
- Methotrexate (Trexall). One of the most commonly used medications to treat rheumatoid arthritis, methotrexate should be stopped three months before trying to get pregnant. ...
- Leflunomide (Arava). ...
- Biologic response modifiers.
Medication
Expect Improvement in Rheumatoid Arthritis Symptoms During Pregnancy. Interestingly, pregnancy usually has a positive effect on rheumatoid arthritis symptoms, albeit temporary. About 70% to 80% of women experience improvement in their RA symptoms during pregnancy.
Procedures
If the drugs you were taking at conception are controlling your disease, your doctor will likely have you continue them throughout pregnancy. RA’s effect on delivery: If arthritis affects your back or hips, you may notice more pain in those joints as your baby grows and places more stress on those joints.
Therapy
Up to date evidence-based solutions particularly focusing on the safe use of disease-modifying antirheumatic drugs and biologic response modifiers to assist rheumatologists in the care of pregnant and lactating women with RA are reviewed.
Self-care
The greatest change you may experience while you’re pregnant is in your treatment of RA. The reason: Some of the medication used to manage the condition are not safe to continue during pregnancy.
Nutrition
Does rheumatoid arthritis get better during pregnancy?
Can I take my arthritis medications while pregnant?
How can rheumatologists help pregnant and lactating women with Ra?
Can I have Ra during pregnancy?

How can I get pregnant with rheumatoid arthritis?
Although controversial studies have suggested that oral contraceptives might prevent rheumatoid arthritis in some women, there is no evidence that they help control symptoms....Until You're Ready to Get Pregnant, Use ContraceptionCondoms.Oral contraceptives.Vaginal ring.Intrauterine device (IUD)
Can rheumatoid arthritis affect your fertility?
Historically, it was believed that RA itself might affect fertility, or the body's ability to conceive. However, if RA disease activity is well controlled, there is no particular reason why most women with RA will not be able to fall pregnant and enjoy a successful pregnancy.
What rheumatoid arthritis drugs are safe during pregnancy?
Drugs that may be safely used during pregnancy include NSAIDs, corticosteroids, plus several DMARDs, including sulfasalazine and hydroxychloroquine. Drugs recommended to be stopped before pregnancy include methotrexate and leflunomide, plus the biologics: anti-TNF agents, rituximab and abatacept.
Can you take methotrexate while trying to conceive?
According to the FDA, males should stop taking methotrexate at least 3 months before getting a partner pregnant. Females should wait for at least one cycle of ovulation before trying to become pregnant.
How long should I be off methotrexate before getting pregnant?
Methotrexate can stay in the body for some time. The drug companies which make methotrexate recommend that women stop treatment with methotrexate at least six months before attempting to conceive.
Can pregnancy worsen rheumatoid arthritis?
Approximately 50% of pregnant women with RA have low disease activity, and 20% to 40% achieve remission by the third trimester; however, nearly 20% will have worse or moderate-to-high disease activity during pregnancy that may require further therapeutic intervention.
Can people with arthritis get pregnant?
Your arthritis is unlikely to affect your fertility, this is your ability to get pregnant. But fertility does decrease with age, so some women will need fertility treatments, such as egg boosting, intrauterine insemination (IUI) or in vitro fertilisation (IVF).
Can you have a baby with arthritis?
But the good news is that, armed with knowledge and a strong health care team, most women with inflammatory types of arthritis and related conditions can have healthy pregnancies.
What happens if you get pregnant after taking methotrexate?
Methotrexate isn't safe during pregnancy Using methotrexate while you're pregnant could end your pregnancy or cause severe birth defects. These birth defects could affect the way your child looks, develops, or functions for the rest of their life.
How soon did you get pregnant after methotrexate?
Owing to concerns about MTX and its metabolites remaining in some organs and possibly affecting pregnancy or fetal development, manufacturers and several sources have arbitrarily recommended that women wait 3 to 6 months to become pregnant after stopping therapy.
Does methotrexate affect female fertility?
MTX treatment is unlikely to have a major effect on short- or long-term fertility in men and women, but a washout period of 6 months cessation of treatment prior to conception is advisable to prevent the small chance of chromosomal abnormalities in offspring.
What is the best way to take care of a baby?
Caring for baby: Taking care of yourself now is especially important – take your medications, eat healthfully, nap when the baby naps and get help from your partner, trusted family and friends and even paid help, if needed or possible. Parenthood is a challenging, lifelong job, but may provide unique joys.
When does RA flare up?
If RA improved during pregnancy it may flare in the weeks or months after delivery as hormones and the immune system return to their pre-pregnancy state. Medication and breast feeding: If you had a reprieve from your RA during pregnancy you may be experiencing more joint pain now.
Is it safe to take DMARDs while pregnant?
However not all DMARDs are safe. Methotrexate, for example should be stopped at least three months before pregnancy because of its potential to cause birth defects. Other medications should be discussed with the rheumatologist, and the individual risks and benefits should be weighed.
Is a cesarean delivery more common in women with RA?
While Cesarean delivery doesn’t appear to be more common in women with RA, research shows that high disease activity during pregnancy increases the risk for pre-term, low birthweight babies and the need for a Cesarean delivery.
