How long do the effects of metoprolol succinate ER tablets last?
The blood pressure lowering effects of metoprolol succinate ER tablets persist for about 24 hours following a single dose. 7.
How often should I take metoprolol succinate?
And metoprolol succinate is available in these strengths: How often you’ll take metoprolol depends on: If you’re taking immediate-release metoprolol oral tablets, you may take them once or twice daily. If you’re taking extended-release metoprolol oral tablets, you’ll take them once daily.
How do you store metoprolol succinate ER 100 mg?
Metoprolol Succinate ER 100 mg 30 Tablets Rx Only Lot#: Exp.Date: Each film-coated tablet contains 95 mg metoprolol succinate equivalent to 100mg metoprolol tartrate, USP. Dosage: See prescriber's instructions. Store at 68 to 77 degrees F. Keep out of the reach of children.
When is metoprolol succinate extended-release used in the treatment of bronchospastic disease?
Because of its relative beta1 cardio-selectivity, however, metoprolol succinate extended-release may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol succinate extended-release.
How long should you take metoprolol succinate?
DosingAdults—At first, 25 milligrams (mg) once a day for 2 weeks. Your doctor may adjust your dose as needed. However, the dose is usually not more than 200 mg per day.Children—Use and dose must be determined by your doctor.
How long do patients stay on metoprolol?
Guidelines recommend beta blocker therapy for three years, but that may not be necessary. Beta blockers work by blocking the effects of the hormone epinephrine, also called adrenaline. Taking beta blockers reduces your heart rate and blood pressure. This eases the workload on your heart and improves blood flow.
Can you stop taking metoprolol after 2 weeks?
Avoid abrupt discontinuation. Stopping metoprolol (both tartrate and succinate) suddenly can exacerbate angina and may increase the risk of a heart attack. Reduce dosage gradually over a few weeks as instructed by your doctor. May interfere slightly with laboratory cholesterol results.
Do you have to stay on metoprolol for life?
You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, strokes, or kidney disease.
Can a person stop taking metoprolol?
WARNING: Do not stop taking this medication without consulting your doctor. Some conditions may become worse when you suddenly stop this drug. Some people who have suddenly stopped taking similar drugs have had chest pain, heart attack, and irregular heartbeat.
Do I have to take beta-blockers forever?
In people who have had a heart attack, beta blockers help reduce the risk of further ones. Guidelines recommend that all patients who have had a heart attack should be prescribed a beta blocker before hospital discharge as part of a package of risk reduction measures. Treatment should usually continue for life.
What are the long term effects of taking metoprolol?
Metoprolol may worsen the symptoms of heart failure in some patients. Check with your doctor right away if you are having chest pain or discomfort, dilated neck veins, extreme fatigue, irregular breathing or heartbeat, swelling of the face, fingers, feet, or lower legs, trouble breathing, or weight gain.
Can you cut metoprolol succinate in half?
DOSAGE AND ADMINISTRATION Metoprolol succinate extended-release tablets are scored and can be divided; however, the whole or half tablet should be swallowed whole and not chewed or crushed.
What does metoprolol withdrawal feel like?
Sudden discontinuation of beta-blockers (such as metoprolol, atenolol and propranolol) can cause a spike in blood pressure and elevated heart rate. People with underlying heart disease may develop chest pain and even have a heart attack.
How long can you stay on beta-blockers for anxiety?
It's important to only use these drugs until your doctor prescribes other treatment. However, if you have panic disorder, your doctor may prescribe benzodiazepines for up to 1 year.
What happens if you stop taking heart medication?
If you suddenly stop taking beta-blockers, your heart rate and blood pressure can go up in the short term from a withdrawal effect. If you stop taking a medicine that keeps your heart rhythm stable or prevents blood clots, you could suffer a heart attack. For the same reasons, never delay refilling a prescription.
How long does a beta blocker last?
Beta blockers are usually prescribed in pill form to be taken orally. The medication works relatively quickly, reaching peak levels in as quickly as one hour. Once it's in your system, the calming effects of a low dose of a beta blocker lasts for a few hours.
Which is safer: metoprolol succinate or tartrate?
Metoprolol succinate and metoprolol tartrate contain the same active drug, metoprolol. The only difference is the salt form. Similar side effects m...
Does metoprolol cause weight gain?
Metoprolol is not likely to cause weight gain. However, weight gain can be a warning sign that heart failure is getting worse. If you are taking me...
Does metoprolol lower blood pressure?
Yes, metoprolol causes the blood vessels to relax, which helps to lower blood pressure. If you are prescribed metoprolol for high blood pressure, y...
