Treatment FAQ

how does chemotherapy and radiation therapy act as a treatment for cancer?

by Dr. Lon Bins Published 3 years ago Updated 2 years ago
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How Radiation Therapy Works Against Cancer. At high doses, radiation therapy kills cancer cells or slows their growth by damaging their DNA. Cancer cells whose DNA is damaged beyond repair stop dividing or die. When the damaged cells die, they are broken down and removed by the body.

Chemotherapy and radiation therapy are both treatments for cancer – the uncontrolled growth and spread of cells to surrounding tissues. Chemotherapy, or “chemo,” uses special drugs to shrink or kill cancer cells. Radiation therapy, or “radiation,” kills these cells with high-energy beams such as X-rays or protons.Jun 23, 2020

Full Answer

Can radiation and chemotherapy be used together to treat cancer?

For some types of cancer, radiation and chemotherapy or other types of anti-cancer drugs might be used together. Certain drugs (called radiosensitizers) help radiation work better by making cancer cells more sensitive to radiation.

What is the role of radiation therapy in cancer treatment?

Radiation therapy remains an important component of cancer treatment with approximately 50% of all cancer patients receiving radiation therapy during their course of illness; it contributes towards 40% of curative treatment for cancer. The main goal of radiation therapy is to deprive cancer cells of their multiplication (cell division) potential.

What is chemotherapy for cancer treatment?

Chemo is used to shrink tumors and/or stop the cancer from growing and spreading. This can help the person with cancer feel better and live longer. In many cases, the cancer doesn’t completely go away, but is controlled and managed as a chronic disease, much like heart disease or diabetes.

What is the difference between chemo and radiation?

Chemotherapy and radiation are two of the most common types of cancer treatments. Whether you receive chemo or radiation will depend on the type and location of your cancer, as well as your overall health status. The major difference between chemo and radiation is the way they’re delivered.

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How does radiation and chemo work together?

In the treatment called chemo-radiation, you will get both chemotherapy and radiation at the same time. Chemotherapy weakens the cancer cells which helps radiation to work better. Your treatment team consists of your medical oncologist and your radiation oncologist.

How does radiation help to treat cancer How does chemotherapy help to treat cancer?

Your cells normally grow and divide to form new cells. But cancer cells grow and divide faster than most normal cells. Radiation works by making small breaks in the DNA inside cells. These breaks keep cancer cells from growing and dividing and cause them to die.

Why would radiation be used as a treatment with chemotherapy?

Radiation therapy involves giving high doses of radiation beams directly into a tumor. The radiation beams change the DNA makeup of the tumor, causing it to shrink or die. This type of cancer treatment has fewer side effects than chemotherapy since it only targets one area of the body.

Can radiation and chemotherapy cure cancer?

Doctors use radiation and chemotherapy to destroy cancer cells. About half of patients are cured -- that is, all of their tumor cells die. The other half of the time, some tumor cells survive treatment.

How does chemotherapy work for cancer?

Chemotherapy damages the genes inside the nucleus of cells. Some drugs damage cells at the point of splitting. Some damage the cells while they're making copies of all their genes before they split. Chemotherapy is much less likely to damage cells that are at rest, such as most normal cells.

How effective is radiation therapy for cancer?

Despite the side effects, radiotherapy can be a highly effective treatment for cancer. 4 out of every 10 cancer cures include radiotherapy as part of the treatment plan.

What is radiation therapy used for?

Radiation therapy (also called radiotherapy) is a cancer treatment that uses high doses of radiation to kill cancer cells and shrink tumors. At low doses, radiation is used in x-rays to see inside your body, as with x-rays of your teeth or broken bones.

What does chemotherapy use?

Chemotherapy is a drug treatment that uses powerful chemicals to kill fast-growing cells in your body. Chemotherapy is most often used to treat cancer, since cancer cells grow and multiply much more quickly than most cells in the body. Many different chemotherapy drugs are available.

Why would radiation therapy be recommended?

Beams of radiation are precisely aimed at the cancer using a machine that moves around your body. Radiation therapy is a type of cancer treatment that uses beams of intense energy to kill cancer cells. Radiation therapy most often uses X-rays, but protons or other types of energy also can be used.

What Is Radiation Therapy?

Radiation therapy uses high-energy particles or waves, such as x-rays, gamma rays, electron beams, or protons, to destroy or damage cancer cells.Yo...

Who Gets Radiation Therapy?

More than half of people with cancer get radiation therapy. Sometimes, radiation therapy is the only cancer treatment needed.

What Are The Goals of Radiation Therapy?