Can a woman have a baby with RA?
For most women with RA, a healthy delivery and baby is possible. Baby’s health: Having RA does not mean health problems for your baby – including RA. Inheritance isn’t 100 percent, says Dr. Birru Talabi. “That is, just because a woman has RA doesn’t mean her children will have RA.”. Disease activity.
Can rheumatoid arthritis cause preterm birth?
Women who have uncontrolled rheumatoid arthritis may be at increased risk of complications such as preterm birth and babies that are small for their gestational age. This may increase the likelihood that the baby requires more medical care early in life.
Can you have a flare after delivery?
Caring for new baby: There’s a possibility that you may experience a flare after delivery and experience a lot of fatigue . “So, it’s important that women who are considering a pregnancy also consider their support systems and make sure they are in place before they deliver,” says Dr. Birru Talabi.
Medications that slow the progression of rheumatoid arthritis
Medications that slow the progression of RA can help reduce your symptoms while preventing joint damage and disability. Options include:
Medications to reduce the inflammation and pain of rheumatoid arthritis
Many people with RA also take medications to help manage pain. You might take these medications temporarily, during a flare-up, or every day depending on your condition and the treatment plan you discuss with your doctor. Pain-relieving options include:
Physical therapy
A physical therapist can also provide pain relief through massages and muscle stimulation. They can teach you exercises to do at home that will build your strength and reduce your pain.
Occupational therapy
An occupational therapist can help you maintain your ability to do everyday tasks on your own. They can also recommend supports and devices to assist you and teach you how to use them. These can include:
Abstract
Rheumatoid arthritis, a chronic inflammatory autoimmune disease with significant physical disability, affects women three times more frequently than men, often in their childbearing years. Parenthood decisions can be challenging, often affected by perceptions of their disease state, health care needs, and complex pharmacological treatments.
Introduction
Rheumatoid arthritis (RA) is a lifelong, systemic autoimmune disease that affects women three times more frequently than men, often in their most productive and childbearing years. 1 Annual incidence of 8.7 per 100,000 between the ages of 18 and 34 years further increases to 36.2 per 100,000 between the ages of 35 and 44 years.
Woman of reproductive potential with RA, not currently planning a family
For all women diagnosed with RA, it is important to get a reproductive history. For patients with childbearing potential, the desire to start or extend their family while on treatment should be ascertained.
Woman with RA who wants to get pregnant
Multiple factors impact the ultimate number of children a woman with RA will have. When evaluating parity of women with inflammatory arthritis compared to controls using the Norwegian Population Registry, it was more likely for women with inflammatory arthritis to remain childless compared to controls.
Woman with RA who calls with positive pregnancy test
In the setting of a positive pregnancy test for a woman on treatment for RA, an individualized discussion for each medication should occur. Also, the possibility but uncertainty of improved disease activity over the course of pregnancy should be discussed. Certain medications will absolutely need to be discontinued, including MTX and LEF.
Woman with RA who is pregnant calls with flare
While fortunately some individuals have improvement in disease activity, not all patients will have improvement, and some will suffer flare during pregnancy. Corticosteroids are an initial first step in pregnancy, and when possible, intra-articular administration is indicated to limit systemic side effects.
Woman with RA who is considering breastfeeding
The decision about breastfeeding must be individualized to take into account the wishes of the mother, health benefits of breastfeeding, the disease activity of RA, and the associated need for medications ( Table 2 ).
How to prevent RA during pregnancy?
Even if your RA goes into remission during pregnancy, the added weight on your body puts more pressure on your joints. Make an effort not to gain more than your doctor recommends. Get your vitamins. You may need more calcium and vitamin D to help prevent the bone thinning that some RA drugs may cause.
What to eat when pregnant with RA?
This makes it especially important to make heart-healthy food choices during pregnancy. Experts recommend a low-fat diet that is high in carbohydrates and fiber. This means plenty of vegetables, fruits, and whole grains.
When do women get diagnosed with rheumatoid arthritis?
Many women with rheumatoid arthritis are diagnosed in their 20s and 30s, just when marriage and family start to take life's center stage. With pain, fatigue, and medication side effects to consider, there's no question that rheumatoid arthritis makes family planning more complicated. But it doesn't have to put your dreams out of reach.
How to get rid of RA after birth?
Exercise after giving birth. It can be hard to find the time and energy to exercise when you have a newborn, but doing so can help you keep a healthy weight, which is good for your joints. Exercise can also help ease joint stiffness and pain. Eat a heart -healthy diet. RA puts you at higher risk of heart disease.
Can rheumatoid arthritis hurt a baby?
Don't Worry That Rheumatoid Arthritis Could Hurt Your Baby. Rheumatoid arthritis itself doesn't seem to harm a developing baby, even if it’s active during pregnancy. In fact, 70% to 80% of women with RA have improved symptoms during pregnancy.
Can pregnancy affect rheumatoid arthritis?
Pregnancy usually has a positive effect on rheumatoid arthritis symptoms . There's even a chance your RA could go into remission while you're pregnant. If your RA symptoms ease during the first trimester, there's a good chance they’ll stay mild through the rest of your pregnancy.