Is Metoprolol a blood thinner?
No, metoprolol is not a blood thinner. It works to relax blood vessels and slow heart rate. Your doctor may prescribe metoprolol tartrate to: Lower...
Should I take metoprolol in the morning or at night?
When you take metoprolol depends on which salt form is prescribed. Metoprolol tartrate is usually taken twice daily, so it may be taken in the morn...
How long does it take for metoprolol to work?
How long it takes metoprolol to work depends on what form is given and what condition is being treated. Effects on heart rate can be seen within on...
Why should you take blood pressure medicine at night?
Research has suggested that taking your blood pressure medication at night instead of in the morning can provide better blood pressure control at n...
Which is safer: metoprolol succinate or tartrate?
Metoprolol succinate and metoprolol tartrate contain the same active drug, metoprolol. The only difference is the salt form. Similar side effects m...
Does metoprolol cause weight gain?
Metoprolol is not likely to cause weight gain. However, weight gain can be a warning sign that heart failure is getting worse. If you are taking me...
Does metoprolol lower blood pressure?
Yes, metoprolol causes the blood vessels to relax, which helps to lower blood pressure. If you are prescribed metoprolol for high blood pressure, y...
Is Metoprolol a blood thinner?
No, metoprolol is not a blood thinner. It works to relax blood vessels and slow heart rate. Your doctor may prescribe metoprolol tartrate to: Lower...
Should I take metoprolol in the morning or at night?
When you take metoprolol depends on which salt form is prescribed. Metoprolol tartrate is usually taken twice daily, so it may be taken in the morn...
How long does it take for metoprolol to work?
How long it takes metoprolol to work depends on what form is given and what condition is being treated. Effects on heart rate can be seen within on...
Why should you take blood pressure medicine at night?
Research has suggested that taking your blood pressure medication at night instead of in the morning can provide better blood pressure control at n...
What is metoprolol succinate?
Metoprolol Succinate ER is a beta-blocker that affects the heart and circulation (blood flow through arteries and veins).
What are the side effects of metoprolol succinate?
Metoprolol Succinate ER side effects. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: very slow heartbeats; a light-headed feeling, like you might pass out;
What medications can affect metoprolol succinate ER?
Many drugs can affect Metoprolol Succinate ER, especially: any other heart or blood pressure medications; epinephrine (Epi-Pen); an antidepressant; an ergot medicine-- dihydroergotamine, ergonovine, ergotamine, methylergonovine; or.
Can you use metoprolol succinate ER?
You should not use Metoprolol Succinate ER if you have a serious heart problem ( heart block, sick sinus syndrome, slow heart rate ), severe circulation problems, severe heart failure, or a history of slow heart beats that caused fainting.
Can metoprolol cause dry mouth?
Ask a doctor before using this medicine if you are breast-feeding. Metoprolol can pass into breast milk and may cause dry skin, dry mouth, diarrhea, constipation, or slow heartbeats in your baby.
Can you stop taking metoprolol ER?
If you need surgery, tell the surgeon ahead of time that you are using Metoprolol Succinate ER. You should not stop using Metoprolol Succinate ER suddenly. Stopping suddenly may make your condition worse. If you have high blood pressure, keep using Metoprolol Succinate ER even if you feel well.
Can you give a child Metoprolol?
Do not give this medicine to a child without medical advice. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether Metoprolol Succinate ER will harm an unborn baby.
What are the side effects of metoprolol?
Metoprolol side effects. Get emergency medical help if you have signs of an allergic reaction to metoprolol: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: very slow heartbeats; a light-headed feeling, like you might pass out;
Why is metoprolol used in the early stages of a heart attack?
Metoprolol is also used to lower your risk of death or needing to be hospitalized for heart failure. Metoprolol injection is used during the early phase of a heart attack to lower the risk of death.
What diseases can metoprolol cause?
diabetes (taking metoprolol may make it harder for you to tell when you have low blood sugar ); liver disease; congestive heart failure; problems with circulation (such as Raynaud's syndrome ); a thyroid disorder; or. pheochromocytoma (tumor of the adrenal gland).
What diseases can you get from taking metoprolol?
asthma, chronic obstructive pulmonary disease ( COPD ), sleep apnea, or other breathing disorder; diabetes (taking metoprolol may make it harder for you to tell when you have low blood sugar ); liver disease; congestive heart failure; problems with circulation (such as Raynaud's syndrome ); a thyroid disorder; or.
What happens if you are allergic to metoprolol?
Get emergency medical help if you have signs of an allergic reaction to metoprolol: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
What drugs can interact with metoprolol?
Many drugs can interact with metoprolol, especially: any other heart or blood pressure medications; epinephrine (Epi-Pen); an antidepressant; an ergot medicine-- dihydroergotamine, ergonovine, ergotamine, methylergonovine; or. an MAO inhibitor -- isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, tranylcypromine.
Can metoprolol cause dry mouth?
Ask a doctor before using this medicine if you are breast-feeding. Metoprolol can pass into breast milk and may cause dry skin, dry mouth, diarrhea, constipation, or slow heartbeats in your baby.
How does metoprolol succinate work?
Metoprolol succinate is a heart medication that works by blocking the effects of epinephrine on beta-1 receptors within the heart tissue, causing the heart to pump more slowly and with less force .
How long does it take for metoprolol to reach peak concentration?
With oral metoprolol succinate extended-release (ER) tablets, peak concentrations are reached in about seven hours following a single dose. With regular dosing; however, concentrations of metoprolol remain steady and do not tend to fluctuate. Usually dosed once daily.
What medications interact with metoprolol succinate?
Common medications that may interact with metoprolol succinate include: some heart medications, such as amiodarone, clonidine, digoxin, diltiazem, propafenone, quinidine, and verapamil. NSAIDs, such as diclofenac, ibuprofen, and indomethacin, may decrease the blood pressure-lowering capabilities of metoprolol.
What class is metoprolol succinate?
Metoprolol succinate belongs to the class of drugs known as beta-blockers.
What are the side effects of taking metoprolol?
If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Heart rate slowing, depression, diarrhea, skin rash and shortness of breath. Side effects are similar for both metoprolol succinate and metoprolol tartrate because they both ...
Can metoprolol succinate be taken with food?
Can be taken once daily. Metoprolol succinate tablets can be taken with or without food. Extended-release tablets may be scored or divided; however, do not crush or chew, swallow whole. Report any shortness of breath or facial swelling immediately to your doctor.
Is metoprolol a beta blocker?
Metoprolol Succinate ER is a selective beta-blocker that is used to lower blood pressure or relieve symptoms of angina in people with heart disease. It may also be used in the treatment of certain types of heart failure. Metoprolol succinate is not interchangeable with metoprolol tartrate. Metoprolol succinate should not be stopped abruptly.
How long does it take for metoprolol to lower blood pressure?
After 9 weeks , metoprolol succinate extended-release alone decreased sitting blood pressure by 6 to 8/4 to 7 mmHg (placebo-corrected change from baseline) at 24 hours post-dose. The combination of metoprolol succinate extended-release with PLENDIL has greater effects on blood pressure.
What is metoprolol succinate?
Metoprolol succinate, is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration , available as extended release tablets. Metoprolol succinate extended-release tablets USP, have been formulated to provide a controlled and predictable release of metoprolol for once-daily administration. The tablets comprise a multiple unit system containing metoprolol succinate in a multitude of controlled release pellets. Each pellet acts as a separate drug delivery unit and is designed to deliver metoprolol continuously over the dosage interval. The tablets contain 95 mg and 190 mg of metoprolol succinate equivalent to 100 mg and 200 mg of metoprolol tartrate, USP, respectively. Its chemical name is (±) 1- (isopropylamino)-3- [p- (2-methoxyethyl) phenoxy]-2-propanol succinate (2:1) (salt). Its structural formula is:
How much metoprolol is excreted in breast milk?
Metoprolol is excreted in breast milk in very small quantities. An infant consuming 1 liter of breast milk daily would receive a dose of less than 1 mg of the drug. Consider possible infant exposure when metoprolol succinate extended-release is administered to a nursing woman. 8.4 Pediatric Use.
What are the symptoms of overdosage of metoprolol succinate?
Signs and Symptoms - Overdosage of metoprolol succinate extended-release may lead to severe bradycardia, hypotension, and cardiogenic shock. Clinical presentation can also include: atrioventricular block, heart failure, bronchospasm, hypoxia, impairment of consciousness/coma, nausea and vomiting.
How many times a day can you take metoprolol?
Metoprolol succinate extended-release administered once a day, and immediate release metoprolol administered once to four times a day, provided comparable total beta1-blockade over 24 hours (area under the beta1-blockade versus time curve) in the dose range 100 to 400 mg.
Can metoprolol succinate be extended?
Metoprolol succina te extended-release tablets intended for once daily administration. For treatment of hypertension and angina, when switching from immediate release metoprolol to metoprolol succinate extended-release, use the same total daily dose of metoprolol succinate extended-release tablets. Individualize the dosage of metoprolol succinate extended-release tablets. Titration may be needed in some patients.
Can metoprolol succinate be used with other antihypertensive agents?
Metoprolol succinate extended-release tablets may be administered with other antihypertensive agents. 1.2 Angina Pectoris. Metoprolol succinate extended-release tablets are indicated in the long-term treatment of angina pectoris, to reduce angina attacks and to improve exercise tolerance. 1.3 Heart Failure.
How many mg of a sulfate can you take a day?
However, the dose is usually not more than 400 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 100 milligrams (mg) per day, given in two divided doses. Your doctor may adjust your dose as needed.
How long does it take to swallow a nasogastric tube?
Swallow the mixture within 60 minutes. Do not store for later use. You may also use a nasogastric tube to give the medicine.
Can you take IBM Micromedex more than once?
Drug information provided by: IBM Micromedex. Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Your dose may need to be changed several times in order to find out what works best for you.
Can you crush blood pressure pills?
You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, strokes, or kidney disease. Swallow the extended-release capsule and tablet whole. Do not crush, break, or chew them.
How long does it take for Toprol XL to work?
Toprol XL (metoprolol succinate) starts to work after about 2 hours, but you won't see full results until about 1 week. You may not feel any different when you take Toprol XL (metoprolol succinate), but this doesn't mean it's not working.
What is toprol XL?
Toprol XL (metoprolol succinate) is a first choice treatment for heart failure since it may prevent long-term heart damage.
What is the difference between Toprol XL and Lopressor?
The main difference between Lopressor and Toprol XL (metoprolol succinate) is that Lopressor (metoprolol tartrate) is an immediate-release tablet which means it must be taken several times per day, whereas Toprol XL (metoprolol succinate) is an extended-release tablet that can be taken once a day.
What are the different types of beta blockers?
Beta blocker medications can treat certain cardiovascular conditions. There are two main types within this medication class: selective and non-selective beta blockers. They each have unique uses, risks, and benefits. Read more in this comparison article at GoodRx.
How long after taking a blood pressure medicine can you check your blood pressure?
Check your blood pressure 1 week after starting this medication and let your doctor know if it hasn't improved.
Is Toprol XL good for heart failure?
Images. Medicare. Toprol XL (metoprolol succinate) is good for controlling chronic chest pain and treating heart failure. It can also be used to treat high blood pressure when other medicines haven't worked.
Can you take Toprol XL with asthma?
Can be used in people between the ages of 6 through 16. Since this beta blocker is selective to the heart & not the lungs, people who have asthma or COPD may have less side effects with Toprol XL (metoprolol succinate) than with other beta blockers.
How long does it take for metoprolol to work?
Metoprolol starts to work after about 2 hours, but it can take up to 1 week to fully take effect.
What is metoprolol succinate used for?
Metoprolol succinate uses. Metoprolol is commonly used to treat chest pain (angina pectoris) and hypertension (high blood pressure). Metoprolol is also used sometimes to prevent migraine headaches and to treat irregular heartbeat (heart arrhythmias) and movement disorders caused by medications for mental illness.
What is metoprolol used for?
Metoprolol also is used to prevent angina (chest pain) and to improve survival after a heart attack. Metoprolol also is used in combination with other medications to treat heart failure. Metoprolol is in a class of medications called beta blockers.
How does metoprolol work?
Like other beta blockers, metoprolol works by changing the way your body responds to some nerve impulses, especially in the heart. It slows down your heart rate and makes it easier for your heart to pump blood around your body.
What are the side effects of metoprolol?
The main side effects of metoprolol are headaches, and feeling dizzy, sick or tired – these are usually mild and short-lived. Metoprolol also goes by the brand name Toprol, Toprol XL and Lopresor. When given by injection, it may be called by the brand name Betaloc.
Does metoprolol lower blood pressure?
Metoprolol works as well as other beta blockers for reducing blood pressure but is less likely to cause side effects. That’s because metoprolol works mainly on the heart. Other beta blockers, such as propranolol, work on the heart but affect other parts of the body as well.
Does metoprolol make you dizzy?
Metoprolol succinate slows down your heart rate and makes it easier for your heart to pump blood around your body. Your very first dose of metoprolol may make you feel dizzy, so take it at bedtime. After that, if you don’t feel dizzy, you can take it in the morning.
What is the name of the drug that metoprolol succinate is based on?
The brand-name medication that metoprolol succinate oral tablet is based on is called Toprol XL. The brand-name medication that metoprolol tartrate oral tablet is based on is called Lopressor. Generic drugs are thought to be as safe and effective as the brand name drug they’re based on.
How does metoprolol get rid of your body?
Your body gets rid of metoprolol by processing it through your liver. If your liver isn’t working as well as it should, the drug may build up in your body. And this can increase your risk of side effects. If you have any liver problems, your doctor may have you start taking a lower dosage of metoprolol than usual.
What is metoprolol used for?
Both of these forms of metoprolol can be used to: prevent ang ina (a type of chest pain) treat high blood pressure. Additionally, metoprolol succinate is used to treat heart failure. And metoprolol tartrate is used to treat a heart attack or prevent one from occurring in the future.
How does metoprolol help with heart pain?
Metoprolol belongs to a group of drugs called beta-blockers. It works by slowing down your heart rate and relaxing your blood vessels. This is how the drug helps to decrease your blood pressure and prevent angina (a type of chest pain ).
What are the interactions with metoprolol?
Interactions. Taking medications, vaccines, foods, and other things with a certain drug can affect how the drug works. These effects are called interactions. Before taking metoprolol oral tablets, be sure to tell your doctor about all medications you take, including prescription and over-the-counter types.
What is the drug group for metoprolol?
Metoprolol belongs to the group of drugs called beta-blockers. Like metoprolol, other drugs called angiotensin-converting enzyme (ACE) inhibitors and diuretics can be used to treat certain heart conditions.
Can you take metoprolol by mouth?
Metoprolol tartrate and metoprolol succinate both come as tablets that you’ll take by mouth.
Medical uses
- Metoprolol Succinate extended-release tablets are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been s…
Management
- Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than 1 drug to achieve blood pressure goals. For specific advice on goals and management, see published gui…
Benefits
- Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits. The lar…
Treatment
- Some antihypertensive drugs have smaller blood pressure effects (as monotherapy) in black patients, and many antihypertensive drugs have additional approved indications and effects (eg, on angina, heart failure, or diabetic kidney disease). These considerations may guide selection of therapy.
Contraindications
- Metoprolol Succinate extended-release tablets is not recommended in pediatric patients < 6 years of age [see Use in Specific Populations (8.4)]. Metoprolol Succinate extended-release tablets are contraindicated in severe bradycardia, second or third degree heart block, cardiogenic shock, decompensated cardiac failure, sick sinus syndrome (unless a permanent pacemaker is in place…
Description
- 50 mg tablets: White, circular, biconvex, film coated tablet debossed with 'C' and 'L' on either side of deep score line on one side and '407' on other side. 100 mg tablets: White circular biconvex film coated tablet debossed with 'C' and 'L' on either side of deep score line on one side and '408' on other side. 200 mg tablets: White capsule shaped biconvex film coated tablet debossed with 'C' …
Risks
- Worsening cardiac failure may occur during up-titration of Metoprolol Succinate extended-release tablets. If such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of Metoprolol Succinate extended-release tablets [see Dosage and Administration (2)]. It may be necessary to lower the dose of Metoprolol Succinate extended-release tablets or tempor…
Interactions
- If Metoprolol Succinate extended-release tablets are used in the setting of pheochromocytoma, it should be given in combination with an alpha blocker, and only after the alpha blocker has been initiated. Administration of beta-blockers alone in the setting of pheochromocytoma has been associated with a paradoxical increase in blood pressure due to the attenuation of beta-mediate…
Safety
- The following adverse reactions are described elsewhere in labeling: Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. The adverse reaction information from clinical trials does, …
Side effects
- Post-operative Adverse Events: In a randomized, double-blind, placebo-controlled trial of 8351 patients with or at risk for atherosclerotic disease undergoing non-vascular surgery and who were not taking betablocker therapy, Metoprolol Succinate extended-release tablets 100 mg was started 2 to 4 hours prior to surgery then continued for 30 days at 200 mg per day. Metoprolol S…
Adverse effects
- Central Nervous System: Confusion, short-term memory loss, headache, somnolence, nightmares, insomnia, anxiety/nervousness, hallucinations, paresthesia.
How It Works
Upsides
Downsides
Bottom Line
Tips
Response and Effectiveness
- With oral metoprolol succinate extended-release (ER) tablets, peak concentrations are reached in about seven hours following a single dose. With regular dosing; however, concentrations of metoprolo...
- The blood pressure lowering effects of metoprolol succinate ER tablets persist for about 24 hours following a single dose.
Interactions
References
Further Information