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HRT can be taken continuously or in cycles. The FDA recommends hormonal replacement therapy should be used at the lowest dose, and for the shortest duration, necessary. Menopause comes to all women. At this time, your body reduces the production of estrogen and progesterone, the hormones that manage your reproductive cycle.
How long should you take hormone replacement therapy?
Women who begin hormone therapy at age 60 or older or more than 10 years from the onset of menopause are at greater risk of the above conditions. But if hormone therapy is started before the age of 60 or within 10 years of menopause, the benefits appear to outweigh the risks. Type of hormone therapy.
When to start hormone therapy for older women?
This will begin six to 12 months after treatment. The maximum effect will occur within three years. During your first year of feminizing hormone therapy, you'll need to see your doctor approximately every three months for checkups, as well as anytime you make changes to your hormone regimen.
How long does feminizing hormone therapy take to work?
How Hormone Therapy Is Given. Hormone therapy may be given in many ways. Some common ways include: Oral. Hormone therapy comes in pills that you swallow. Injection. The hormone therapy is given by a shot in a muscle in your arm, thigh, or hip, or right under the skin in the fatty part of your arm, leg, or belly. Surgery.
How is hormone therapy given?

How long does it take for female hormone therapy to work?
Feminizing hormone therapy will begin producing changes in your body within weeks to months. Your timeline might look as follows: Decreased libido. This will begin one to three months after starting treatment.
How long do the treatment effects of hormone therapy last?
They may last for 2 to 30 minutes and you may have a few a month or more often. They are the same as the hot flushes women have when going through menopause. , because these drugs cut testosterone production off altogether. Getting overheated, drinking tea or coffee, and smoking can all make flushes worse.
What is the duration of hormone therapy?
Standard recommendations — The standard recommendation for duration of menopausal hormone therapy (MHT) use has been five years or less (and not beyond age 60 years) [66]. However, for most women, hot flashes persist for as long as 10 to 20 years after the final menstrual period.
How long does it take hormone therapy to begin working?
It may take a few weeks to feel the effects of treatment and there may be some side effects at first. A GP will usually recommend trying treatment for 3 months to see if it helps. If it does not, they may suggest changing your dose, or changing the type of HRT you're taking.
What are the negative effects of hormone therapy?
Hormone therapy side effects can include vaginal dryness, discharge, itching, or irritation. It can also cause changes to the menstrual cycle and cause vaginal bleeding that is not related to a period. Hot flashes and night sweats. Hot flashes are very common for people receiving hormone therapy.
What happens after hormone therapy?
Hormone therapy can cause a decrease in muscle tissue and an increase in body fat. This can change the way your body looks and how physically strong you feel. Some men also experience muscle aches or joint pain while they're on hormone therapy. This can happen when you lose muscle.
Does HRT make you look younger?
By supplementing your body's natural hormone levels, HRT can help you maintain a more youthful body composition. While this effect is particularly evident in men, research suggests that women can also benefit. HRT is also known to help women maintain softer, smoother skin, resulting in a younger look.
Does HRT cause weight gain?
Many women believe that taking HRT will make them put on weight, but there's no evidence to support this claim. You may gain some weight during the menopause, but this often happens regardless of whether you take HRT. Exercising regularly and eating a healthy diet should help you to lose any unwanted weight.
Can you have a periods while on hormone replacement therapy?
Answer From Tatnai Burnett, M.D. Some forms of menopause hormone therapy may cause monthly bleeding. These include cyclic hormone therapy preparations that contain a combination of estrogen and progestin. Progestin helps protect the uterus from endometrial cancer if you have an intact uterus.
What should I expect the first week of HRT?
When starting HRT, it's very common to experience some initial side effects or start-up symptoms such as breast tenderness or breast size increase. Some women describe slight nausea, headaches or abdominal bloating. Light erratic bleeding is also quite usual.
Does HRT help with weight loss?
Many women actually find that they lose weight by using HRT as it shifts the metabolism back into a pre-menopausal metabolic state. Progesterone can sometimes cause fluid retention which can mimic weight gain, but there are alterations that can be made to the regime to minimise this impact.
How will HRT make me feel?
Some women who use HRT say they feel bloated or have breast soreness. Nausea, dizziness, headaches, and blurry vision are also possible side effects, as is vaginal bleeding.
What Are The Benefits of Hormone Therapy?
The benefits of hormone therapy depend, in part, on whether you take systemic hormone therapy or low-dose vaginal preparations of estrogen. 1. Syst...
