how do histamine h2 antagonists help in the treatment of an ulcer quizlet

H 2 -antihistamines are widely used for the treatment of acid-peptic disease, including duodenal and gastric ulcers and gastroesophageal reflux disease

. H 2 -antihistamines bind to H 2 receptors of gastric parietal cells and reduce both stimulated and basal gastric acid production and secretion that is induced by histamine.

Full Answer

How do histamine H2 receptor antagonists work?

Jan 25, 2018 · OVERVIEW. The selective histamine type 2 receptor antagonists/blockers (H2 blockers) are widely used in the treatment of acid-peptic disease, including duodenal and gastric ulcers, gastroesophageal reflux disease and common heartburn. The four H2 blockers in current use are available by prescription as well as over-the-counter, and are some of the most widely …

What are histamine-2 receptor antagonists (H2RAs) used for in children?

How do histamine H2 antagonists help in the treatment of an ulcer? False. Antacids are not used in the treatment of peptic ulcer. ... Which adverse reaction would not be expected with the use of histamine H2 antagonist. False. ... Quizlet Live. Quizlet Learn. Diagrams. Flashcards. Mobile. Help. Sign up. Help Center.

What is the mechanism of action of H2 receptor blockers?

H 2 -antihistamines are widely used for the treatment of acid-peptic disease, including duodenal and gastric ulcers and gastroesophageal reflux disease. H 2 -antihistamines bind to H 2 receptors of gastric parietal cells and reduce both stimulated and basal gastric acid production and secretion that is induced by histamine.

Are H2 blockers effective for acid-peptic disease?

How do histamine (H2) blockers help heal gastric ulcers? a. They promote cell division. b. They neutralize acids that are present in the stomach. c. They decrease the amount of acid secreted by stomach cells. d. They increase the rate that stomach contents move into the intestinal tract.

How do H2 receptor antagonists interfere with the absorption of other drugs?

H2-receptor antagonists may interfere with the absorption of other drugs or themselves by altering gastric emptying, binding directly to another drug , or altering intragastric pH. Cimetidine has been reported to delay gastric emptying, whereas ranitidine and nizatidine accelerate it. Antacids and sucralfate bind to and inhibit the absorption of H2-receptor antagonists by 10–25%. Certain drugs that are weak bases, such as the antifungal medications ketoconazole and itraconazole, require an acid environment for optimal absorption. As the pH rises in response to H2-receptor antagonists, the absorption of these drugs decreases.

What receptor antagonists act on gastric parietal cells?

Mechanism of action. Histamine H 2 receptor antagonists act competitively with histamine at receptors on gastric parietal cells. They reduce basal acid secretion and pepsin production and prevent the increase in secretion that occurs in response to several secretory stimuli.

What is the peak plasma concentration of ranitidine?

Pharmacokinetic studies in children suggest that peak plasma ranitidine concentration occurs 2.5 hours after dosing with a half-life of 2 hours.

How long does ranitidine stay in your system?

Tachyphylaxis, or diminution of the response, to intravenous ranitidine and escape from its acid inhibitory effect have been observed after 6 weeks, and tolerance to oral H 2 RA in adults and children is well recognized. In general, H 2 RAs are considered safe.

Can Ranitidine cause thrombocytopenia?

Although thrombocytopenia may occur, it is often difficult to determine the sole cause in critically ill patients. Ranitidine should be avoided in patients with acute porphyria. Tachyphylaxis is well documented for intravenous and oral H 2 receptor blockers in adult and pediatric populations.

Is cipridine a chronic GERD medication?

2 Tolerance to the H 2 RA class of medications does develop in both children and adults. Thus, H 2 RAs are not ideal for chronic therapy for GERD in pediatric populations.

Does famotidine cause headaches?

Famotidine, the most commonly studied H 2 RA, has been shown to cause agitation and signs concerning for headaches in infants. 47 Other side effects include dizziness, constipation, anemia, and urticaria.

What are the intended responses for H2 blockers?

The intended responses for H2 blockers are: secretion of gastric acid is decreased, symptoms of GERD are decreased, and ulcers are healed and prevented. A patient who has been taking nizatidine (Axid) for the last month has all of the following blood laboratory results.

What causes ulcers in the stomach?

Research has shown that 80% to 90% of gastric ulcers are caused by infection with the Helicobacter pylori (H. pylori) bacteria. H. pylori infection is present in 20% to 30% of people in the United States. Some people experience no signs or symptoms, whereas others develop ulcers.

What is the purpose of sucralfate?

Sucralfate is a cryoprotective drug. These drugs form a thick coating that covers an ulcer to protect the open sore from further damage and allow healing to occur. Histamine blockers decrease secretion of gastric acids. Proton pump inhibitors block secretion of gastric acids.

What is the most common symptom of a peptic ulcer?

ANS: C. The most common symptom of a peptic ulcer is burning, gnawing pain caused by stomach acid coming into contact with the open wound (ulcer). It often occurs when the stomach is empty and can be relieved by eating foods that buffer stomach acids or by taking a drug that reduces stomach acid such as an antacid.

Why does the stomach secrete a thick gel-like mucus?

Because the acids can damage the stomach lining, the stomach secretes a thick gel-like mucus to protect it. Neither the esophagus nor the duodenum has this protection. Stomach contents that reflux up into the esophagus are highly acidic and cause inflammatory damage with ulcer formation to the lining.

How do proton pump inhibitors work?

Decreasing the stimulation of H2 receptors. ANS: C. Proton pump inhibitors (PPIs) work by completely blocking the production of stomach acid. These drugs block the action of "pumps" located in acid-secreting cells, which totally blocks stomach acid secretion.

Does smoking cause ulcers?

Neither dairy products nor exercise promote ulcer formation or delay or reduce healing.