Precautions
Follow your doctor's instructions very closely. Your doctor will determine how long to treat you with this medicine. Reclast is often given for only 3 to 5 years. Comments: Retreatment may be considered in patients who have relapsed, based on increases in serum alkaline phosphatase or failure to achieve normalization of serum alkaline phosphatase.
How long should I take Reclast?
Common side effects of Reclast include: hypophosphatemia, hypokalemia, and hypomagnesemia. Other side effects include: hypocalcemia. See below for a comprehensive list of adverse effects. Along with its needed effects, zoledronic acid (the active ingredient contained in Reclast) may cause some unwanted effects.
What are the side effects of Reclast?
Eat high-fiber foods. This may help decrease constipation by adding bulk to your bowel movements. High-fiber foods include fruit, vegetables, whole-grain breads and cereals, and beans. Your healthcare provider or dietitian can help you create a high-fiber meal plan.
How do you get rid of constipation after a bowel movement?
The signs and symptoms of acute phase reaction occurred in Study 1 following Reclast infusion including fever (18%), myalgia (9%), flu-like symptoms (8%), headache (7%), and arthralgia (7%).
What are the signs and symptoms of acute phase reactions to Reclast?
Is constipation a side effect of Reclast?
Fever, nausea, constipation, anemia, and shortness of breath are the most frequently reported side effects. Low blood pressure, abdominal pain, and vomiting may also occur. A lowering in the levels of certain electrolytes such as phosphate, potassium, and magnesium may occur.
How long do side effects from Reclast infusion last?
What about side effects? The most common side effects with the injection are bone, muscle and joint pains, flu like illness and headache. The flu like symptoms generally disappears after 24-48 hours and usually occurs only after the first injection.
Can a Reclast infusion cause constipation?
diarrhea, constipation, joint or muscle pain, or. injection site reactions (pain, redness, swelling).
How long after Reclast infusion Do side effects start?
The most common side effects you might experience after your zoledronic acid (Reclast) infusion include fever, chills, muscle aches, headache, and joint stiffness. Most of these side effects occur within the first 3 days after your infusion.
How do I stop Reclast side effects?
Most of these side effects are mild and occur within 3 days of treatment. Flu-like symptoms may be reduced by taking acetaminophen or ibuprofen after the treatment. If any of these effects worsen or last more than 4 days, tell your doctor or pharmacist promptly.
How long do side effects last after zoledronic acid infusion?
The majority of the side effects, such as fever and chills, pain in the muscles or joints, and headache, occur within the first three days following the dose of Zoledronic acid 5 mg. The symptoms are usually mild to moderate and go away within three days.
How do you feel after Reclast infusion?
“1st infusion of Reclast has left me feeling fatigued with terrible pain and swelling in hands, especially thumb joints that is not improving after nearly two weeks along with overall body aches and pains, headache and difficulty sleeping . I would never consider taking this drug again!”
How long do bisphosphonates side effects last?
In patients who receive IV bisphosphonate therapy, a transient acute phase reaction may occur; it usually lasts 24 to 72 hours and is characterized by fever, myalgias, and arthralgias.
Does Reclast improve bone density?
Fosamax and other drugs such as Actonel, Boniva, and Reclast increase bone density and help prevent and treat osteoporosis and/or reduce the risk of fractures.
How long does it take for a Reclast infusion to work?
Patients who experience flu-like symptoms typically feel them after the first treatment — and they generally see an improvement within 48 hours. Less common side effects include heartburn, stomach ulcers, and swallowing difficulties.
Can I take ibuprofen after Reclast infusion?
Interactions between your drugs Talk to your doctor before using zoledronic acid together with ibuprofen. If you take a medication like zoledronic acid by mouth, combining it with ibuprofen may increase your risk of developing gastrointestinal ulcers and bleeding.
Can you drink alcohol after Reclast infusion?
What drugs and food should I avoid while taking Reclast (Zoledronic Acid)? Avoid smoking, or try to quit. Smoking can reduce your bone mineral density, making fractures more likely. Avoid drinking large amounts of alcohol.
Before Taking This Medicine
You should not be treated with Reclast if you are allergic to zoledronic acid.You also should not receive Reclast if you have: 1. low levels of cal...
