
Medication
The recommended treatment at all stages of this disease is the antibiotic penicillin. If you’ve been infected for less than a year, you may need just one injection of penicillin to be cured. But you may need more doses if you’ve had syphilis for more than a year.
Self-care
Within 10 days to 3 months after sex with someone who has syphilis, one or more painless ulcers will form where there was contact. Ulcers usually form within 3 to 4 weeks. Within 1 to 5 weeks, ulcers heal without treatment. But, this does not mean you no longer have syphilis.
Nutrition
You can also be infected with syphilis for years and not notice any symptoms. But since syphilis doesn’t go away on its own, if you have signs or symptoms of syphilis, you should get tested for it, and treated if you have it. How Long Does Syphilis Last After Treatment?
How long does it take before you can treat syphilis?
Yes. If you have syphilis in any stage, penicillin is the best treatment. The disease is usually cured by this treatment. In the case of penicillin allergies, your health care provider may prescribe a different medicine. How Long Should You Take Amoxicillin For Syphilis?
How long it will take to recover from syphilis?
Does syphilis go away on its own?
Can syphilis be cured at any stage?

How long does it take for syphilis to go away with treatment?
You may have one or more sores. The chancre disappears within three to six weeks. Swollen lymph glands in your neck, armpits or groin.
How long does syphilis take to work?
It can take 3 weeks or more for the symptoms of syphilis to appear after you're infected. Sometimes the symptoms can improve or go away completely, but if you have not been treated the infection is still in your body. This means you can still pass it on and you're at risk of getting serious problems later on.
How do I know if my syphilis treatment worked?
After you're treated for syphilis, your doctor will ask you to:Have periodic blood tests and exams to make sure you're responding to the usual dosage of penicillin. ... Avoid sexual contact with new partners until the treatment is completed and blood tests indicate the infection has been cured.More items...•
How long does it take for syphilis to go away with penicillin?
If you had syphilis for more than one year, you need three shots—one shot a week for three weeks. If you're allergic to penicillin, be sure to tell your doctor. If you have an advanced case of syphilis, you may need stronger treatment. You may get shots of penicillin every day for 10 days.
How quickly does penicillin shot work?
You should begin to feel better during the first few days of treatment with penicillin G injection. If your symptoms do not improve or get worse, call your doctor. Use penicillin G injection for as long as your doctor tells you that you should, even if you feel better.
How long does penicillin take to work?
Antibiotics begin to work right after you start taking them. However, you might not feel better for 2 to 3 days. How quickly you get better after antibiotic treatment varies. It also depends on the type of infection you're treating.
How long do syphilis sores last?
Primary Stage Because the sore is painless, you may not notice it. The sore usually lasts 3 to 6 weeks and heals regardless of whether you receive treatment. Even after the sore goes away, you must still receive treatment. This will stop your infection from moving to the secondary stage.
Why do I keep testing positive for syphilis?
The most common reason for a false-positive is that a person produces antibodies that "fool" the syphilis test. This may occur because the antibodies are similar to the syphilis antibody or because they interfere with chemical reactions needed to perform the test for syphilis.
How soon after syphilis treatment Can you retest?
After treatment for primary or secondary syphilis, it is recommended that a person be retested after 6 months, and once again after a year. If you are treated in the latent period, follow up tests are recommended after 6 months, 12 months & again at 24 months.
How long does it take to cure syphilis with doxycycline?
However, multiple therapies might be effective for nonpregnant persons with penicillin allergy who have primary or secondary syphilis. Doxycycline (100 mg orally 2 times/day for 14 days) (600,601) and tetracycline (500 mg orally 4 times/day for 14 days) have been used for years and can be effective.
What is the strongest antibiotic for STD?
Single-dose therapy with azithromycin is as effective as a seven-day course of doxycycline (Vibramycin). Doxycycline is less expensive, but azithromycin may be cost-beneficial because it provides single-dose, directly observed therapy. Erythromycin and ofloxacin (Floxin) also may be used to treat C.
Can you transmit syphilis after treatment?