Most types of radiation therapy don’t reach all parts of the body, which means they’re not helpful in treating cancer that has spread to many place...

How Is Radiation Therapy given?

Radiation therapy can be given in 3 ways: 1. External radiation (or external beam radiation): uses a machine that directs high-energy rays from out...

Who Gives Radiation Therapy Treatments?

During your radiation therapy, a team of highly trained medical professionals will care for you. Your team may include these people: 1. Radiation o...

Does Radiation Therapy Cause Cancer?

It has long been known that radiation therapy can slightly raise the risk of getting another cancer. It’s one of the possible side effects of treat...

Does Radiation Therapy Affect Pregnancy Or Fertility?

Women: It’s important not to become pregnant while getting radiation – it can harm the growing baby. If there’s a chance you might become pregnant,...

Questions to Ask About Radiation Therapy

Before treatment, you’ll be asked to sign a consent form saying that your doctor has explained how radiation therapy may help, the possible risks,...

Will I Be Radioactive During Or After External Radiation Treatment?

External radiation therapy affects cells in your body only for a moment. Because there’s no radiation source in your body, you are not radioactive...

How does radiation help cancer cells?

But cancer cells grow and divide faster than most normal cells. Radiation works by making small breaks in the DNA inside cells. These breaks keep cancer cells from growing and dividing and cause them to die.

What is the best treatment for cancer?

Radiation may be used by itself in these cases to make the cancer shrink or completely go away. In some cases, chemotherapy or other anti-cancer drugs may be given first. For other cancers, radiation may be used before surgery to shrink the tumor ...

How is radiation given?

Radiation therapy can be given in 3 ways: 1 External radiation (or external beam radiation): uses a machine that directs high-energy rays from outside the body into the tumor. It’s done during outpatient visits to a hospital or treatment center. It's usually given over many weeks and sometimes will be given twice a day for several weeks. A person receiving external radiation is not radioactive and does not have to follow special safety precautions at home. 2 Internal radiation: Internal radiation is also called brachytherapy. A radioactive source is put inside the body into or near the tumor. With some types of brachytherapy, radiation might be placed and left in the body to work. Sometimes it is placed in the body for a period of time and then removed. This is decided based on the type of cancer. Special safety precautions are needed for this type of radiation for a period of time. But it's important to know if the internal radiation is left in the body, after a while it eventually is no longer radioactive. 3 Systemic radiation: Radioactive drugs given by mouth or put into a vein are used to treat certain types of cancer. These drugs then travel throughout the body. You might have to follow special precautions at home for a period of time after these drugs are given.

What doctor is trained to treat cancer?

Radiation oncologist: This doctor is specially trained to treat cancer with radiation. This person oversees your radiation treatment plan. Radiation physicist: This is the person who makes sure the radiation equipment is working as it should and that it gives you the exact dose prescribed by your radiation oncologist.

What is the treatment for cancer that has returned?

To treat cancer that has returned (recurred) If a person's cancer has returned (recurred), radiation might be used to treat the cancer or to treat symptoms caused by advanced cancer. Whether radiation will be used after recurrence depends on many factors.

Why do people get radiation to their head?

This is done to help prevent cancer from spreading to the head even before it can.

How does cancer spread?

Cancer can spread from where it started to other body parts. Doctors often assume that a few cancer cells might already have spread even when they can’t be seen on imaging scans like CT scans or MRIs. In some cases, the area where the cancer most often spreads to may be treated with radiation to kill any cancer cells before they grow into tumors. For instance, people with certain kinds of lung cancer may get radiation to the head, even when there is no cancer known to be there, because their type of lung cancer often spreads to the brain. This is done to help prevent cancer from spreading to the head even before it can. Sometimes, radiation to prevent future cancer can be given at the same time that radiation is given to treat existing cancer, especially if the area the cancer might spread to is close to the tumor itself.

Learn more about each treatment, their differences, side effects, and more

Jennifer Welsh is a Connecticut-based science writer and editor with over ten years of experience under her belt. She’s previously worked and written for WIRED Science, The Scientist, Discover Magazine, LiveScience, and Business Insider.

What Is Chemotherapy?

One of the oldest treatments for cancer is chemotherapy, in which drugs are given through an intravenous (IV) injection or orally. Chemotherapy can have effects system-wide, which means it impacts your whole body. 1

What Is Radiation?

Radiation is a high-energy invisible light wave. Because it has a lot of energy, it can be directed at cancer cells to damage their genetic material, ultimately killing them. 2

Benefits and Risks of Chemotherapy

Chemotherapy is an essential treatment option for many cancers. The drugs used in chemotherapy are often given so that they can reach and kill cancer cells system-wide, outside of the primary tumor your doctor may have discovered.