Reclast Dosing Information
Usual Adult Dose for Paget's Disease:5 mg IV infusion, at a constant infusion rate, over no less than 15 minutesCalcium and vitamin D supplementati...
What Should I Avoid While Receiving Reclast?
Avoid smoking, or try to quit. Smoking can reduce your bone mineral density, making fractures more likely.Avoid drinking large amounts of alcohol....
What Other Drugs Will Affect Reclast?
Zoledronic acid can harm your kidneys. This effect is increased when you also use certain other medicines, including: antivirals, chemotherapy, inj...
How long does reclast last?
The optimal duration of use of Reclast has not been determined. Discontinuation of therapy should be considered by doctors after 3 to 5 years in patients with osteoporosis at a low risk of fracture.
What is a reclast?
Reclast is a brand (trade) name for zoledronic acid. Zoledronic acid strengthens bones and may be used for the treatment or prevention of osteoporosis. It works by inhibiting osteoclasts which are responsible for breaking down and reabsorbing bone (by a process known as bone resorption).
Why is reclast used?
Reclast may be used to treat or prevent osteoporosis caused by menopause, steroid use, or low hormone levels due to gonadal failure. Reclast may also be used to increase bone mineral density in men and to treat Paget's disease of the bone in men and women.
What medications interact with reclast?
Common medications that may interact with Reclast include: aminoglycoside antibiotics, such as amikacin, gentamicin, kanamycin, neomycin, paromomycin, or tobramycin. angiogenesis inhibitors, such as bevacizumab or everolimus. aspirin.
Can reclast be discontinued?
Reclast should be discontinued if this occurs. May interact with some other medicines such as aminoglycosides or calcitonin (may have an additive calcium-lowering effect), loop diuretics (an additive sodium-lowering effect) as well as other drugs that may also adversely affect the kidneys.
Is reclast a generic?
Reclast is available as a generic under the name zoledronic acid. 3. Downsides. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:
Is reclast a good bisphosphonate?
The effectiveness of Reclast is comparable to most other bisphosphonates; however, because it has a very favorable dosing regimen, its real-life benefits are more mainly due to the fact that people taking oral bisphosphonates are not very compliant.
What are the symptoms of reclast?
Reclast was associated with signs and symptoms of an acute phase reaction: myalgia (17.1%), fever (15.7%), fatigue (12.4%), arthralgia (11.1%), pain (10.5%), chills (9.8%), headache (9.8%), influenza-like illness (8.5%), malaise (5.2%), and back pain (3.3%), which occurred within the first 3 days following the dose of Reclast. The majority of these symptoms were mild to moderate and resolved within 3 days of the event onset but resolution could take up to 7-14 days. The incidence of these symptoms decreased with subsequent doses of Reclast.
What is a reclast?
What Is Reclast? Reclast (zoledronic acid) is a bisphosphonate used to treat Paget's disease, high blood levels of calcium caused by cancer ( hypercalcemia of malignancy, multiple myeloma (a type of bone marrow cancer) or cancer that has spread from elsewhere in the body to the bone, to treat or prevent osteoporosis in postmenopausal women, ...
Why is it not always possible to reliably estimate the frequency of drug reactions?
Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Can you breastfeed while taking reclast?
Reclast should not be used during pregnancy. It may harm a fetus. It is unknown if this medication passes into breast milk. Breastfeeding while using this drug is not recommended. Consult your doctor before breastfeeding.
How long does reclast last?
Follow your doctor's instructions very closely. Your doctor will determine how long to treat you with this medicine. Reclast is often given for only 3 to 5 years.
How long does zoledronic acid stay in your system?
Zoledronic acid can remain in your body for weeks or years after your last dose. Use effective birth control to prevent pregnancy while using this medicine. Talk with your doctor about the need to prevent pregnancy after you stop using Reclast. This medicine may affect fertility (ability to have children) in women.
Can a reclast cause kidney problems?
Reclast can cause serious kidney problems, especially if you are dehydrated, if you take diuretic medicine, or if you already have kidney disease. Call your doctor if you urinate less than usual, if you have swelling in your feet or ankles, or if you feel tired or short of breath.
Can reclast cause jaw pain?
Some people using medicines similar to Reclast have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms of this condition may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums.