Is there a cure for rheumatoid arthritis?
Know That the Future Looks Bright for Rheumatoid Arthritis Treatment. New biologic drugs for RA have created a new era of treatment for rheumatoid arthritis, according to rheumatologists. With early and aggressive treatment, most people with RA can avoid joint deformities and major disability.
What kind of medicine do you take for RA?
If you have rheumatoid arthritis (RA), your doctor may suggest you get an infusion treatment -- medicine that goes into your body through a needle they place in a vein. One type of medication that you may take as infusions are biologic drugs. Some also come as injections that you give yourself at home.
How to get an infusion?
To get an infusion, you'll need to go to a doctor's office or clinic. Biologic drugs bring down inflammation in your body to prevent joint damage. Your doctor might put you on one of these drugs if your symptoms haven't improved with a disease-modifying drug like methotrexate.
Can you take medicine before an infusion?
You may get medicine before your treatment to relax you if you're nervous. While the medicine goes in, you can read a book or watch a movie. Side Effects of Infusion Treatments. Infusions can cause mild reactions like: Pain, redness, or swelling of your skin where the needle goes in. Headache.
Can you give yourself shots with an infusion?
There are pros and cons to both methods. An infusion may be a better option if you don't like to give yourself shots and you don't want to take your medicine as often.
Rheumatoid Arthritis and Fertility
RA has been linked to infertility and difficulty in getting pregnant. One 2019 study showed that getting pregnant took more than 12 months in 42% of females with RA compared to 12% in the general population. 1
RA and Gestation
Your RA may be easier to manage during your pregnancy. Research has shown that disease activity improved in 60% of people with RA during pregnancy and flared in 46.7% postpartum. 4 This may be due to hormonal and immune system changes in pregnancy that protect the unborn baby and are also beneficial to pregnant people with RA. 3 5
Arthritis and Postpartum
After giving birth, arthritis symptoms can increase if they were in remission (times when symptoms become less intense) during pregnancy. Postpartum flare-ups are common for a variety of reasons, including:
Summary
Pregnancy can exacerbate the joint pain caused by any type of arthritis because of the increased strain on your body as your baby grows. Besides rheumatoid arthritis, other types of arthritis generally don't cause issues with fertility and development of the baby.
A Word From Verywell
Arthritis is a lifelong condition that can affect everyday life. Rheumatoid arthritis may impact fertility, but there are ways to successfully and safely get pregnant and give birth to a healthy child.
Frequently Asked Questions
Sometimes. Joint pain is common in pregnant people due to physical strain, increased weight gain, and the loosening of joints during pregnancy. While some people have lower disease activity during pregnancy, others may experience more severe symptoms, which can include worsening of pain in the knee.
What to do during labor and delivery?
During labor and delivery, it will be important to choose positions that don't put too much stress or strain on the affected joints. Talk to the physician who manages your arthritis — and your prenatal practitioner — about which positions might work best.
Can a new mom have a flare up after delivery?
However, it’s not uncommon for new moms to experience flare-ups during the first three months postpartum. A 2008 study of new moms with RA in the Netherlands found that 39 percent had at least one moderate flare-up after delivery. Doctors and researchers aren't exactly sure why your symptoms get better during pregnancy.
Can you take baby aspirin while pregnant?
Other medications, including aspirin (regular, not baby aspirin) and some non-steroidal anti-inflammatory drugs (NSAIDs), can be taken safely during some parts of pregnancy but not others. Herbal remedies should be avoided completely, unless okayed by your prenatal practitioner.
Can pregnancy affect RA?
Rheumatoid arthritis (a condition in which a person's immune response attacks healthy tissue and organs) isn't likely to affect your pregnancy very much, but pregnancy may affect your RA — often for the better.
Does pregnancy affect immune system?
Your immune system goes through a lot of changes when you're expecting, and pregnancy lowers your immune response to keep your body from rejecting the fetus as "foreign.". That may have the added benefit of tamping down your haywire immune system, which in turn lowers the inflammatory response that causes the pain of RA.
Can you take methotrexate while pregnant?
The reason: Some of the medication used to manage the condition are not safe to continue during pregnancy. You should discuss your RA medications with your primary care doctor or OB/GYN even before you become pregnant, since some medications (especially methotrexate) should be stopped before conception.
Can you improve your symptoms while pregnant?
Odds are also great that your symptoms will improve while you're expecting. Just be sure to get the proper medical care and supervision, and as always, bring up any questions or concerns you have with your practitioner as your pregnancy progresses.

Diagnosis
Treatment
Clinical Trials
Lifestyle and Home Remedies
Specialist to consult
Coping and Support
- Rheumatoid arthritis can be difficult to diagnose in its early stages because the early signs and symptoms mimic those of many other diseases. There is no one blood test or physical finding to confirm the diagnosis. During the physical exam, your doctor will check your joints for swelling, r…
Preparing For Your Appointment
- There is no cure for rheumatoid arthritis. But clinical studies indicate that remission of symptoms is more likely when treatment begins early with medications known as disease-modifying antirheumatic drugs (DMARDs).