Which Is Harder on the Body: Chemo or Radiation?

It is difficult to say what cancer therapy will be more difficult for your body to handle. Different types and dosages of both chemotherapy and radiation will have different effects.

Can Chemo and Radiation Be Used Together to Treat Cancer?

Some cancers can be treated with just radiation. These are most often cancers caught early—before they've grown large or started to spread.

Managing the Side Effects of Cancer Treatment

Many of the side effects of cancer treatment can be effectively managed or lessened. Palliative care (treatment to reduce the burden of symptoms) is an important part of any cancer treatment plan.

What is the goal of chemo?

The goal of chemotherapy is to slow or stop cancer growth and prevent it from spreading to other areas of the body via metastasis. There are various types of chemotherapy, each working slightly differently.

What to expect from chemotherapy and radiation?

What to expect. Summary. Chemotherapy and radiation therapy are cancer treatments. They use different approaches to shrink tumors, kill cancer cells, and prevent cancer from spreading. A cancer diagnosis can be life changing. Individuals with the condition may need to consider treatment options, including chemotherapy and radiation.

What is systemic radiation?

Systemic radiation: An IV infusion or medication delivers radiation throughout the patient’s body. With some early-stage cancers, radiation may be the first line of defense to prevent the disease from spreading. For other cancers, doctors may use radiation to shrink the tumor before surgery.

What is the definition of chemo?

The definition of chemotherapy. Doctors prescribe chemotherapy as the first line of treatment for a wide range of cancers. However, they may also use the term “chemotherapy” to refer to any medication to treat a disease. , a large group of drugs that can slow or stop the growth of cells.

Does radiation help with endometrial cancer?

A 2019 study tested the combination of radiation and chemotherapy for stage 3 or 4 endometrial cancer. Compared to chemotherapy alone, the addition of radiation did not increase the time between remission and relapse. The right treatment depends on many factors.

Can radiation therapy be combined with chemotherapy?

Healthcare professionals may combine radiation with chemotherapy to increase its effectiveness. Radiation therapy falls into three broad categories: External radiation: A doctor directs radiation from outside the body to target the tumor. Internal radiation: Healthcare professionals place a radiation source inside the body to attack tumor cells.

Can radiation damage cancerous cells?

and radiation damage both healthy cells and cancerous cells, the side effects are similar. Some of the most common side effects include: These side effects may be worse when someone has radiation and chemotherapy at the same time. People may experience other side effects depending on the specific drug or treatment area.

What is the treatment for cancer?

Cancer Treatment: Radiation Therapy Versus Chemotherapy. Cancer can be an ugly disease and take its toll on anyone’s body. If your oncologist recently gave you a diagnosis, you want to know what your outlook is and how you can conquer the illness.

What is skin cancer?

In oncology, skin cancer is known as one of the most common types of cancer in the U.S. This article provides answers to common questions that people often have about the disease.Like many cancers, skin cancer develops due to irrepressible multiplication of damaged cells. Skin cell damage is often caused by exposure to ultraviolet (UV)…

Can you be scared of cancer?

You may feel scared or nervous about your recent diagnosis. However, your oncologist can help you get the right treatment and feel more at ease. Radiation and chemotherapy both produce side effects. However, each can be effective at eliminating the cancer from your body. Make an appointment with your oncologist today so you can start the process of revitalizing your health.

Can cancer be overwhelming?

Cancer treatments can be overwhelming to patients and the people surrounding them. Many families battle cancer every day. Some of them are new to this fight. The stress from cancer treatments often makes treatments seem unclear. Communicating with your doctor can help remove this confusion. If you want to find out more about the types…

Can radiation and chemotherapy be used together?

Sometimes, the oncologist will use the two treatments together. While chemotherapy aims to keep the disease from spreading , radiation focuses on particular cells. Chemotherapy can also affect the entire body, while radiation repairs only the affected cells. Both treatments can cause side effects, including hair loss, nausea and fatigue.

How does radiation help cancer?

When radiation is combined with surgery, it can be given: 1 Before surgery, to shrink the size of the cancer so it can be removed by surgery and be less likely to return. 2 During surgery, so that it goes straight to the cancer without passing through the skin. Radiation therapy used this way is called intraoperative radiation. With this technique, doctors can more easily protect nearby normal tissues from radiation. 3 After surgery to kill any cancer cells that remain.

Why do people with cancer need radiation?

Why People with Cancer Receive Radiation Therapy. Radiation therapy is used to treat cancer and ease cancer symptoms . When used to treat cancer, radiation therapy can cure cancer, prevent it from returning, or stop or slow its growth. When treatments are used to ease symptoms, they are known as palliative treatments.