Can you take reclast with kidney disease?
severe kidney disease. You should not be treated with Reclast if are currently using any other bisphosphonate (such as alendronate, etidronate, ibandronate, pamidronate, risedronate, or tiludronate). To make sure Reclast is safe for you, tell your doctor if you have ever had: kidney disease; hypocalcemia;
How long does it take for bisphosphonate to cause pain?
Rarely patients have reported severe bone, joint and muscle pain that begins from 1 day to one month after starting any bisphosphonate, including Zolendronic acid.
How long does zolendronic acid last?
Zolendronic acid is given as an infusion (through a vein in your arm) lasting 15 minutes. You should drink 2 glasses of fluid at least one hour before receiving your infusion. You may eat normally before your infusion. Zolendronic acid infusions are once a year.
What is zoledronic acid (Reclast)?
Zoledronic acid (Reclast) is a bisphosphonate. Bisphosphonates work to slow down bone breakdown so the body can make new, healthy, and strong bone. Zoledronic acid (Reclast) helps raise bone mineral density (BMD), which is a measure of how dense your bones are.
Frequently asked questions about zoledronic acid (Reclast)
What's the difference between zoledronic acid (Reclast) and zoledronic acid (Zometa)?
Pros and cons of zoledronic acid (Reclast)
Lowers the risk of fractures in different parts of the body, including the hip and back
Pharmacist tips for zoledronic acid (Reclast)
Don't take zoledronic acid (Zometa) at the same time, since zoledronic acid (Reclast) and Zometa contain the same active ingredient. Taking medications with the same active ingredient at the same time can raise your risk of side effects.
What are the side effects of zoledronic acid (Reclast)?
With any medication, there are risks and benefits. Even if the medication is working, you may experience some unwanted side effects.
What are the risks and warnings for zoledronic acid (Reclast)?
Zoledronic acid (Reclast) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options
Interactions between zoledronic acid (Reclast) and other medications
Zoledronic acid (Reclast) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.
Answers
I was very fortunate. I had 4 Reclast infusions. Then actually having no significant side effect. I was already being treated for depression so had that medication already in my system. Unfortunately, I developed osteonecrosis ONJ which is a side effect of most of the osteoporosis drugs.
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How to stop constipation?
Prevent constipation: Drink liquids as directed. You may need to drink extra liquids to help soften and move your bowels. Ask how much liquid to drink each day and which liquids are best for you. Eat high-fiber foods. This may help decrease constipation by adding bulk to your bowel movements. High-fiber foods include fruit, vegetables, whole-grain ...
How to get rid of constipation in the intestines?
Exercise regularly. Regular physical activity can help stimulate your intestines. Walking is a good exercise to prevent or relieve constipation. Ask which exercises are best for you. Schedule a time each day to have a bowel movement. This may help train your body to have regular bowel movements.
How to train your body to bowel movement?
This may help train your body to have regular bowel movements. Bend forward while you are on the toilet to help move the bowel movement out. Sit on the toilet for at least 10 minutes, even if you do not have a bowel movement. Talk to your healthcare provider about your medicines.
What does it mean when you have a hard bowel movement?
WHAT YOU NEED TO KNOW: Constipation is when you have hard, dry bowel movements, or you go longer than usual between bowel movements.
What foods can help with constipation?
This may help decrease constipation by adding bulk to your bowel movements. High-fiber foods include fruit, vegetables, whole-grain breads and cereals, and beans. Your healthcare provider or dietitian can help you create a high-fiber meal plan.
Can opioids cause constipation?
Talk to your healthcare provider about your medicines. Certain medicines, such as opioids, can cause constipation. Your provider may be able to make medicine changes. For example, he or she may change the kind of medicine, or change when you take it.
Can laxatives help with bowel movement?
Medicine such as a laxative may help relax and loosen your intestines to help you have a bowel movement. Your provider may recommend you only use laxatives for a short time. Long-term use may make your bowels dependent on the medicine.
How It Works
This medication is used to treat a certain type of bone disease (Paget's disease) that causes abnormal and weak bones. Zoledronic acid is also used to treat bone loss (osteoporosis) in men and in women after menopause who are at high risk of having broken bones (fractures). It may also be used to treat or prevent osteoporosis in people who are taking corticosteroid medications (such as prednisone) for long periods.