More doses are needed to treat someone who has had syphilis for longer than a year. Can I get syphilis again after I've been treated? Yes, you can get syphilis again. You can get it from an untreated partner or a new partner who is infected.
How long do syphilis sores last?
Primary Stage Because the sore is painless, you may not notice it. The sore usually lasts 3 to 6 weeks and heals regardless of whether you receive treatment. Even after the sore goes away, you must still receive treatment. This will stop your infection from moving to the secondary stage.
How long can you have syphilis without knowing?
And because the sores aren't painful and can live in hidden places, you may not notice them. Chancres typically show up anywhere between 3 weeks and 3 months after you get the infection.
What does syphilis look like in the beginning?
The first sign of syphilis is a small sore, called a chancre (SHANG-kur). The sore appears at the spot where the bacteria entered your body. While most people infected with syphilis develop only one chancre, some people develop several of them. The chancre usually develops about three weeks after exposure.
Will syphilis go away on its own?
Primary syphilis: The first stage happens two to 12 weeks after exposure to the bacteria. During this stage, a smooth, red sore called a chancre develops on the genitals or in the mouth. It goes away on its own in a few weeks or months.
Can syphilis be cured?
Syphilis can be cured with the right antibiotics. However, treatment will not undo any damage that the infection has already caused. If playback doesn't begin shortly, try restarting your device. Videos you watch may be added to the TV's watch history and influence TV recommendations.
Does penicillin kill syphilis?
Treatment will kill the syphilis bacterium and prevent further damage, but it will not repair damage already done. Selection of the appropriate penicillin preparation is important to properly treat and cure syphilis.
Is there a cure for syphilis?
What is the treatment for syphilis? There are no home remedies or over-the-counter drugs that will cure syphilis, but syphilis is easy to cure in its early stages.
Can you take penicillin for syphilis?
Combinations of some penicillin preparations (e.g., Bicillin C-R, a combination of benzathine penicillin and procaine penicillin) are not appropriate treatments for syphilis, as these combinations provide inadequate doses of penicillin.
Nontreponemal Tests and Traditional Algorithm
False-positive nontreponemal test results can be associated with multiple medical conditions and factors unrelated to syphilis, including other infections (e.g., HIV), autoimmune conditions, vaccinations, injecting drug use, pregnancy, and older age ( 566, 569 ).
Treponemal Tests and Reverse Sequence Algorithm
The majority of patients who have reactive treponemal tests will have reactive tests for the remainder of their lives, regardless of adequate treatment or disease activity. However, 15%–25% of patients treated during the primary stage revert to being serologically nonreactive after 2–3 years ( 570 ).
Cerebrospinal Fluid Evaluation
Further testing with CSF evaluation is warranted for persons with clinical signs of neurosyphilis (e.g., cranial nerve dysfunction, meningitis, stroke, acute or chronic altered mental status, or loss of vibration sense).
Special Considerations
Parenteral penicillin G is the only therapy with documented efficacy for syphilis during pregnancy. Pregnant women with syphilis at any stage who report penicillin allergy should be desensitized and treated with penicillin (see Management of Persons Who Have a History of Penicillin Allergy).
Management of Sex Partners
Sexual transmission of T. pallidum is thought to occur only when mucocutaneous syphilitic lesions are present. Such manifestations are uncommon after the first year of infection.
How long does a Jarisch Herxheimer reaction last?
Signs and symptoms include a fever, chills, nausea, achy pain and a headache. This reaction usually doesn't last more than one day.
What test can confirm syphilis?
Blood. Blood tests can confirm the presence of antibodies that the body produces to fight infection. The antibodies to the syphilis-causing bacteria remain in your body for years, so the test can be used to determine a current or past infection. Cerebrospinal fluid.
How to prevent HIV infection?
Avoid sexual contact with new partners until the treatment is completed and blood tests indicate the infection has been cured. Notify your sex partners so that they can be tested and get treatment if necessary. Be tested for HIV infection.
What to do when you have a pre-appointment?