What is intraoperative radiation therapy?

During surgery, so that it goes straight to the cancer without passing through the skin. Radiation therapy used this way is called intraoperative radiation.

What is brachytherapy with liquid source?

Learn more about brachytherapy. Internal radiation therapy with a liquid source is called systemic therapy. Systemic means that the treatment travels in the blood to tissues throughout your body, seeking out and killing cancer cells.

What is the best radiation treatment for thyroid cancer?

A systemic radiation therapy called radioactive iodine, or I-131, is most often used to treat certain types of thyroid cancer.

What is the treatment for cancer that has spread to the bone called?

Pain from cancer that has spread to the bone can be treated with systemic radiation therapy drugs called radiopharmaceuticals.

What is external beam radiation therapy?

External Beam Radiation Therapy. External beam radiation therapy comes from a machine that aims radiation at your cancer. The machine is large and may be noisy. It does not touch you, but can move around you, sending radiation to a part of your body from many directions.

How is chemotherapy given?

Chemotherapy is a medication given to treat cancer that’s designed to kill cancer cells. It’s usually taken by mouth or given through an infusion into a vein or medication port. There are many different types of chemotherapy drugs.

What is the radiation used to treat a tumor?

External beam radiation. This method uses beams of radiation from a machine that focuses directly on the site of your tumor. Internal radiation. Also called brachytherapy, this method uses radiation (either liquid or solid) that’s placed inside your body near where the tumor is.

How does radiation therapy work?

Radiation therapy involves giving high doses of radiation beams directly into a tumor. The radiation beams change the DNA makeup of the tumor, causing it to shrink or die. This type of cancer treatment has fewer side effects than chemotherapy since it only targets one area of the body.

How is chemo delivered?

Chemotherapy is delivered through an infusion into a vein or medication port, or it can be taken orally.

How does chemo work?

How chemotherapy works. Chemotherapy medications are designed to destroy cells in the body that divide rapidly — specifically, cancer cells. However, there are cells in other parts of your body that also divide rapidly but aren’t cancer cells. Examples include the cells in your:

How to deal with side effects of cancer?

Here are some tips to cope with the side effects of cancer treatments: Ask your doctor about medications you can take to treat nausea and vomiting. Place an alcohol pad on the bridge of your nose if you’re experiencing nausea. Eat popsicles to ease the pain from mouth sores.

What is the best treatment for cancer?

However, there are many treatment options that work to fight off cancer cells and prevent them from spreading. Chemotherapy and radiation are among the most effective treatments for most types of cancer. Although they have the same goals, there are key differences between the two types ...

What type of radiation is used to treat cancer?

Types of radiation used to treat cancer: photons radiation (x-rays and gamma rays), which are widely used. Photon beams carry a low radiation charge and have a much lower mass. X-rays and gamma rays are routinely used photons in radiation therapy to treat various cancers.

What is the goal of radiation therapy?

The main goal of radiation therapy is to deprive cancer cells of their multiplication potential and eventually kill the cancer cells. Cancer cells whose DNA is damaged beyond repair stop dividing and die. However, the mechanism of cell death response to irradiation is complex.

What organelles are sequestered in radiation?

It is characterized by the formation of double-membrane vacuoles in the cytoplasm, which sequester organelles such as condensed nuclear chromatin and ribosomes 49, 50. Various genes and intracellular pathways have been reported to be involved in the different types of radiation induced cell death.

What is the role of mitochondria in apoptosis?

Apoptosis is characterized by cell shrinkage and formation of apoptotic bodies. Mitochondria play a major role for the apoptotic cell death 41. Blebbing of cell membrane is often seen with condensed chromatin with nuclear margination and with DNA fragmentation.

What is autophagy in cancer?

Autophagy:Autophagy is a more recent phenomenon described. It is a form of cancer cell death in response to radiation. Autophagy is a genetically regulated form of programmed cell death in which the cell digests itself that involves autophagic/lysosomal compartment.

What is the biological target of radiation?

The biological target of radiation in the cell is DNA. Extensive damage to cancer cells DNA can lead to cell death. DNA double-strand breaks (DSBs) are more responsible for most cells killing, even a single DSB is sufficient to kill a cell or disturb its genomic integrity by the radiation treatment.

What are the hallmarks of cancer?

Hanahan and Weinberg 4have identified six cancer cell phenotypes or hallmarks of cancer: cells with unlimited proliferative potential, environmental independence for growth, evasion of apoptosis, angiogenesis, invasion and metastasis to different parts of body.

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