For what purpose azelastine is used?
Azelastine nasal spray is used to help relieve symptoms (eg, stuffy or runny nose, itching, sneezing) of seasonal (short-term) or perennial (year-round) allergic rhinitis (hay fever), vasomotor rhinitis, or other upper respiratory allergies.
What is the mechanism of action of azelastine?
Azelastine antagonizes the actions of histamine, resulting in the relief of histamine-mediated allergy symptoms. Onset of action occurs within 15 minutes with intranasal formulations and as quickly as 3 minutes with ophthalmic solutions.
Does azelastine cause sedation?
This medicine may cause some people to become dizzy, drowsy, or less alert than they are normally. Even if used at bedtime, it may cause some people to feel drowsy or less alert on arising.
How long does it take for azelastine to start working?
A rapid onset of action within 15 minutes, as shown with azelastine nasal spray, may enhance compliance with therapy. Onset of action of azelastine hydrochloride nasal spray in relieving nasal symptoms of seasonal allergic rhinitis.
Is azelastine a mast cell stabilizer?
Azelastine, a member of this newest generation, has multiple effects as an antihistamine, mast cell stabilizer, and inhibitor of inflammatory mediators. Azelastine was first approved in 1996 as a nasal spray to treat symptoms of seasonal allergic disease and in 1999 for nonallergic vasomotor rhinitis.
Is azelastine an anti inflammatory?
Azelastine demonstrated anti-inflammatory effects in laboratory animals and in clinical studies in patients with seasonal allergic rhinitis including significant reductions in inflammatory cell migration, mediator lev- els, and intercellular adhesion molecule-1 expression.
What is azelastine side effects?
A bitter taste in the mouth, drowsiness, tiredness, nasal discomfort, sneezing fits, cough, nose bleeds, runny nose, dry mouth, headache, or red eyes may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Does azelastine affect sleep?
Drowsiness warning Azelastine nasal spray causes drowsiness. Don't drive, use machinery, or do other dangerous activities until you know how azelastine affects you. Also, don't drink alcohol or take other medications that may make you feel drowsy while using this drug. It may make your drowsiness worse.
Can azelastine cause rapid heartbeat?
Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue. breathing problems. fast heartbeat.
Can you use azelastine long term?
No unwanted effects were reported by patients continuing treatment. In addition, results of nasal biopsies indicate that with the dose used azelastine nasal spray is a safe drug for long-term treatment of perennial allergic rhinitis.
When should I take azelastine?
Adults and children 12 years of age and older—2 sprays in each nostril once a day or 1 or 2 sprays in each nostril 2 times a day (every 12 hours). Do not use more than 4 sprays in each nostril per day (24 hour period).
Can azelastine cause weight gain?
68 male alleges 10 pound weight gain over 8 week period after being started on nasal steroid (fluticasone propionate) and nasal H1-receptor antagonist (azelastine hydrochloride), not the combination preparation, without any dietary or medical changes.
What is Zytiga used for?
Prostate cancer that has metastasized (spread to other parts of the body). It is used: In patients whose disease is castration resistant ( has not responded to treatments that lower testosterone levels). This use is approved for the Zytiga brand name of abiraterone acetate.
Why are drugs studied?
Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.
Is abiraterone acetate approved for Zytiga?
In patients whose disease is high-risk and castration sensitive (has responded to treatments that lower testosterone levels). This use is approved for the Zytiga brand name of abiraterone acetate. Abiraterone is also being studied in the treatment of other types of cancer.
Is abiraterone acetate methylprednisolone?
This use is approved for the Zytiga brand name of abiraterone acetate. With methylprednisolone in patients whose disease is castration resistant. This use is approved for the Yonsa brand name of abiraterone acetate. In patients whose disease is high-risk and castration sensitive (has responded to treatments that lower testosterone levels).
Is a syringe a substitute for medical advice?
It is not a substitute for medical advice. The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. Please see your health care professional for more information about your specific medical condition and the use of this drug.
Why do we give steroids?
The length and strength of a steroid prescription depends on the situation. If you’re gasping for air due to asthma or COPD, we’ll give very high-dose steroids because your lungs and the airways are inflamed. Struggling to breathe can be life-threatening, so we want to bring that down quickly with that high dose.