May Treat: Paget's disease of bone · Glucocorticoid-induced osteoporosis · Humoral hypercalcemia of malignancy · Osteoporosis in male patient · Post-menopausal osteoporosis and more
Drug Class: Bone Resorption Inhibitors - Bisphosphonates
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: This drug should not be given to breastfeeding mothers
May Treat: Paget's disease of bone · Glucocorticoid-induced osteoporosis · Humoral hypercalcemia of malignancy · Osteoporosis in male patient · Post-menopausal osteoporosis and more
Drug Class: Bone Resorption Inhibitors - Bisphosphonates
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: This drug should not be given to breastfeeding mothers
Alcohol: Limit intake while taking this medication
Driving: May cause drowsiness or dizziness. Use caution
Manufacturer: NOVARTIS
- Do not take while breast feeding or when pregnant
- Tell doctor your complete medical history
- Rarely can cause kidney problems
- Do not take while breast feeding or when pregnant
- Tell doctor your complete medical history
- Rarely can cause kidney problems
- Call Dr immediately if any eye problems occur
- Tell dentist you are on this medication.
- Lab tests may be ordered to monitor therapy
- For iv solution, piggyback, bottle products : Before use, important to read the Medication Guide. Infuse this drug via a vein (intravenously). Drink plenty of fluids. Tell MD and pharmacist all drugs you are taking.
Upsides
Downsides
Bottom Line
Tips
Response and Effectiveness
- Reclast may be used to treat or prevent osteoporosis caused by menopause, steroid use, or low hormone levels due to gonadal failure.
- Reclast may also be used to increase bone mineral density in men and to treat Paget's disease of the bone in men and women.
- Reclast only requires administration every year for the treatment of osteoporosis, and every t…
- Reclast may be used to treat or prevent osteoporosis caused by menopause, steroid use, or low hormone levels due to gonadal failure.
- Reclast may also be used to increase bone mineral density in men and to treat Paget's disease of the bone in men and women.
- Reclast only requires administration every year for the treatment of osteoporosis, and every two years for the prevention of osteoporosis.
- Reclast is available as a generic under the name zoledronic acid.
Interactions
- If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: 1. Fever, nausea, constipation, anemia, and shortness of breath are the most frequently reported side effects. Low blood pressure, abdominal pain, and vomiting may also occur. 2. A lowering in the levels of certain ele…
References
- Reclast may be used to treat or prevent osteoporosis caused by menopause, steroid use or gonadal failure, in the treatment of Paget's disease, and to increase bone mineral density in men. Reclast o...
Further Information
- You may need to take supplementary calcium or vitamin D if your dietary intake is inadequate. Your doctor will advise you about this.
- Tell your doctor if you have ever had kidney problems in the past before taking Reclast.
- Make sure you get your laboratory tests done to test for creatinine) during the course of your Reclast therapy.
- You may need to take supplementary calcium or vitamin D if your dietary intake is inadequate. Your doctor will advise you about this.
- Tell your doctor if you have ever had kidney problems in the past before taking Reclast.
- Make sure you get your laboratory tests done to test for creatinine) during the course of your Reclast therapy.
- Make sure you have a dental check-up before you start Reclast. Talk to both your dentist and doctor if you require dental surgery or tooth extraction and you have been administered Reclast. Keep go...
What Is Zolendronic Acid (Reclast®)?
- The effectiveness of Reclast is comparable to most other bisphosphonates; however, because it has a very favorable dosing regimen, its real-life benefits are more mainly due to the fact that people...
- After treatment with Reclast, BMD increased 11% from baseline after one year of treatment and 20.7% from baseline after two years of treatment.
How Do I Take It?
- Medicines that interact with Reclast may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with Reclast. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be mana…
What About Side Effects?
- Reclast (zoledronic acid) [Package Insert]. 05/2021. Novartis Pharmaceuticals Corporation https://www.drugs.com/pro/reclast.html
What About Other medications?
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Reclast only for the indication prescribed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Copyright 1996-2022 Drugs.com. Revision date: November 4, 2021. Medical Dis…
What Else Should I Know?
- Zolendronic acid is used to treat or prevent osteoporosis. Osteoporosis is a disease which causes bones to become thin. You are at risk for osteoporosis if you are: