when driving or operating ma…
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Bottom Line

  • Zoloft is an effective antidepressant with less potential for drowsiness than many other antidepressants.
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Tips

  1. Administer once daily either morning or evening. If Zoloft makes you drowsy, take it at bedtime. May be taken with or without food; however, this needs to be consistent.
  2. Talk to your doctor if your mood worsens or you experience any suicidal thoughts particularly during the first few months of therapy.
  3. Seek urgent medical advice if symptoms consistent with serotonin syndrome (such as agitati…
  1. Administer once daily either morning or evening. If Zoloft makes you drowsy, take it at bedtime. May be taken with or without food; however, this needs to be consistent.
  2. Talk to your doctor if your mood worsens or you experience any suicidal thoughts particularly during the first few months of therapy.
  3. Seek urgent medical advice if symptoms consistent with serotonin syndrome (such as agitation, hallucinations, fast heart rate, dizziness, flushing, nausea, diarrhea) develop.
  4. Do not stop suddenly as withdrawal symptoms may occur. When the time comes to discontinue Zoloft, your doctor will advise you how to taper the dose down.

Response and Effectiveness

  • Peak effects are seen within 4.5 to 8 hours. Some reduction in symptoms of depression or anxiety may be seen within the first week of taking Zoloft; however, it may take up to six weeks for the ful...
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Interactions

  • Medicines that interact with Zoloft may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with Zoloft. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed. Com…
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References

  • Zoloft (sertraline hydrochloride) [Package Insert]. Revised 10/2021. Roerig https://www.drugs.com/pro/zoloft.html
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Further Information

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Zoloft only for the indication prescribed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Copyright 1996-2022 Drugs.com. Revision date: February 11, 2022. Medical Disc…
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