What are the natural parts of the body?
Steroids are a natural part of your body. They’re hormones that help regulate your body’s reaction to infection or injury, the speed of your metabolism and more. In medicine, we can use artificial steroids called corticosteroids to help break fevers, bring down inflammation and reduce pain. Available as pills, creams and injections, manufactured ...
Can steroid pills make you sleepy?
Most commonly, they can make you feel more active, or even euphoric. If you end up taking your steroid dose later in the day, they can keep you awake at night and impact your sleep/wake cycle. Steroids can also cause confusion, especially in older patients and when given in high doses for long periods.
Do steroids help with fatigue?
In addition, MD Anderson research has shown that steroids can help ease cancer-related fatigue, which is different from the tiredness you may feel after a long day. Typically, your energy level is much lower than it was previously, and you can't really pinpoint one cause.
Is steroid therapy a part of cancer treatment?
But steroids have been a part of cancer care for decades. We’re very aware of the effects related to these drugs, and we know how to manage them. As with all medications, your medical team always considers the risks versus the benefits of including a steroid as a part of your cancer care.
Can steroids cause pain?
Inflammation is your body naturally responding to an event, whether it is trying to heal a wound or fight an infection. Both of those are good things, but they can sometimes cause pain. Steroids can help bring down inflammation and in turn can help manage pain. In cancer treatment, steroids have multiple roles.
Does a syringe help with nausea?
Second, they’re very effective at bringing down nausea and vomiting related to chemotherapy.
Use in Cancer
Dexamethasone is approved to be used to reduce inflammation and suppress (lower) the body's immune response.
More About Dexamethasone
Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug.
Clinical Trials Accepting Patients
Find Clinical Trials for Dexamethasone - Check for trials from NCI's list of cancer clinical trials now accepting patients.
How is radiation given?
Radiation therapy can be given in 3 ways: 1 External radiation (or external beam radiation): uses a machine that directs high-energy rays from outside the body into the tumor. It’s done during outpatient visits to a hospital or treatment center. It's usually given over many weeks and sometimes will be given twice a day for several weeks. A person receiving external radiation is not radioactive and does not have to follow special safety precautions at home. 2 Internal radiation: Internal radiation is also called brachytherapy. A radioactive source is put inside the body into or near the tumor. With some types of brachytherapy, radiation might be placed and left in the body to work. Sometimes it is placed in the body for a period of time and then removed. This is decided based on the type of cancer. Special safety precautions are needed for this type of radiation for a period of time. But it's important to know if the internal radiation is left in the body, after a while it eventually is no longer radioactive. 3 Systemic radiation: Radioactive drugs given by mouth or put into a vein are used to treat certain types of cancer. These drugs then travel throughout the body. You might have to follow special precautions at home for a period of time after these drugs are given.
What doctor is trained to treat cancer?
Radiation oncologist: This doctor is specially trained to treat cancer with radiation. This person oversees your radiation treatment plan. Radiation physicist: This is the person who makes sure the radiation equipment is working as it should and that it gives you the exact dose prescribed by your radiation oncologist.
What is the treatment for cancer that has returned?
To treat cancer that has returned (recurred) If a person's cancer has returned (recurred), radiation might be used to treat the cancer or to treat symptoms caused by advanced cancer. Whether radiation will be used after recurrence depends on many factors.
How does radiation help cancer cells?
But cancer cells grow and divide faster than most normal cells. Radiation works by making small breaks in the DNA inside cells. These breaks keep cancer cells from growing and dividing and cause them to die.
Why do people get radiation to their head?
This is done to help prevent cancer from spreading to the head even before it can.
How does cancer spread?
Cancer can spread from where it started to other body parts. Doctors often assume that a few cancer cells might already have spread even when they can’t be seen on imaging scans like CT scans or MRIs. In some cases, the area where the cancer most often spreads to may be treated with radiation to kill any cancer cells before they grow into tumors. For instance, people with certain kinds of lung cancer may get radiation to the head, even when there is no cancer known to be there, because their type of lung cancer often spreads to the brain. This is done to help prevent cancer from spreading to the head even before it can. Sometimes, radiation to prevent future cancer can be given at the same time that radiation is given to treat existing cancer, especially if the area the cancer might spread to is close to the tumor itself.