At the time you make the appointment, ask if there's anything you need to do in advance. Write down any symptoms you're experiencing, including any that may seem unrelated to the reason for which you scheduled the appointment .
Can you take penicillin while pregnant?
Women who are allergic to penicillin can undergo a desensitization process that may allow them to take penicillin. Even if you're treated for syphilis during your pregnancy, your newborn child should be tested for congenital syphilis and if infected, receive antibiotic treatment.
Can you cure syphilis with penicillin?
When diagnosed and treated in its early stages, syphilis is easy to cure. The preferred treatment at all stages is penicillin, an antibiotic medication that can kill the organism that causes syphilis. If you're allergic to penicillin, your doctor may suggest another antibiotic or recommend penicillin desensitization.
How long do side effects of syphilis last?
Joint or muscle pain. All of the above, plus nausea and chills. If you do have side effects, they typically only last about 24 hours. Once you’ve completed your treatment, the antibiotics will kill the bacteria that cause syphilis and prevent any additional problems from occurring because of that particular case.
Can you get syphilis again?
And, they’ll advise you to be tested for HIV and avoid all sexual contact until blood tests confirm you’re cured. And remember that getting treatment doesn’t mean you can’t get syphilis again or spread it at a later time.
Can syphilis cause blindness?
Syphilis can cause blindness or paralysis. It increases your chances of getting and spreading HIV, the virus that causes AIDS. Over time, it can damage your organs and even lead to death. And, of course, if you’re not treated, you’ll likely spread the STD to your sexual partner.
Can you give penicillin to a newborn?
Yes. If you’re expecting, it’s especially important to seek treatment because you could pass the disease on to your fetus or newborn. Again, your doctor will give you penicillin. If you’re allergic to it, your doctor will have you go through a special process to enable you to take the antibiotic.
How long does it take to get penicillin for syphilis?
Here’s how you may get the antibiotic: Early stage: One shot of penicillin. Late stage: Three shots of penicillin, with one shot given each week for three weeks. Syphilis affects your nervous system: Penicillin given through an IV (intravenous) infusion, with treatment given once a week for two weeks. To treat syphilis with penicillin, you need ...
How long after syphilis treatment can you have sex?
To treat syphilis with penicillin, you need a shot or IV infusion. Taking penicillin pills cannot cure you. You should not have sex for at least 1 week after treatment and until all symptoms have gone away.
What happens if you catch syphilis in a late stage?
If the syphilis was caught in a late stage, it may have affected your body in other ways. You may need other medical tests. People also need follow-up syphilis blood tests to make sure the syphilis treatment worked. Taking good care of yourself also plays an important role in your treatment.
How long does it take for a bacterial reaction to go away?
It’s possible that the person’s immune system is reacting to the dying bacteria. The reaction clears quickly on its own, usually disappearing completely within 24 hours.
What to do if you have syphilis?
If you might have syphilis, your doctor will order a blood test. If this blood test is positive, the lab typically performs a second test on your blood to confirm that you have syphilis. If you have syphilis, you need treatment.
Can you take penicillin while pregnant?
These antibiotics can be less effective at treating syphilis. If you are pregnant and allergic to penicillin, you must treat with penicillin. It’s the only antibiotic that can treat both mother and baby. A method called “desensitization” is used so that you can be safely treated with penicillin.
Does a doctor have to report syphilis to the local health department?
It will also prevent them from giving the infection back to you or to other people. Your doctor is required by law to report all syphilis infections to the local health department. If you prefer, the health department can help notify your partner (s) that they need to be tested.
What was the first treatment for syphilis?
The early treatments of syphilis. In the early 16th century, the main treatments for syphilis were guaiacum, or holy wood, and mercury skin inunctions or ointments, and treatment was by and large the province of barber and wound surgeons.
When was syphilis first discovered?
Up until the early 20th century it was believed that syphilis had been brought from America and the New World to the Old World by Christopher Columbus in 1493. In 1934 a new hypothesis was put forward, that syphilis had previously existed in the Old World before Columbus.
Why was syphilis so feared?
From its beginning, syphilis was greatly feared by society – because of the repulsiveness of its symptoms, the pain and disfigurement that was endured, the severe after effects of the mercury treatment, but most of all, because it was transmitted and spread by an inescapable facet of human behaviour, sexual intercourse.
Where did the word "syphilis" come from?
The name for the disease, ‘syphilis’, originates from an epic Latin poem Syphilis, sive morbus gallicus, ‘Syphilis, or the French disease’ , published in 1530 by Girolamo Fracastoro (L. Hieronymus Fracastorius).
Who was the first physician to study syphilis?
In 1736 Jean Astruc , a French royal physician and professor of medicine at Montpellier and Paris, wrote one of the first great medical works on syphilis and venereal disease, De Morbus Veneris .
Who discovered syphilis?
In 1913 Joseph Waldron Moore and Hideyo Noguchi isolated the syphilis spirochaete Spirochaeta pallida, which had previously been discovered in 1905 by Fritz Schaudinn, from the brains of people who had died from a condition called “general paralysis of the insane”, establishing syphilis as the cause of this condition.
Did syphilis increase in the Vietnam War?
During each of the World Wars, the Korean war and the Vietnam War, the incidence of syphilis, and STD’s in general, rose sharply but only briefly. After 1943 and with the advent of penicillin and institution of public health measures, its incidence declined again, although in past decades it has slowly increased. [9]
How does syphilis spread?
Syphilis is spread through direct contact with the sores of an infected person. This usually happens through sexual activity, especially unprotected sex. It can also spread through sharing needles or contact with the blood of an infected person .
How to treat syphilis?
Antibiotics help treat the bacteria that caused your syphilis. Take your medicine as directed. Contact your healthcare provider if you think your medicine is not helping or if you have side effects. Tell him of her if you are allergic to any medicine. Keep a list of the medicines, vitamins, and herbs you take.
How long does it take for syphilis to get better?
This happens as the antibiotic starts to kill the bacteria that caused your syphilis. These symptoms usually get better in 1 or 2 days. Drink plenty of liquids and rest during this time.
Can acetaminophen cause liver damage?
Acetaminophen can cause liver damage if not taken correctly. Do not use more than 4 grams (4,000 milligrams) total of acetaminophen in one day. NSAIDs , such as ibuprofen, help decrease swelling, pain, and fever. This medicine is available with or without a doctor's order.
Does acetaminophen help with fever?
Acetaminophen decreases pain and fever. It is available without a doctor's order. Ask how much to take and how often to take it. Follow directions. Read the labels of all other medicines you are using to see if they also contain acetaminophen, or ask your doctor or pharmacist.
Do syphilis symptoms go away?
You are pregnant and think you have syphilis. You have a new rash, sore throat, or swollen joint. Your symptoms do not go away after treatment, or they come back. You have questions or concerns about your condition or care.

Nontreponemal Tests and Traditional Algorithm
Treponemal Tests and Reverse Sequence Algorithm
Cerebrospinal Fluid Evaluation
Diagnosis
Specialist to consult
Treatment
Clinical Trials
- The majority of patients who have reactive treponemal tests will have reactive tests for the remainder of their lives, regardless of adequate treatment or disease activity. However, 15%–25% of patients treated during the primary stage revert to being serologically nonreactive after 2–3 years (570). Treponemal antibody titers do not predict treatmen...
Coping and Support
- Further testing with CSF evaluation is warranted for persons with clinical signs of neurosyphilis (e.g., cranial nerve dysfunction, meningitis, stroke, acute or chronic altered mental status, or loss of vibration sense). All patients with ocular symptoms and reactive syphilis serology need a full ocular examination, including cranial nerve evaluation. If cranial nerve dysfunction is present, a …
Preparing For Your Appointment
- Tests
Syphilis can be diagnosed by testing samples of: 1. Blood.Blood tests can confirm the presence of antibodies that the body produces to fight infection. The antibodies to the syphilis-causing bacteria remain in your body for years, so the test can be used to determine a current or past inf…