What Are The Risks of Hormone Therapy?
In the largest clinical trial to date, a combination estrogen-progestin pill (Prempro) increased the risk of certain serious conditions, including:...
Who Should Consider Hormone Therapy?
Despite its health risks, systemic estrogen is still the most effective treatment for menopausal symptoms. The benefits of hormone therapy may outw...
Who Should Avoid Hormone Therapy?
Women who have or previously had breast cancer, ovarian cancer, endometrial cancer, blood clots in the legs or lungs, stroke, liver disease, or une...
If You Take Hormone Therapy, How Can You Reduce Risk?
Talk to your doctor about these strategies: 1. Find the best product and delivery method for you. You can take estrogen in the form of a pill, patc...
What Can You Do If You Can't Take Hormone Therapy?
You may be able to manage menopausal hot flashes with healthy-lifestyle approaches, such as keeping cool, limiting caffeinated beverages and alcoho...
The Bottom Line: Hormone Therapy Isn't All Good Or All Bad
To determine if hormone therapy is a good treatment option for you, talk to your doctor about your individual symptoms and health risks. Be sure to...
How often should hormones be reevaluated?
For best results, hormone therapy should be tailored to each person and reevaluated every so often to be sure the benefits still outweigh the risks.
What is hormone replacement therapy?
By Mayo Clinic Staff. Hormone replacement therapy is medication that contains female hormones. You take the medication to replace the estrogen that your body stops making during menopause. Hormone therapy is most often used to treat common menopausal symptoms, including hot flashes and vaginal discomfort.
How old do you have to be to start hormone therapy?
Age. Women who begin hormone therapy at age 60 or older or more than 10 years from the onset of menopause are at greater risk of the above conditions. But if hormone therapy is started before the age of 60 or within 10 years of menopause, the benefits appear to outweigh the risks. Type of hormone therapy.
What is systemic estrogen?
Systemic estrogen — which comes in pill, skin patch, ring, gel, cream or spray form — typically contains a higher dose of estrogen that is absorbed throughout the body. It can be used to treat any of the common symptoms of menopause. Low-dose vaginal products.
How to manage hot flashes during menopause?
You may be able to manage menopausal hot flashes with healthy-lifestyle approaches such as keeping cool, limiting caffeinated beverages and alcohol, and practicing paced relaxed breathing or other relaxation techniques. There are also several nonhormone prescription medications that may help relieve hot flashes.
How old do you have to be to take estrogen?
Use the lowest effective dose for the shortest amount of time needed to treat your symptoms. If you're younger than age 45, you need enough estrogen to provide protection against the long-term health effects of estrogen deficiency.
Does estrogen help with menopause?
Estrogen can ease vaginal symptoms of menopause, such as dryness, itching, burning and discomfort with intercourse. Need to prevent bone loss or fractures. Systemic estrogen helps protect against the bone-thinning disease called osteoporosis.
When does hormone therapy start?
If used in an adolescent, hormone therapy typically begins at age 16. Ideally, treatment starts before the development of secondary sex characteristics so that teens can go through puberty as their identified gender. Many trans girls are treated with a medication to delay the start of puberty. Gender affirming hormone therapy is not typically used ...
Why do people need feminizing hormone therapy?
Typically, people who seek feminizing hormone therapy experience discomfort or distress because their gender identity differs from their sex assigned at birth or sex-related physical characteristics (gender dysphoria).
How can feminizing hormone therapy help with gender dysphoria?
Feminizing hormone therapy can: Make gender dysphoria less severe. Reduce psychological and emotional distress. Improve psychological and social functioning. Improve sexual satisfaction. Improve quality of life.
What are the risks of feminizing hormones?
Complications of feminizing hormone therapy might include: A blood clot in a deep vein (deep vein thrombosis) or in a lung (pulmonary embolism) High triglycerides, a type of fat (lipid) in your blood. Weight gain.
What age should a child be to see a doctor for transgender?
Adolescents younger than age 18, accompanied by their parents or guardians, also should see doctors and behavioral health providers with expertise in pediatric transgender health to discuss the risks of hormone therapy, as well as the impact and possible complications of gender transition in that age group.
Can you use gender affirming hormone therapy for children?
Gender affirming hormone therapy is not typically used in children. Feminizing hormone therapy isn't for all trans women. Your doctor might discourage feminizing hormone therapy if you: Had or have a hormone-sensitive cancer, such as prostate cancer.
Does estrogen affect transgender women?
Other side effects of estrogen use in trans women include reduced libido, erectile function and ejaculation. Erectile function might improve with the use of oral medications such as sildenafil (Viagra) or tadalafil (Adcirca, Cialis).
Overview
This gender-affirming treatment uses female hormones to create a more feminine appearance. Feminizing hormone therapy may be used as a standalone treatment or combined with gender affirmation surgery.
Procedure Details
The timing is up to you and your healthcare provider. Some people affirm their new gender identity first by changing their names and dressing differently. But this isn’t a requirement.
Recovery and Outlook
Many transwomen find relief from gender dysphoria with this type of therapy. Having physical attributes that match your gender identity can ease anxiety and depression. Transwomen also have improved self-esteem and self-image. These factors contribute to a better quality of life.
When to Call the Doctor
Certain side effects of estrogen and anti-androgens can be a sign of complications. Some can become severe or need immediate medical attention.
How does hormone therapy work?
Hormone therapy is used to: Treat cancer. Hormone therapy can lessen the chance that cancer will return or stop or slow its growth. Ease cancer symptoms. Hormone therapy may be used to reduce or prevent symptoms in men with prostate cancer who are not able to have surgery or radiation therapy.
What is hormone therapy?
Credit: iStock. Hormone therapy is a cancer treatment that slows or stops the growth of cancer that uses hormones to grow. Hormone therapy is also called hormonal therapy, hormone treatment, or endocrine therapy.
What are the side effects of hormone therapy for prostate cancer?
Some common side effects for men who receive hormone therapy for prostate cancer include: hot flashes. loss of interest in or ability to have sex. weakened bones. diarrhea. Nausea. enlarged and tender breasts. fatigue.
Why does hormone therapy cause side effects?
Because hormone therapy blocks your body’s ability to produce hormones or interferes with how hormones behave, it can cause unwanted side effects. The side effects you have will depend on the type of hormone therapy you receive and how your body responds to it. People respond differently to the same treatment, so not everyone gets the same side effects. Some side effects also differ if you are a man or a woman.
What is the treatment for cancer that has returned?
This is called neoadjuvant therapy. Lower the risk that cancer will come back after the main treatment. This is called adjuvant therapy. Destroy cancer cells that have returned or spread to other parts of your body.
Does insurance pay for hormone therapy?
Most insurance plans pay for hormone therapy for their members. To learn more, talk with the business office where you go for treatment. You can also go to the National Cancer Institute database, Organizations that Offer Support Services and search "financial assistance.".
What age do women go on hormone therapy?
Critics point out that the average age of a woman in that study was 63. Hormone therapy may just have a different effect depending on the age at which you start it. So, many women who go into surgical menopause when they're under 50 go onto HRT.
Why can't I get HRT at 50?
That's because their supply of estrogen would naturally drop during menopause anyway.
How many hot flashes do menopausal women have?
One out of four menopausal women has severe hot flashes. Treatment with hormone therapy cuts down the number of hot flashes per week by 75%. So if a woman had 24 hot flashes per week, HRT would drop that number to six. That could make a big difference in the quality of their day-to-day life.
What is it called when the ovaries are removed?
The removal of the ovaries is called an oophorectomy. The procedure is often combined with a hysterectomy -- removal of the uterus -- but not always.
How many times more likely is a woman to die from heart disease if she had her ovaries removed?
A 2006 study showed that women who had their ovaries removed before age 45 were 1.7 times as likely to die -- from any cause -- than average.
Does HRT help with hot flashes?
Some women find that their menopausal symptoms -- the hot flashes, the vaginal dryness, the sleep problems -- are unbearable and nothing seems to work. HRT can be quite effective in preventing and reversing many symptoms. For example, some studies show that it can cut the number of hot flashes by 75%.
Can you take estrogen and progestin with ovaries removed?
But women who have only the ovaries removed need both estrogen and progestin. That's because estrogen alone can increase the risk of cancer in the uterus. Adding progestin removes this risk.
How many women are still taking estrogen and progestin?
After a year of therapy, the investigators found that nearly 70% of the women taking the daily, continuous combination therapy -- that is, estrogen and progestin daily -- were still taking their medication. Less than 55% of the other group were still taking their medication, and they were also twice as likely to switch medications.
Is it easier to stick with HRT?
April 3, 2000 (New York) -- If you are considering hormone replacement therapy (HRT), consider this: If you and your doctor can find a therapy that eliminates monthly and irregular bleeding, it may be easier for you to stick with the program . And if you are already on HRT and have spotting or monthly bleeding, you can ask your doctor about other ...
How does testosterone help women?
In addition to increasing the libido, and increasing health and vitality overall, testosterone therapy in women can also: 1 Encourage improved heart health 2 Help to prevent osteoporosis by strengthening bones and increasing density 3 Increases muscle mass and reduce fat 4 Improve mood 5 Improve sleep
What happens when a woman goes through menopause?
However, when a woman is going through menopause, along with estrogen depletion, she is also losing her ability to produce adequate amounts of testosterone. A woman with low testosterone, will have trouble producing new blood cells, maintaining her libido or sex drive, and will find it harder to build muscle and burn fat.
What is transdermal testosterone?
Transdermal testosterone is a form of testosterone replacement therapy that is given using transdermal (skin) patches. In addition to increasing the libido, and increasing health and vitality overall, testosterone therapy in women can also: Encourage improved heart health. Help to prevent osteoporosis by strengthening bones and increasing density.
Why is testosterone important for women?
Unlike being necessary in vast amounts to provide for the development of “maleness” in men, in women, testosterone is necessary for: Fertility. Sex drive. Red blood cell production. Muscle mass and fat distribution. When a women is experiencing low testosterone, all of the above can be negatively affected.
Does testosterone increase pleasure?
According to Dr. Alan Malabanan, assistant professor of medicine at Harvard Medical School, “Studies of postmenopausal women have found that taking testosterone (often in addition to the hormone therapy women are already taking to treat menopause symptoms) increases sexual desire and pleasure compared with a placebo (inactive treatment).”.
Does testosterone help with menopause?
Loss of bone density. Current research indicates that women who are on estrogen replacement for menopausal symptoms, can also benefit when testosterone therapy is added as an adjunct to estrogen replacement in these women. Testosterone, when used in this way, seems to specifically help with the sexual wellness issues typical ...
Can testosterone be used for low testosterone?
While testosterone is the male hormone, and testosterone replacement therapy is most often used to treat men with low testosterone, you may be surprised to learn that women can benefit from testosterone therapy as well.
Can anticoagulants be prescribed with hormone therapy?
Anticoagulants are commonly prescribed in these instances, however, doctors have been cautious to prescribe them when the patient is also on hormone therapy. These actions had become common practice despite there being no clinical evidence, Martinelli said.
Can you take Coumadin with hormone replacement?
Coumadin, a popular anticoagulant drug, can now be prescribed with hormone replacement therapies. Getty Images. It was previously believed that the combination of prescription anticoagulants (blood thinners) and hormone replacement therapy increased women’s risk of blood clots. However, a new study published in the journal Blood suggests ...
Is it safe to take hormone therapy and anticoagulants at the same time?
However, a new study published in the journal Blood suggests the combination is safe. "While it has been common practice among health care providers to avoid prescribing hormone therapy and anticoagulants at the same time, there has been no evidence to support this decision," said senior author Dr. Ida Martinelli, of the A.

Overview
Why It's Done
Risks
- Talk to your doctor about the changes in your body and any concerns you might have. Complications of feminizing hormone therapy might include: 1. A blood clot in a deep vein (deep vein thrombosis) or in a lung (pulmonary embolism) 2. High triglycerides, a type of fat (lipid) in your blood 3. Weight gain 4. Infertility 5. High potassium (hyperkalemia) 6. High blood pressure (…
How You Prepare
- Before starting feminizing hormone therapy, your doctor will evaluate your health to rule out or address any medical conditions that might affect or contraindicate treatment. The evaluation might include: 1. A review of your personal and family medical history 2. A physical exam, including an assessment of your external reproductive organs 3. Lab tests measuring your lipids…
What You Can Expect
- During the procedure
Typically, you'll begin feminizing hormone therapy by taking the diuretic spironolactone (Aldactone) at doses of 100 to 200 milligrams daily. This blocks male sex hormone (androgen) receptors and can suppress testosterone production. After four to eight weeks, you'll begin takin…
Results
- During your first year of feminizing hormone therapy, you'll need to see your doctor approximately every three months for checkups, as well as anytime you make changes to your hormone regimen. Your doctor will: 1. Document your physical changes 2. Monitor your hormone concentration, and use the lowest dose necessary to achieve desired physical effects 3. Monitor changes in your lip…
Clinical Trials
- Explore Mayo Clinic studiesof tests and procedures to help prevent, detect, treat or manage conditions.