How many people with cancer get radiation?
More than half of people with cancer get radiation therapy. Sometimes, radiation therapy is the only cancer treatment needed and sometimes it's used with other types of treatment. The decision to use radiation therapy depends on the type and stage of cancer, and other health problems a patient might have.
What is intraoperative radiation therapy?
During surgery, so that it goes straight to the cancer without passing through the skin. Radiation therapy used this way is called intraoperative radiation.
How does radiation help cancer?
When radiation is combined with surgery, it can be given: 1 Before surgery, to shrink the size of the cancer so it can be removed by surgery and be less likely to return. 2 During surgery, so that it goes straight to the cancer without passing through the skin. Radiation therapy used this way is called intraoperative radiation. With this technique, doctors can more easily protect nearby normal tissues from radiation. 3 After surgery to kill any cancer cells that remain.
What is brachytherapy with liquid source?
Learn more about brachytherapy. Internal radiation therapy with a liquid source is called systemic therapy. Systemic means that the treatment travels in the blood to tissues throughout your body, seeking out and killing cancer cells.
What is the best radiation treatment for thyroid cancer?
A systemic radiation therapy called radioactive iodine, or I-131, is most often used to treat certain types of thyroid cancer.
What is the treatment for cancer that has spread to the bone called?
Pain from cancer that has spread to the bone can be treated with systemic radiation therapy drugs called radiopharmaceuticals.
Why do people with cancer need radiation?
Why People with Cancer Receive Radiation Therapy. Radiation therapy is used to treat cancer and ease cancer symptoms . When used to treat cancer, radiation therapy can cure cancer, prevent it from returning, or stop or slow its growth. When treatments are used to ease symptoms, they are known as palliative treatments.
What is external beam radiation therapy?
External Beam Radiation Therapy. External beam radiation therapy comes from a machine that aims radiation at your cancer. The machine is large and may be noisy. It does not touch you, but can move around you, sending radiation to a part of your body from many directions.
What is the treatment for cancer called?
A different type of cancer treatment, called oncolytic virus therapy, is sometimes described as a type of cancer treatment vaccine. It uses an oncolytic virus, which is a virus that infects and breaks down cancer cells but does not harm normal cells. The first FDA-approved oncolytic virus therapy is talimogene laherparepvec (T-VEC, or Imlygic®).
How do cancer treatments work?
Treatment vaccines can help the immune system learn to recognize and react to these antigens and destroy cancer cells that contain them. Cancer treatment vaccines may be made in three main ways. They can be made from your own tumor cells. This means they are custom-made so that they cause an immune response against features ...
Why do cancer cells die?
As the virus makes more and more copies of itself, it causes cancer cells to burst and die. The dying cells release new viruses and other substances that can cause an immune response against cancer cells throughout the body.
What is cancer treatment?
Cancer treatment vaccines are a type of immunotherapy that treats cancer by strengthening the body’s natural defenses against the cancer. Unlike cancer prevention vaccines, cancer treatment vaccines are designed to be used in people who already have cancer—they work against cancer cells, not against something that causes cancer.
What is the cause of T-VEC?
T-VEC can cause: Tumor lysis syndrome. As tumor cells die, they break apart and release their contents into the blood. This causes a change in certain chemicals in the blood, which may cause damage to organs, including the kidneys, heart, and liver.
What is Sipuleucel T used for?
Sipuleucel-T is used to treat men with prostate cancer: That has spread to other parts of the body. Who have few or no symptoms. Whose cancer does not respond to hormone treatment. T-VEC is used to treat some patients with melanoma that returns after surgery and cannot be removed with more surgery.
What does it mean when your eyes hurt?
Pain, burning or tingling in a blister around the mouth, genitals, fingers, or ears. Eye pain, sensitivity, discharge from the eyes, and blurry vision. Weakness in the arms and legs. Extreme fatigue and drowsiness.
